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  • Hippocampal
  • To establish the precise localization of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning of the three major hippocampal pathways: the perforant path, mossy fiber, and Schaffer collateral. (jneurosci.org)
  • Pregnenolone sulfate enhances survival of adult-generated hippocampal granule cells via sustained presynaptic potentiation. (nih.gov)
  • neuron
  • This neuron-specific, SCF-like complex therefore provides a localized signal to attenuate presynaptic differentiation. (nih.gov)
  • Unexpectedly, however, using sensory-evoked activity patterns recorded from the developing mouse cortex in vivo, the synaptic learning rule that we uncover here relies solely on the presynaptic neuron. (sebbm.es)
  • plasticity
  • Together, these findings underscore that vesicular transporter expression is used endogenously to directly regulate the extent of glutamate release, providing a concise presynaptic mechanism for controlling the quantal efficacy of excitatory transmission during synaptic refinement and plasticity. (jneurosci.org)
  • potentiation
  • PREGS-inducted presynaptic potentiation required a co-activation of α7 nicotinic acetylcholine receptor (α7nAChR), NMDA receptor (NMDAr) and sigma-1 receptor (σ1R), while its maintenance after PREGS-washout depended only on NMDAr and neuronal NO synthase (nNOS) activation. (nih.gov)
  • influx
  • An increase in P could be caused by an enhanced Ca 2+ influx [e.g., broadening of the presynaptic action potential (AP)] ( 16 - 18 ). (pnas.org)
  • Nervous System
  • Next, we review the remarkable conservation of presynaptic homeostasis at the Drosophila, mouse, and human neuromuscular junctions and emerging parallels at synaptic connections in the mammalian central nervous system. (uzh.ch)
  • actin
  • Because PI(4,5)P 2 participates in both clathrin coat and actin nucleation, it is important to identify how the presynaptic pool of PI(4,5)P 2 is generated and maintained ( Wenk and De Camilli, 2004 ). (rupress.org)
  • Does β-pix contribute to actin polymerization and SV clustering at presynaptic sites? (jneurosci.org)
  • responses
  • At the presynaptic level, diinosine pentaphosphate, Ip5I, is a good tool to specifically block dinucleotide responses, which are inhibited at low nM concentration, versus the high μM concentrations required to block ATP responses. (mendeley.com)