TumorsCarcinoma of the lungNSCLCMetastasisTumorMetastaticCarcinomasNodulesMalignanciesHemoptysisSquamousColorectalPathologyMalignant melanomaCarcinoidsIdiopathicTumourEGFRPrecursorNeoplasmSarcomatoidNeuroendocrine carcinomaCancerClinicalPredominantNoduleMediastinalPrognosisAlterationsRenalLymphomaCasesGeneticInfectionPatientsCaseEntityDiseaseCommonCommonly
Tumors17
- In mice, traditional chemoradiotherapy concurrent with the injection of DEK-containing exosomes resulted in eradication of primary tumors together with formerly resistant CSCs without recurrence or metastasis. (bvsalud.org)
- Myoepithelial Carcinoma of the lung is a rare subset of primary salivary-type tumors, accounting for less than 1% in all lung tumors [ 1 ]. (biomedcentral.com)
- And compared to adenocarcinoma prostate tumors, tumors of the t-SCNC subtype are thought to have less hormone signaling and lower prostate-specific antigen . (healthyprostateclub.com)
- Primary malignant melanoma of the lung is extremely rare and only accounts for 0.01% of all primary lung tumors [ 1 ]. (biomedcentral.com)
- Pleomorphic adenoma was the most common in primary benign tumors group with 29 cases, Warthin tumors were in the second place with 14 cases. (selcukmedj.org)
- Adenoid cystic carcinoma, adenocarcinoma and expleomorphic adenoma were observed as primary malignant tumors. (selcukmedj.org)
- Fifteen of the 16 previous cases of primary renal SS were diagnosed using reverse-transcription polymerase chain reaction to detect the SYT-SSX gene fusion transcript caused by the t(X;18) translocation,2,3 whereas in the one remaining case a t(X;18) translocation was identified by cytogenetic analysis but no further karyotypic details were published.2 Therefore, the background cytogenetic profile of these tumors was unknown. (the-medical-dictionary.com)
- Pancoast tumors are a rare form of non-small cell lung cancer (NSCLC) that arise in the apex (top) of the lung, specifically in the superior pulmonary sulcus. (com.bd)
- Primary spinal primitive neuroectodermal tumors (PNETs) are very rare conditions. (sagepub.com)
- Meningiomas are the most frequently diagnosed of all primary brain tumors, including glioblastomas, and of all other central nervous system tumors. (amjcaserep.com)
- In lymphomas I have conducted studies in rare aggressive primary cutaneous tumors such as gamma/delta T cell lymphoma (expanding the description of the epidermotropic variant) as well as more indolent entities such as lymphomatoid papulosis (type D) and CD4-positive small to medium size T cell lymphoproliferative disorders. (mdanderson.org)
- The current TNM staging system is used for non-small cell lung cancer (NSCLC) and more recently neuroendocrine tumors including small cell lung cancer (SCLC), and provides a framework for the assessment of prognosis and the assignment of therapy for patients with a new diagnosis of lung cancer using the histopathologic evaluation of the primary tumor (T), lymph nodes (N), and metastatic disease (M). (sts.org)
- Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
- More and more evidences suggest that primary colon and rectum tumors should not be considered as a single disease entity. (oncotarget.com)
- Genomic instability (measured by fraction of genome altered, FGA) and proportion of clonal and subclonal mutations (measured by intratumoral heterogeneity (ITH) score) in primary and metastatic tumors were compared. (springernature.com)
- Meningioma comprises about one fourth of all primary tumors of the central nervous system (CNS). (medscape.com)
- It is the most common primary intracranial neoplasm and the most diversified in histologic patterns among all primary tumors of the CNS. (medscape.com)
Carcinoma of the lung3
- Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. (biomedcentral.com)
- Here we present a case of a 68-year-old patient with stage IVB primary myoepithelial carcinoma of the lung who harbored EGFR exon 19 deletion and KRAS mutation and underwent icotinib targeted therapy, achieving partial response (PR) with progression free survival (PFS) of 3 months. (biomedcentral.com)
- Herein we describe a case of a giant cell carcinoma of the lung with hypertrophic pulmonary osteoarthropathy as a paraneoplastic syndrome. (biomedcentral.com)
NSCLC5
- Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
- Analysis of rare fusions in NSCLC: Genomic architecture and clinical implications. (cdc.gov)
- Fusion between echinoderm microtubule-associated proteinlike 4 ( EML4 ) and ALK is seen in approximately 2-7% of patients with NSCLC adenocarcinomas. (medscape.com)
- Almost all of the pulmonary symptoms of NSCLC can be mimicked by a postobstructive pneumonia. (sts.org)
- This study aimed to analyze whether tumor response to immunotherapy differs between pulmonary lesions (PL) and LM in NSCLC and to explore potential mechanisms through multiomics analysis. (bmj.com)
Metastasis10
- The start of chemotherapy treatment usually requires a delay of about 4 weeks after surgical resection in patients with primary colorectal cancer and synchronous distant metastasis. (sagepub.com)
- Furthermore, extracranial metastatic meningioma remains extremely rare (0.1%), with the most common location for metastasis being the lung. (amjcaserep.com)
- Metastasis of lung cancer to the skin is uncommon, presenting in 0.22% to 12% of lung cancer patients, and it is extremely rare for skin metastasis to be the first clinical manifestation of lung cancer. (e-acfs.org)
- This prompted clinicians to consider skin metastasis of a pulmonary malignancy. (e-acfs.org)
- LCNEC mainly metastasizes to visceral organs, such as the liver, bone, and brain, and it only shows metastasis to the skin in very rare cases. (e-acfs.org)
- A previous study reported that skin metastasis, an uncommon clinical symptom of pulmonary malignancy, is found in 0.22% to 12% of patients with lung cancer [ 4 ]. (e-acfs.org)
- 5 ], 15 out of 16 patients with skin metastasis of pulmonary malignancy were grade 4 and exhibited metastases to other organs such as the bone, brain, lung, and liver, in addition to the skin. (e-acfs.org)
- The occurrence of skin metastasis as the initial presentation of lung cancer is extremely rare, and it suggests a poor prognosis. (e-acfs.org)
- There have been few reported cases of skin metastasis from pulmonary malignancy as the first presentation [ 4 , 6 , 7 ]. (e-acfs.org)
- Of these 33 patients, 14 had lymph node metastasis and three had multiple primary lesions of pure AC or SCC at diagnosis, which were surgically resected. (springernature.com)
Tumor7
- Tumor therapeutics often target the primary tumor bulk but fail to eradicate therapy-resistant cancer stem cells (CSCs) in quiescent state. (bvsalud.org)
- EGFR mutation is very common in lung adenocarcinoma, but it has not been reported in this tumor owing to the rarity of the disease and lack of attempts to characterize it molecularly. (biomedcentral.com)
- A dermatological examination and gallium scintigraphy were conducted to determine the primary tumor site, but no suspicious lesions, expect for the right lung mass, were found. (biomedcentral.com)
- Most previous cases of primary renal synovial sarcoma were confirmed by molecular biology techniques, which detected the SYT-SSX gene fusion transcript typical of this tumor, but no details of the other chromosomal anomalies have been published. (the-medical-dictionary.com)
- Giant cell cancer of the lung (GCCL) has been reported as a relatively rare malignant tumor with a poor prognosis. (biomedcentral.com)
- Rarely, a large or infiltrative tumor burden limits alveolar function (e.g., diffuse lepidic adenocarcinoma or lymphangitic carcinomatosis). (sts.org)
- Adrenal myelolipoma is a rare benign tumor originating from the adrenal cortex. (journalajrru.com)
Metastatic6
- The most common category of nonmesotheliomatous cancer to involve the pleura is represented by extrapleural primary malignancies that secondarily involve the pleura via metastatic spread. (medscape.com)
- Later, biopsy from the pulmonary nodules showed a metastatic meningioma. (amjcaserep.com)
- Herein, we report an unusual case of a metastatic skin lesion as the first sign of primary pulmonary LCNEC, in a 63-year-old woman with no pulmonary symptoms or personal history of smoking or pulmonary disease. (e-acfs.org)
- Build 300 cases breast cancer TMA containing primary tumour and matched metastatic LN for various subtypes (luminal, HER2, Triple negative). (biobanking.org)
- Previous studies had generated insight into metastatic patterns and showed that different primary cancers tended to metastasize with different frequencies and to different sites [ 4 , 5 ]. (oncotarget.com)
- Although pulmonary carcinoids show relatively good prognosis in comparison to carcinomas, metastatic disease and relapse do occur. (who.int)
Carcinomas5
- Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. (medlineplus.gov)
- Exploring the molecular features and genetic prognostic factors of pulmonary high-grade neuroendocrine carcinomas. (cdc.gov)
- Vast majority of them are squamous cell carcinomas (SCC) which include conventional, verrucous, and spindle cell (sarcomatoid) subtypes. (webpathology.com)
- Background Microsatellite lack of stability (MSI) resulting from inactivation of the DNA mismatch fix program (MMR) characterizes a highly immunological subtype of colorectal carcinomas. (immune-source.com)
- Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
Nodules6
- Computed tomography (CT) revealed multiple nodules and blockage of the pulmonary artery. (sagepub.com)
- During her course of management, she was found to have progressive pulmonary nodules. (amjcaserep.com)
- Is the combination of bilateral pulmonary nodules and mosaic attenuation on chest CT specific for DIPNECH? (biomedcentral.com)
- On chest CT, DIPNECH exhibits bilateral pulmonary nodules and mosaic attenuation in most patients. (biomedcentral.com)
- We searched the Mayo Clinic records from 2015 to 2019 for patients with bilateral pulmonary nodules and mosaic attenuation on CT who had a diagnostic lung biopsy. (biomedcentral.com)
- Various disorders can manifest the CT pattern of bilateral pulmonary nodules together with mosaic attenuation, and this combination is nonspecific for DIPNECH, which was found in only 10% of our cohort. (biomedcentral.com)
Malignancies2
- Hypertrophic pulmonary osteoarthritis may occur as a secondary manifestation of lung malignancies. (biomedcentral.com)
- Other primary anal malignancies are rarer and include basal cell carcinoma, primary anal adenocarcinoma, Paget disease (primary and secondary), neuroendocrine carcinoma, and malignant melanoma. (webpathology.com)
Hemoptysis1
- The aggressive nature of LCNEC, coupled with uncommon pulmonary symptoms such as cough, hemoptysis, and post-obstructive pneumonia, makes it difficult to diagnose in its early stages. (e-acfs.org)
Squamous4
- In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
- Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. (medlineplus.gov)
- 200 cases of FFPE tissue sections from breast, lung adenocarcinoma, and lung squamous cell carcinoma with matching normal tissue (only pathology data requested). (biobanking.org)
- Additionally, surgical samples from seven patients diagnosed with EGFR -mutant primary lung squamous carcinoma (LUSC) were collected. (springernature.com)
Colorectal1
- Data queried for this analysis include colorectal adenocarcinoma (2010-2011) from the Surveillance, Epidemiology, and End Results Program (SEER) database. (oncotarget.com)
Pathology3
- More importantly, given the rise and progress in molecular pathology particularly in fields such as pulmonary adenocarcinomas, it is of great current interest to know any molecular variations in post ADT neuroendocrine differentiation and pure NEPC. (healthyprostateclub.com)
- Penile fracture is a rare and unusual pathology resulting from a tear of the tunica albuginea of an erect penis. (journalajrru.com)
- To address this aim we have designed the lungNENomics study, an international cohort of over 250 cases of pulmonary carcinoids, with clinical data and central pathology review, as well as whole-genome sequencing, RNA sequencing, DNA methylation array, and digital spatial profiling data. (who.int)
Malignant melanoma3
- Primary malignant melanoma of the lung (PML) is extremely rare. (biomedcentral.com)
- Typically, 15-20% of malignant melanomas have mutations in the neuroblastoma RAS viral oncogene homolog ( NRAS ) gene [ 4 ], but no cases of NRAS -mutated primary malignant melanoma of the lung have been reported in the English literature. (biomedcentral.com)
- We present the case of a 74-year-old female, who died of primary malignant melanoma of the lung involving an NRAS mutation. (biomedcentral.com)
Carcinoids3
- sequenced the whole exome of 69 pulmonary carcinoids reporting the most frequently DNA alterations found in these neoplasms. (springeropen.com)
- Mutation or loss of this gene can be found in 13% of sporadic pulmonary carcinoids and seem to be associated to shorter survival [ 13 ]. (springeropen.com)
- While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)
Idiopathic3
- atypical adenomatous hyperplasia and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia. (ersjournals.com)
- The clinical manifestations are renal disease, idiopathic pulmonary fibrosis (IPF), heart failure, end-stage liver diseases, and so on ( Bataller and Brenner, 2005 ). (frontiersin.org)
- Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is characterized by multifocal proliferation of pulmonary neuroendocrine cells. (biomedcentral.com)
Tumour1
- As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
EGFR7
- To our knowledge, this study describes the first documented case of primary myoepithelial carcinoma lung cancer patient harboring EGFR exon 19 deletion and KRAS mutation, and showed clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment in this patient. (biomedcentral.com)
- Therefore, it is unknown whether targeted therapies such as EGFR-TKI could achieve similar response in primary myoepithelial carcinoma as in lung adenocarcinoma. (biomedcentral.com)
- Clinical Impact of Genomic and Pathway Alterations in Stage I EGFR-Mutant Lung Adenocarcinoma. (cdc.gov)
- In general, activating EGFR mutations are more commonly observed in patients with adenocarcinomas and no prior history of smoking, as well as in females and those of Asian descent. (medscape.com)
- [ 7 ] researchers identified EGFR mutations in 50.5% of surgically resected lung adenocarcinomas. (medscape.com)
- Use of the EGFR-TKIs gefitinib, erlotinib, and afatinib is limited to patients with adenocarcinomas who have known activating EGFR mutations. (medscape.com)
- Whole-exome sequencing was performed on microdissected ASCs and EGFR -positive primary LUSCs. (springernature.com)
Precursor1
- Many studies now justify that AAH is a precursor to adenocarcinoma 4 - 14 . (ersjournals.com)
Neoplasm2
- A primary malignant neoplasm of epithelial liver cells. (lookformedical.com)
- Kaposiform hemangioendothelioma (KHE) is a rare locally aggressive vascular neoplasm that occurs mainly in the pediatric population. (springeropen.com)
Sarcomatoid1
- If primary renal SS is indeed a form of sarcomatoid differentiation that arises from renal cell carcinoma (RCC), then it is reasonable to expect that the t(X;18)(p11.2:q11.2) translocation associated with the SS phenotype would occur within a cytogenetic profile characteristic of the underlying RCC subtype. (the-medical-dictionary.com)
Neuroendocrine carcinoma3
- Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. (e-acfs.org)
- Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of lung cancer, accounting for 1% to 3% of all lung cancers, and is known for its aggressive behavior [ 1 ]. (e-acfs.org)
- Small cell neuroendocrine carcinoma of the uterine cervix (SCNEC) is a rare cancer involving the human papilloma virus (HPV), and has few available treatments. (biomedcentral.com)
Cancer16
- [ 5 ] An earlier report, in 1956, by Babolini and Blasi, described the same clinicopathological entity using the nomenclature, "The pleural form of primary cancer of the lung. (medscape.com)
- Rb is encoded by the human retinoblastoma gene RB1 that was initially cloned from children with a rare form of eye cancer of the same name. (healthyprostateclub.com)
- In some cases, the drug-resistant cancer may look and behave differently than the original cancer, so much so that it is considered a different subtype of the disease. (healthyprostateclub.com)
- For example, some men who were originally diagnosed with adenocarcinoma prostate cancer develop t-SCNC after treatment with abiraterone or enzalutamide. (healthyprostateclub.com)
- Since this is a relatively rare type of cancer, large studies haven't been conducted, but, from the number of cases reported, there is usually a swelling around the affected area, and often there is pain or discomfort (however, some patients can have no pain or discomfort at all). (the-medical-dictionary.com)
- Unlike other Gulf countries, adenocarcinoma was the predominant type in both Qatari nationals and expatriates (43.9% of lung cancer types). (who.int)
- Hypertrophic pulmonary osteoarthropathy is a rare syndrome characterized by a triad that includes periostitis, digital clubbing, and painful arthropathy of the large joints, especially large joints in the lower limbs with lung cancer. (biomedcentral.com)
- Hypertrophic pulmonary osteoarthropathy (HPOA) is a paraneoplastic syndrome that occurs in patients with lung cancer. (biomedcentral.com)
- it can be lower or higher depending on the subtype and stage of the cancer. (medlineplus.gov)
- Simultaneous Interrogation of Cancer Omics to Identify Subtypes With Significant Clinical Differences. (cdc.gov)
- Breast cancer in men is relatively rare and its coexistence with other primary non-breast cancers exceptional. (sagepub.com)
- Here, we report the case of a 50-year-old man who presented with symptoms of rectal adenocarcinoma and in whom a synchronous, asymptomatic cancer of the left breast was found. (sagepub.com)
- Molecular Diagnostic and Prognostication Assays for the Subtyping of Urinary Bladder Cancer Are on the Way to Illuminating Our Vision. (who.int)
- As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers. (mdanderson.org)
- This project aims to decipher lung cancer evolution and address the primary study endpoint. (researchgate.net)
- The primary disease of Trousseau's syndrome is often highly advanced cancer, and treatment of the primary disease after cerebral infarction is often difficult. (springeropen.com)
Clinical4
- The most important clinical marker for HBL is serum alpha-fetoprotein (AFP), except in the case of some rare variants of HBL and hepatocellular carcinoma that exhibit lower AFP levels. (wikipedia.org)
- It is, however, rare to observe ASS association with B cell lymphoma presenting severe pneumonia as the first clinical manifestation. (bvsalud.org)
- The clinical stage was c-T2bN0M0 with paraneoplastic syndrome as a hypertrophic pulmonary osteoarthropathy. (biomedcentral.com)
- Clinical symptoms can be categorized simply as pulmonary, extrapulmonary thoracic, and extrathoracic symptoms. (sts.org)
Predominant1
- Mutations were associated with the micropapillary predominant subtype and the presence of the lepidic pattern (formerly known as bronchioloalveolar carcinoma). (medscape.com)
Nodule1
- We report a case of a patient with biopsy-proven endometrial adenocarcinoma with suspicious lung nodule, Stage IVB. (amjcaserep.com)
Mediastinal1
- Based on the radiopathological result, he was diagnosed with stage IVB myoepithelial carcinoma accompanied by metastases in the left pulmonary hilum, mediastinal lymph nodes, and cervical vertebra. (biomedcentral.com)
Prognosis1
- The median age for the diagnosis of neuroblastoma is 22 months, being rare in adolescence and adulthood but showing poor prognosis when it does present in those age groups. (wikipedia.org)
Alterations1
- Salivary Gland Polymorphous Adenocarcinoma: Clinicopathological Features and Gene Alterations in 36 Japanese Patients. (nagoya-u.ac.jp)
Renal2
- Primary synovial sarcoma rarely originates in the renal parenchyma. (the-medical-dictionary.com)
- VVe present a case of primary renal SS assessed by standard cytogenetic analysis, which confirms a karyotype that is characteristic of SS as opposed to RCC with or without further genetic aberrations. (the-medical-dictionary.com)
Lymphoma1
- Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes. (who.int)
Cases8
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
- [ 12 ] Rare cases of primary pulmonary or pleural DSRCT have subsequently been identified. (medscape.com)
- On the basis of post-operative histopathologic assessement, 61 of the cases were found to be primary benign, 3 of the cases primary malignant and 2 of the cases secondary malignant. (selcukmedj.org)
- In rare cases, the genetic change is inherited and is present in all the body's cells (germline mutations). (medlineplus.gov)
- Rare cases of anal SCC occur in patients with Crohn disease or immunosuppressive states . (webpathology.com)
- KRAS mutations are also predominantly found in adenocarcinomas and are seen in approximately 25% of cases. (medscape.com)
- Some are of different histological subtypes (including the category extremely rare occurrences (and will normally have been `flagged' `uncertain histology') within the total of morphologically verified as such by some verification procedure within the registry or at cases for the particular ICD category. (who.int)
- 100 cases of rare tumours - fibrolamellar hepatocellular carcinoma. (biobanking.org)
Genetic1
- Family communication and patient distress after germline genetic testing in individuals with pancreatic ductal adenocarcinoma. (cdc.gov)
Infection2
- Homologous virus‒virus interaction implies that cross-reactive immunity against a first virus prevents infection with a second virus (e.g., among different influenza subtypes or lineages) ( 2 ). (cdc.gov)
- The occurrence of SCC and adenocarcinoma is associated with HPV16 infection, while that of SCNEC is associated with HPV18 infection [ 17 ]. (biomedcentral.com)
Patients1
- Archived (formalin-fixed paraffin-embedded) FFPE samples from thirty-three patients diagnosed with primary lung ASC underwent surgical resection at Shanghai Chest Hospital between 2017 and 2019 were involved. (springernature.com)
Case1
- However, in the case of rarer, more-genetically-linked blastomas, practitioners may karyotype the patient before proceeding with treatment. (wikipedia.org)
Entity1
- Upper lumber hernia is a rare entity which can cause obstruction and strangulation. (springeropen.com)
Disease2
- The biomarker research projects are focused on organ transplantation (liver, kidney, heart), heart failure, and chronic obstructive pulmonary disease (COPD). (biobanking.org)
- The lungNENomics project aims to address these important questions, and will continue to improve the biological understanding of this exceedingly rare and understudied disease. (who.int)
Common1
- This and other ALK rearrangements are more common in nonsmokers or light smokers and in those with adenocarcinomas. (medscape.com)
Commonly1
- Although muco-submucosal elongated polyps are commonly reported in the large intestine, they are rare in the small. (springeropen.com)