• The plasticity and heterogeneity of fibroblasts in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC) has emerged as a key factor in determining tumor growth and therapeutic response. (elifesciences.org)
  • Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with 1 and 5-year survival rates of ~18% and 7% respectively. (nih.gov)
  • Due to the high frequency of RAS mutations in PDAC, we hypothesized that pelareorep would promote selective reovirus replication in pancreatic tumors and enhance the anticancer activity of gemcitabine. (nih.gov)
  • The most frequent type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which accounts for up to 90% of pancreatic adenocarcinoma cases [ 3 ]. (hindawi.com)
  • Advanced hepatocellular carcinoma, pancreatic ductal adenocarcinoma (PDAC) and biliary tract cancer. (medscape.com)
  • Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignant tumor with an extremely poor prognosis in digestive tumors. (jcancer.org)
  • Tumor tissues and adjacent normal pancreatic tissues were collected from 89 patients with PDAC. (jcancer.org)
  • Pancreatic ductal adenocarcinoma (PDAC), originating from the ductal epithelium of the pancreas, accounts for more than 90% of all pancreatic cancer cases. (jcancer.org)
  • While single-cell transcriptomics has been used previously to study the cellular composition of primary tumor tissues of pancreatic ductal adenocarcinoma (PDAC), this study also used the technology to profile individual cells from dissociated primary tumors and biopsies of metastatic tissues, those cancerous lesions that have spread throughout the body from the primary tumor. (medicalxpress.com)
  • Primary tumors and core needle biopsies of metastatic lesions from PDAC patients were sequenced using the Chromium single cell RNA-Seq platform. (medicalxpress.com)
  • The proposed study is designed to examine the effects of AZD0171 and durvalumab in combination with standard-of-care chemotherapy in patients with pancreatic ductal adenocarcinoma (PDAC). (uclahealth.org)
  • I. To determine the rates of high-grade pancreatic neoplasia precursors (intraductal papillary mucinous neoplasm (IPMN)-high-grade dysplasia (HGD)) and pancreatic intraepithelial neoplasia-3 [PanIN-3]) and pancreatic ductal adenocarcinoma (PDAC) among all study participants. (centerwatch.com)
  • In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. (lu.se)
  • [ 6 ] Multisection computed tomography (CT) scanning is generally accepted to be the first line of investigation in a patient with suspected pancreatic cancer. (medscape.com)
  • The fact that over 90% of pancreatic cancer cases are discovered in the late stage emphasizes the role of radiology in early detection and determination of resectability of the tumor. (medscape.com)
  • PD analysis revealed reovirus replication within pancreatic tumor and associated apoptosis. (nih.gov)
  • Advanced pheochromocytoma/paraganglioma (PPGL) or pancreatic neuroendocrine tumor (pNET). (medscape.com)
  • Pancreatic cancer is a highly malignant tumor with poor diagnosis in the digestive system. (jcancer.org)
  • Imaging studies did not show any primary tumor in the pancreas but did reveal a deep vein thrombosis of the left lower extremity and a pulmonary embolism. (aacc.org)
  • It is the most frequent malignant tumor of the biliary tract and is the second most common primary hepatic tumor after hepatoma. (medscape.com)
  • The images in the slide are of cytologic samples from fine-needle aspiration (FNA) of pancreatic adenocarcinomas: (A) well-differentiated tumor, (B) moderately differentiated tumor, (C) moderately to poorly differentiated tumor, and (D) poorly differentiated tumor. (medscape.com)
  • The image portrays a progressive model of pancreatic cancer, from normal epithelium to invasively growing tumor. (medscape.com)
  • CAFs are closely associated with primary tumor cells and participate in the neoplastic process, making them a therapeutic target. (neuromics.com)
  • Researchers used a relatively new technique known as single-cell sequencing to genetically identify cell types, and subtypes, that occur in pancreatic tumors , and identify the various cells in the tumor 's stroma, a substance surrounding the tumor that can hide the cancer from the body's immune system. (medicalxpress.com)
  • The study, "Single-Cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions," was published in the scientific journal Genome Medicine . (medicalxpress.com)
  • In this respect, in contrast to predictors based for each serum protein was determined by comparing the samples upon tumor characteristics at the time of surgery, serum is a par- collected at the primary operation and then 3-6 mo later. (lu.se)
  • before resection of the primary tumor and then postoperatively every 6-12 mo, resulting in three to five samples per patient. (lu.se)
  • Much debate surrounds the sensitivity and specificity of imaging investigations in the diagnosis and staging of pancreatic carcinoma. (medscape.com)
  • Pancreatic cancer is the fourth leading cause of cancer-related death in the USA and Europe [ 1 ], and it is expected to overtake lung carcinoma as the second leading cause by 2030 [ 2 ]. (hindawi.com)
  • IPN-01087 is under development for recurrent head and neck squamous cell carcinoma, pancreatic, neuroendocrine prostate, colorectal, gastric and Ewing sarcoma.It is an radioconjugate combining actinium-225 with IPN-1087. (globaldata.com)
  • It is administered through intravenous route.It was under development for solid tumors including pancreatic ductal adenocarcinoma, gastric cancer, colorectal cancer, melanoma, head and neck cancer squamous cell carcinoma, Ewing sarcoma and gastrointestinal stromal tumors. (globaldata.com)
  • A 51-year-old woman presented with progressive severe icterus associated with advanced inoperable pancreatic carcinoma. (aacc.org)
  • Soft-tissue metastases from a primary carcinoma are rare lesions. (amjcaserep.com)
  • Pancreatic cancer is one of the deadliest and most difficult cancers to treat. (elifesciences.org)
  • Carriers of germline mutations in CDKN2A have, besides their high risks of melanoma, also increased risks of pancreatic, lung, laryngeal and oropharyngeal cancers. (wikipedia.org)
  • Pancreatic ductal adenocarcinoma is the most common form of pancreatic cancer and it is the most lethal of all solid cancers. (ohsu.edu)
  • The investigators concluded, "Most pancreatic cancers diagnosed within the CAPS high-risk cohort in the recent years have had stage I disease with long-term survival. (ascopost.com)
  • For treatment of neuroendocrine cancers (i.e., carcinoid tumors and pancreatic endocrine tumors) involving the liver. (aetna.com)
  • Approximately 80% of all pancreatic cancers are adenocarcinomas, with only 2% of exocrine pancreatic tumors diagnosed as benign. (medscape.com)
  • Mutations in K- ras are found in more than 90% of diagnosed pancreatic cancers. (medscape.com)
  • Mutations in P16 are seen in 80-95% of diagnosed pancreatic cancers. (medscape.com)
  • Alterations in P53 are found in 50-75% of diagnosed pancreatic cancers. (medscape.com)
  • Alterations in SMAD4 are seen in approximately 55% of diagnosed pancreatic cancers. (medscape.com)
  • Overexpression of C16orf74 is involved in aggressive pancreatic cancers. (nih.gov)
  • Patients with advanced pancreatic cancers and weight loss may have general laboratory evidence of malnutrition (eg, low serum albumin or cholesterol level). (medscape.com)
  • Pancreatic tumors primarily metastasize to the liver and the lung. (damonrunyon.org)
  • However, it is unclear whether primary tumors and associated metastases during disease progression are metabolically different. (damonrunyon.org)
  • Intrahepatic cholangiocarcinoma constitutes about 15% of all primary liver tumors. (medscape.com)
  • Mutational profile of colorectal cancer lung metastases and paired primary tumors by targeted next generation sequencing: implications on clinical outcome after surgery. (cdc.gov)
  • Pancreatic cancer is occult without specific symptoms, which means that many patients exhibit locally advanced disease or metastasis at the time of diagnosis [ 1 , 2 ]. (jcancer.org)
  • Biopsy of the liver revealed metastasis of a moderately differentiated adenocarcinoma, possibly of pancreatic origin. (aacc.org)
  • Grants classified within the biology field of interest focus on understanding the development, progression, and metastasis (spread) of pancreatic cancer. (pancan.org)
  • We report the case of a 74-year-old woman who presented with late-onset (recurrent disease), solitary, subcutaneous metastasis in the posterior aspect of the left thigh, deriving from a pancreatic head adenocarcinoma, 2 years after initial treatment with R0 resection (pancreaticoduodenectomy) and adjuvant chemotherapy. (amjcaserep.com)
  • Solitary soft-tissue metastasis from a pancreatic adenocarcinoma after initial curative treatment is very rare. (amjcaserep.com)
  • Zurück zum Zitat Haeno H, Gonen M, Davis MB, Herman JM, Iacobuzio-Donahue CA, Michor F. Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. (springermedizin.at)
  • This predict the likelihood of a later recurrence, i.e., an indicator that unique longitudinal sample material was collected from each pa- allows risk assessment for breast cancer metastasis, would be tient between 0 and 36 mo after the primary operation. (lu.se)
  • The insidious and nonspecific symptoms of the disease make it difficult to diagnose, and cases of pancreatic cancer that can be definitively diagnosed are usually already in advanced stages. (hindawi.com)
  • The American Cancer Society estimated that in 2022, there would be 62,210 new cases of pancreatic cancer and 49,830 deaths from pancreatic cancer (25,970 in men and 23,860 in women). (medscape.com)
  • Scan from axial multisection CT in a patient with pancreatic cancer shows a low-attenuating mass in the head of the pancreas, adjacent to the superior mesenteric vein (SMV). (medscape.com)
  • One recently developed reagent recognizes a molecule associated with human pancreatic cancer cells as well as precancerous lesions of the pancreas. (ohsu.edu)
  • As reported in the Journal of Clinical Oncology by Dbouk et al, in the multicenter Cancer of Pancreas Screening-5 (CAPS5) study and in the total CAPS cohort (CAPS1-5 studies), cases of pancreatic ductal adenocarcinoma among enrolled high-risk individuals that were screen-detected during surveillance were diagnosed at earlier stages vs those diagnosed outside of surveillance. (ascopost.com)
  • Chemoembolization (CE) for other indications including palliative treatment of liver metastases from other non-neuroendocrine primaries (e.g., breast cancer, cervical cancer, colon cancer, esophageal cancer, melanoma, rhabdomyosarcoma, or unknown primaries) and CE of the pancreas for pancreatic cancer. (aetna.com)
  • Most ductal adenocarcinomas are tough and gritty gray-white clumps that mainly metastasize in the head of the pancreas. (medscape.com)
  • Approximately 75% of all pancreatic carcinomas occur within the head or neck of the pancreas, 15-20% occur in the body of the pancreas, and 5-10% occur in the tail. (medscape.com)
  • Dr. Sivanand aims to study how metabolic alterations impact pancreatic ductal adenocarcinoma metastases. (damonrunyon.org)
  • Drug-eluting beads trans-arterial chemoembolization for leiomyosarcoma, liver metastases from colorectal cancer, and for primary and liver-dominant metastatic disease of the liver. (aetna.com)
  • Intra-hepatic chemotherapy for other indications not listed above, including treatment of liver primaries or metastases from other primaries (e.g., breast) besides colorectal cancer. (aetna.com)
  • Intra-hepatic microspheres for metastases from esophageal cancer, gallbladder cancer, uveal melanom a, liver metastases of pancreatic adenocarcinoma, and other indications not listed above. (aetna.com)
  • Soft-tissue metastases from a pancreatic adenocarcinoma are extremely rare. (amjcaserep.com)
  • In a patient who had been diagnosed in 2006 with appendiceal adenocarcinoma with peritoneal metastases after an incomplete surgery, palliative chemotherapy was administered. (karger.com)
  • [2] Histologically, most pancreatic adenocarcinomas are moderately to poorly differentiated. (medscape.com)
  • Evidence suggests that EUS is similar to CT for diagnosis and staging of pancreatic cancer. (medscape.com)
  • In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
  • Currently, I am working on the role of lineage-specific trnascription factors in pancreatic ductal adenocarcinomas. (helsinki.fi)
  • With a prevalence of 80-85%, ductal adenocarcinomas are far more common than all other histologic subtypes of pancreatic cancer. (medscape.com)
  • The M. D. Anderson group,[12] and for an even longer time the group from the Fox-Chase Cancer Center,[ 13] have been the pioneers of upfront (neoadjuvant) therapy for potentially resectable pancreatic cancer and continue to be outspoken advocates of this concept. (cancernetwork.com)
  • Results of a phase II study on the use of neoadjuvant chemotherapy (FOLFIRINOX or GEM/nab-PTX) for borderline-resectable pancreatic cancer (NUPAT-01). (springermedizin.at)
  • Neoadjuvant FOLFIRINOX in patients with borderline resectable pancreatic cancer: a systematic review and patient-level meta-analysis. (springermedizin.at)
  • Areas of research focus are beta cell replacement therapies for the treatment of diabetes, the identification of lung progenitor cell populations involved in lung repair, and in the diagnosis of pancreatic cancer. (ohsu.edu)
  • Our laboratory, in collaboration with Dr. Brett Sheppard, M.D., of OHSU, has focused on development of reagents that will facilitate early diagnosis and/or treatment of pancreatic cancer. (ohsu.edu)
  • This paper reports the psychological impact of a pancreatic cancer diagnosis and subsequent pancreaticoduodenectomy, exploring how patients' lives alter following surgery and how they seek support. (bmj.com)
  • NAPOLI-3: A randomized, open-label phase 3 study of liposomal irinotecan + 5‑fluorouracil/leucovorin + oxaliplatin (NALIRIFOX) versus nab-paclitaxel + gemcitabine in treatment-naïve patients with metastatic pancreatic ductal adenocarcinoma (mPDAC). (springermedizin.at)
  • Primary outcomes are overall response rate (ORR) and progression-free survival (PFS). (medscape.com)
  • Identification of C16orf74 as a marker of progression in primary non-muscle invasive bladder cancer. (nih.gov)
  • Not only do these wrap pancreatic tumours in a dense, protective layer, they also foster complex relationships with the cancerous cells: some fibroblasts may fuel tumour growth, while other may help to contain its spread. (elifesciences.org)
  • This thesis entails a thorough histopathological characterization of retrospectively collected tumours from a consecutive cohort of patients with resected periampullary adenocarcinoma, followed by tissue microarray-based immunohistochemical studies of eight candidate protein biomarkers. (lu.se)
  • The role of radiotherapy and chemoradiation in the management of primary liver tumours. (cancercentrum.se)
  • Together our results indicate that, despite the heterogeneity characterising pancreatic cancer tumorspheres, we can identify a functional vulnerability that represents a window for pharmacological intervention and development of novel therapeutic strategies. (lu.se)
  • Cancer-associated fibroblasts heterogeneity in pancreatic ductal adenocarcinoma. (lu.se)
  • In addition, a growing number of clinical cases have found that pancreatic cancer exhibits significant resistance to traditional treatment options, including chemotherapy, radiation, and immunotherapy [ 6 , 7 ]. (hindawi.com)
  • This document summarizes recommendations for the clinical and imaging work-up of pancreatic and biliary tract lesions along with indications for cytologic study of these lesions. (cytojournal.com)
  • Prebrushing and FNA requirements are discussed including consent forms and information to be included in the requisition form for optimal cytologic evaluation of pancreatic and biliary tract specimens. (cytojournal.com)
  • Gemcitabine combined with oxaliplatin (GEMOX) in advanced biliary tract adenocarcinoma: a GERCOR study. (cancercentrum.se)
  • The role of staging laparoscopy in primary gall bladder cancer--an analysis of 409 patients: a prospective study to evaluate the role of staging laparoscopy in the management of gallbladder cancer. (cancercentrum.se)
  • Role of Dimerized C16orf74 in Aggressive Pancreatic Cancer: A Novel Therapeutic Target. (nih.gov)
  • MRI is also helpful in evaluating and characterizing liver lesions in patients with pancreatic cancer. (medscape.com)
  • The primary objective was Clinical Benefit Rate (complete response (CR) + partial response (PR) + stable disease (SD) ≥ 12 weeks) and secondary objectives include overall survival (OS), toxicity, and pharmacodynamics (PD) analysis. (nih.gov)
  • This resistance makes surgery the best option for pancreatic adenocarcinoma (PAAD) treatment, and for 10-20% of patients who undergo surgery, the 5-year survival rate is still only 15-25% [ 8 ]. (hindawi.com)
  • Overall survival (OS) and quality of life (QoL) are the primary outcome measures. (medscape.com)
  • Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
  • Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)
  • The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
  • A primary reason for the low survival rate for patients with pancreatic adenocarcinoma is the inability to diagnose this cancer during early stage disease. (ohsu.edu)
  • Median overall survival was 9.8 years (95% CI = 5.2 years-not estimable) among those with screen-detected disease vs 1.5 years (95% CI = 0.50 years-not estimable) among patients diagnosed with pancreatic ductal adenocarcinoma outside surveillance (hazard ratio = 0.13, 95% CI = 0.03-0.50, P = .003). (ascopost.com)
  • [1] The overall average 5-year survival rate for patients with pancreatic cancer is 11%, though survival is highly dependent on staging. (medscape.com)
  • In 2020, the five-year survival rate for pancreatic cancer is only about 10%, though that represents progress from the dismal 6% rate in 2014. (medicalxpress.com)
  • Novel three?lncRNA signature predicts survival in patients with pancreatic cancer. (cdc.gov)
  • relied on tumour samples obtained from pancreatic cancer patients. (elifesciences.org)
  • Surgery is the only potentially curative treatment modality for early-stage pancreatic cancer. (medscape.com)
  • Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK) [("Merrimack" or the "Company")] announced that Ipsen, SA ("Ipsen") issued a press release today reporting its primary analysis of the results of its Phase III NAPOLI 3 trial of Onivyde® (irinotecan liposome injection) plus 5 fluorouracil/leucovorin and oxaliplatin (NALIRIFOX regimen) as a treatment of first line metastatic pancreatic ductal adenocarcinoma (mPDAC). (biospace.com)
  • Cholangiocarcinoma in primary sclerosing cholangitis. (cancercentrum.se)
  • The value of F-18 FDG PET in patients with primary sclerosing cholangitis and cholangiocarcinoma using visual and semiquantitative analysis. (cancercentrum.se)
  • The primary outcome was age-Adjusted annual incidence of PAC. (elsevierpure.com)
  • 2 ], who observed an increase in the incidence in the last decades, especially in women, and again mucinous adenocarcinoma being the one with the highest prevalence (48%), pointing to an increased incidence of mucinous adenocarcinoma in men (1.0 per million person-years) and women (1.9 per million person-years). (karger.com)
  • Both the incidence and the death rates for pancreatic cancer are increasing. (medscape.com)
  • The PYCR1 may serve as a potential therapeutic and prognostic biomarker for the treatment of pancreatic cancer. (jcancer.org)
  • Therefore, there is an urgent need to explore effective diagnostic, therapeutic, and prognostic targets for patients with pancreatic cancer. (jcancer.org)
  • P isters and colleagues from the M. D. Anderson Cancer Center offer a state-of-the-art discussion of the staging and treatment of pancreatic cancer. (cancernetwork.com)
  • Their treatise addresses most of the current issues of controversy surrounding this disease from a largely nonparochial standpoint, and should serve as a primer for the multidisciplinary approach to the treatment of pancreatic ductal cancer. (cancernetwork.com)
  • In the fight against pancreatic cancer, clinical trials often provide the best treatment options. (pancan.org)
  • Merrimack Pharmaceuticals, Inc. (Nasdaq: MACK) [("Merrimack" or the "Company")] announced that Ipsen, SA ("Ipsen") has issued a press release today reporting its primary analysis of the results of its Phase 3 trial of Onivyde® (irinotecan liposomal injection) as a treatment of second line small cell lung cancer (SCLC). (biospace.com)
  • Led by the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, and by HonorHealth Research and Innovation Institute, an international team of researchers have described in detail the individual cells that comprise the pancreatic cancer microenvironment, a critical step in devising new treatment options for patients with this aggressive and difficult-to-treat disease. (medicalxpress.com)
  • Surgery is the primary mode of treatment for pancreatic cancer. (medscape.com)
  • Primary purpose: Treatment. (who.int)
  • key elements include the following: oral water as negative intraluminal contrast, 120 to 150 mL of iodinated contrast material administered intravenously at a rate of 3 to 4 mL/s, and scanning with thin (2-3 mm) collimation during the pancreatic parenchymal phase (at 25-35 s), with scanning performed at 60 to 70 s during the liver phase. (medscape.com)
  • Transarterially administered gene therapy for primary and secondary liver malignancies. (aetna.com)
  • Occasionally, the presence of pancreatic cancer is suggested by elevated liver transaminase, bilirubin, and alkaline phosphatase levels on testing performed for other purposes. (medscape.com)
  • PanIN = pancreatic intraepithelial neoplasia. (medscape.com)
  • Pancreatic ductal adenocarcinoma has a poor clinical outcome and responses to immunotherapy are suboptimal. (elifesciences.org)
  • Among newly diagnosed patients with pancreatic cancer, which of the following clinical examination findings is most commonly noted? (medscape.com)
  • Conclusions We report demographic and clinical risk factors for PAC after SOT, many of which were present before transplant and are common to sporadic pancreatic cancer. (elsevierpure.com)
  • Single-cell transcriptome analysis can offer important clinical insights on individual cell subpopulations and provide clues for developing novel therapeutic strategies for both targeted therapies and immunotherapies," said Haiyong Han, Ph.D., a professor in TGen's Molecular Medicine Division and head of the institute's Pancreatic Cancer Research Laboratory. (medicalxpress.com)
  • The workup of a biliary stricture, pancreatic cyst or solid mass requires a carefully orchestrated sequence of clinical and imaging studies which may be followed by cytologic investigation. (cytojournal.com)
  • Short-course neoadjuvant FOLFIRINOX versus upfront surgery for resectable pancreatic head cancer: A multicenter randomized phase-II trial (NORPACT-1). (springermedizin.at)
  • I am interested in understanding the role of cancer-specific enhancers and specifically the super enhancer architecture in primary and cancer cells. (helsinki.fi)
  • Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
  • Jaundice and weight loss are the most common symptoms plaguing patients with pancreatic cancer. (medscape.com)
  • The initial symptoms of pancreatic cancer are often quite nonspecific and subtle in onset. (medscape.com)
  • MethodsBlood samples were collected from 15 consecutive patients with newly diagnosed pancreatic cancer and 30 matched healthy controls. (lancs.ac.uk)
  • In this short review, we aim to summarize the essential news and highlights in pancreatic cancer that were presented at ASCO 2023. (springermedizin.at)
  • Which of the following histologic subtypes of pancreatic cancer is the most common? (medscape.com)