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  • LAMA2
  • Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses. (genetex.com)
  • fibrillar
  • In skin and ovary, fibrillar immunoreactivity for the laminin α4, β1, β2 and γ1 chains, type IV and XVIII collagens and nidogen-1 was found in the basement membrane region of the lymphatic endothelium, whereas also heterogeneous reactivity for the laminin α5 chain was detected in the digestive tract. (springer.com)
  • thus
  • Difficulties in prosthetic joint infections are, (I) a higher age of patients, and, thus an associated presence of other medical risk factors, (II) often long courses of treatment regimes depending on the bacterium and its antibiotic resistance, (III) an increased mortality, and (IV) a high economic burden for removal and reimplantation of an infected prosthetic device. (medsci.org)
  • glycoprotein
  • In addition to the laminin α4, β1, β2 and γ1 chains, type IV and XVIII collagens and nidogen-1, carcinoma lymphatics showed immunoreactivity for the laminin α5 chain and Lutheran glycoprotein, a receptor for the laminin α5 chain. (springer.com)
  • The distribution of the laminin α5 chain and Lutheran glycoprotein proposes a difference between normal and carcinoma lymphatic capillaries. (springer.com)
  • tumor
  • The lymphocyte homing receptor CD44 attracted considerable interest, when it was described that CD44 splice variants (CD44v) suffice to confer a metastatic phenotype to locally growing tumor cells ( 1 ). (aacrjournals.org)
  • A hallmark in pancreatic ductal adenocarcinoma (PDA) is the presence of 'desmoplasia,' which is defined as proliferation of fibrotic tissue with an altered ECM conducive to tumor growth and metastasis. (aacrjournals.org)
  • vivo
  • Conclusion- We demonstrate that the tPA-dependent interaction and cleavage of the NR1 subunit of N -methyl- d -aspartate receptors occurs in vivo after stroke and that this interaction is a relevant therapeutic target for stroke treatment. (ahajournals.org)
  • findings provide evidence
  • Together, these findings provide evidence that an innate immune pattern recognition receptor functions autonomously in neurons to regulate axonal growth and advances a novel hypothesis that this class of receptors may contribute to injury and limited CNS regeneration. (jneurosci.org)
  • glial
  • These results are incorporated into an integrated model of pronephric duct guidance consistent with all present evidence, proposing roles for the previously implicated glial cell-line derived neurotrophic factor and its receptor as well as for laminin 1 and α6β1 integrin. (biologists.org)
  • cell surface
  • Assembly of one, a densely-distributed reticular matrix, was accompanied by a redistribution of cell-surface dystroglycan and cytoskeletal utrophin into matrix-receptor-cytoskeletal complexes. (biologists.org)
  • Toll is a cell surface receptor with well described roles in the developmental patterning of invertebrates and innate immunity in adult Drosophila . (jneurosci.org)
  • matrix
  • Ultrastructural analysis revealed that laminin treatment induced the formation of a linear electron-dense extracellular matrix ( lamina densa ) separated from plasma membrane by a narrow lucent zone ( lamina lucida ). (biologists.org)
  • neurons
  • The effect of poly I:C is dependent on the presence of functional TLR3 in neurons, and appears to be active at the growth cone because it causes profound growth cone collapse, but does not elicit cell death in sensory neurons. (jneurosci.org)
  • type
  • In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. (genecards.org)
  • The gene product is a member of the cadherin superfamily, characterized by the presence of cadherin-type repeats. (atlasgeneticsoncology.org)
  • function
  • Mammalian toll-like receptors represent a family of Toll orthologs that function in innate immunity by recognizing molecular motifs unique to pathogens or injured tissue. (jneurosci.org)
  • Toll-like receptors (TLRs) likely serve the major function of transducing danger signals. (jneurosci.org)