Pressor response reflexes in response. Medical search. Frequent questions

Stimulation of the mesencephalic locomotor region elicits exaggerated sympathetic nerve and pressor responses in spontaneously hypertensive rats (SHR) as compared with normotensive Wistar-Kyoto rats (WKY). (bvsalud.org)

To test the hypothesis that the responses in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) during SpMA are exaggerated with hypertension, this study aimed to compare the responses in decerebrate, paralyzed SHR, WKY, and normotensive Sprague-Dawley (SD) rats. (bvsalud.org)
Exaggerated Exercise Pressor Reflex in Male UC Davis Type 2 Diabetic Rats is Due to the Pathophysiology of the Disease and not Aging. (utexas.edu)
GsMTx-4 normalizes the exercise pressor reflex evoked by intermittent muscle contraction in early-stage type 1 diabetic rats. (utexas.edu)
Effects of acute hyperglycemia on the exercise pressor reflex in healthy rats. (utexas.edu)

Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage. (lgmpharma.com)

Minimal reflex bradycardia (angiotensin II CNS action resets baroreceptor reflex system, making it less sensitive). (pharmacology2000.com)
Classically, the Cushing reflex has been reported as the occurrence of hypertension, bradycardia and apnoea following intracranial hypertension. (tati.hu)

Blockade of N-methyl-D-aspartate (NMDA) receptors by intrathecal injection of DL-2-amino-5-phosphonovaleric acid had no effect on the initial phase of the pressor, ventilatory, and RSNA responses to contraction but did attenuate the secondary phase of these responses. (psu.edu)
Subsequent blockade of non-NMDA receptors in the lumbosacral spinal cord by intrathecal injection of 6-cyano-7-nitroquinoxaline-2,3-dione attenuated both the initial phase of the pressor, RSNA, and ventilatory responses to contraction and the secondary phase of these responses. (psu.edu)
Our findings suggest that non-NMDA receptors mediate the spinal transmission of the initial and secondary phases of the pressor, RSNA, and ventilatory responses to contraction and tendon stretch. (psu.edu)
The exercise pressor reflex (EPR) plays an essential role in cardiovascular and ventilatory responses to physical activity. (ijpp.com)
In thirteen cats anesthetized with α-chloralose, we compared the cardiovascular and ventilatory responses to both static contraction and tendon stretch of a hindlimb muscle group, the triceps surae, with those to contraction and stretch of a forelimb muscle group, the triceps brachii. (elsevierpure.com)

Cushing reflex (also referred to as the vasopressor response, the Cushing effect, the Cushing reaction, the Cushing phenomenon, the Cushing response, or Cushing's Law) is a physiological This is different from a hemorrhagic or bleeding stroke in which blood leaks out of a burst blood vessel or vascular malformation. (tati.hu)

The pressor responses to simultaneous static contraction and diencephalic stimulation were significantly smaller than the algebraic sum of the pressor responses to contraction and diencephalic stimulation evoked separately. (elsevierpure.com)
Static contraction and stretch of both muscle groups increased mean arterial pressure and heart rate, and the responses were directly proportional to the developed tension. (elsevierpure.com)
Our results suggest that in the anesthetized cat the cardiovascular responses to both static contraction and tendon stretch are greater when arising from forelimb muscles than from hindlimb muscles. (elsevierpure.com)

Hypertensive response in face of increased ICP. (tati.hu)

To assess the possibility of neural occlusion we recorded, in chloralose-anesthetized cats, the pressor responses to statically contracting the hindlimb muscles and to electrically stimulating histologically confirmed sites in the posterior hypothalamus and subthalamus. (elsevierpure.com)
Hayashi, N , Hayes, SG & Kaufman, MP 2001, ' Comparison of the exercise pressor reflex between forelimb and hindlimb muscles in cats ', American Journal of Physiology - Regulatory Integrative and Comparative Physiology , vol. 281, no. 4 50-4, pp. (elsevierpure.com)

Labetalol HCl's beta 1 -receptor blockade in man was demonstrated by a small decrease in the resting heart rate, attenuation of tachycardia produced by isoproterenol or exercise, and by attenuation of the reflex tachycardia to the hypotension produced by amyl nitrite. (guidelinecentral.com)
One of the most essential parts of the reflex response to physical effort in human is the exercise pressor reflex (EPR) which consists of mechanoreflex and metaboreflex. (ijpp.com)
[ 1 , 9 ] In this review, we present experiments addressing the issue of interactions between mechano- and metaboreceptors, as well as between EPR and other reflexes involved in cardiovascular control during exercise. (ijpp.com)
Abstract Women exhibit an attenuated exercise pressor reflex (EPR) when compared to men. (cn1699.cn)
Recently, the lab has been focusing on determining the mechanisms by which exercise training improves cardiovascular function during physical activity in hypertension with the goals of identifying: i) novel treatments for the abnormal response to exercise in the disease and ii) new treatment therapies for the disease. (utsouthwestern.edu)
In the present study, to investigate an effect of pressor response on NVC, static handgrip exercise (HG) and post-exercise muscle ischaemia (PEMI) were applied as stimulations which cause an acute elevation in MAP induced by an activation of the sympathetic nerve. (biomedcentral.com)
The PCAv response itself to static exercise has not yet been studied. (biomedcentral.com)
Study Three assessed the interactive effects of age and sex on the neuro-cardiovascular responses to fatiguing exercise. (uwo.ca)
Conversely, the loss of estradiol following menopause did not affect the neuro-cardiovascular responses to fatiguing rhythmic handgrip exercise amongst women. (uwo.ca)
Finally, Study Four aimed to determine the role of biological sex and oral contraception on sympathetic AP discharge as well as the vasoconstrictor responses to changes in AP discharge during fatiguing static handgrip exercise amongst young adults. (uwo.ca)
This area is known to be important in the exercise pressor reflex in animals. (ox.ac.uk)

Pretreatment with phentolamine significantly reduced the duration but not the magnitude of the pressor response elicited by MDMA. (erowid.org)
Furthermore, insulin receptor blockade with GSK1838705 significantly suppressed the insulin-induced augmentation in CAP-activated currents (n = 13) as well as the response magnitude of CAP-induced action potentials (n = 9). (bvsalud.org)
The magnitude of the NVC increased during the cold pressor test (CPT), accompanied by an increase in the baseline PCAv with pressor response [ 3 ]. (biomedcentral.com)
In addition to the effect of MAP at baseline, i.e., before visual stimulation, on the magnitude of the NVC, a possible MAP increase in response to visual stimulation could affect the NVC. (biomedcentral.com)

The drug may reduce the pressor responses to epinephrine. (nih.gov)
Accordingly, the compensatory reflex mechanisms that come into play with a pronounced increase in blood pressure do not antagonize the direct cardiac actions of epinephrine as much as with catecholamines that have a predominant action on alpha receptors. (drugs-library.com)

The medullary ischemic reflex is a big response to a drop in blood pressure in the brain particularly in the medulla, where the lack of oxygen due to decreased perfusion triggers an autonomic response from the cardiac and vasomotor centers. (tati.hu)

However, neurotoxic treatment did not significantly affect baroreceptor reflex function. (erowid.org)

Although neural occlusion has been suggested to occur between the central and reflex mechanisms increasing arterial pressure, evidence consistent with this phenomenon is lacking. (elsevierpure.com)
Underlying mechanisms of increased pressor responses to stress in Blacks are poorly understood. (edu.au)

Labetalol HCl produces dose-related falls in blood pressure without reflex tachycardia and without significant reduction in heart rate, presumably through a mixture of its alpha- and beta-blocking effects. (guidelinecentral.com)

In decerebrate unanesthetized cats we tested the hypothesis that glutamatergic-receptor blockade in the lumbosacral spinal cord attenuated the reflex increases in mean arterial pressure, inspired minute ventilation, and renal sympathetic nerve activity (RSNA) evoked by static contraction of the triceps surae muscles. (psu.edu)

Additionally, we investigated whether insulin potentiates sympathetic nerve activity (SNA) responses to CAP. (bvsalud.org)

Cushings reflex = a hypothalamic response to brain ischemia wherein the sympathetic nervous system is activated which causes increased peripheral vascular What is this response. (tati.hu)
The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. (lgmpharma.com)
Overall, this series of studies provides new knowledge regarding the impact of age, sex, as well as endogenous and exogenous sex hormones on the regulation of muscle sympathetic AP discharge and the peripheral vasomotor responses to these efferent vasoconstrictor signals. (uwo.ca)

In addition, NMDA- receptor blockade had no effect on the pressor or RSNA responses to tendon stretch, whereas non-NMDA-receptor blockade abolished these responses. (psu.edu)

and (2) pressor response accompanied by metaboreflex modifies the NVC. (biomedcentral.com)

Any of the reflexes initiated by several stimuli originating in widely separated receptors whose impulses follow the final common path to the effector organ and reinforce one another. (unboundmedicine.com)
Two or more reflexes initiated simultaneously in different receptors that involve the same motor center but produce opposite effects. (unboundmedicine.com)
outbreaks of response and disease heart versus heart Also on CVD P and congestive levosimendan hyperopia in receptors with vector late-life: the Plavix Use for Treatment Of Congestive Heart growth( PLUTO-CHF) dentistry. (seabaygame.com)

We also recorded the pressor responses to topical application of capsaicin onto the intestine and to stimulation of these diencephalic sites. (elsevierpure.com)
In addition, it is demonstrated that insulin augments the sympathetic nerve activity response to capsaicin in vivo. (bvsalud.org)

We reported that insulin sensitizes the response of thin-fibre primary afferents, as well as the dorsal root ganglion (DRG) that subserves them, to mechanical stimuli. (bvsalud.org)
However, little is known about the effects of insulin on primary neuronal responses to chemical stimuli. (bvsalud.org)

The purpose of this study was to characterize the mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve responses elicited by the acute administration of MDMA and to determine whether neurotoxic doses of MDMA change cardiovascular and/or cardiovascular reflex function. (erowid.org)
Likewise, the renal SNA response to CAP after intramuscular injection of insulin (n = 8) was significantly (P (bvsalud.org)
HydrALAZINE usually increases renin activity in plasma, presumably as a result of increased secretion of renin by the renal juxtaglomerular cells in response to reflex sympathetic discharge. (nih.gov)

Sexual stimulation is necessary to activate response. (medscape.com)
Any reflex produced by stimulation of the auditory nerve, esp. (unboundmedicine.com)
No study observed has as yet the response of MAP against visual stimulation. (biomedcentral.com)
In the present study, we describe the response of PCAv to a visual stimulation during HG and PEMI. (biomedcentral.com)

After an initial dosage of 8 to 12 mcg per minute via intravenous infusion, assess patient response and adjust dosage to maintain desired hemodynamic effect. (nih.gov)
thus, the inability of the simultaneous maneuvers to evoke pressor responses that summed algebraically was not due to the fact that they caused a maximal effect. (elsevierpure.com)
Following IV administration, rapid pressor effect. (pharmacology2000.com)
Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. (lgmpharma.com)
May decrease pressor effect. (medicscientist.com)

May increase pressor response, resulting in severe hypertension. (medicscientist.com)

These results indicate that the acute administration of MDMA and d-amphetamine produce similar cardiovascular and sympathetic responses. (erowid.org)
One still unresolved question is whether the Cushing response is a non-synaptic acute brainstem ischemic mechanism or part of a larger physiological reflex for arterial blood He graduated from the University of Saskatchewan in 1994. (tati.hu)
As a result of the Cushing reflex, the Cushing triad is typically observed in the later stages of acute head injury. (tati.hu)

In a simple reflex this includes a sensory receptor, afferent or sensory neuron, reflex center in the brain or spinal cord, one or more efferent neurons, and an effector organ. (unboundmedicine.com)
Most reflexes, however, are more complicated and include internuncial or associative neurons intercalated between afferent and efferent neurons. (unboundmedicine.com)
Such reflexes always involve two efferent neurons (preganglionic and postganglionic). (unboundmedicine.com)

Neurotoxic doses of MDMA (20 mg/kg, s.c., b.i.d. for 4 days) significantly enhanced the bradycardic component of the Bezold-Jarisch reflex elicited by i.v. serotonin when tested either 2 days or 2 weeks after the last neurotoxic treatment. (erowid.org)
Neurotoxic doses of MDMA can also significantly alter cardiovascular reflex function. (erowid.org)
The Cushing reflex is a well-recognized response to significantly elevated intracranial pressure (ICP). (tati.hu)

Abstract Background and Aim Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, result. (cn1699.cn)

Higher diastolic pressor and heart rate responses to the cold pressor test were observed in Black compared to Caucasian Africans. (edu.au)

however, this reflex is typically described as occurring Cushing Triad: EMS tips for increased intracranial pressure Pathophysiology. (tati.hu)

It is likely that the exaggerated sympathetic nerve and pressor responses during SpMA in SHR are induced along a central command pathway independent of the arterial baroreflex and/or result from central command-induced inhibition of the baroreflex. (bvsalud.org)
the elevation of arterial pressure in response to cerebral ischemia. (tati.hu)

This article highlights the clinical importance of the EPR deterioration in heart failure pathophysiology and discusses potential therapies focused on restoring the reflex pathways. (ijpp.com)

We observed that age, but not sex, affected sympathetic vascular transduction, with older adults (regardless of sex) demonstrating attenuated vasoconstrictor responses following bursts of sympathetic discharge. (uwo.ca)

These results indicate that NVC was maintained during HG via contributions from both the pressor response and vasodilatation. (biomedcentral.com)

May increase pressor response. (medicscientist.com)

Conventional RAS involves the conversion of inactive angiotensinogen into angiotensin I (Ang I) in the presence of renin which is released from the kidney in response to low blood volume. (hindawi.com)

Absence of this reflex occurs in blindness and in injuries to cranial nerves III, V, and VII. (unboundmedicine.com)

Intravenous injection produces an immediate and intensified response. (drugs-library.com)

This chapter briey discusses the major surface and internal structures of the brain (summarized in Fig. Massive ICP rise leads to cerebral ischemia, Cushing Reflex(CNS ischemic response) Result of cerebral ischemia due to ICP. (tati.hu)
This is called the Cushing reflex and is a variant of the cerebral ischemic response. (tati.hu)

A pressor response may result following doxapram administration. (lgmpharma.com)

Notably, amongst males, testosterone was inversely related with the change in blood pressure, but positively related with AP recruitment, indicating that the lower testosterone levels may be driving these larger pressor and attenuated sympathetic responses amongst older males. (uwo.ca)

Anatomy46

Organisms10

Diseases18

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology4

Phenomena and Processes47

Disciplines and Occupations1

Information Science1

Health Care2

Spontaneously hypertensive rats1

Rats4

Skeletal muscle1

Bradycardia2

Ventilatory5

Vasopressor1

Contraction3

Hypertensive1

Hindlimb muscles2

Exercise11

Magnitude4

Epinephrine2

Autonomic1

Baroreceptor reflex1

Mechanisms2

Tachycardia1

Static contraction1

Potentiates1

Peripheral3

RSNA1

Metaboreflex1

Receptors3

Capsaicin2

Stimuli2

Renal3

Stimulation4

Effect5

Hypertension1

Acute3

Neurons3

Significantly3

Abstract1

Cold-pres1

Typically1

Arterial2

Heart1

Vasoconstrictor1

Results indicate1

Increase1

Renin1

Occurs1

Intravenous1

Cerebral2

Result1

Blood1