Wakefulness-Promoting AgentsReceptors, Adrenergic, alpha-2Interleukin 1 Receptor Antagonist ProteinEndpoint DeterminationNeurokinin-1 Receptor AntagonistsDose-Response Relationship, DrugTreatment OutcomePurinergic P1 Receptor AntagonistsRats, Sprague-DawleyHistamine H2 AntagonistsDouble-Blind MethodPiperidinesSerotonin 5-HT3 Receptor AntagonistsExcitatory Amino Acid AntagonistsTime FactorsAngiotensin Receptor AntagonistsDopamine AntagonistsSerotonin 5-HT2 Receptor AntagonistsAdenosine A2 Receptor AntagonistsHormone AntagonistsAdenosine A1 Receptor AntagonistsRats, WistarPurinergic P2 Receptor AntagonistsNarcotic AntagonistsHistamine H1 AntagonistsMuscarinic AntagonistsReceptors, EndothelinGABA-A Receptor AntagonistsAdrenergic alpha-1 Receptor AntagonistsSerotonin AntagonistsGABA AntagonistsSialoglycoproteinsHistamine AntagonistsProspective StudiesReceptors, Adrenergic, alphaTetrazolesalpha 1-AntitrypsinPyridinesLeukotriene AntagonistsReceptor, Endothelin AReceptors, SerotoninSulfonamidesReceptors, N-Methyl-D-AspartateSerotonin 5-HT1 Receptor AntagonistsNicotinic AntagonistsDrug Administration ScheduleDizocilpine MaleateReceptors, Interleukin-1IndolesAdrenergic alpha-2 Receptor AntagonistsAdrenergic alpha-AntagonistsBiphenyl CompoundsBenzazepinesQuinuclidinesPiperazinesRadioligand AssayDrug Therapy, CombinationBenzimidazolesDrug InteractionsKaplan-Meier EstimatePeptides, CyclicXanthinesLosartanGuinea PigsPyrazolesSerotonin Receptor AgonistsHistamine H3 AntagonistsQuinolinesBinding, CompetitiveCells, CulturedFollow-Up StudiesHypoxia-Inducible Factor 1, alpha SubunitQuinoxalinesAzepinesResearch DesignEndothelin-1GABA-B Receptor AntagonistsSignal TransductionSubstance Palpha7 Nicotinic Acetylcholine ReceptorNeuronsSerotoninBlood PressureReceptors, BradykininPyrrolidinesCimetidineReceptors, Neurokinin-1TriazolesAdenosine A3 Receptor AntagonistsReceptor, Endothelin BPurinergic P2X Receptor AntagonistsAdministration, OralPlatelet Aggregation InhibitorsBehavior, AnimalDisease Models, AnimalReceptors, Adrenergic, alpha-1Interleukin-1Purinergic P2Y Receptor AntagonistsReceptors, CholecystokininImidazoles