RetinopathyNephropathyKetoacidosisCardiovascular DiseasesMacrovascularPeripheralMetabolismRetinalAtherosclerosisGestational diabetesRenalHypertensionDiseasesMyocardial InfarctionDevelopment of diabetic footT2DMPatients with diabetesPancreasNeuropathyNonketotic hypeMicrovascularEndocrinologyAcuteCoronary ArteryObesityGlycemic controlRisk of diabeticAmputationIncidenceIllnessDiseaseDiagnosisLower limbComplications of diabeDysfunctionTreatmentSeverityKidneyChronicLeukocyteOccurrenceFattyMicroangiopathyMetabolicEndothelialBlood vesselsFindingsClinical trialsInsulin levels dueHyperglycemiaOnsetDisorders
Retinopathy13
- Diabetes mellitus (DM) is associated with macrovascular and microvascular complications (coronary artery disease, ischemic stroke, peripheral arterial disease, nephropathy, and retinopathy) [ 1 , 2 ]. (hindawi.com)
- Diabetic retinopathy in 2% of patients leads to complete blindness. (rv.ua)
- Cluster 3 in 18 patients with high function of ß-cells (HOMA-B 228.53±63.32%), severe insulin resistance (HOMA-IR 6.92±4.77), features were high incidence of men, shorter duration of diabetes, lower fasting glycemia and HbA1c, lower diastolic BP and eGFR, high incidence of early development of diabetic retinopathy after 4.00±3.6 years. (bvsalud.org)
- A large body of evidence now implicates increased leukocyte-endothelial cell adhesion as a key early event in the development of diabetic retinopathy. (diabetesjournals.org)
- Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
- Based on the prominent role of TNF-α in the development of diabetic retinopathy, these observations further validate the significance of core 2 GlcNAc-T in the pathogenesis of capillary occlusion, thereby enhancing the therapeutic potential of specific enzyme inhibitors. (diabetesjournals.org)
- Diabetic retinopathy is a progressive vision-threatening complication of diabetes, characterized by capillary occlusion, formation of microvascular lesions, and retinal neovascularization adjacent to ischemic areas of the retina ( 1 - 2 ). (diabetesjournals.org)
- Among the most frequent retinal diseases there are age-related macular degeneration, hereditary retinal degenerations (including retinitis pigmentosa), complicated myopia, diabetic retinopathy. (suaway.com)
- It turned out that peptide bioregulators are most effective in case of age-related macular degeneration, retinitis pigmentosa, complicated myopia, diabetic retinopathy. (suaway.com)
- One of the most severe complications of the diabetes mellitus is a diabetic retinopathy, that is a progressive lesion of the retina, requiring laser and surgical intervention. (suaway.com)
- Long-term complications from high blood sugar can include heart disease , strokes , diabetic retinopathy where eyesight is affected, kidney failure which may require dialysis , and poor circulation of limbs leading to amputations . (thediabeticpharmacist.com)
- This publication is dedicated to the application of a complex of peptide bioregulators being highly effective in treatment of different retinal diseases (diabetic retinopathy, pigment retinitis, age-related macular degeneration etc. (antiaging-peptides.com)
- Although diabetic nephropathy, neuropathy and retinopathy are the most common microvascular complications of hyperglycemia, it also affects choroid plexus. (scialert.net)
Nephropathy4
- Protective Effects of Lithospermic Acid B on Diabetic Nephropathy in OLETF Rats Comparing with Amlodipine and Losartan. (e-dmj.org)
- We examined the effects of LAB on the prevention of diabetic nephropathy compared with amlodipine, a calcium channel blocker, and losartan, an angiotensin receptor blocker, in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes. (e-dmj.org)
- CONCLUSION: These results suggest that LAB has beneficial effects on the diabetic nephropathy in OLETF rats by decreasing oxidative stress and inflammation as potent as losartan. (e-dmj.org)
- Activation of NF-kappaB and AP-1 in Peripheral Blood Mononuclear Cells Isolated from Patients with Diabetic Nephropathy. (e-dmj.org)
Ketoacidosis5
- Acute complications are complications that develop rapidly and can be exemplified as diabetic ketoacidosis (DKA), hyperglycemic hyperosmolar state (HHS), lactic acidosis (LA), and hypoglycemia. (wikipedia.org)
- Diabetic ketoacidosis (DKA) is one of the life-threatening severe complications of diabetes that demands immediate attention and intervention. (wikipedia.org)
- Hamura turned around diabetic ketoacidosis medications to look at him, and said with national diabetes medical suppliers ccs a smile Okay, you can take charge of Beicheng District, and the rest of the area will be taken care of by other heroes However, your speed is not as treatment for diabetic peripheral angiopathy good as mine and Xiaolongjuan's in this aspect. (moviebill.com)
- It is not unusual for patients with type 1 diabetes to present with diabetic ketoacidosis (DKA). (medscape.com)
- The acute complication of ketoacidosis , a feature of type 1 diabetes , is uncommon. (thediabeticpharmacist.com)
Cardiovascular Diseases3
- This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
- Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
- 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
Macrovascular5
- The limited available evidence suggests that near-normal glycemic targets should be the standard for younger patients with relatively recent onset of type 2 diabetes mellitus and little or no micro- or macrovascular complications, with the aim of preventing complications over the many years of life. (nih.gov)
- Diabetes mellitus (DM) is associated with macrovascular and microvascular complications. (hindawi.com)
- Prevention of macrovascular disease in patients with diabetes mellitus: opportunities for intervention. (uchicago.edu)
- These approaches aim atreducing postprandial oxidative stress CONCLUSIONS - Our study confirms micro- and macrovascular endothelial dysfunction (vitamins C and E, statins, and partly folic accompanied by increased oxidative stress following a real-life, heat-processed, AGE-rich meal in individuals with type 2 diabetes and suggests benfotiamine as a potential treatment. (health-abstracts.com)
- Connective Tissue Growth Factor (CTGF) has recently been shown to be over-expressed in kidney, myocardium and aorta in diabetic animals, implicating CTGF role in the pathogenesis of both microvascular and macrovascular diabetic complications ( Brownlee, 2001 ). (scialert.net)
Peripheral3
- Antiplatelet agents are effective in primary and secondary prevention of arterial thrombosis (cardiovascular events, ischaemic stroke, and peripheral arterial occlusive disease). (hindawi.com)
- In individuals with diabetes, the body's ability to produce or utilize insulin, a hormone that helps to regulate blood sugar levels, suffers diabetic peripheral angiopathy without gangrene. (microqnix.com)
- Nerve growth factors (NGF) are believed to regulate peripheral and central nervous system, neuronal differentiation, and regeneration of damaged nerves, and their role in diabetic neuropathy is being emphasized these days. (e-dmj.org)
Metabolism1
- Products selected for testing in patients with diabetes due to the possibility of its positive effects on different types of metabolism of the body and improve the trophic tissue. (rv.ua)
Retinal2
- In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
- The exact pathogenic mechanism by which capillary nonperfusion, as demonstrated by fluorescein angiography, occurs is still unclear, but recent experimental animal studies ( 3 - 5 ) demonstrate that increased leukocyte entrapment in retinal capillaries of diabetic rats is an early event associated with areas of capillary nonperfusion and the development of endothelial cell damage. (diabetesjournals.org)
Atherosclerosis1
- The most well-known of these early agents was Lipostabil Endovena® (Aventis Pharma, Germany), an intravenous agent for the treatment of hyperlipidemia, fat emboli, diabetic angiopathy, atherosclerosis, and other intravascular lipid abnormalities. (jcadonline.com)
Gestational diabetes6
- The 3rd significant kind of diabetes, called gestational diabetes , impacts pregnant ladies who have never ever had the disease. (microqnix.com)
- After delivery, blood sugar levels in women with gestational diabetes generally go back to normal. (microqnix.com)
- The possibility of getting type 2 diabetes later on in life is increased for women who had gestational diabetes during pregnancy. (microqnix.com)
- Hypertriglyceridemia-induced acute pancreatitis seldom occurs in the second trimester of pregnancy with gestational diabetes mellitus. (bvsalud.org)
- We report a case of abruptio placentae and epileptic seizure following perinatal hyperglycaemia in woman with gestational diabetes mellitus and hypertriglyceridemia-induced acute pancreatitis. (bvsalud.org)
- Type 2 diabetes makes up about 90% of cases of diabetes with the other 10% due primarily to diabetes mellitus type 1 and gestational diabetes . (thediabeticpharmacist.com)
Renal2
- Retina is as a rule damaged in case of the following diseases: hypertension, diabetes mellitus, renal insufficiency etc. (suaway.com)
- Moreover, NGFs and receptors are also expressed in retina and renal mesangial cells, suggesting their possible role in the common pathogenesis of diabetic microvascular complications. (e-dmj.org)
Hypertension2
- Platelets have a "key role" in atherogenesis and its thrombotic complications in subjects with DM [ 3 ], and the concomitant presence of multiple "classical" cardiovascular risk factors (arterial hypertension, cigarette smoking, and hyperlipidemia) in diabetic subjects contributes to enhanced atherothrombotic risk. (hindawi.com)
- Many people with hypertension are either diabetic or pre-diabetic and have elevated insulin levels due to insulin resistance. (thediabeticpharmacist.com)
Diseases7
- Cardiovascular (CV) diseases are the leading cause of morbidity and mortality in diabetic patients. (hindawi.com)
- In the structure of endocrine diseases diabetes mellitus (DM) up to 70% of cases. (rv.ua)
- Complications of diabetes are secondary diseases that are a result of elevated blood glucose levels that occur in diabetic patients. (wikipedia.org)
- These peptides (Normoftal, Pancragen, Vesugen, Crystagen, Pinealon and others) are widely used in the medical practice as the means for prevention and treatment of different eye diseases. (suaway.com)
- Adapted from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). (diabetes.org)
- ABSTRACT Chronic diseases such as diabetes and vascular disease are a major public health problem in Lebanon, where primary care is not well developed. (who.int)
- Until recently, the majority of the research investigating vitamin K's potential for the prevention and treatment of age-associated diseases has been conducted using pharmacological doses of supplemental K1 or MK-4. (vitamindwiki.com)
Myocardial Infarction1
- In DM risk of death from myocardial infarction or other vascular accident is 4-5 times higher than that in the absence of diabetes. (rv.ua)
Development of diabetic foot2
- Angle α, k-value and fibrinogen have clinical significance on the risk of occurrence and development of diabetic foot, which can contribute to early diagnosis and early clinical intervention in DF. (biomedcentral.com)
- A poorly fitted shoe is one of many contributory factors in the development of diabetic foot ulcers. (faoj.org)
T2DM6
- BACKGROUND: Diabetes mellitus (T2DM) is a serious medical and social problem. (bvsalud.org)
- The possibility of cluster analysis for different durations of diabetes, in different cohorts to identify phenotypic clusters of T2DM and validation by reproducing clusters is relevant. (bvsalud.org)
- MATERIALS AND METHODS: Cluster analysis of K-means was performed in 2131 patients with T2DM, aged 44 to 70 years, with a duration of diabetes of 6.42±5.66 years, living in the Novosibirsk region based on 5 variables - HbA1c, age at -diagnosis, BMI, HOMA-IR, HOMA-B. All patients a complete clinical and laboratory examination. (bvsalud.org)
- CONCLUSION: Cluster analysis in patients with different durations of diabetes mellitus confirmed the possibility of using cluster analysis to identify T2DM phenotypes in the Russian population. (bvsalud.org)
- This clinical study enrolled 163 type 2 diabetes mellitus (T2DM) patients, who were divided into the diabetes with DF (84 cases) group, diabetes with no DF (79 cases) group. (biomedcentral.com)
- A large clinical study found that the prevalence of PAD in patients with T2DM was 23.5% [ 2 ], and diabetic patients with combined PAD are more likely to develop ulceration and gangrene of the limb, significantly increasing the risk of amputation. (biomedcentral.com)
Patients with diabetes8
- For the treatment of patients with diabetes secondary to severe disease herbs can be used as aids to the calculation of the possible lower dosages of medicines, providing a more long-term remission, prevention of complications. (rv.ua)
- A fingerstick glucose test is appropriate for virtually all patients with diabetes. (medscape.com)
- The literature offers sparse information about foot anthropometrics in patients with diabetes related to foot length, foot width and toe height, although these measurements are important in shoe fitting. (faoj.org)
- The purpose of this study was to describe the foot anthropometrics in groups of patients with diabetes, in groups representing the general population and to explore whether foot anthropometrics differ between patients with diabetes and the general population. (faoj.org)
- Foot anthropometrics (foot length, foot width and maximum toe height) was measured in 164 patients with diabetes, with and without neuropathy (n = 102 and n = 62 respectively). (faoj.org)
- Age, gender and BMI influence the foot anthropometrics, however, when adjusting for theses variables the index foot length/width was lower (2.58) in patients with diabetes without neuropathy vs. controls (2.63), p = 0.018. (faoj.org)
- Moreover, patients with diabetes with neuropathy had wider feet (98.6 mm) compared with the controls (97.0 mm), p = 0.047. (faoj.org)
- Patients with diabetes seemed to have a wider forefoot width and a lower foot length to foot width ratio compared to the controls. (faoj.org)
Pancreas7
- Diabetes arises from either inadequate insulin production by the pancreas or improper insulin utilization by the body's cells. (microqnix.com)
- Type 1 diabetes is caused by the pancreas' inability to produce adequate insulin as a result of beta cell loss. (microqnix.com)
- Type 1 diabetes is an autoimmune disorder in which the body's body immune system attacks and destroys the insulin-producing cells in the pancreas. (microqnix.com)
- Type 2 diabetes is a metabolic disorder that occurs when the body ends up being resistant to the effects of insulin and/or the pancreas is not able to produce enough insulin to stay up to date with the body's requirements. (microqnix.com)
- A type of cell in the pancreas. (diabetes.org)
- Type 1 diabetes is a chronic illness characterized by the body's inability to produce insulin due to the autoimmune destruction of the beta cells in the pancreas. (medscape.com)
- [ 2 ] This is in contrast to diabetes mellitus type 1 , in which there is an absolute insulin deficiency due to destruction of islet cells in the pancreas . (thediabeticpharmacist.com)
Neuropathy2
- A type of neuropathy resulting in pain, weakness and/or wasting in the muscles. (diabetes.org)
- In vivo corneal confocal microscopy (IVCCM) is being recognized as a non-invasive, early diagnostic tool for diabetic neuropathy, for it provides a clear image of corneal subbasal nerve plexus in detail. (e-dmj.org)
Nonketotic hype1
- People with type 2 diabetes mellitus may rarely present with nonketotic hyperosmolar coma (a condition of very high blood sugar associated with a decreased level of consciousness and low blood pressure ). (thediabeticpharmacist.com)
Microvascular2
- In vivo Corneal Confocal Microscopy and Nerve Growth Factor in Diabetic Microvascular Complications. (e-dmj.org)
- CONCLUSION: Our results provide a possibility of using novel tools, IVCCM and NGF, as common diagnostic tools for diabetic microvascular complications, but it should be followed by a large population study. (e-dmj.org)
Endocrinology1
- Endocrinology 2018 Conference is based on the theme of Reconnoitering the Challenges Concerning Endocrinology and Diabetes Research . (endocrineconferences.com)
Acute2
- These complications can be divided into two types: acute and chronic. (wikipedia.org)
- Diabetes mellitus and cardiovascular disease increase the overall risk of acute and chronic osteomyelitis. (medscape.com)
Coronary Artery1
- 3), obesity (4), coronary artery disease(5), congestive heart failure (6), and type1 (7) and type 2 (8) diabetes. (health-abstracts.com)
Obesity6
- Type 2 diabetes is more common in older folks, type 2 diabetes has actually ended up being more widespread in younger people as an outcome of a marked increase in childhood obesity rates. (microqnix.com)
- Type 2 diabetes, on the other hand, is frequently related to obesity and a sedentary lifestyle, but can also be caused by genetics or certain medical conditions. (microqnix.com)
- Type 2 diabetes is frequently associated with obesity and a sedentary lifestyle. (microqnix.com)
- Other health problems compound the chronic complications of diabetes such as smoking, obesity, high blood pressure, elevated cholesterol levels, and lack of regular exercise. (wikipedia.org)
- Obesity is thought to be the primary cause of type 2 diabetes in people who are genetically predisposed to the disease. (thediabeticpharmacist.com)
- Rates of diabetes have increased markedly over the last 50 years in parallel with obesity. (thediabeticpharmacist.com)
Glycemic control2
- A close relationship between poor glycemic control and increased platelet activity (estimated by measuring mean platelet volume-MPV-as part of whole blood count) in patients with type 2 DM has been suggested [ 4 ]. (hindawi.com)
- Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)
Risk of diabetic2
- The clusters differed in the clinical characteristics of patients, the frequency and risk of diabetic complications. (bvsalud.org)
- There is a lack of uniform quantitative standards for biomarkers that predict the risk of diabetic foot occurrence and progression. (biomedcentral.com)
Amputation4
- Frequent and serious complication of diabetes are also oklyuzionnye vascular limbs, which usually leads to the development of gangrene and amputation, which in turn causes the growth of early disability of patients and deaths. (rv.ua)
- Diabetes prevention, detection and management should be prioritized in any attempt to reduce the current incidence of amputation in Lebanon. (who.int)
- Yet the rising was to highlight the major burden of reason) for surgery according to the incidence of diabetes and vascular dis- amputation and to set standards for patient's hospital record. (who.int)
- In Lebanon, the preva- could be achieved in order to support main indication was recorded for each lence of type 2 diabetes was 13.1% for the development of programmes for patient from either trauma, diabetes, those aged 30+ years in 1994-95 [2] amputation prevention and care. (who.int)
Incidence1
Illness4
- Diabetes is a persistent illness that impacts the way the body processes blood sugar level (glucose). (microqnix.com)
- Insulin resistance, an illness in which cells do not react to insulin as it should, is the precursor to type 2 diabetes . (microqnix.com)
- To sum it up, Diabetes is a persistent illness that impacts the method the body processes blood sugar (glucose). (microqnix.com)
- Complications of diabetes are a strong risk factor for severe COVID-19 illness. (wikipedia.org)
Disease9
- The individualization of HbA(1c) targets has gained more traction after recent clinical trials in older patients with established type 2 diabetes mellitus failed to show a benefit from intensive glucose-lowering therapy on cardiovascular disease (CVD) outcomes. (nih.gov)
- 2. Schmidt AM, Crandall J , Hori O, Cao R and Lakatta E. Elevated plasma levels of vascular cell adhesion molecule-1 (VCAM-1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease. (einsteinmed.edu)
- With this in mind, there is no doubt that, to prevent severe complications of diabetes and stabilization of the disease, patients should receive adequate systemic therapy aimed at improving the microcirculation in the tissues and the stabilization of metabolic processes in them. (rv.ua)
- It is essential to note that diabetes is a persistent disease that needs long-lasting management. (microqnix.com)
- A better mechanistic understanding of how bacteria invade, survive within, and trigger pathologic remodeling of bone could lead to new therapies aimed at prevention or treatment of osteomyelitis, as well as amelioration of disease morbidity. (medscape.com)
- AIM: Identify clusters of type 2 diabetes mellitus in patients with different disease duration based on five variables: HbA1c, age at diagnosis, BMI, HOMA-IR, HOMA-B and study the clinical features and complication rates in each cluster in the Novosibirsk region. (bvsalud.org)
- diovascular disease (10) or diabetes (11)but even in healthy subjects (12). (health-abstracts.com)
- Type 2 diabetes is typically a chronic disease associated with a ten-year-shorter life expectancy. (thediabeticpharmacist.com)
- Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
Diagnosis1
- The International Working Group on the Diabetic Foot has developed guidelines for the diagnosis of the diabetic foot. (biomedcentral.com)
Lower limb2
- Statistical studies show that over 50% of all lower limb amputations due to diabetes. (rv.ua)
- The occurrence of diabetic foot is closely related to micro-angiopathy, micro-thrombosis in the lower limb, which may predate the presentation of diabetic foot. (biomedcentral.com)
Complications of diabe1
- The complications of diabetes can dramatically impair quality of life and cause long-lasting disability. (wikipedia.org)
Dysfunction1
- Postprandial OBJECTIVE - Diabetes is characterized by marked postprandial endothelial dysfunction induced by hyperglycemia, hypertriglyceridemia, advanced glycation end products (AGEs), and dicarbonyls (e.g., methylglyoxal [MG]). In vitro hyperglycemia-induced MG formation and endothelial dysfunction could be blocked by benfotiamine, but in vivo effects of benfotiamine on and occurs not only in patients with car- postprandial endothelial dysfunction and MG synthesis have not been investigated in humansuntil now. (health-abstracts.com)
Treatment13
- Although, currently, treatment has proven useful in reducing vascular events, diabetic patients continue to have a higher risk of adverse cardiovascular events compared with those in nondiabetic patients. (hindawi.com)
- Available antiplatelet agents, such as cyclooxygenase-1 (COX-1) inhibitors (aspirin), ADP P2Y 12 receptor antagonists, and GP IIb/IIIa receptor inhibitors, are effective and save in the treatment and prevention of thrombotic events, these drugs interfere with the platelet activation process, including adhesion, release, and aggregation. (hindawi.com)
- Along with medication, phytotherapeutic means having a mild and versatile effect, can be successfully used in conjunction with diet as a base therapy in the treatment of patients with latent or mild form of diabetes. (rv.ua)
- Tomsk and Voronezh have been studied biologically active food additives (BAA) MEMORY RISE (production company ARTLIFE ) for the prevention and treatment of diabetic angiopathies, including diabetic foot. (rv.ua)
- Ginsenosides extracted from ginseng, which is derived from the roots and rhizomes of Panax ginseng C. A. Meyer, have been used in China as an adjuvant in the treatment of diabetes mellitus. (frontiersin.org)
- Rg1, Rg3, Rb1, and compound K demonstrated the most promising therapeutic prospects as potential adjuvant medicines for the treatment of diabetes. (frontiersin.org)
- Treatment for diabetes usually involves a mix of lifestyle modifications and medication. (microqnix.com)
- For people with type 1 diabetes, treatment includes daily insulin injections and tracking of blood sugar level levels. (microqnix.com)
- For people with type 2 diabetes, treatment might consist of lifestyle changes such as weight-loss and regular exercise, as well as oral medications to help control blood glucose levels. (microqnix.com)
- The treatment for diabetes typically includes a mix of way of life modifications and medication. (microqnix.com)
- what is the treatment for type 1 diabetes mellitus After seeing the milk, pastries, cup noodles and snacks in the refrigerator, there were no insulin medication for type 1 diabetes serious ingredients, and Hamura gave up his plan to find Jiang at her home Just by looking at the food in the refrigerator, Hamura what is the treatment for type 1 diabetes mellitus could tell Kasumi Oka Shiwa Should not cook. (moviebill.com)
- 4 Yes, do you have natural treatment feline diabetes anything else to say? (moviebill.com)
- A set of peptides for the treatment course is designed taking into consideration specificity of the eye ball structure, and depending on the allocation and type of the damage as well as on the general state of the patient it includes peptides of the retina, thymus, pineal gland, cortex, vessels and other. (suaway.com)
Severity2
- Number of observations was 23 patients of different age and sex with different forms and severity of diabetes. (rv.ua)
- Research suggests that fibrinogen (Fib) concentrations are used to assess the occurrence and severity of diabetic foot (DF) and to monitor the progression of diabetic foot in patients. (biomedcentral.com)
Kidney2
- The most severe clinical manifestations of diabetes develops in the presence of microangiopathy in the retina and kidney. (rv.ua)
- [ 6 ] In the developed world, and increasingly elsewhere, type 2 diabetes is the largest cause of nontraumatic blindness and kidney failure . (thediabeticpharmacist.com)
Chronic2
- The role of chronic administration of antiplatelet drugs in primary prevention of arterial vascular events is known to be less clear than in secondary prevention, and, also in diabetic patients, the decision to give primary prophylaxis should be taken on an individual-patient basis, after a careful evaluation of the balance between the expected benefits and the risk of major bleedings. (hindawi.com)
- During chronic diabetes and tends to progress, but we know that good diabetes compensation in light of its forms is possible to achieve long-term remission, while moderate forms can be transformed into light and heavy forms - a moderate. (rv.ua)
Leukocyte1
- 4. Rauch U, Crandall J, Osende J, Fallon J, Cheseboro J, Fuster V, Badimon J. Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus Type 2. (einsteinmed.edu)
Occurrence3
- Therefore, finding indicators that predict the risk of occurrence and progression of diabetic foot and early intervention can help improve the quality of life. (biomedcentral.com)
- AIMS/HYPOTHESIS: The aim of this study was to develop a simulation model for type 2 diabetes that can be used to estimate the likely occurrence of major diabetes-related complications over a lifetime, in order to calculate health economic outcomes such as quality-adjusted life expectancy. (ox.ac.uk)
- METHODS: Equations for forecasting the occurrence of seven diabetes-related complications and death were estimated using data on 3642 patients from the United Kingdom Prospective Diabetes Study (UKPDS). (ox.ac.uk)
Fatty1
- Elevated blood fatty-acid concentrations (associated with insulin resistance and diabetes mellitus Type 2), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels. (thediabeticpharmacist.com)
Microangiopathy1
- When there are two types of diabetes vascular lesion: large - macroangiopathy and small - microangiopathy. (rv.ua)
Metabolic1
- Diabetes mellitus type 2 (formerly noninsulin-dependent diabetes mellitus (NIDDM) or adult-onset diabetes ) is a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. (thediabeticpharmacist.com)
Endothelial2
- Diabetic microvasular complications, which are considered as an important group of hyperglycemia imperfections, caused by increased endothelial permeability and can progress to severe impairments in several organs. (scialert.net)
- Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
Blood vessels1
- They play a role in damaging blood vessels, which can lead to diabetes complications. (diabetes.org)
Findings1
- See Clinical Findings in Diabetes Mellitus, a Critical Images slideshow, to help identify various cutaneous, ophthalmologic, vascular, and neurologic manifestations of DM. (medscape.com)
Clinical trials2
- Large clinical trials have shown that antiplatelet agents are effective in the prevention of recurrent cardiovascular events in diabetes. (hindawi.com)
- Dr. Crandall is Professor of Medicine at Albert Einstein College of Medicine, where she is director of the Diabetes Clinical Trials Unit and a principal investigator for several NIH sponsored clinical trials, including the Diabetes Prevention Program Outcome Study (for which she holds several national leadership positions, including Executive Committee membership) and the Glycemia Reduction Approaches in Diabetes (GRADE) study. (einsteinmed.edu)
Insulin levels due1
- DKA results from significantly low insulin levels due to various factors including undiagnosed diabetes (people who did not know they have diabetes), missed or delayed doses, insufficient insulin administration, or undergoing physiological stress (e.g. infection, surgery, Stroke, or trauma). (wikipedia.org)
Hyperglycemia1
- Over decades, steady interest in fructosamine was largely sustained by its role as a key intermediate structure in the Maillard reaction that is responsible for the organoleptic and nutritional value of thermally processed foods, and for pathophysiological effects of hyperglycemia in diabetes. (bvsalud.org)
Onset2
- Formerly, this type was described as "adult-onset diabetes" or "non-insulin-dependent diabetes mellitus. (microqnix.com)
- Some non-modifiable risk factors such as age at diabetes onset, type of diabetes, gender, and genetics may influence risk. (wikipedia.org)
Disorders1
- Prevention of vascular disorders in diabetic patients using dietary supplements ART LIFE. (rv.ua)