• Homologous sequences are orthologous if they are inferred to be descended from the same ancestral sequence separated by a speciation event: when a species diverges into two separate species, the copies of a single gene in the two resulting species are said to be orthologous. (wikipedia.org)
  • Homology candidate relations are integrated into a global network and groups of homologous genes are extracted by applying a community detection algorithm. (biomedcentral.com)
  • Homologous genes can be distinguished into paralogous, when homology occurs within the same genome, or orthologous, when homology occurs between different genomes. (biomedcentral.com)
  • Bioinformatics strategies were used to find other homologous genes and proteins, which can also degrade HCH present in various bacteria for controlling of pollution and offer clue to prevent its entry in the food chain. (ispub.com)
  • In the present investigation, RNA-dependent RNA polymerase sequence was retrieved from NCBI followed by its domain analysis to find out the effective part of the sequence later on 3D structure of the domain modeling by comparative homology modeling approach, including a thorough screening of the homologous sequences to domain by sequence alignment technique. (academicjournals.org)
  • We speculate that once the initial test is passed, the mismatch insensitive binding in the heteroduplex allows short mismatched regions to be incorporated in otherwise homologous strand exchange products even though sequences with less homology are eventually rejected. (ibpc.fr)
  • The term "percent homology" is often used to mean "sequence similarity", that is the percentage of identical residues (percent identity), or the percentage of residues conserved with similar physicochemical properties (percent similarity), e.g. leucine and isoleucine, is usually used to "quantify the homology. (wikipedia.org)
  • This involves that the term "percent homology" is a misnomer. (wikipedia.org)
  • While both new isolates are of the Asian genotype, DNA sequencing shows only 98 percent homology--potentially indicating they are the result of two separate introductions. (vin.com)
  • Homology among DNA, RNA, or proteins is typically inferred from their nucleotide or amino acid sequence similarity. (wikipedia.org)
  • Based on the definition of homology specified above this terminology is incorrect since sequence similarity is the observation, homology is the conclusion. (wikipedia.org)
  • Multiple clonal bands in HT had sequence similarity (homology) of 62-100% with the clonal band in the lymphoma from the same patient. (bmj.com)
  • Pleckstrin homology domain. (embl.de)
  • Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)
  • It shares homology with the mating-type protein, Mc, from the fission yeast Schizosaccharomyces pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. (nih.gov)
  • These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)
  • RecA family proteins are responsible for homology search and strand exchange. (ibpc.fr)
  • The results show that nonnative proteins are more structured and less solvent exposed than commonly believed. (lu.se)
  • The absorption of LMW proteins occurs in the PTC through clathrin-mediated endocytosis via 2 multiligand receptors (megalin and cubilin) present in the PTC apical border. (medscape.com)
  • Sequence homology is the biological homology between DNA, RNA, or protein sequences, defined in terms of shared ancestry in the evolutionary history of life. (wikipedia.org)
  • Partial homology can occur where a segment of the compared sequences has a shared origin, while the rest does not. (wikipedia.org)
  • WGS reveals that there is a great complexity in both HPV sequences present and the HPV integrations events in HPV positive OPSCCs tumors. (biomedcentral.com)
  • sequencing showed 100% homology to the species with the proposed name " M. tilburgii " ( 4 ). (cdc.gov)
  • Samples that display microbial growth are returned to the AWRI, where a combination of metagenomic DNA sequencing, strain isolation and whole-genome sequencing are used to identify and characterise the species present in each sample. (awri.com.au)
  • Homology analysis indicates at least 37 different species of yeast across the dataset, with some species present in more than one sample. (awri.com.au)
  • Since its introduction to North America in the early 1900s, white pine blister rust (WPBR) caused by the fungal pathogen Cronartium ribicola has resulted in substantial economic losses and ecological damage to native North American five-needle pine species. (frontiersin.org)
  • I present a case study demonstrating how an integrative approach can be applied in systematics to describe a new lepidopteran species and genus. (helsinki.fi)
  • During the study, we found out that the species has been present in collections for at least 128 years but has not been formally described. (helsinki.fi)
  • Strong punctate immunoreactivity was present in the inner plexiform layer (IPL) of all three species. (nih.gov)
  • The results suggest a high degree of sequence homology between the rho subunits of different vertebrate species, and they show that the retinal localization of GABA(C) receptors is similar across different species. (nih.gov)
  • In addition, our results provide electrophysiological confirmation of map features that have been documented in other cortical areas and primate species by optical imaging. (jneurosci.org)
  • Because many laboratories use tests that do not routinely distinguish Mycobacterium tuberculosis from closely related species, these laboratories report culture results as being positive or negative for " Mycobacterium tuberculosis complex. (cdc.gov)
  • These 7 species are approximately identical in DNA homology studies. (cdc.gov)
  • The second one uses machine learning techniques to find biological homology between the genomes of different viruses. (researchsquare.com)
  • The results of the biological tests will decide how well the models represent the theory of the 11β-HSD2 selectivity. (helsinki.fi)
  • Another viral sequence encoded a protein with 70% amino acid homology to the predicted RdRp. (virology.ws)
  • X: any amino acid except Pro) present in newly synthesized protein in yeast and mammalian cells. (elifesciences.org)
  • As such, we present information about the phylogenetic relationship of all identified bivalve caspases in relation to their homology to well-established vertebrate and invertebrate caspases. (exeter.ac.uk)
  • In addition, complementary DNAs for nine style S -glycoproteins have been sequenced 7-10 and have homology with two fungal ribonucleases. (nature.com)
  • More concretely, we show that the first Khovanov homology is supported in a single quantum grading determined by the Seifert genus of the link, where the group is free abelian and of rank determined by the Seifert graph of any of its positive link diagrams. (hu-berlin.de)
  • While studies of non-model organisms are critical for many research areas, such as evolution, development, and environmental biology, they present particular challenges for both experimental and computational genomic level research. (biomedcentral.com)
  • These tasks were approached with computational methods: homology modeling, docking, ligand-based pharmacophore modeling and virtual screening. (helsinki.fi)
  • Although the precise pathogenic mechanism of GDM has not been fully elucidated, it may occur as a result of abnormal glucose regulation and increased IR, inducing the disorders of glucose metabolism. (hindawi.com)
  • Here we present the free-, ligand (dGTP)- and inhibitor (GTP)-bound structures of hexameric E. coli dGTPase. (biorxiv.org)
  • To obtain these structures, we applied UV-fluorescence microscopy, video analysis and highly automated goniometer-based instrumentation to map and rapidly position individual crystals randomly-located on fixed target holders, resulting in the highest indexing-rates observed for a serial femtosecond crystallography (SFX) experiment. (biorxiv.org)
  • Moreover, we completely classify the contact structures with contact surgery number one on S¹xS², the Poincaré homology sphere, and the Brieskorn sphere Σ(2,3,7). (hu-berlin.de)
  • As one ingredient of the proofs of the above results we generalize computations of the homotopical invariants of contact structures to contact surgeries with more general surgery coefficients which might be of independent interest. (hu-berlin.de)
  • In the absence of experimentally determined protein structures, a homology-based model may serve as a good starting point for investigation of sequence-structure-function relationships. (biomedcentral.com)
  • Although homology-modeled structures may often not be accurate enough to allow characterization of protein-protein or protein-inhibitor interactions at the atomic level, they can suggest which sequence regions or individual amino acids are essential functional components of the protein. (biomedcentral.com)
  • It prevents fertilization by pollen bearing an S -allele identical to either of the two S -alleles present in the female sporophytic tissues. (nature.com)
  • Other workshop critical review papers are addressing aspects related to homology (the nature of the rat lung tumors and their potential counter- part in humans) as well as the types of nonneoplastic responses seen in laboratory animals and the potential mechanisms responsible for these effects. (cdc.gov)
  • The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
  • The present invention relates generally to compositions and methods for modulating the activation of nuclear factor κB (NF-κB). (justia.com)
  • IKK epsilon is an IKK-related kinase with 30% structural homology to IKK alpha and beta, and is present in a subset of IKK complexes. (rndsystems.com)
  • Individual HPV integrations were found to be highly disruptive resulting in structural variations and copy number changes at or around the integration sites. (biomedcentral.com)
  • Rosen Law Firm, a global investor rights law firm, reminds purchasers of the securities of Homology Medicines, Inc. (NASDAQ: FIXX) between June 10, 2019 and February 18, 2022, inclusive (the "Class Period"), of the important May 24, 2022 lead plaintiff deadline . (globenewswire.com)
  • For IκBα, the stimulus-induced phosphorylation at serines 32 and 36 renders the inhibitor a target for ubiquitination at lysines 21 and 22, resulting in degradation. (justia.com)
  • The viral integration and disruption of the E2 gene would increase expression of the oncogenes E6 and E7 resulting in the degradation of the tumor suppressors p53 and pRB which could eventually lead to cancer development [ 4 , 5 ]. (biomedcentral.com)
  • Therefore, the present study proposes the three‑dimensional structure of the helicase/protease enzyme of SPONV through homology modeling, using the crystal structure of the Dengue virus‑4 helicase/protease of the same viral family as a template. (spandidos-publications.com)
  • The viral helicase constitutes the main subject in the present study. (spandidos-publications.com)
  • however, we present experimental and theoretical results suggesting that the heteroduplex stability is insensitive to mismatches. (ibpc.fr)
  • This suggests a possible extension of our results to L-space knots. (hu-berlin.de)
  • Genomic sequencing of A. fulgidus suggests that three [Ni-Fe]-CODHs are present, a "bacterial" monomeric CooS and two archaeal CdhAB-type CODHs [ 9 - 11 ]. (hindawi.com)
  • This negative surface provides binding sites for enzymes and cofactors of the coagulation system, resulting in the formation of a clot (secondary hemostasis). (medscape.com)
  • 1, 2 During the last decade, there have been several reports of patients who are described as having a 22q13 monosomy resulting from simple terminal deletions. (bmj.com)
  • We discovered that these deletions were the result of either HPV integration into the human genome or HPV-HPV sequence junctions. (biomedcentral.com)
  • Activation of AMPK by low energy supply and phosphorylation of LKB1 results in an inhibition of mTOR , thus decreasing energy-consuming processes, in particular translation and, thus, cell growth. (sdbonline.org)
  • Pan-genome approaches afford the discovery of homology relations in a set of genomes, by determining how some gene families are distributed among a given set of genomes. (biomedcentral.com)
  • A challenge on this field is that of designing fast and adaptive similarity measures in order to find a suitable pan-genome structure of homology relations. (biomedcentral.com)
  • We present PanDelos, a stand alone tool for the discovery of pan-genome contents among phylogenetic distant genomes. (biomedcentral.com)
  • Genes present in every genome are core genes of the pan-genome and they may be involved in essential living functionalities. (biomedcentral.com)
  • Singleton genes are present only in one genome and represent some genome-specific functionality. (biomedcentral.com)
  • The 16S rDNA is present in scattered form in the entire genome of bacteria. (ispub.com)
  • We will describe how to construct cellular sheaves in polymake, in order to compute tropical homology. (mpg.de)
  • In addition, we also discuss characterizing slopes and provide results in the opposite direction, i.e. describe cases in which the Stein trace, or the contactomorphism type of an r-surgery, uniquely determines the Legendrian isotopy type. (hu-berlin.de)
  • Western Blot (WB) immunoglobulin G results from cutaneous cases. (cdc.gov)
  • The diagnosis of measles is confirmed by laboratory test results, including a positive result for measles-specific immunoglobulin M (IgM) titre, significant increase in measles-specific immunoglobulin G (IgG) titre using paired serum, the detection of measles virus (MV) by reverse transcription polymerase chain reaction (RT-PCR) or isolation of MV in cell culture. (who.int)
  • biodegradable enzymes present in the genes of some bacteria degrade HCH in soil. (ispub.com)
  • Suitable notions are needed to define adaptive thresholds especially when they present non-uniform phylogenetic distances. (biomedcentral.com)
  • RESULTS: in this work, we investigated the presence of caspase homologues using a combination of bioinformatics and phylogenetic analyses. (exeter.ac.uk)
  • The docking results revealed that the compounds orientate differently in the enzymes. (helsinki.fi)
  • We determine the structure of the Khovanov homology groups in homological grading 1 of positive links. (hu-berlin.de)
  • Individuals with Myhre syndrome often have problems with the structure of the heart that are present at birth (congenital heart defects). (medlineplus.gov)
  • Homology models of RNA-dependent RNA polymerase domain was finally taken into consideration to focus on the prediction of the specific ligand binding site by docking against antiviral drug Ribavirin, with an aid of AutoDock4.2. (academicjournals.org)
  • Protein-protein interactions also resulted in significant variations in reduced macromolecular diffusion under crowded conditions, while metabolites exhibited significant two-dimensional surface diffusion and altered protein-ligand binding that may reduce the effective concentration of metabolites and ligands in vivo. (elifesciences.org)
  • This bleeding is painful and leads to long-term inflammation and deterioration of the joint (typically the ankles in children, and the ankles, knees, and elbows in adolescents and adults), resulting in permanent deformities, misalignment, loss of mobility, and extremities of unequal lengths. (medscape.com)
  • The directed expression of Buffy in the dopamine producing neurons, via aDdc-Gal4 transgene, resulted in flies with increased climbing ability and enhanced survival, while the inhibition of Buffy in the dopaminergic neurons reduced climbing ability over time prematurely, similar to the phenotype observed in the alpha-synuclein-induced Drosophila model of PD. (sdbonline.org)
  • In complementary experiments the overexpression of Buffy in the developing eye suppressed the mild rough eye phenotype that results from Gal4 expression and from alpha-synuclein expression. (sdbonline.org)
  • The experimental results have shown that the majority of techniques gave the same global results concerning the origin(s) and inter-host(s) of SARS-COV-2. (researchsquare.com)
  • Our results support a model in which the gametophytic self-incompatibility system in N. alata acts through a cytotoxic mechanism directed against pollen RNA. (nature.com)
  • As an application, we present some novel results for the Kuramoto model defined on a ring and compute the longest possible edge length for a stable solution. (illinois.edu)
  • Analysis revealed that Buffy acted to rescue the associated loss of locomotor ability observed in the alpha-synuclein-induced model of PD, while Buffy RNA interference resulted in an enhanced alpha-synuclein-induced loss of climbing ability. (sdbonline.org)
  • The expression of human α-synuclein transgene in neuronal populations that include dopamine producing neurons under the control of Ddc -Gal4 produces a robust Parkinson disease model, and results in severely reduced lifespan and locomotor dysfunction. (sdbonline.org)
  • The homology model of 11β-HSD2 was constructed using SwissModeler and it showed satisfying superimposition both with is template 17β-HSD1 and 11β-HSD1. (helsinki.fi)
  • The interaction pair for this hydrogen bond donor feature was not observed in the homology model. (helsinki.fi)
  • A distinct group of 22q13 monosomies has been reported that result from the formation of a ring chromosome which combines loss of some long arm material with loss of part of the short arm, with no clinical consequences. (bmj.com)
  • is a renowned medicine food homology plant, reports of excessive cadmium (Cd) levels are common, which affects its safety for clinical use and food consumption. (techscience.com)
  • Two days demonstrated by the present case, where the later, due to lack of clinical improvement, patient is infected with HIV, the fungus can an aliquot of the admission CSF was tested cause an infection regardless of the immune and found to have a cryptococcal antigen status of the patient. (who.int)
  • A minimally hypomorphic mutation in Btk resulting in reduced B cell numbers but no clinical disease. (lu.se)
  • 10 Monosomies for 22q13 have also been reported that result from unbalanced translocation with an acrocentric short arm. (bmj.com)
  • The classical active IKK complex, composed of IKK alpha, IKK beta, and two forms of processed IKK gamma, phosphorylates and inactivates IkB, resulting in the release and nuclear translocation of active NFkB. (rndsystems.com)
  • For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
  • These results clearly show that at least two related but distinct RNA viruses are present in Nymph Lake. (virology.ws)
  • We show that the index calculation can be related to a dual calculation which is done on the first homology group of the graph, rather than the vertex space. (illinois.edu)
  • We also show that this representation is computationally attractive for relatively sparse graphs, where the dimension of the first homology group is low, as is true in many applications. (illinois.edu)
  • We also show that several infinite families of Heegaard Floer L-space knots have vanishing first Khovanov homology. (hu-berlin.de)
  • Section 4 gives the experimental protocol and the results of applying the aforementioned techniques to analyze the genomes of this virus. (researchsquare.com)
  • We also present data suggesting that an initial homology test of 8 contiguous bases rejects most interactions containing more than 1/8 mismatches without forming a detectable 20 bp product. (ibpc.fr)
  • In the present article, we perform cortical type analysis of the neocortex of adult rats, Rhesus macaques, and humans to propose hypotheses on homology of cortical areas applying the principles of the Hypothesis on the Dual Origin of the Neocortex. (springer.com)
  • Here, we present an absolute temporal multi-omic analysis of a minimalistic cellulose-degrading and methane-producing consortium (SEM1b), which was resolved at the strain level and augmented with two strain isolates 10 . (nature.com)
  • To join the Homology class action, go to https://rosenlegal.com/submit-form/?case_id=4851 or call Phillip Kim, Esq. (globenewswire.com)
  • its role is to extract relevant information from a given sequence and to present it in a numeric form. (researchsquare.com)
  • The results obtained from the present studies provide new insights into the broad screening of certain putative marker inhibitors of the RNA-dependent RNA polymerase concomitant with their application in the relevant drug designing. (academicjournals.org)
  • Typically, the term "retained dose" in particulate inhalation studies refers to the amount of particles present at specific respiratory tract sites that is the net difference between deposition and clearance processes. (cdc.gov)
  • A PSI-BLAST (Position Specific Iterated-Basic Local Alignment Search Tool) [ 7 ] search with default parameters was performed against the Protein Data Bank (PDB) to find a suitable template for homology modeling. (biomedcentral.com)
  • As a result of the thicker skin, affected individuals typically have fewer facial creases (wrinkles) than others of their age. (medlineplus.gov)
  • Interestingly, the resulting hyperplastic glia express high levels of key components of the lysosomal-autophagic compartment, including vacuolar-type H(+)-ATPase (V-ATPase) subunits and ref(2)P (refractory to Sigma P), the Drosophila homolog of SQSTM1/p62. (sdbonline.org)
  • Curve C* of Figure 1 illustrates the type of retained lung burden seen with excessively high expo- sures that lead to impairment of AM-mediated particle clearance resulting in "lung overload. (cdc.gov)
  • Chronic exposures result in respiratory tract burdens that continue to increase over time until the rate of deposition is offset by the rate of clearance, thereby resulting in a steady-state burden from that time on. (cdc.gov)
  • Enteroviruses are shed in respiratory secretions and stool and sometimes are present in the blood and cerebrospinal fluid of infected patients. (msdmanuals.com)
  • miR-126 mimics downregulated the expression of IRS-1 and GOLPH3 protein and suppressed the proliferation, migration and invasion of ESCC cells, whereas miR-126 inhibitors led to the opposite results. (spandidos-publications.com)
  • A search of a 35-kilobase region of the human Y chromosome necessary for male sex determination has resulted in the identification of a new gene. (nih.gov)
  • In bacteria, homology search begins after RecA binds an initiating single-stranded DNA (ssDNA) in the primary DNA-binding site, forming the presynaptic filament. (ibpc.fr)
  • There are more than one record in the search results.Please specify issue. (go.jp)
  • Subcellular Distribution and Chemical Forms of Cadmium in the Medicine Food Homology Plant Platycodon grandiflorum (Jacq. (techscience.com)
  • These results establish biochemical profiles for kimchi extracts, and indicate that metabolomics can be used in the discrimination of food origins. (go.jp)
  • In the present study, the efficacy of Rhodococcus erythropolis DSM 44308 towards biodesulphurization of a Turkish lignite (TL) sample has been studied. (researchgate.net)
  • To the best of our knowledge, the biodesulphurization approach indicated in the present study using R. erythropolis is being reported for the first time. (researchgate.net)
  • The aim of the present study was to eluci- date the biology and prognostic role of the second ER, ERh, in patients treated with adjuvant tamoxifen. (lu.se)
  • Toxicologists and risk asses- sors are faced with a series of judgments when deciding whether to use the animal data and then with various extrapolations if the animal results are used. (cdc.gov)
  • RESULTS: A six class solution best fit the female data. (cdc.gov)
  • In particular, our results suggest that inhibitory mechanisms may be involved in the generation of fractures and singularities. (jneurosci.org)