AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsHealth Care
Adenocarcinoma, MucinousAdenocarcinomaAppendiceal NeoplasmsCarcinoma, Signet Ring CellPseudomyxoma PeritoneiRectal FistulaCecal NeoplasmsCystadenoma, MucinousUrachal CystCalymmatobacteriumPerineumCystadenocarcinoma, MucinousMucin-2MucinsColorectal NeoplasmsStomach NeoplasmsNeoplasm StagingOvarian NeoplasmsTumor Markers, BiologicalImmunohistochemistryColonic NeoplasmsRectal NeoplasmsMicrosatellite InstabilityPrognosisKaplan-Meier EstimateLung NeoplasmsPancreatic NeoplasmsEsophageal NeoplasmsAdenocarcinoma, PapillaryBarrett EsophagusCarcinoma, Pancreatic DuctalAdenocarcinoma, Bronchiolo-Alveolar
Intraductal papillary mucinous neoplasmPapillaryCarcinomaMetaplasiaTumorsAdenomaEpithelialMucinNeoplasms of the pancreasSignetMetastasisSubtypesCysticGastric cancerCarcinomasLesionEpitheliumPancreaticCancersCystadenocarcinomaObstructionTumorPrimaryAppendicealPrecursorTumoursDifferentiationHistopathologicalColonPelvicPrognosisMetastasesMetastatic diseaseClinicalAbdominalBladderClinicallyDiffuseLymphMalignanciesDifferentialPeritonealFindings
Intraductal papillary mucinous neoplasm5
  • Intraductal papillary mucinous neoplasm (IPMN) is a non-invasive mucin-producing neoplasm of the pancreas arising from the main pancreatic duct or side-branches. (utoronto.ca)
  • To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
  • Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
  • INTRODUCTION Since the 1st description more than three decades ago1, intraductal papillary mucinous neoplasm (IPMN) of the pancreas has become widely recognized as one of the most common cyst-forming pancreatic neoplasms, and several variants of intraductal neoplasms have been described including the gastric, intestinal, or pancreatobiliary subtypes2C9. (opioid-receptors.com)
  • The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. (biomedcentral.com)
Papillary2
  • Histologically, IPMNs are lined by flat or papillary mucinous epithelium of gastric, intestinal, pancreatobiliary, or oncocytic type, exhibiting varying degrees of dysplasia, and surrounded by dense fibrotic stroma. (utoronto.ca)
  • Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
Carcinoma16
  • Adenocarcinoma of the cervix is less common than squamous cell carcinoma, although its relative prevalence is increasing. (nih.gov)
  • After transurethral resection, pathology showed intestinal mucinous carcinoma. (bvsalud.org)
  • The differential diagnosis includes glandular differentiation of transitional cell carcinoma and direct extension or metastatic spread of adenocarcinoma arising primarily from the colon, prostate, appendix or endometrium. (biomedcentral.com)
  • This is an open label Phase 1b/2 study to evaluate the efficacy and safety of ACR-368 as monotherapy or in combination with ultralow dose gemcitabine in participants with platinum-resistant ovarian carcinoma, endometrial adenocarcinoma, and urothelial carcinoma based on Acrivon's OncoSignature® test status. (uclahealth.org)
  • Adenoid cystic carcinoma, adenocarcinoma and expleomorphic adenoma were observed as primary malignant tumors. (selcukmedj.org)
  • However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
  • IPMN is thought to represent a precursor lesion to pancreatic adenocarcinoma due to its association with invasive carcinoma [ 5 ]. (gastrores.org)
  • In addition to CEA being used to stratify mucinous vs. non-mucinous lesions, several studies have attempted to correlate pancreatic cyst fluid CEA level and the presence of invasive carcinoma, with discordant results [ 17 , 18 ]. (gastrores.org)
  • Despite the troubles of 41575-94-4 determining the degree of invasive carcinoma in many cases, the overall end result appears relatively beneficial and considerably better than that of standard ductal adenocarcinoma, even when only the instances with invasive carcinoma are considered. (opioid-receptors.com)
  • We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
  • However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
  • Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. (asploro.com)
  • This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
  • A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
  • The mastoid skin lesion was originally diagnosed by two separate institutes to be most likely a metastatic mucinous carcinoma. (asploro.com)
  • The tumorigenesis progression of GC is involved in multiple stages and develops from normal epithelia, chronic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia to carcinoma [ 6 , 7 ]. (biomedcentral.com)
Metaplasia4
  • intestinal metaplasia with goblet cells and neuroendocrine cells are present in some cases. (nih.gov)
  • There may be a progression from mucinous metaplasia to mucinous adenoma and then mucinous adenocarcinoma. (bvsalud.org)
  • The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
  • It is widely accepted that chronic GERD leads to inflammation and ulceration of the esophageal squamous mucosa and that persistent and recurrent inflammation and ulceration may lead to columnar metaplasia and, ultimately, intestinal metaplasia. (jcancer.org)
Tumors8
  • Double-contrast upper GI series and barium swallows may be helpful in delineating the extent of disease when obstructive symptoms are present or when bulky proximal tumors prevent passage of the endoscope to examine the stomach distal to an obstruction (more common with gastroesophageal [GE]-junction tumors). (medscape.com)
  • Malignant tumors of the appendix can be classified into mucinous epithelial neoplasms, neuroendocrine tumors (typical carcinoids), goblet cells or composite carcinoids, lymphomas, adenocarcinomas and lymphoid or mesenchymal sarcomas. (rojes.org)
  • Histologically, more than half of appendicular tumors are of neuroendocrine origin, while the rest are adenocarcinomas (mucinous, signet ring or non-mucin-secreting). (rojes.org)
  • The World Health Organization (WHO) classification is more detailed and, in addition to the adenocarcinoma, describes other gastric tumors of lower frequency, taking into consideration histological characteristics as well as and molecular phenotype. (medconsonline.com)
  • most of these tumors are adenocarcinomas containing pools of mucin. (biomedcentral.com)
  • By contrast, a rare subset of CRC tumors that show microsatellite instability (MSI-high) demonstrate marked responses to PD-1 therapy, similar to or exceeding that observed in other highly mutated cancers such as melanoma and lung adenocarcinoma. (cancer.gov)
  • IT-Ks20.10 represents an excellent marker for certain types of carcinomas such as adenocarcinomas of the colon, transitional cell carcinomas of the bladder and Merkel cell tumors of the skin. (progen.com)
  • Adenocarcinomas of breast, lung, endometrium and ovary (non-mucinous) as well as neuroendocrine tumors of the lung are essentially negative. (progen.com)
Adenoma2
  • Minimal deviation adenocarcinoma (MDA) of mucinous type (adenoma malignum) is considered an extremely well differentiated variant of GAS and is encompassed within the category of GAS. (nih.gov)
  • Pseudomyxoma Peritonei ( PMP ) is a more common name given to the "jelly belly" syndrome caused by mucinous adenoma and mucinous adenocarcinoma. (cancerindex.org)
Epithelial1
  • Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
Mucin3
  • Mucinous cystadenocarcinoma account for about a fifth of appendix tumours, these produces mucin (a jelly-like substance). (cancerindex.org)
  • Prostate biopsies showed mucinous adenocarcinoma in six of eight cores with large collections of mucin dissecting the prostatic parenchyma. (biomedcentral.com)
  • Bladder washings and biopsies revealed copious amounts of mucin with associated malignant nests and single cells also consistent with mucinous adenocarcinoma. (biomedcentral.com)
Neoplasms of the pancreas1
  • In contrast, mucinous cystic neoplasms of the pancreas occur almost exclusively in women, arise in the body/tail, do not communicate with a pancreatic duct, and exhibit dense ovarian-type stroma. (utoronto.ca)
Signet3
  • Less common tumours of the appendix include signet-ring cell adenocarcinoma and paraganglioma . (cancerindex.org)
  • The histologic appearance of bladder adenocarcinoma can be enteric, signet ring, mucinous, clear cell, hepatoid and mixed types. (biomedcentral.com)
  • In this report, we present the serial computerized tomography (CT) features of a locally advanced calcified signet-ring cell gastric cancer that showed partial response to chemotherapy. (biomedcentral.com)
Metastasis1
Subtypes2
  • Most cases of stomach cancers are gastric carcinomas, which can be divided into a number of subtypes, including gastric adenocarcinomas. (wikipedia.org)
  • Four main histologic subtypes of IPMN have been described: gastric, intestinal, pancreaticobiliary and oncocytic. (gastrores.org)
Cystic4
  • Pathologically, multiple cystic structures consisting of cuboidal epithelium containing mucinous material are seen in the submucosa and may extend to penetrate the muscularis propria. (radiologytoday.net)
  • Whereas serous cystic neoplasms are benign, IPMNs as well as mucinous cystic neoplasms can progress to invasive adenocarcinoma and require surgical resection. (utoronto.ca)
  • In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
  • During the diagnostic workup for pancreatic cysts, CEA is often utilized to distinguish those pancreatic cystic lesions that are likely to be mucinous [ 13 - 16 ]. (gastrores.org)
Gastric cancer2
  • The Lauren system classifies gastric cancer pathology as either type I (intestinal) or type II (diffuse). (medscape.com)
  • If the cancer originates from the stomach glandular tissue, the medical term for such a condition is gastric adenocarcinoma, or gastric cancer. (medconsonline.com)
Carcinomas3
  • Transitional cell and squamous cell carcinomas are the most common but there are three reported cases of mucinous adenocarcinoma. (biomedcentral.com)
  • The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
  • Mucinous skin carcinomas are mostly seen in the head and neck region and isolated specimens from this area should raise suspicion for a PMCS. (asploro.com)
Lesion3
  • Concomitant cystitis glandularis occurs in the majority of cases, but is not considered a definitive precursor lesion since adenocarcinoma can develop in the absence of cystitis glandularis and only a small number of bladders with cystitis glandularis actually develop malignancies [ 2 ]. (biomedcentral.com)
  • Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. (asploro.com)
  • Conclusion: right-sided pelvic lesion consistent with ovarian mucinous cystadenomatous-type lesion. (amsj.org)
Epithelium2
  • The endocervix is lined by columnar mucinous epithelium and in continuity with vaginal mucosa, the ectocervix is lined by squamous epithelium. (cytojournal.com)
  • Among sporadic endometrial cancers, when present, the microsatellite instability is confined to the malignant cells, and is not seen in the adjacent normal epithelium. (medmuv.com)
Pancreatic4
  • Most patients are asymptomatic but may also present with pancreatic duct obstruction and/or pancreatitis. (utoronto.ca)
  • Herein, we present the largest clinicopathologic studies of ITPN in an effort to more fully define the histologic and immunohistochemical features, medical behavior, and similarities and variations from IPMNs as well as other pancreatic neoplasms. (opioid-receptors.com)
  • Most pancreatic cancers are adenocarcinomas. (medicinenet.com)
  • Risk factors for Rem-Panc recurrence were reported to be the presence of high-grade dysplasia in resected specimens, positive surgical margins, and a family history of pancreatic ductal adenocarcinoma (PDAC). (biomedcentral.com)
Cancers2
  • Primary adenocarcinoma of the urinary bladder accounts for approximately 0.5-2% of all bladder cancers [ 1 ]. (biomedcentral.com)
  • Diet-induced obesity led to altered acetylation of lysine 27 on histone H3 (H3K27ac) and to altered monomethylation of lysine 4 on histone H3 (H3K4me1) at numerous loci, with concomitant changes in the expression of genes that were functionally relevant to intestinal cancers. (biomedcentral.com)
Cystadenocarcinoma1
  • Mucinous cystadenocarcinoma of the appendix complicated with spontaneous cutaneous fistula. (rojes.org)
Obstruction1
Tumor1
  • We present the case of a 40-year-old woman with recurrent lower urinary tract infections, submitted to imaging tests, which showed a bladder tumor. (bvsalud.org)
Primary4
  • Primary mucinous adenocarcinoma is an extremely rare type of bladder cancer, with aggressive behavior and poor response to chemotherapy and radiotherapy. (bvsalud.org)
  • We report a 57-year-old Caucasian man presenting with penile discharge for 30 years following ileal conduit surgery for neurogenic bladder, and who was found to have primary mucinous adenocarcinoma of his defunctionalized bladder. (biomedcentral.com)
  • We describe the fifth case of primary mucinous adenocarcinoma arising in a longstanding defunctionalized bladder. (biomedcentral.com)
  • Pseudomyxoma peritonei (PMP) is a rare, slow growing mucinous ascites, typically associated with primary appendiceal or ovarian neoplasm [1]. (amsj.org)
Appendiceal2
  • Appendiceal mucinous neoplasms represent an extremely small percentage of all appendectomy specimens. (rojes.org)
  • 2] Aleter A, El Ansari W, Toffaha A, Ammar A, Shahid F, Abdelaal A. Epidemiology, histopathology, clinical outcomes and survival of 50 cases of appendiceal mucinous neoplasms: Retrospective cross-sectional single academic tertiary care hospital experience. (rojes.org)
Precursor1
Tumours2
  • Of the remaining non-HPV associated tumours, the most frequent is gastric-type adenocarcinoma (GAS), which is recognised by the World Health Organization as a form of mucinous adenocarcinoma of the cervix. (nih.gov)
  • About two thirds of appendix tumours are carcinoid tumours which develop in hormone-producing cells that are present in many parts of the body, including the appendix. (cancerindex.org)
Differentiation1
Histopathological1
  • The histopathological examination of the appendectomy specimen established the diagnosis of infiltrative mucinous adenocarcinoma at the level of the adventitia. (rojes.org)
Colon3
  • Most cases occur in the 60s and 70s, while cases before age 50 are uncommon unless a family history of early colon cancer is present. (symptoms101.com)
  • This picture depicts an abdominal CT scan of a 7 year-old boy with a mucinous adenocarcinoma of the ascending colon. (medscape.com)
  • Mesenteric fat, vessels and lymph nodes were resected en block with the ascending colon. (medscape.com)
Pelvic1
  • We present a case of polypoid endometriosis in a postmenopausal 58 years old patient presenting with a pelvic retroperitoneal nodule mimicking a neoplasm. (fortuneonline.org)
Prognosis1
  • GAS has a much poorer prognosis than HPV-associated cervical adenocarcinoma, with propensity for presentation at advanced stage and wide dissemination to unusual sites such as the ovary, omentum and peritoneum. (nih.gov)
Metastases1
Metastatic disease1
  • Adenopathy, hepatomegaly, or pulmonary signs may be present with metastatic disease. (cancer.gov)
Clinical3
  • We present the case of a 44-year-old patient who presented to the Emergency Unit of "Saint John" Clinical Emergency Hospital Bucharest with an altered general condition, severe pain in the right iliac fossa associated with episodes of nausea, vomiting and fever. (rojes.org)
  • On admission, the clinical examination of the patient revealed a spontaneously painful abdomen, exacerbated on palpation in the right iliac fossa that associated signs of peritoneal irritation with accelerated intestinal transit. (rojes.org)
  • However, the probability that the disease is not present when the clinical signs are negative is acceptable in most of the endometriosis sites. (jogcr.com)
Abdominal1
  • CT is also indicated to exclude other potential intra-abdominal pathologies that present with symptoms similar to those of chronic pancreatitis, but CT cannot exclude a diagnosis of CP and cannot exclusively diagnose early or mild CP. (medscape.com)
Bladder1
  • The potential for adenocarcinoma to develop in the defunctionalized bladder that is left in-situ at the time of urinary diversion is rare [ 3 - 5 ]. (biomedcentral.com)
Clinically1
  • Intrahepatic bile duct cancer may be relatively indolent and difficult to clinically differentiate from metastatic adenocarcinoma deposits in the liver. (tri-kobe.org)
Diffuse1
  • According to the Laurén classification, gastric adenocarcinomas are divided into the intestinal, diffuse and indeterminate (having an uncommon histology) type. (medconsonline.com)
Lymph1
Malignancies1
  • Adenocarcinoma of the stomach constitutes 90-95% of all gastric malignancies. (medscape.com)
Differential1
Peritoneal2
  • Mucinous material fills the peritoneal cavity, causing enlargement of the abdomen and has been described as "jelly belly", due to its appearance at laparotomy [2]. (amsj.org)
  • Ascites is present in the peritoneal cavity and there is streaking of the omentum. (amsj.org)
Findings1
  • Together with the strong link between GERD and esophageal adenocarcinoma, these findings suggest that bile salts play a role in the pathophysiology of BE and EAC. (jcancer.org)