Presenilin-1Presenilin-2PresenilinsAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesAlzheimer DiseaseAmyloid beta-Protein PrecursorMembrane ProteinsEndopeptidasesReceptors, NotchAmyloid beta-PeptidesMutationHelminth ProteinsReceptor, Notch1History, Early Modern 1451-1600Cell LineProtein Structure, TertiaryPeptide FragmentsMembrane GlycoproteinsBrainMolecular Sequence DataMice, TransgenicPeptide HydrolasesCaenorhabditis elegans ProteinsAmino Acid SequenceNeuronsPlaque, AmyloidNeuropil ThreadsTransfectionCHO CellsReceptor, Notch2Protein BindingCricetinaebeta CateninKv Channel-Interacting ProteinsProtein Processing, Post-TranslationalAnimals, Genetically ModifiedAmyloidogenic ProteinsCaenorhabditis elegansSignal TransductionCricetulusGlycogen Synthase Kinase 3OvipositionDrosophila ProteinsPrecipitin TestsMice, KnockoutCarbamatesEndoplasmic ReticulumPhenotypeDipeptidesBiotinylationProteolysisReceptor, EphB2Cell MembraneBlotting, WesternImmunoprecipitationDantroleneCells, CulturedCalbindin 1Subcellular FractionsSequence Homology, Amino AcidImmunohistochemistryNeurofibrillary TanglesChromosomes, Artificial, P1 BacteriophageHEK293 CellsAge of OnsetImmunoblottingCateninsEphrin-B2Protease Nexinstau ProteinsDrosophilaCytoskeletal ProteinsFibroblastsModels, BiologicalGlycogen Synthase KinasesVoltage-Gated Sodium Channel beta-2 SubunitArmadillo Domain ProteinsHydrolysisFilaminsMutagenesisAmyloidCOS CellsPhotoaffinity LabelsProtease InhibitorsDimerizationMuscle Relaxants, CentralAspartic AcidHippocampusBrain ChemistryGlycosylationAmino Acid SubstitutionRNA InterferenceRecombinant ProteinsProtein TransportCadherinsDNA, HelminthTransgenesDisease Models, AnimalCatalytic Domain