• The CD8α and β chains (CD8a and CD8b, respectively) form a heterodimer on the surface of most thymocytes and a subpopuplation of mature T-lymphocytes (ie, MHC class I-restricted T cells, including most T suppressor/cytotoxic cells). (bdbiosciences.com)
  • infiltrates consisted mainly of CD8-positive suppressor/cytotoxic and CD4-positive helper T lymphocytes. (lookformedical.com)
  • Therefore, there is good representation of both T helper and cytotoxic T cells (a neoplastic process could have predominantly one or the other or dual positive CD4 and CD8). (labce.com)
  • The CD markers that should be there are present, and there is a good representation of both helper and cytotoxic T cells. (labce.com)
  • In order for this strategy to be effective, latently infected cells must be killed either by the cytopathic effect of reactivated HIV gene expression, or by HIV-specific cytotoxic T lymphocyte (CTL). (frontiersin.org)
  • However, this strategy for the eradication of HIV hinges on the assumption that latently infected cells will be killed by the reactivation of latent proviruses, either as a result of cytopathic effects of HIV gene expression, or through lysis by HIV-specific cytotoxic T lymphocyte (CTL). (frontiersin.org)
  • Functionally inert HIV-specific cytotoxic T lymphocytes do not play a major role in chronically infected adults and children. (ox.ac.uk)
  • The highly sensitive quantitation of virus-specific CD8(+) T cells using major histocompatibility complex-peptide tetramer assays has revealed higher levels of cytotoxic T lymphocytes (CTLs) in acute and chronic virus infections than were recognized previously. (ox.ac.uk)
  • CD4 helper T-cells which alert the immune the studied infants were from low socio- system to an attack by a pathogen and the economic status families according to the CD8 suppressor T-cells which destroy cells classification of Park and Park [11]. (who.int)
  • A low ratio of CD4+ (helper) any chromosomal or hereditary disorder lymphocytes relative to CD8+ (suppressor) that caused the malnutrition. (who.int)
  • The LSM 12.125 antibody reacts with the canine form of the 56 kDa transmembrane glycoprotein, CD4, present on the T-helper/inducer subset of normal canine donor peripheral blood lymphocytes. (bdbiosciences.com)
  • A decreased proportion of circulating CD4-positive helper T cells relative to total T cell count. (nih.gov)
  • However, this finding has triggered further interest in utilising tumour-specific MHC-II to harness sustained anti-tumour immunity through the activation of CD4 + T helper cells. (portlandpress.com)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • CD4 counts (also known as T-helper cells) provide a measure of a person's immune function. (cdc.gov)
  • The LSM 8.358 antibody reacts with a CD3-like T-cell receptor-associated cell-surface antigen found on thymocytes and peripheral T lymphocytes. (bdbiosciences.com)
  • Immunohistochemically, the vast majority of the infiltrating cells stained positive for CD3 (Figure 6 ) and over half of them were positive for CD2 and T-cell intracellular antigen 1 (TIA1). (upmc.edu)
  • MHC-I and MHC-II proteins are key components of the antigen presentation machinery responsible for neoantigen presentation to CD8 + and CD4 + T lymphocytes, respectively. (portlandpress.com)
  • The percentage of positive tissue staining of HLA class I antigen in cervical cancer, CIN, chronic cervicitis and peri-cancer tissues were 40%, 95%, 100.0% and 100.0%, respectively. (wjon.org)
  • Human leukocyte antigen-I (HLA- = 1 \* ROMAN I), CD8 and CD4 molecules are important parts of human immune system. (wjon.org)
  • The major function of HLA-I is to present viral antigens to immune cells such as T cells then to induce the antigen-specific CTL activity in human body. (wjon.org)
  • The relative number of different lymphocyte subsets remained constant throughout the experiment. (usda.gov)
  • The mechanism was perhaps related to inhibiting lymphocyte apoptosis and promoting the balance of Th1/Th2 cell subsets. (hindawi.com)
  • The level of The infants with PEM were enrolled in T-lymphocyte subsets in peripheral blood the study after fulfilling a set of inclusion provide information about the development criteria. (who.int)
  • With the advent of the human immunodeficiency virus (HIV) pandemic, there has been a tendency to overlook the role of malnutrition in immunodeficiency, and indeed, only a handful of studies have investigated the CD4 + and CD8 + lymphocyte subsets in severely malnourished children [ 3 , 4 ]. (biomedcentral.com)
  • The objective of this study was to report the clinical features, haematological findings and CD4 + and CD8 + lymphocyte subsets of severely malnourished children with regard to their HIV status. (biomedcentral.com)
  • Furthermore, MP increased WBC and HGB counts and reduced the ratio of G0/G1 phase obviously, increased the proportion of S phase and G2/M phase in peripheral blood lymphocytes, increased the counts of CD4+ T cells and the ratio of CD4+/CD8+, and reduced the inhibition rate of splenic lymphocytes. (hindawi.com)
  • T-lymphocyte counts, with special emphasis and stunted children has not changed dra- on the effect of nutritional rehabilitation. (who.int)
  • The aim of this study was to describe the clinical features, haematological findings and CD4 + and CD8 + cell counts of severely malnourished children in relation to human immunodeficiency virus (HIV) infection. (biomedcentral.com)
  • In this paper, we report the complete results of the HIV tests as well as the CD4 + and CD8 + cell counts and percentages of the 315 children. (biomedcentral.com)
  • The CD4 cell counts were obtained by using the Becton Dickinson MultiTEST reagent in TrueCOUNT tubes (Becton Dickinson Immunocytometry Systems, San Jose, CA). Comparison of this method with CD4 counts calculated from CBC absolute lymph counts from fresh whole blood X CD4% from the frozen whole blood resulted in a correlation coefficient of 0.9872. (cdc.gov)
  • Among HIV-infected individuals, measurement of CD4 counts is often used to demonstrate how well anti-HIV drugs are working. (cdc.gov)
  • The distribution on lymphocytes for canine is similar to that found for both human and monkey, with the majority of CD4-positive lymphocytes being CD8-negative and lacking reactivity with antibodies to B- or NK-cell markers. (bdbiosciences.com)
  • The pan T cell markers are within a few percentage points of one another, which translates to the sample having all markers that should be present and no values being skewed toward one marker. (labce.com)
  • The B cells that are present, though a small percentage of the total lymphocytes, have no abnormal markers. (labce.com)
  • T lymphocytes were analyzed for the expression of autophagy-specific markers by biochemical, molecular, and histological assays in peripheral blood and labial gland biopsies. (biomedcentral.com)
  • A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). (scirp.org)
  • The present prospective study, carried out over fifteen years, describes the pattern of natural course of disease progression in a group of ART naive male professional blood donors with asymptomatic HIV-1 infection in relation to serum iron status, viral load, peripheral CD4 + T lymphocyte count, serum levels of cytokines and immune activation markers viz. (scirp.org)
  • Purpose: The present study aimed to examine the clinical implications of CD4, CD8, and FOXP3 expression on the prognosis of human epidermal growth factor receptor 2 (HER2)-positive breast cancer using a web-based database, and to compare the immunohistochemical expression of T-lymphocyte markers using primary and metastatic HER2-positive tumor tissues before and after HER2-targeted therapy. (elsevierpure.com)
  • Methods: Using the cBioPortal for Cancer Genomics and Kaplan-Meier plotter, the mRNA expression, association between T-lymphocyte markers, and survival in HER2-positive cancers were investigated according to various cutoff levels. (elsevierpure.com)
  • Results: HER2 mRNA was mutually exclusive of T-lymphocyte markers, and a significant correlation between T-cell markers was observed in the cBioPortal for Cancer Genomics. (elsevierpure.com)
  • However, in the intrinsic HER2-positive subtype, the individual analyses of T-cell markers except for FOXP3 and combined analysis showed significantly favorable survival irrespective of cutoff points. (elsevierpure.com)
  • Although the small clinical sample size made it difficult to show the statistical relevance of immunohistochemistry findings, good responses to neoadjuvant treatments might be associated with positive expression of combined T-lymphocyte markers, and approximately half of the samples showed discordance of combined markers between baseline and resistant tumors. (elsevierpure.com)
  • Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
  • Mycobacterium bovis, the causative agent of bovine tuberculosis is known to persist within granulomas, distinct lesions represented by a caseonecrotic core surrounded by epithelioid macrophages, T-lymphocytes, B-lymphocytes, Langhans-type multinucleated giant cells and fibroblasts. (usda.gov)
  • iNOS positive cells consisted of epithelioid macrophages and multinucleated giant cells surrounding central areas of caseous necrosis. (usda.gov)
  • In the lymphoid aggregate, 20% macrophages are seen, while 30% B-L or plasma cells and remainder T-L (with a ratio of CD4: CD8 = up to 4: 1). (labpedia.net)
  • It is found in the secondary granules of neutrophils and macrophages, and it is secreted by epithelial cells, monocytes, macrophages, T lymphocytes, and mast cells when in contact with PAMPs. (peptidesforresearch.com)
  • Differentiating between low-grade lymphoma and reactive lymphocytes is often difficult by morphology alone as reactive lymphoid cells may acquire activation morphology from being exposed to different cytokines within the body fluid. (cytojournal.com)
  • High serum iron was associated with elevated levels of Th 2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. (scirp.org)
  • In the present study we investigated Th17-related cytokines in RA BM. (biomedcentral.com)
  • Cutaneous T-cell lymphoma (CTCL) (see the image below) is a heterogeneous group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin, with no evidence of extracutaneous disease at the time of diagnosis. (medscape.com)
  • This is a normal peripheral blood lymphocyte population with no indication of a neoplastic process. (labce.com)
  • CD4 in the canine is also present on monocytes and granulocytes, but in higher numbers than what is seen for human. (bdbiosciences.com)
  • Regulatory T cells (Tregs) play a critical role in maintaining immune modulation and are present in normal peripheral blood in low numbers (5 to 10% of CD4+ T cells or 1 to 2% of total lymphocytes). (bdbiosciences.com)
  • The aggressive T-cell/histiocyte-rich large B-cell lymphoma and the indolent nodular lymphocyte-predominant Hodgkin's lymphoma are both characterized by a paucity of tumor cells embedded in an overwhelming background. (haematologica.org)
  • Design and Methods We collected 33 cases of T-cell/histiocyte-rich large B-cell lymphoma and 56 cases of nodular lymphocyte-predominant Hodgkin's lymphoma and performed microarray gene expression profiling on ten cases of each lymphoma, to obtain a better understanding of the lymphoma host response. (haematologica.org)
  • By quantitative reverse transcriptase polymerase chain reaction we verified that these 20 selected cases were representative of the entire population of T-cell/histiocyte-rich large B-cell and nodular lymphocyte-predominant Hodgkin's lymphomas. (haematologica.org)
  • Results We observed that the microenvironment in nodular lymphocyte-predominant Hodgkin's lymphoma is molecularly very similar to a lymph node characterized by follicular hyperplasia, while the microenvironment in T-cell/histiocyte-rich large B-cell lymphoma is clearly different. (haematologica.org)
  • Conclusions The gene expression profile of T-cell/histiocyte-rich large B-cell lymphoma, in comparison with that of nodular lymphocyte-predominant Hodgkin's lymphoma, shows features suggestive of a distinct tolerogenic host immune response that may play a key role in the aggressive behavior of this lymphoma, and that may serve as a potential target for future therapy. (haematologica.org)
  • 1 Initial studies demonstrated that a particular subgroup of T-cell-rich B-cell lymphomas mirror nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) and are characterized by a T-cell and histiocyte-rich stroma. (haematologica.org)
  • This report is of a case of nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) with a good outcome in a 58-year-old Nigerian HIV-positive man who was being treated with ART. (amjcaserep.com)
  • Histopathology was consistent with nodular lymphocyte-predominant-type Hodgkin's lymphoma (NLHPL). (amjcaserep.com)
  • CD68 positive cells were a prominent feature of granulomas at all time-points examined. (usda.gov)
  • We found that the levels of B cells, T cells, and NK cells were similar, IC-expressing CD4 + and CD4 + CD8 + double positive T cells were higher, while CD8 + T cells and CD4 − CD8 − double negative T cells were significantly lower in CRC tumors. (mdpi.com)
  • It also triggers activated B-LYMPHOCYTES to differentiate into IMMUNOGLOBULIN-secreting cells. (lookformedical.com)
  • CD10 is not present on the B cells. (labce.com)
  • Most lymphocytes in this sample are T cells, which are also normal. (labce.com)
  • Scattered mitoses, as well as necrotic areas and oedema, were present, and cells infiltrated the meninges, perivascular spaces and vessel walls. (upmc.edu)
  • Almost half of the cells were positive for the activated T-cell marker granzyme B, and some for CD7. (upmc.edu)
  • Although the aberrant activation of the T cell response observed in pSS has partially been explained by the interaction of T lymphocytes both with the ductal epithelium and the infiltrating B cells via costimulatory molecules (i.e. (biomedcentral.com)
  • In addition, the feasibility of imaging of DAbR1-positive T cells in vivo after intravenous injection of 86 Y/ 177 Lu-AABD was studied and radiation doses determined. (snmjournals.org)
  • Imaging studies showed 86 Y-AABD was retained by DAbR1-positive T cells while it continuously cleared from normal tissues, allowing for in vivo tracking of intravenously administered CAR T cells. (snmjournals.org)
  • However, a review of current data reveals little evidence that CTL retain an antiviral effector capacity in patients on fully suppressive ART, implying that the HIV-specific CTL present in these patients will not be able to eliminate HIV-infected CD4 + T cells effectively. (frontiersin.org)
  • The WAS-related disorders, which include Wiskott-Aldrich syndrome, X-linked thrombocytopenia (XLT), and X-linked congenital neutropenia (XLN), are a spectrum of disorders of hematopoietic cells, with predominant defects of platelets and lymphocytes caused by pathogenic variants in WAS. (nih.gov)
  • Concordant with these findings, significantly increased percentages of CD3 + CD4 + IL-17 + and CD3 + CD4 + IL-17 + IFN-γ + cells were present in RA BM in comparison to OA BM samples. (biomedcentral.com)
  • In the present study we hypothesized that the RA BM microenvironment supports the development of Th17 cells and Th17 cell response. (biomedcentral.com)
  • This procedure allows CDC to determine the distribution of CD4 cells in a random sample of HIV-positive individuals. (cdc.gov)
  • We present a method enabling simultaneous, ultra-high throughput single-cell barcoding of millions of cells for targeted analysis of proteins and RNAs. (nature.com)
  • Flow cytometer analyses demonstrated an increased frequency following the stimulation with Concanavalin A. The frequency of mAb 4-13- and mAb 4-58-positive cells matched the total frequency of CD4- and CD8-positive cells. (uni-muenchen.de)
  • By contrast the antibodies 1-19, 2-52, 4-36, 4-55 and 6-39 are B-cell-specific, since they were present on cells that were Ig-positive. (uni-muenchen.de)
  • Preliminary data suggests that mab 4-39 is binding to a lektin, that can be found mainly on B-Lymphocytes and endothelial cells. (uni-muenchen.de)
  • In addition, tumor infiltrating mononuclear cells (TIMC) and T cell subpopulations (CD4, CD8, T-bet and FoxP-3) were quantified. (oncotarget.com)
  • Immunohistochemical examination demonstrated that these accumulated lymphocytes mainly comprised small- to medium-sized T cells expressing CD3, CD4, CD5, CD7, and CD103, but lacking CD8, CD56, and Epstein-Barr virus-encoded small RNAs. (springeropen.com)
  • There was 93% donor T-lymphocytes, 20% donor B-lymphocytes, and 5% donor myeloid cells, indicative of some donor stem cell engraftment. (frontiersin.org)
  • Results: NiONP exposure resulted in dose-dependent increases in the total number of immune cells present in the lungs of all animals. (cdc.gov)
  • Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)
  • Also, the term "primary cutaneous CD4 + small/medium T-cell lymphoma" was changed to "primary cutaneous CD4 + small/medium T-cell lymphoproliferative disorder" because of its indolent clinical behavior and uncertain malignant potential. (medscape.com)
  • 6 However, using a stricter definition requiring the presence of a prominent histiocytic component as a major feature and almost complete absence of small B lymphocytes, the unique character of this lymphoma has been demonstrated. (haematologica.org)
  • A literature review showed that the risk of developing Hodgkin lymphoma (HL) is about 10 times higher in HIV-positive patients compared to HIV-negative patients [2]. (amjcaserep.com)
  • All enrolled thymic lymphocytes is widely accepted as infants were breastfed in addition to receiv- an indicator of the depression of thymus- ing some traditional foods, according to dependent immune competence associated their age. (who.int)
  • We also found a positive correlation between autophagy enhancement and the increased salivary gland expression of IL-21 and IL-23, providing a further link between innate and adaptive immune responses in pSS. (biomedcentral.com)
  • The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
  • In conclusion, we developed and characterized a novel immunocompetent mouse model of HPV-positive OSCC that exhibits increased radiosensitivity and enables studies of immune-based treatment approaches in HPV-positive OSCC. (biomedcentral.com)
  • Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. (lww.com)
  • Such phenotypically silent CTLs, which lack cytolytic function and do not produce interferon (IFN)-gamma, have been hypothesized to explain the persistence of virus in the face of a quantitatively large immune response, particularly when CD4 help is impaired. (ox.ac.uk)
  • Higher innate immune cell (e.g., neutrophils) influx was observed in all groups, but increases in the number and proportionality of lymphocytes in the BAL were only detected in hTLR-4 positive animals. (cdc.gov)
  • CD20-positive B lymphocytes were seen only occasionally. (lookformedical.com)
  • Occasional lymphocytes expressed CD4, CD5, CD8 and CD30, while staining for the B-cell marker CD20 and for CD56, activin receptor-like kinase 1 (Alk1) and T-cell receptor alpha/beta (TCR alpha/beta) was consistently negative. (upmc.edu)
  • According to analysis of the Kaplan-Meier plotter, the impact of T-lymphocyte marker expression on survival was statistically insignificant in clinical HER2-positive tumors, irrespective of the cutoff levels. (elsevierpure.com)
  • Results: Patients with MMR-D showed a higher T-bet/CD4 ratio ( p = 0.02), a higher rate of CD80 expression and CD8 lymphocyte infiltration compared to those with no MMR-D. Moreover, in the MMR-D group, the Treg marker FoxP-3 was not expressed ( p = 0.05). (oncotarget.com)
  • These studies demonstrate that HerpV is a promising immunotherapy candidate for genital herpes, and provide a foundation for evaluating HerpV in human HSV-2(+) subjects with the intent of eliciting CD4(+) and CD8(+) T cell responses to a broad array of viral antigens. (nih.gov)
  • These findings suggest that CD4 + T lymphocyte autophagy could play a key role in pSS pathogenesis. (biomedcentral.com)
  • Recent thymic emigrants represented 12% of the total T-lymphocyte population. (frontiersin.org)
  • DOTA antibody reporter 1 (DAbR1) comprises a single-chain fragment of the antilanthanoid-DOTA antibody 2D12.5/G54C fused to the human CD4-transmembrane domain and binds irreversibly to lanthanoid ( S )-2-(4-acrylamidobenzyl)-DOTA (AABD). (snmjournals.org)
  • In addition to HIV antibody testing in NHANES, whole-blood samples were collected and stored for future CD4 testing once the HIV status of the sample was known. (cdc.gov)
  • Whole EDTA anti-coagulated blood stored at -70°C from the 31 HIV antibody-positive participants from NHANES 1999-2004 and 34 age-matched controls were used. (cdc.gov)
  • If confirmed by Western blot or other supplemental test, a positive antibody test means that a person is infected with HIV and is capable of transmitting the virus to others. (cdc.gov)
  • Since there is transplacental passage of maternal HIV antibody, antibody tests for HIV are expected to be positive in the serum of both infected and uninfected infants born to a seropositive mother. (cdc.gov)
  • The Cambridge Biotech HIV-1 Western Blot Kit, when used as directed, will detect antibodies to HIV-1 when present in human serum or plasma. (cdc.gov)
  • In the current study, we aimed to investigate the possible pathogenic implication of autophagy in T lymphocytes in patients with pSS. (biomedcentral.com)
  • However, the HIV-positive children were more likely to have persistent diarrhoea than the HIV-uninfected severely malnourished children (odds ratio (OR) 2.0, 95% confidence interval (CI) 1.2-3.6). (biomedcentral.com)
  • Cellular composition in the spleen exhibited similar alterations as those seen in the lymph nodes, except for one notable difference-in the lymph nodes, NiONP was associated with an increase in the CD4:8 T-cell ratio in hTLR-4 positive females and males, but in the spleen, this ratio was significantly decreased in hTLR-4 positive males. (cdc.gov)
  • Leukocytosis is present in 2-5% of patients. (medscape.com)
  • Our study provides evidence for the first time that autophagy is upregulated in CD4 + T lymphocyte salivary glands from pSS patients. (biomedcentral.com)
  • The majority of adult patients who are positive for anti-MOG autoantibodies exhibit ON or TM, while ADEM with or without ON is the most frequent presentation in pediatric patients with MOGAD. (encyclopedia.pub)
  • Some patients with HPV-positive OSCC have a better prognosis and respond better to various treatment modalities, including radiotherapy or immunotherapy. (biomedcentral.com)
  • 7 Patients with THRLBCL frequently present with stage III or IV disease, splenomegaly, hepatomegaly and bone marrow involvement. (haematologica.org)
  • NHL presents in extranodal form more frequently in HIV-positive than in HIV-negative patients. (revistagastroenterologiamexico.org)
  • The associations of the expression of HLA-I, CD8 and CD4 with the clinicopathologic profiles of the patients were analyzed. (wjon.org)
  • Pneumonia: Monitor for signs and symptoms of pneumonia in HIV-infected patients, especially those predisposed to pneumonia (e.g., low initial CD4 cell count). (nih.gov)
  • Patients present with recurrent infections associated with T-lymphocytopenia, characteristically presenting later than patients with classical severe combined immunodeficiency (SCID). (frontiersin.org)
  • Patients present with predominantly T-lymphocytopenia, and the immunological presentation characteristically is later than patients with classical severe combined immunodeficiency (SCID) ( 4 ). (frontiersin.org)
  • Mucosal candidias is well documented, and patients can also present with disseminated BCG infection if they have been vaccinated. (frontiersin.org)
  • Furthermore, a statistically significant correlation was detected between lymphocyte autophagy levels, disease activity, and damage indexes. (biomedcentral.com)
  • Primary Sjögren's syndrome (pSS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands and peripheral lymphocyte perturbation. (biomedcentral.com)
  • An even stronger association between tetramer-derived numbers and intracellular cytokine staining for IFN-gamma was present (r = 0.97). (ox.ac.uk)
  • When compared with the HIV-negative children, the HIV-positive children showed a significantly lower median white blood cell count (10700 versus 8700) and lymphocyte count (4033 versus 2687). (biomedcentral.com)
  • The CD4 + cell percentages were more likely to be lower in children with non-oedematous malnutrition than in those with oedematous malnutrition even after controlling for the HIV infection. (biomedcentral.com)
  • HerpV is observed to be immunogenic, generating CD4(+) and CD8(+) T cell responses in three mouse strains including HLA-A2 transgenic mice. (nih.gov)
  • Two monoclonal HPV-positive OSCC mouse cell lines were established by inducing the expression of HPV-16 oncogenes E6 and E7 in the MOC1 OSCC cell line using retroviral transduction. (biomedcentral.com)
  • Although the cell lines did not differ in their intrinsic radiosensitivity, one of the HPV-positive tumor models, MOC1-HPV K1, showed a significantly longer growth delay after irradiation with a single dose of 15 Gy compared to parental MOC1 tumors. (biomedcentral.com)
  • Characteristics of the newly developed HPV-positive OSCC tumor models correlate with the transcriptomic profile of MOC1-HPV cell lines. (biomedcentral.com)
  • The present study indicates that body iron overload resulting from excess intake of iron may be associated with qualitative defects in cell mediated immunity at early stage of HIV-1 infection that may facilitate subsequent acquisition of pulmonary tuberculosis, shorter ARI free duration and reduced survival. (scirp.org)
  • The Cambridge Biotech HIV-1 Western Blot Kit is manufactured by Calypte Corporation from HIV-I propagated in an H9/HTLV-IIIb T-lymphocyte cell line. (cdc.gov)
  • At 4 years of age and 29 months post-transplant, the patient demonstrated normal T-lymphocyte and natural killer cell numbers. (frontiersin.org)
  • Strong positive associations were observed between cell numbers derived by the Elispot and the tetramer assay (r = 0.90). (ox.ac.uk)
  • Lymphocytes comprised 3.25% of the BAL cell pool in females at 14d (compared to 1.12% in DM, 2.13% in hTLR-4 negative) and 2.30% in males at 7 d (compared to 0.88% DM, 1.28% in hTLR-4 negative). (cdc.gov)
  • In females, lymph node cell number peaked at 14 d, increasing 1.5-fold over DM control values in the hTLR-4 negative group (5.01x106) and 2.5-fold in hTLR-4 positive females (6.46x106). (cdc.gov)
  • Total cell number reached 1.2x control values (5.21x106) in the hTLR-4 negative group and 1.7x (5.62x106) in hTLR-4 positive males. (cdc.gov)
  • Increases in lymph node CD4+ T-cell and B-cell activation were observed in both females and males but increases in the proportionality of these two lymphocyte populations were only noted in hTLR-4 positive females. (cdc.gov)
  • The children showed a high prevalence of infections: pneumonia (68%), diarrhoea (38%), urinary tract infection (26%) and bacteraemia (18%), with no significant difference with regard to the HIV status (HIV-positive versus HIV-negative children). (biomedcentral.com)
  • HIV CD4 seroprevalence trends infection were also seen. (cdc.gov)
  • More than 60% of HPV-positive, mildly dysplastic lesions resolves spontaneously, and immunodeficiency is associated with increased incidence of persistent HPV infection. (wjon.org)
  • A mathematical model and CD4+ lymphocyte dynamics in HIV infection. (cdc.gov)
  • 1993. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. (cdc.gov)
  • [ 4 . 5 ] Adding to the challenge, classic lymphoglandular bodies, representing remnants of lymphocyte cytoplasm, are typically inconspicuous or absent in effusion fluids, in contrast to FNA material from solid specimens. (cytojournal.com)
  • In the advanced stage, the thyroid tissue is replaced by lymphocytes and fibrosis. (labpedia.net)
  • [ 49 ] Thus, a general classification of disease that combines elements of both of these systems is based on the number of skin lesions present and the number of bacilli found on tissue smears. (medscape.com)
  • The positive tissue staining percentage of CD4 in the tissues above was 45%, 80%, 100% and 100%, respectively. (wjon.org)
  • CD4 plus CD8 equals the total CD3 (55 + 33 = 88). (labce.com)
  • however, the few statistically significant changes observed occurred in the hTLR-4 positive groups. (cdc.gov)
  • Immunohistochemistry analysis was performed using paired primary and metastatic tissues of 29 HER2- positive tumors treated with systemic chemotherapy and HER2- directed therapy. (elsevierpure.com)
  • We chose the tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and peri-cancer tissues, and then detected the expression of HLA-I, CD8 and CD4 using SP immunohistochemistry. (wjon.org)
  • Lymphocyte proliferative responses to phytohemagglutinin were normal. (frontiersin.org)
  • However, in most cases there are specific features that may aid in differentiating small reactive from non-reactive lymphocytes including the round shape of the nucleus, the absence of visible nucleoli and the presence of fine clumped chromatin. (cytojournal.com)
  • Immunoreactivity for iNOS was present with the appearance of the first microscopic lesions at PID 28. (usda.gov)
  • However, not all lymphoid lesions at present can be precisely placed into one of these categories. (medscape.com)
  • B-lymphocyte-specific membrane protein that plays a role in the regulation of cellular calcium influx necessary for the development, differentiation, and activation of B-lymphocytes. (cusabio.com)
  • NiONP exposure induced several notable changes in lymph node cellular composition as well-most of which were seen exclusively in hTLR-4 positive mice and were overall more pronounced in females. (cdc.gov)
  • PNP is expressed at high levels in lymphocytes and causes the release of ribose phosphate by converting inosine to hypoxanthine, guanosine to guanine, and deoxyguanosine to guanine. (frontiersin.org)
  • The present study included 46 infants re- always been the focus of attention in mal- cruited from the Children's Hospital, Ain nutrition diseases in infancy. (who.int)
  • Herein, we present a severe case of the disease with disseminated skin lesions that progressed to death in an immunosuppressed patient in Belo Horizonte, Minas Gerais, Brazil. (scielo.br)
  • The novel observation of this study is that the CD4 + percentages in both HIV-positive and HIV-negative children without oedema were lower that those in children with oedema. (biomedcentral.com)
  • Therefore, the aim of our study was to develop a transplantable immunocompetent mouse model of HPV-positive OSCC and characterize it in vitro and in vivo. (biomedcentral.com)
  • In one Ethiopian study, the following criteria had a sensitivity of 97% with a positive predictive value of 98% in diagnosing leprosy. (medscape.com)
  • The aim of our study is to examine the expression of HLA-I, CD8 and CD4 in various cervical diseases and investigate their association with cervical cancer. (wjon.org)
  • The present study also measured patient TB clinic. (who.int)