• You will investigate the sex-specific progression of left ventricular diastolic dysfunction towards heart failure with preserved ejection fraction in adults with high cardiovascular risk, with a special focus on the role of insulin signaling. (epidemiologie.nl)
  • Heart failure with preserved ejection fraction (HFpEF) is a highly prevalent syndrome, especially among elderly women, with scarce treatment options. (epidemiologie.nl)
  • The goal of this PhD project is to investigate which panels of biomarkers can predict the progression of left ventricular diastolic dysfunction towards heart failure with preserved ejection fraction in men and women. (epidemiologie.nl)
  • Left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ejection fraction (HFpEF) are microcirculation defects following diabetes mellitus (DM). (maastrichtuniversity.nl)
  • With respect to patients with LVH and systolic dysfunction (ejection fraction less than 40 percent), evidence-based trials have led to the development of consensus guidelines for the management of heart failure. (aafp.org)
  • Anaemia was more common in patients with diabetes (p=0.028) and in those with increased left ventricular ejection fraction (p=0.005). (bvsalud.org)
  • Conclusions--Malignant LVH is predictive of progression to asymptomatic LV dysfunction, HF (particularly HF with reduced ejection fraction), and cardiovascular death. (johnshopkins.edu)
  • Meta-analytic data have recognized to PDE5i a protective role on the cardiovascular health in patients with decreased left ventricular ejection fraction. (unicz.it)
  • Indeed, such a definition of diastolic HF has been adopted by the majority of previous reports, w5 and is supported by the results of recent studies which indicate that the presence of diastolic dysfunction may be assumed in patients presenting with HF and normal LV ejection fraction (LVEF). (bmj.com)
  • Diabetes can cause heart failure independently of ischemic heart disease by causing a diabetic cardiomyopathy that may manifest in the setting of normal or reduced left ventricular ejection fraction. (diabetes.ca)
  • Coronary Microvascular Dysfunction and Heart Failure With Preserved Ejection Fraction as Female-pattern Cardiovascular Disease: The Chicken or the Egg? (medscape.com)
  • Left ventricular hypertrophy (LVH) is a common clinical problem, and the number of patients with LVH is increasing. (aafp.org)
  • Long-term hypertension (HTN) can lead to structural and functional changes in patients with HF, such as concentric and eccentric hypertrophy, left ventricular fibrosis, and cardiac remodeling [ 11 ]. (hindawi.com)
  • In CRIC participants without heart failure, serum cardiac troponin T (cTnT) is associated with left ventricular hypertrophy (LVH) and LV systolic dysfunction but not with LV diastolic dysfunction. (cristudy.org)
  • In CRIC participants without heart failure, N-terminal pro-B-type natriuretic peptide (NT-proBNP) had strong associations with prevalent left ventricular hypertrophy (LVH) and LV systolic dysfunction. (cristudy.org)
  • Hispanics with chronic kidney disease are found to be at higher risk of left ventricular hypertrophy than non-Hispanic whites, and have more severe coronary artery calcification than non-Hispanic blacks. (cristudy.org)
  • Malignant" left ventricular (LV) hypertrophy (LVH): LVH combined with an elevated cardiac biomarker reflecting either injury (high-sensitivity cardiac troponin T), or strain (amino-terminal pro-B-type natriuretic peptide) has predicted accelerated progression to HF. (johnshopkins.edu)
  • 180 mm Hg and at least 1 other clinical abnormality typically associated with hypertension (eg, hypertensive retinopathy, left ventricular hypertrophy, or proteinuria). (avma.org)
  • Left ventricular hypertrophy also occurs frequently in these patients representing another powerful and independent risk factor for cardiovascular morbidity and mortality in ADPKD. (jscimedcentral.com)
  • Hypertrophic cardiomyopathy (HCM) is a primary disease involving myocardial fiber hypertrophy, disarrangement, and myocardial hypertrophy, especially asymmetric left ventricular hypertrophy. (biomedcentral.com)
  • An echocardiogram demonstrated still left ventricular hypertrophy conserved systolic function impaired diastolic function and moderate aortic stenosis. (sciencepop.org)
  • Mechanisms of Disease: Software of High-Throughput Systems Tivozanib Over the past 10 to 20 years we have come to appreciate the pathophysiologic roles of inflammation fibrosis hypertrophy apoptosis autophagy electrical remodeling cellular proliferation endothelial dysfunction and angiogenesis in the progression of cardiovascular disease. (sciencepop.org)
  • Focal hypertrophy of the basal inter-ventricular septum can be seen in up to 20% of cardiac patients without HCM, being more prevalent in the elderly and hypertensives. (heart.org)
  • These changes in turn can lead to the development of left ventricular hypertrophy (LVH), coronary artery disease (CAD), various conduction system diseases, and systolic and diastolic dysfunction of the myocardium, complications that manifest clinically as angina or myocardial infarction, cardiac arrhythmias (especially atrial fibrillation), and congestive heart failure (CHF). (medscape.com)
  • Two-dimensional echocardiogram (parasternal long axis view) from a 70-year-old woman showing concentric left ventricular hypertrophy and left atrial enlargement. (medscape.com)
  • Gross specimen of the heart with concentric left ventricular hypertrophy. (medscape.com)
  • Electrocardiographic results are often abnormal in patients with PAH, revealing right atrial enlargement, right axis deviation, right ventricular hypertrophy, and characteristic ST depression and T-wave inversions in the anterior leads. (medscape.com)
  • Hypertensive emergency pathophysiology includes:[citation needed] Abrupt increase in systemic vascular resistance, likely related to humoral vasoconstrictors Endothelial injury and dysfunction Fibrinoid necrosis of the arterioles Deposition of platelets and fibrin Breakdown of normal autoregulatory function The resulting ischemia prompts further release of vasoactive substances including prostaglandins, free radicals, and thrombotic/mitotic growth factors, completing a vicious cycle of inflammatory changes. (wikipedia.org)
  • Oxidative stress, nitric oxide (NO) dysregulation, and endothelial dysfunction play an essential role in the deterioration of HF. (hindawi.com)
  • 2020). But another hypothesis is that the extreme inflammation, possibly with a cytokine storm, along with coagulation abnormalities and endothelial dysfunction, cause plaque instability in coronary arteries and results in coronary thrombosis (Tersalvi et al. (keraltyhospital.com)
  • TRT itself is able to decrease endothelial dysfunction, oxidative stress and inflammation, thus lowering the cardiovascular risk. (unicz.it)
  • However, it is established that Fontan patients have poor exercise capacity, associated with a greater risk of morbidity and mortality, in addition to decreased muscle mass, abnormal muscle function, and endothelial dysfunction contributing to disease progression. (stanford.edu)
  • Other abnormalities such as biventricular diastolic dysfunction, endothelial dysfunction and increased carotid intima media thickness are present even in young ADPKD patients with normal blood pressure and well-preserved renal function. (jscimedcentral.com)
  • it is made of a thin layer of endothelial cells which leave a smooth coating allowing the blood to flow through easily. (nursinganswers.net)
  • The study indicated that although right ventricular function indices may be normal at rest in hyperthyroid patients, they are impaired during the stress tests, and these patients lack a normal right cardiac reserve. (ac.ir)
  • 1 In recent years, hyperthyroidism-associated cardiac dysfunctions were more widely recognized. (ac.ir)
  • Current therapy is aimed at preserving sinus rhythm and suppressing tachycardia, reducing elevated left atrial and diastolic pressures without excessively reducing preload and depressing cardiac output, and preventing or treating the confounding condition of myocardial ischemia. (aafp.org)
  • Diastolic dysfunction is the predominant cardiac abnormality in this syndrome, which is associated with increased risk of hospitalisation and death. (bmj.com)
  • Left atrial (LA) function is an important determinant of the left ventricular (LV) filling, playing a key role in maintaining optimal cardiac performance. (openveterinaryjournal.com)
  • Myxomatous mitral valve disease (MMVD) is the most prevalent cardiac disease in dogs and is characterized by a slow, progressive myxomatous degeneration of the mitral valve leaflets, leading to mitral valve regurgitation (MR) of increasing severity and subsequent left atrial (LA) and left ventricular (LV) dilatation ( Ljungvall and Häggström, 2016 ). (openveterinaryjournal.com)
  • The diagnosis of chronic Q fever was not made until after the patients had elective cardiac valve surgery for progressive valvular dysfunction. (cdc.gov)
  • Prognosis was assessed by a composite of death, cardiac transplantation, and left ventricular assist device implantation. (chop.edu)
  • Patients with the R14del mutation are characterised by older age at onset, low-voltage electrocardiograms and a high frequency of ventricular arrhythmias. (uoa.gr)
  • Arrhythmias are also common with atrial fibrillation being most prevalent. (keraltyhospital.com)
  • Ventricular arrhythmias also occur with resultant sudden death (P. P. Liu et al. (keraltyhospital.com)
  • Background: Since hyperthyroidism could be associated with right ventricular dysfunction, this study intended to investigate right ventricular (RV) function using strain echocardiography in hyperthyroid patients both at rest and in maximum-stress conditions. (ac.ir)
  • 6 - 8 As many studies supported the hypothesis that right ventricular (RV) disorders are correlated with increased risk of morbidity and mortality, RV function assessments are pushed to the forefront of clinical work. (ac.ir)
  • Anaemia and renal dysfunction are associated with an increased morbidity and mortality in heart failure (HF) patients.Objective. (bvsalud.org)
  • Heart failure (HF) is a worldwide pandemic that is associated with high morbidity and mortality and becoming more prevalent despite significant advancements in treatments and prevention strategies due to the enormous economic burden [ 1 , 2 ]. (hindawi.com)
  • Even so, the dispute considering Brugada syndrome as an independent entity or forming part of the spectrum of arrhythmogenic right ventricular cardiomyopathy is still controversial. (bvsalud.org)
  • The diseases of greatest importance, because of their prevalence, are mitral regurgitation in dogs (degenerative mitral valve disease), hypertrophic cardiomyopathy in cats, dilated cardiomyopathy (DCM) in dogs, arrhythmogenic right ventricular cardiomyopathy in Boxers and Bulldogs, and heartworm disease. (merckvetmanual.com)
  • To estimate the frequency and impact of anaemia and renal dysfunction on in-hospital outcomes in patients with HF.Methods. (bvsalud.org)
  • The overall median eGFR was 75.9 mL/min/1.73 m2 and renal dysfunction was detected in 60 (31.1%) patients. (bvsalud.org)
  • Renal dysfunction was associated with hypertension (p=0.01), diabetes mellitus (p=0.01) and a lower haemoglobin level (p=0.008). (bvsalud.org)
  • Neither renal dysfunction nor anaemia was significantly associated with the length of hospital stay or in-hospital mortality.Conclusion. (bvsalud.org)
  • Anaemia and renal dysfunction are prevalent in HF patients, but neither was an independent predictor of length of stay or in-hospital mortality in this population. (bvsalud.org)
  • This suggests that retinovascular pathology may indicate macrovascular disease even after adjustment for renal dysfunction and traditional risk factors. (cristudy.org)
  • La enfermedad renal crónica y la anemia son frecuentes en la insuficiencia cardíaca (IC) y su presencia se asocia con un peor pronóstico en estos pacientes. (revistanefrologia.com)
  • Además, en un análisis post hoc de un ensayo clínico, la ferroterapia mejoró la función renal en pacientes con IC y ferropenia. (revistanefrologia.com)
  • Hypertension is a common early symptom, and occurs in approximately 60% of patients before renal dysfunction. (jscimedcentral.com)
  • The effects of nesiritide on renal function and diuretic responsiveness in acutely decompensated heart failure patients with renal dysfunction. (wustl.edu)
  • Comorbidities, such as renal dysfunction and propensity for hyperkalemia, are more prevalent in people with diabetes and may influence heart failure drug doses and monitoring of therapy but not therapeutic targets. (diabetes.ca)
  • Data regarding the prevalence of left ventricle systolic dysfunction (LVSD) and heart failure (HF) are still conflicting. (nih.gov)
  • left ventricle systolic dysfunction. (nih.gov)
  • However, a recent study from Israel suggests that the troponin release may originate more from the right ventricle than from the left ventricle (Szekely et al. (keraltyhospital.com)
  • RCM may manifest as a solitary abnormality, although restrictive filling patterns of the left ventricle can also be seen in patients with dilated or hypertrophic cardiomyopathy. (medscape.com)
  • Mitral regurgitation (MR) is caused by the retrograde flow of blood from the left ventricle (LV) into the left atrium (LA) through the mitral valve (MV), causing a systolic murmur heard best at the apex of the heart with radiation to the left axilla. (nih.gov)
  • Nonetheless, a recent review has highlighted the disconnect between Doppler echo measurements and true diastolic properties of the left ventricle, and has questioned the prevailing assumption that HF with preserved systolic function is always caused by diastolic dysfunction. (bmj.com)
  • This may involve a change in the spatial relationship between ascending aorta (AA) and left ventricle (LV) due to elongation or tortuosity of arteriosclerotic AA. (heart.org)
  • Suppose the left ventricle encounters either absolute or relative functional insufficiency (called left ventricular heart failure or left-sided heart failure). (centralindiachronicle.com)
  • LVH, defined as an increase in the mass of the left ventricle, is caused by the response of myocytes to various stimuli accompanying elevated BP. (medscape.com)
  • Mitral stenosis is narrowing of the mitral orifice that impedes blood flow from the left atrium to the left ventricle. (msdmanuals.com)
  • Mitral Regurgitation Mitral regurgitation (MR) is incompetency of the mitral valve causing flow from the left ventricle (LV) into the left atrium during ventricular systole. (msdmanuals.com)
  • Abnormalities in hematologic, metabolic, and bone metabolism parameters are also more prevalent in Hispanics with CKD. (cristudy.org)
  • The aims of this study were to (1) examine development of sinus node dysfunction (SND), atrial and ventricular tachyarrhythmias, and (2) study progression of atrioventricular conduction abnormalities in young adult patients with repaired cAVSD. (1library.net)
  • Dynamic (cine) cardiovascular MRI showed normal systolic ventricular function without any wall motion abnormalities. (cmaj.ca)
  • Cardiovascular magnetic resonance images showing normal systolic left ventricular function on cine imaging without wall motion abnormalities (A, short-axis end-systolic phase). (cmaj.ca)
  • Morphologic findings include atrial enlargement without increased ventricular wall thickness or ventricular cavity dilation, the absence of eosinophilic infiltration, and the absence of pericardial disease. (medscape.com)
  • citation needed] In the brain, hypertensive encephalopathy - characterized by hypertension, altered mental status, and swelling of the optic disc - is a manifestation of the dysfunction of cerebral autoregulation. (wikipedia.org)
  • With recent evidence demonstrating the critical role of RV in a number of disorders, including pulmonary hypertension (PH), congenital heart disease, ischemic heart disease, and left ventricular (LV) dysfunction prognosis, the determination of the RV feature becomes quickly essential in clinical practice. (ac.ir)
  • Hypertension was more prevalent in women, in Arabs than non-Arabs and in older age groups. (who.int)
  • Type 2 diabetes often occurs in association with other cardiovascular (CV) risk factors, such as hypertension, dyslipidemia, smoking and obesity, which, together, are strongly associated with atherosclerosis, ischemic heart disease and left ventricular (LV) dysfunction (1) . (diabetes.ca)
  • In approximately a third of patients with pulmonary arterial hypertension (PAH), echocardiography demonstrates right-to-left shunting across a patent foramen ovale (see the image below). (medscape.com)
  • 2 Thus, diastolic evaluation is an important component of the evaluation of the patient with systolic left ventricular (LV) impairment. (bmj.com)
  • Dyslipidemia, identified as increased low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), triglyceride (TG) levels, and/or decreased high-density lipoprotein cholesterol (HDL-C), is found to be associated with decreased systolic and diastolic left ventricular function and increased risk of cardiovascular disease (CVD) [ 6 - 9 ]. (hindawi.com)
  • HCM is a prevalent inherited cardiovascular disease with diverse genotypes, phenotypes, clinical symptoms, and natural histories [ 1 ]. (biomedcentral.com)
  • A variety of observations suggest that coronary microvascular dysfunction (CMD) is related to the pathogenesis of cardiovascular disease, including myocardial ischaemia and heart failure. (medscape.com)
  • If the process is not stopped, homeostatic failure begins, leading to loss of cerebral and local autoregulation, organ system ischemia and dysfunction, and myocardial infarction. (wikipedia.org)
  • Pulsed-wave tissue Doppler imaging (TDI) of the left ventricular longitudinal myocardial velocity associated with atrial contraction (A'), both at the level of the interventricular septum and the LV free wall, was also used as an indicator of LA function. (openveterinaryjournal.com)
  • Specifically, does primary CMD lead to ventricular remodelling/diastolic dysfunction and HFpEF or do alterations in myocardial remodelling/diastolic dysfunction observed in HFpEF lead to secondary CMD, i.e. the chicken or the egg? (medscape.com)
  • Little is yet known about the pathophysiological mechanisms underlying the progression from an asymptomatic stage defined as left ventricular diastolic dysfunction to clinical heart failure. (epidemiologie.nl)
  • We hypothesize that an impaired insulin signaling combined with heightened systemic inflammation might be associated with the progression of diastolic dysfunction towards HFpEF. (epidemiologie.nl)
  • Patients with LVH tend to be older and more obese, have higher blood pressure and be more likely to have preexisting coronary artery disease and depressed left ventricular systolic function. (aafp.org)
  • The radiation targets IMC and SCL, showed a statistically significant trend for an increased risk of stroke with daily fraction dose.A study of 199 patients with BC, examined by coronary angiography, detected a four- to seven-fold increase of high grade coronary artery stenosis in mid and distal left anterior descending artery (LAD), including distal diagonal branch, when comparing women with irradiated left-sided BC to those with right-sided. (kb.se)
  • An increase of clinically significant coronary artery stenosis was found in pre-specified hotspot areas for radiation among women irradiated to the left breast/chest wall or to the IMC. (kb.se)
  • Thus, the coronary arteries should be regarded as organs at risk in RT of BC.In a study of 15 BC patients treated with 3D conformal RT, a marked difference in dose distribution in mid and distal LAD between left- and right-sided BC was demonstrated. (kb.se)
  • On the contrary, tangential RT to the left breast without regional lymph node irradiation yielded coronary artery max doses of approximately 50 Gray to distal LAD, probably not safe concerning late radiation vascular effects.To conclude, we found cardiovascular side effects in women irradiated for BC, resulting in stroke and coronary artery disease, and showed an association between the targets for RT and the anatomical location of these vascular events. (kb.se)
  • In nondiabetic patients, a number of factors may be used to stratify the level of risk of coronary disease, including clinical history, resting ventricular function, exercise capacity, the presence and extent of ischemia at single-photon emission-computed tomography (SPECT), or stress echo. (diabetesjournals.org)
  • [ 1 , 2 ] CMD is due to changes in the function and structure of the coronary microcirculation and, in the absence of obstructive coronary artery disease (CAD), is more prevalent among women, is poorly understood mechanistically, and therefore represents a major unmet therapeutic need. (medscape.com)
  • Patients with severe CSA also had a higher incidence of nonsustained ventricular tachycardia (P=0.05). (elsevierpure.com)
  • Case Description -2 spayed female (8 and 9 years old) and 1 sexually intact male (6.5 years old) Boxers were treated because of sustained ventricular tachycardia by electrical cardioversion. (avma.org)
  • Analysis of the ECG rhythm strips for the 8- and 6.5-year-old dogs indicated a right ventricular origin of the ventricular tachycardia. (avma.org)
  • Analysis of the ECG rhythm strip for the 9-year-old Boxer indicated a left ventricular origin of the ventricular tachycardia. (avma.org)
  • The electrical cardioversion procedure was performed 2 times (5-day interval between procedures) in the 9-year-old female as a result of relapse of the ventricular tachycardia condition. (avma.org)
  • Clinical Relevance -Results and follow-up monitoring suggested electrical cardioversion of sustained ventricular tachycardia may be a safe and effective treatment in Boxers that are unresponsive to medical treatment. (avma.org)
  • Background - The prevalence and characteristics of sleep-disordered breathing in patients with asymptomatic left ventricular (LV) dysfunction are unknown. (elsevierpure.com)
  • Conclusions - CSA is highly prevalent in patients with asymptomatic LV dysfunction. (elsevierpure.com)
  • Malignant LVH was associated with 7.0-, 3.5-, and 2.6-fold adjusted increases in incidence of HF, cardiovascular death, and asymptomatic LV dysfunction, respectively, versus group 1. (johnshopkins.edu)
  • We confirm that Brugada syndrome is the same entity as sudden night death, highly prevalent in Southeast Asian countries (Thailand, Philippines and Japan), both of which share mutations in the same gene: SCN5A. (bvsalud.org)
  • Also, symptomatic HF is more prevalent in patients with DM1 despite their limited levels of physical activity. (nih.gov)
  • Therefore, we evaluated the prevalence of sleep-disordered breathing in patients with LV dysfunction without overt heart failure and tested the hypothesis that sleep-disordered breathing is linked to greater hemodynamic and autonomic impairment. (elsevierpure.com)
  • For patients with LVH and diastolic dysfunction, there is no evidence-based consensus as to optimal management. (aafp.org)
  • Heart failure (HF) patients frequently develop brain deficits that lead to cognitive dysfunction (CD), which may ultimately also affect survival. (encyclopedia.pub)
  • Carbon dioxide levels were fluctuated in patients with either acute or chronic HF and were inversely related to left ventricular end-diastolic pressures, leading to constriction/dilatation of central nervous system (CNS) blood vessels [ 2 ] . (encyclopedia.pub)
  • Patients' medical files were evaluated for occurrence of SND, atrioventricular conduction block (AVB), atrial and ventricular tachyarrhythmias. (1library.net)
  • Chez les patients hypertendus, le taux de mortalité était plus élevé uniquement chez les patients admis pour un infarctus du myocarde avec sus-décalage du segment ST. Après ajustement des résultats en fonction des variables de référence, l'hypertension s'est révélé être un facteur prédictif indépendant de l'insuffisance cardiaque (OR = 1,31) et de l'accident vasculaire cérébral (OR = 2,47). (who.int)
  • Left Ventricular Systolic Dysfunction in Patients Diagnosed With Hypertrophic Cardiomyopathy During Childhood: Insights From the SHaRe Registry (Sarcomeric Human Cardiomyopathy). (chop.edu)
  • At initial SHaRe Registry site evaluation, 56 (5.5%) patients with childhood-diagnosed HCM had prevalent LVSD, and 92 (9.1%) developed incident LVSD during a median follow-up of 5.5 years. (chop.edu)
  • Despite most of the patients could be weaned from cardiopulmonary bypass (CPB) with pharmacotherapy and intra-aortic balloon pump (IABP), at least 1% evolves with progressive organ dysfunction in spite of optimized management and needed advanced mechanical circulatory support [2] . (rbccv.org.br)
  • An increasingly prevalent cause in older patients is mitral annular calcification with extension of calcification into the leaflets, causing them to stiffen and not open fully. (msdmanuals.com)
  • Excluding left-sided heart disease, including diastolic dysfunction, is especially important in these patients because of major treatment implications. (medscape.com)
  • Typical hemodynamic characteristics include normal systolic function and equalization of increased ventricular end-diastolic pressures. (medscape.com)
  • Thyroid hormones have significant effects on the heart and cardiovascular system, and hyperthyroidism affects left ventricular systolic and diastolic function differently. (ac.ir)
  • Echocardiographic assessment of diastolic function makes the diagnosis of diastolic HF more specific, allows serial assessment of the response of diastolic dysfunction to treatment, and facilitates inclusion of more homogeneous populations into intervention trials. (bmj.com)
  • Unrecognized HFpEF is more prevalent in women with diabetes compared to men with diabetes and therefore sex-specific diagnostic strategies are needed. (maastrichtuniversity.nl)
  • This is consistent with a growing body of work from our group showing that women with CMD often have left ventricular (LV) diastolic dysfunction, [ 5 , 11 , 12 ] and are at increased risk of developing HFpEF. (medscape.com)
  • LV dysfunction can be clinically silent or associated with the typical clinical signs and symptoms of heart failure (e.g. peripheral edema, shortness of breath, fatigue), although the elderly may have atypical symptoms (2) . (diabetes.ca)
  • The measurement of plasma BNP and NT-pro-BNP, which are acutely released by ventricular myocytes when the myocardium is stretched due to increased filling pressures, may help make an accurate diagnosis where clinical uncertainty exists (3) . (diabetes.ca)
  • Ischemia adds risk that is incremental to clinical risks and LV dysfunction. (diabetesjournals.org)
  • In the elderly, such decline becomes more prevalent (up to 60%) and shows-up with erectile dysfunction (ED) and hypoactive sexual desire. (unicz.it)
  • Chronic obstructive pulmonary disease and deep vein thrombosis: a prevalent combination. (wustl.edu)
  • 50%), significant valvar dysfunction (such as mitral regurgitation or aortic stenosis), and pericardial disease. (bmj.com)
  • The development of left ventricular systolic dysfunction (LVSD) in hypertrophic cardiomyopathy (HCM) is rare but serious and associated with poor outcomes in adults. (chop.edu)
  • Thoracic aortic aneurysms were more prevalent in those with HIV (37.5% vs 26.7%, p (bvsalud.org)
  • The pathogenesis is not clear, but it is interesting that, in general, inflammation of the left atrial tissue is believed to be the common substrate for this arrhythmia. (keraltyhospital.com)
  • Conversely, hypoxia can promote tissue dysfunction and disease development through immune cell dysregulation in pathological immune niches [ 8 ]. (biomedcentral.com)