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  • bone
  • Diagnosis requires bone marrow examination and exclusion of other conditions that can cause myelofibrosis (secondary myelofibrosis). (merckmanuals.com)
  • There are four main myeloproliferative diseases, which can be further categorized by the presence of the Philadelphia chromosome:[citation needed] In 2008, the World Health Organization listed these diagnoses as types of MPD: Chronic myelogenous leukemia (BCR-ABL1-positive) Chronic neutrophilic leukemia Polycythemia vera Primary myelofibrosis Essential thrombocythemia Chronic eosinophilic leukemia (not otherwise specified) Mastocytosis All MPNs arise from precursors of the myeloid lineages in the bone marrow. (wikipedia.org)
  • Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer. (wikipedia.org)
  • The primary sign of myelofibrosis is reactive bone marrow fibrosis, but it is often accompanied by: Abdominal fullness related to an enlarged spleen (splenomegaly). (wikipedia.org)
  • Bone pain Bruising and easy bleeding due to inadequate numbers of platelets Cachexia (loss of appetite, weight loss, and fatigue) Enlargement of both the liver and spleen Fatigue Gout and high uric acid levels Increased susceptibility to infection, such as pneumonia Pallor and shortness of breath due to anemia In rarer cases, a raised red blood cell volume Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules. (wikipedia.org)
  • also known as carbon monofluoride Popular Mobilization Forces (Iraq), an Iraqi state-sponsored umbrella organization Potential of mean force, in chemistry, potential giving the average force on a particle from a set of molecules Presidential Management Fellows Program, a US government fellowship Presidential Medal of Freedom, The USA's highest civilian award Primary myelofibrosis, a disease affecting the bone marrow. (wikipedia.org)
  • phase
  • We report data from the single-arm, lead-in cohort of an open-label phase 1b/2 trial of glasdegib in patients with primary/s. (bioportfolio.com)
  • As of 2011, momelotinib is being developed as a drug for myelofibrosis and currently undergoes Phase I/II clinical trials. (wikipedia.org)
  • treatment
  • Disease response and progression was evaluated using the International Working Group for myelofibrosis Research and Treatment Response Criteria. (clinicaltrials.gov)
  • Objective response (OR), defined as CR (complete remission) + PR (partial remission) + CI (clinical improvement) for myelofibrosis (MF) patients after 3 cycles of treatment. (clinicaltrials.gov)
  • First generation - thalidomide Second generation - lenalidomide and pomalidomide Third generation - apremilast The primary use of IMiDs in medicine is in the treatment of cancers and autoimmune diseases (including one that is a response to the infection leprosy). (wikipedia.org)
  • venous
  • Hydroxyurea treated patients had a lower incidence of arterial thrombosis, lower incidence of severe bleeding and lower incidence of transformation to myelofibrosis, but the risk of venous thrombosis was higher with hydroxycarbamide than with anagrelide. (wikipedia.org)
  • contrast
  • In contrast TSAT can decrease during inflammation and in addition it follows diurnal variations.The aim of our present study is to asses the levels of LPI in patients with in iron overloaded MDS patients (low and high risk), and also patients with primary myelofibrosis, in order to find out any laboratory correlations between LPI, TSAT and srum ferritin levels. (clinicaltrials.gov)
  • By contrast, the myeloproliferative neoplasm, primary myelofibrosis (PMF), is characterized by abnormal CD34 + cell trafficking, resulting in constitutive mobilization of CD34 + cells ( 5 - 8 ). (aacrjournals.org)
  • drug
  • The main purpose of this investigational research study is to determine how safe and tolerable the study drug siltuximab is in patients with myelofibrosis (MF). (bioportfolio.com)
  • clone
  • Primary hypereosinophilia is due to the development of a clone of eosinophils, i.e. a group of genetically identical eosinophils derived from a significantly mutated ancestor cell. (wikipedia.org)
  • disease
  • Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. (bioportfolio.com)
  • Unlike classical Kostmann disease, SCN5 also has defective platelet aggregation (thrombasthenia) and myelofibrosis. (wikipedia.org)