Although as many as 20-25% of white US adults are believed to be lactase deficient, the true prevalence of this condition is unknown, as noted in a comprehensive National Institute of Health (NIH) consensus conference on the topic. (medscape.com)
On average, both African Americans and Hispanic Americans consume less than the recommended levels of dairy foods, and perceived or actual lactose intolerance can be a primary reason for limiting or avoiding dairy intake, while true lactose intolerance prevalence is not known in these populations. (medscape.com)
Lactase enzyme3
Hypolactasia is the term specifically for the small intestine producing little or no lactase enzyme. (wikipedia.org)
Conversely, food intolerance refers to an inability to digest certain food types because our digestive system does not produce the requisite lactase enzyme to help breakdown lactose into its constituent glucose and galactose. (ulcertalk.com)
Improvement of lactose digestion in a previously intolerant child or adult is caused by growth of lactose-digesting bacteria rather than an induction in activity of the lactase enzyme because lactase is a noninducible enzyme. (medscape.com)
Genotype2
Assuming an association between CC genotype and hypolactasia, and CT and TT genotypes with lactase persistence, 356 (62.8%) individuals had hypolactasia and 211 (37.2%) had lactase persistence. (biomedcentral.com)
The CC genotype of the 13910 C/T polymorphism of the LCT gene is linked to such late-onset primary hypolactasia. (medscape.com)
1 Lactose intolerance related to primary or secondary lactase deficiency may cause abdominal pain and distension, borborygmi, flatus and diarrhoea induced by bacterial metabolism of undigested lactose in dairy products. (bmj.com)
PRS complement traditional genetic testing and have shown utility in establishing a proper diagnosis and guiding primary and secondary prevention. (bvsalud.org)
This includes primary genetic and also secondary LD due to infection or other conditions that affect the mucosal integrity of the small bowel. (bmj.com)
Transformation of the Malaysian economy from primary and secondary sector to tertiary sector has brought about rapid industrialisation and change of job patterns. (biomedcentral.com)
Adulthood1
It is estimated that 75% of adults show some decrease in lactase activity during adulthood worldwide. (superhomeo.com)
Deficiency3
Milk intolerance is more frequently due to milk-protein allergy than primary lactase deficiency. (medscape.com)
Childhood-onset and adult-onset lactase deficiency are extremely common and are inherited in an autosomal recessive manner. (medscape.com)
Doctors distinguish between a lactase deficiency, called hypolactasia, and a complete lack of lactase, alactasia, which is a rare congenital disability. (facty.com)
Polymorphism2
Some scientists believe that human adult lactase polymorphism evolved in the Neolithic period, after animal milk became available for the nutrition of older children and adults. (medscape.com)
The genetic mechanism of lactase persistence in adult Caucasians is mediated by a single C→T nucleotide polymorphism at the LCTbo −13'910 locus on chromosome-2. (bmj.com)
Amounts of lactase1
Some of us continue to produce lactase as adults, while others produce such little amounts of lactase that any amount of dairy products can cause immediate digestive distress. (mygenefood.com)
Lactose-intolerant1
About 70% of the adult world population is lactose-intolerant, due to low levels of intestinal lactase, also called lactase-phlorizin hydrolase (LPH), a β-D-galactosidase found in the apical surface of the intestinal microvilli. (researchgate.net)
This process occurs in the majority of adults. (mygenefood.com)
Digest1
A hypersensitive reaction to certain types of food such as dairy is referred to as a food allergy, since it is our immune system which is reacting to the sugars and proteins found in milk products, in a way that doesnt help us to digest the food properly. (ulcertalk.com)
Currently, it affects 6%-8% of children and 2% of adults worldwide 2,3 . (bvsalud.org)
Problem1
Primary adult-type hypolactasia - a clinical problem or a harmless discomfort? (medscirev.com)
Human2
In this study, lactose synthesis and catabolism in the human body are presented, also the types of lactose intolerance, as well as the methods of diagnosing this condition, are discussed. (researchgate.net)
Lactase activity decays during childhood in the majority of human populations leading to adult-type hypolactasia. (bmj.com)
Worldwide, around 65% of adults are affected by lactose malabsorption. (wikipedia.org)
Small1
The augmented water content in the stools (above the normal value of approximately 10 mL/kg/d in the infant and young child, or 200 g/d in the teenager and adult) is due to an imbalance in the physiology of the small and large intestinal processes involved in the absorption of ions, organic substrates, and thus water. (medscape.com)
Raz M, Sharon Y, Yerushalmi B, Birk R. Frequency of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups. (medscape.com)
Food1
Food and health data were obtained through Food Balance Sheets, Malaysian Adult Nutrition Survey (MANS) and National Health and Morbidity Surveys (NHMS) for year-to-year review. (biomedcentral.com)
Lactose11
It shows complete association with intestinal disaccharidase activity, with the genotype CC −13 910 meaning adult-type hypolactasia (primary LM) and the genotypes CT −13 910 and TT −13 910 lactose absorption. (nature.com)
OBJECTIVES: The objective of the study was to estimate lactose from foods reported in the Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) and determine the interaction between lactose consumption, LP genotype, and gut microbiome in an observational cross-sectional study of healthy adults in the United States (US). (bvsalud.org)
METHODS: Average daily lactose consumption was estimated for 279 healthy US adults, genotyped for the lactase gene -13910G>A polymorphism (rs4988235) by matching ASA24-reported foods to foods in the Nutrition Coordinating Center Food and Nutrient Database. (bvsalud.org)
adult-type hypolactasia) or acquired: the most common being lactose intolerance, typically secondary to a damage of the mucosa, such as a viral enteritis or conditions that cause mucosal atrophy, such as celiac disease. (medscape.com)
The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research. (biomedcentral.com)
The C/C(-13910) and G/G(-22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. (cdc.gov)
Lactase gene1
Pitfalls in LightCycler diagnosis of the single-nucleotide polymorphism 13.9 kb upstream of the lactase gene that is associated with adult-type hypolactasia. (cdc.gov)
Genetically2
Continued production of lactase throughout adult life (lactase persistence, LP) is a genetically determined trait and is found at moderate to high frequencies in Europeans and some African, Middle Eastern and Southern Asian populations (see Additional File 1 and Figure 1 ). (biomedcentral.com)
In addition it should be noted that while in most cases the presence/absence of intestinal lactase in an adult is likely to be genetically determined, the loss of lactase can also be caused by gut trauma such as gastroenteritis [ 3 - 6 ]. (biomedcentral.com)
Gene1
Individuals suffering from ATH (adult-type hypolactasia), defined by the LCT (gene encoding lactase-phlorizin hydrolase) C/C(-13910) genotype (rs4988235), use less milk and dairy products and may have higher plasma HDL (high-density lipoprotein) and lower triacylglycerol (triglyceride) concentrations than their counterparts without ATH. (nih.gov)
Malabsorption1
Despite the slow development of pancreatic amylase, whose secretion reaches adult levels during the end of the first year of life, cooked starch malabsorption is rare in infants because of the activity of the brush-border bound glucoamylase, an esoglycosidase that develops early in life. (medscape.com)
Mammals1
An estimated 65% of human adults (and most adult mammals) downregulate the production of intestinal lactase after weaning. (biomedcentral.com)
Patients1
Improving diagnosis of adult-type hypolactasia in patients with abdominal complaints. (cdc.gov)