Loading...
  • axon
  • Partial membrane loss at axon terminals was also evident, accompanied by degenerative membranes in the same areas. (jneurosci.org)
  • Utilizing recent improvements in the signal-to-noise ratio of voltage-sensitive dye imaging in mouse brain slices, we demonstrate that intracortical axon collaterals and en passant presynaptic terminals of layer 5 pyramidal cells exhibit a high density of Kv1 subunit-containing ion channels, which generate a slowly inactivating K + current critically important for spike repolarization in these compartments. (jneurosci.org)
  • However, it is unknown whether en passant presynaptic terminals located on axon collaterals also contain Kv1 channels and propagate broadened spikes during subthreshold somatic depolarization. (jneurosci.org)
  • mitochondria
  • By 100 weeks (late clinical stage), PAS-positive granules and spheroids had increased significantly in the distal parts of axons, and ultrastructural examination revealed that these granules were, in fact, mitochondria with degenerative inner membranes. (jneurosci.org)
  • synaptic activity
  • Here, we sought to localize PDK1 in the NMJ and investigate the hypothesis that synaptic activity and muscle contraction regulate in parallel PDK1 and cPKCβI phosphorylation in the membrane fraction. (frontiersin.org)
  • However, synaptic activity specifically enhanced phosphorylation of PDK1 in the membrane, an important subcellular location for PDK1 function. (frontiersin.org)
  • structural
  • Overall, the findings presented in this thesis demonstrate that the structural organization of membranes is governed by a hierarchy of interactions with hydrophobic mismatch emerging as one of the fundamental principles. (uni-goettingen.de)
  • small
  • Information flow in the nervous system depends on the triggered release of packets of neurotransmitter contained in small synaptic vesicles (SVs) in the presynaptic terminal. (pnas.org)
  • presence
  • Imaging mass spectrometry showed a prominent increase of docosahexaenoic acid-containing phosphatidylcholine in the gray matter, suggesting insufficient membrane remodeling in the presence of iPLA 2 β deficiency. (jneurosci.org)
  • negative
  • At 15 weeks (preclinical stage), periodic acid-Schiff (PAS)-positive granules were frequently observed in proximal axons and the perinuclear space of large neurons, and these were strongly positive for a marker of the mitochondrial outer membrane and negative for a marker of the inner membrane. (jneurosci.org)