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Tetracycline ResistanceTetracyclineTetracyclinesR FactorsDrug Resistance, MicrobialAnti-Bacterial AgentsOxytetracyclineConjugation, GeneticMinocyclineDNA Transposable ElementsMicrobial Sensitivity TestsDrug Resistance, BacterialDNA, BacterialPlasmidsEscherichia coliGenes, BacterialBacterial ProteinsAntiportersChlortetracyclineErythromycinDrug Resistance, Multiple, BacterialBacteroidesDoxycyclineDrug ResistanceMolecular Sequence DataChloramphenicolEnterococcus faecalisPenicillin ResistanceTransformation, BacterialMannheimiaStreptomycinExtrachromosomal InheritanceChromosomes, BacterialDNA Restriction EnzymesBase SequenceMutationDemeclocyclineNeisseria gonorrhoeaeDrug Resistance, MultipleManureCloning, MolecularClindamycinSequence Analysis, DNAChloramphenicol ResistanceStreptococcusDrug Resistance, NeoplasmStaphylococcus aureusStaphylococcusDeoxyribonuclease HindIIIAmpicillinPolymerase Chain ReactionMacrolidesKanamycinGene Transfer, HorizontalPasteurella multocidaCampylobacter fetusCampylobacter jejuniFecesTrimethoprimAmino Acid SequenceBahrainNucleic Acid HybridizationFusaric AcidPenicillinsCampylobacterPhenotypeDisease ResistanceRepressor ProteinsElectrophoresis, Gel, Pulsed-FieldCampylobacter coliPasteurellaSpectinomycinSwineVascular ResistanceStaphylococcus PhagesBacteroides fragilisMouthBacteriaClostridium perfringensEnterobacteriaceaeDrug Resistance, ViralIntegronsGonorrheaRecombination, GeneticCulture MediaRestriction MappingNeisseriaceaeBlotting, SouthernStreptococcus pyogenesCarrier ProteinsMycobacteriaceaeMethacyclineGram-Negative BacteriaCheeseChromosome MappingStreptococcus pneumoniaeActinobacillus pleuropneumoniaeEscherichia coli InfectionsStreptococcal InfectionsAeromonas
AmpicillinAntibioticsMacrolidesGenesStrainsFluoroquinolonesBacteriaCiprofloxacinStreptomycinPenicillinAntimicrobialsErythromycinGeneDeterminantsTigecyclineProportion of tetracyclineSusceptibleSalmonellaColiEfflux pumpsBacterialInfectionsAntibacterialPenicillinsPlasmidSusceptibilityResistant to at leastMechanismsWidespreadTetMPulsed-field gel electDrug-resistanceGonorrhoeaeStaphylococcusUrinaryMutationsPrevalenceDerivativeAureusColistinHighGenotypicMonitor antibiotic
Ampicillin9
Antibiotics37
  • However, treatment has been compromised by the absence of routine antimicrobial susceptibility testing in clinical care and evolution of antimicrobial resistance to the antibiotics used to treat gonorrhea. (cdc.gov)
  • Finally, the applicability to tetracyclines antibiotics determination in real samples was evaluated through the successful determination of four target analytes in swine, cow manure, and mixture of animal manure with inorganic fertilizer. (hindawi.com)
  • Extensive use of veterinary antibiotics in livestock farming, however, has promoted the development of antibiotic resistance in farm environments. (hindawi.com)
  • Little is known about the environmental behavior and fate of antibiotics in manure after cropland application because of analytical difficulties and time-consuming procedures encountered when trying to analyze trace levels of these compounds in the presence of complex matrices such as manure [ 3 ]. (hindawi.com)
  • Tetracyclines (TCs) are an extremely important group of antibiotics with a broad spectrum of activity against Gram-positive and Gram-negative bacteria [ 4 ]. (hindawi.com)
  • The E. coli isolate from the patient was also resistant to antibiotics in at least five additional antibiotic classes, including cephalosporins, fluoroquinolones, sulfonamides, aminoglycosides, and tetracyclines. (cdc.gov)
  • causing gastroenteritis has developed resistance to commonly used antibiotics. (biomedcentral.com)
  • Even when the antibiotic tetracycline is present, the cells use the pump to export the antibiotics from the cell and 'buy time for the cell' to acquire resistance. (axios.com)
  • Within the environment the presence of heavy metals and antibiotics may apply an additional selective pressure on bacteria resulting in the accumulation of heavy metal resistance genes in plasmids which can be transmitted to other bacteria. (confex.com)
  • Regulatory controls and prudent‐use practices are the primary strategies used to control resistance, and these are probably very important to limit the emergence of resistance to new antibiotics. (beefresearch.org)
  • The ability of bacteria to quickly develop resistance to commonly used antibiotics is a huge hurdle in the path of disease treatment. (kenyon.edu)
  • Because of this, there is an ever-present need to develop new antibiotics that are use novel mechanisms to overcome multidrug-resistance and prevent microbial growth. (kenyon.edu)
  • Monitoring resistance to antibiotics in wild animals may assist in evaluating tendencies in the evolution of this major public health problem. (mdpi.com)
  • We collected draft genome sequence data and associated metadata data on 76 N. gonorrhoeae strains from around the globe and searched for known determinants of antibiotics resistance within the strains. (peerj.com)
  • Strains with resistance phenotypes to more recent antibiotics ( azithromycin and cefixime ) were mostly found in two of the five population subgroups. (peerj.com)
  • The data suggest that the mucoid phenotype could be associated with extrachromsomal element(s) carrying resistance genes to antibiotics and that these extrachromosomal elements may not harbour resistance determinants to chloramphenicol. (scirp.org)
  • antibiotics from · E coli strains had complete resistance to some of the critically fresh poultry important antibiotics such as erythromycin, cefoxitin and excreta in Sierra streptomycin. (who.int)
  • We transferred the packed excreta samples to the regional certified categorization classified lab on the same day to test the presence of any bacteria and its antibiotics into three groups. (who.int)
  • response to various antibiotics (antibiotic resistance). (who.int)
  • In cases where the bacteria is not responding to the antibiotics, we further investigated to know whether they are not responding to limited drugs or more than three drugs (Multi-drug Resistance). (who.int)
  • Invariably, all bacterial samples had resistance to at least one of these eight antibiotics. (who.int)
  • Some of the important antibiotics such as erythromycin, Streptomycin, cefoxitin, and tetracycline were 100% resistant. (who.int)
  • Most of the E.coli isolates were resistance to more than three antibiotics. (who.int)
  • Many commensals and pathogenic organisms have developed resistance to well established and newer antibiotics. (jidc.org)
  • were resistant to at least 14 antibiotics especially tetracycline-class antibiotics. (ac.bd)
  • Since current antibiotics are rapidly becoming ineffective, novel strategies to combat resistance are needed. (hal.science)
  • Tetracycline is one of the widely used antibiotics for the treatment of infections with significant therapeutic effect due to its broad spectrum. (congressapp.ir)
  • In the current study, antibiotic resistance phenotypes of the highlighted Lactobacillus plantarum and Lactobacillus paracasei against eight antibiotics (amoxicillin, tetracycline, erythromycin, clindamycin, chloramphenicol, streptomycin, kanamycin, ciprofloxacin) and antibiotic resistance genes of these strains were investigated. (ugm.ac.id)
  • Thirty-seven isolates (4.4%) throughout Australia had altered resistance to this group of antibiotics (QRNG) with 23 of these showing high level resistance. (health.gov.au)
  • Milk contaminated with bacteria antimicrobial resistance (AMR) in which is resistant to antibiotics, may adversely affect the response to treatment with antibiotics in humans when suffering from infectious diseases and using antibiotics in therapy. (undip.ac.id)
  • The samples were tested for the presence of pathogenic bacteria and for its resistance to several kinds of antibiotics. (undip.ac.id)
  • Chromosomally mediated resistance is more general and involves mutations that alter cell wall permeability or the affinity of binding proteins to antibiotics. (pediagenosis.com)
  • The concordance between phenotypic and genotypic resistance was 92.38% overall for five antibiotics in four classes. (who.int)
  • N. gonorrhoeae has developed resistance to to front-line antibiotics triggered a global action plan from first-line antibiotics such as sulfonamides, penicil ins, WHO to control the spread and impact of gonococcal tetracyclines, macrolides, fluoroquinolones and early resistance and a call for international col aborative ac- cephalosporins. (who.int)
  • The 16.9% the strains presented multiple resistance (3 or more antibiotics) with 37 different phenotypes. (bvsalud.org)
  • The problem of Helicobacter pylori resistance to antibiotics: a systematic review in Latin America. (bvs.br)
  • 86). A high level of resistance to the antibiotics tested was found, especially among Acinetobacter spp. (who.int)
Macrolides4
  • While tetracyclines, macrolides, lincosamides, and quinolones have historically been used for treatment of infections due to these organisms, acquired resistance is now well documented and varies according to drug, organism, and patient population. (medscape.com)
  • Macrolides, tetracyclines, and fluoroquinolones are used to treat M. pneumoniae infections, and macrolides are recommended in children, due to the potential adverse effects of tetracyclines and fluoroquinolones. (annals.edu.sg)
  • More than 80% of the strains included in this study carried genes associated with resistance to tetracycline, lincosamides and macrolides. (biomedcentral.com)
  • Additionally, resistance can be readily induced in vitro in B. anthracis to a variety of antimicrobial classes including fluoroquinolones, tetracyclines, macrolides, penicillins, and other -lactams ( 8, 13- 16 ). (cdc.gov)
Genes29
  • WGS identified antimicrobial resistance genes in isolates from two ill people. (cdc.gov)
  • The presence of these resistance genes correlated with results from standard antibiotic susceptibility testing methods used by CDC's National Antimicrobial Resistance Monitoring System (NARMS) laboratory conducted on clinical isolates from three ill people in this outbreak. (cdc.gov)
  • All the Salmonella isolates were subjected to whole genome sequencing, bioinformatics analysis for serovar predictions, multi-locus sequence types, antimicrobial resistance genes, and plasmid types by using the in-house Galaxy platform. (frontiersin.org)
  • Furthermore, significant advancements have been achieved in understanding and prediction of antimicrobial resistance of the Salmonella ( 11 , 14 , 18 , 19 ), and the knowledge of the antimicrobial resistance genes and plasmids are improving. (frontiersin.org)
  • Strains of E. coli that exhibited resistance phenotypes were genetically analyzed to identify the presence of antibiotic resistance and virulence genes. (vin.com)
  • Shared resistance genes (including blaTEM, strA, and tetB) were documented in both gull and wastewater E. coli samples. (vin.com)
  • Using technology with real-time viewing, a team of scientists say in Science Thursday they can now show how quickly E. coli becomes resistant to tetracycline - finding that bacteria can pass genes with resistance to each other and then use a pump to keep most of the antibiotic out for the 2 hours it takes to render the previously sensitive bacteria resistant to the drug. (axios.com)
  • The presence of antibiotic resistant bacteria in clinics and in the environment is a growing concern because plasmid encoded genes that confer antibiotic resistance are becoming more prevalent in gram-negative bacteria. (confex.com)
  • Among the most common antibiotic resistance genes are those that confer resistance to aminoglycosides, used heavily in clinics and agriculture. (confex.com)
  • Pathogenic Klebsiella pneumoniae can cause respiratory and urinary tract infections and the presence of resistance genes may make treatment of such infections more difficult. (confex.com)
  • Within this plasmid approximately four thousand base pairs upstream of the IncN conjugative region, there is a multiresistance region encoding resistance to neomycin ( aph-(3')-I ) followed by genes that confer resistance to puromycin, streptomycin ( aada1 -like), spectinomycin ( aada1 -like), and trimethoprim ( dfr12 ). (confex.com)
  • Upstream of the arsenic resistance operon is a heavy metal response regulator gene followed by genes that confer resistance to heavy metals: copper, lead, cadmium, zinc, and mercury. (confex.com)
  • This is the first report of an isolate that contains this arrangement of the arsenic resistance operon, chrA gene, and multiple antibiotic resistance genes encoded on plasmids. (confex.com)
  • The accumulation of heavy metal resistance genes and a multidrug-resistance region in an environmental bacterial isolate could indicate a reservoir of heavy metal resistance genes which may aid in the persistence of multidrug-resistance bacteria in the environment. (confex.com)
  • Five integron associated resistance genes (aadA, aadB, pse-1, oxa-2 and dhfr) were identified. (usda.gov)
  • We show that this method activates the resistance genes while not having any antibacterial activity against susceptible bacteria. (beefresearch.org)
  • Subsequently, we harvested RNA from the bacteria and used a molecular assay (real‐time PCR) to quantify changes in expression of two tetracycline efflux pump genes. (beefresearch.org)
  • The aims of this research work were to determine the patterns of antibiotic resistance in Escherichia coli isolates from the meat of wild or domestically reared pigeons from Spain, to detect the presence of virulence and antibiotic resistance genes, and to carry out a phylogenetic classification of the isolates. (mdpi.com)
  • Antibiotic resistance of the strains, antibiotic resistance genes, and biofilm formation capacity of the strains were evaluated. (bvsalud.org)
  • Relapse infection usually results from resistance to the antibiotic, acquired genes, or persister cells. (bvsalud.org)
  • Here we ask, are the antibiotic resistance genes in the coliforms in the effluent of WAWTP descended from a recent common ancestor strain? (mcmaster.ca)
  • If, on the other hand, the antibiotic resistance genes in the bacterial flora of the WAWTP have more than one origin, identification and elimination of the source(s) could be difficult. (mcmaster.ca)
  • There was considerable diversity of antibiotic resistance patterns and antibiotic resistance genes among the effluent and influent coliform isolates of the WAWTP, suggesting multiple genetic ancestry. (mcmaster.ca)
  • Using the same logic, the evidence presented here is not compatible with a single ancestral origin of the antibiotic resistance genes in the isolates described herein. (mcmaster.ca)
  • Each group of the predicted products of resistance genes was further aligned using multiple sequence comparison by log- expectation and their functions were verified using comprehensive antibiotic resistance database 2020. (ugm.ac.id)
  • Genome sequence of the four strains verified the presence of the tetracycline, β-lactamase and ciprofloxacin resistance genes as well as multidrug resistance efflux systems. (ugm.ac.id)
  • Occurrence of the resistance genes was correlated to the phenotype results, except for amoxicillin and aminoglycosides. (ugm.ac.id)
  • thus, horizontal transfer of the antibiotic resistance genes unlikely occurred. (ugm.ac.id)
  • METHODS: Polymerase chain reaction was used to test for the presence of genes for zinc and cadmium resistance (czrC), methicillin resistance (mecA), and staphylococcal complement inhibitor (scn). (cdc.gov)
Strains16
  • Our study demonstrated the prevalence of antimicrobial resistance in Salmonella strains isolated from pig slaughterhouses in China and suggested that the genomic platform can serve as routine surveillance along with the food-chain investigation. (frontiersin.org)
  • A programme-specific quality assurance programme is conducted annually and a series of reference strains pertinent to the regional patterns of resistance were made available. (health.gov.au)
  • Of the remaining 139 patients, 125 (90%) had M. pneumoniae strains that had wild-type sequence and were presumed to be macrolide-susceptible, and 14 (10%) patients had strains with mutations conferring macrolide resistance. (annals.edu.sg)
  • The A2063G point mutation accounted for all 14 M. pneumoniae strains with macrolide resistance. (annals.edu.sg)
  • We present our study on the efficacy and phenotypic impact of compensatory evolution in Escherichia coli strains carrying multiple resistance mutations. (elifesciences.org)
  • The Multiple Antibiotic Resistance (MAR) index shows the themucoid strains with a high MAR index range of 0.7 - 1.0 with a median MAR index of 0.8, while the non-mucoid strains had a MAR index of 0.2 - 0.8 with a median MAR index of 0.35. (scirp.org)
  • Furthermore, the extrachromosomal elements bearing the mucoid phenotype and the resistance elements in the mucoid strains do not significantly impact on the fitness of the cognate strain. (scirp.org)
  • The antibiotic resistance pattern of Klebsiella pneumoniae strains were investigated by Kirby-Bauer method. (congressapp.ir)
  • Results: Of 164 strains of Klebsiella pneumoniae, 72 strains (43.90%) were resistant to tetracycline. (congressapp.ir)
  • Conclusion: Tetracycline-resistant strains of Klebsiella pneumoniae have a relatively high prevalence in Gerash. (congressapp.ir)
  • The presence of high tetracycline resistance in Klebsiella pneumoniae strains as a common cause of urinary tract infection in Gerash is a concern. (congressapp.ir)
  • All strains showed resistance to aminoglycoside and ciprofloxacin but sensitive to amoxicillin, clindamycin and erythromycin. (ugm.ac.id)
  • Resistance to chloramphenicol and tetracycline varied within the strains. (ugm.ac.id)
  • Two strains were sensitive and others were intermediate resistance to chloramphenicol. (ugm.ac.id)
  • One strain was resistant to tetracycline, while the other three strains demonstrated intermediate resistance to the antibiotic. (ugm.ac.id)
  • one sample presented the pathogen Staphylococcus aureus, two showed the presence of lactic acid bacteria (Lactococcus lactis), and the vast majority (68.18%) of strains were composed of species of the Enterobacteriaceae family, with the prevalence of the genera Escherichia, Enterobacter, and Klebsiella. (scielo.org)
Fluoroquinolones1
Bacteria21
  • Bacteria with this resistance mechanism have now been identified from humans, food, environmental samples, and food animals in at least 20 countries around the world. (cdc.gov)
  • The presence of the mcr-1 gene on a plasmid means that colistin resistance can be shared with other more resistant bacteria such as CRE, raising the possibility that untreatable bacteria could develop. (cdc.gov)
  • CDC's National Antimicrobial Resistance Monitoring System, in collaboration with the Food and Drug Administration (FDA) and the U.S. Department of Agriculture (USDA), will continue to look for mcr-1 mediated colistin resistance in enteric bacteria from humans, retail meat, and food animals. (cdc.gov)
  • Drug-resistant bacteria producing a resistance factor, TetA efflux pump (in red), during treatment with tetracycline antibiotic (in green). (axios.com)
  • This study shows that these inhibitors could have a second, indirect, effect: They could block the transfer of resistance between bacteria during treatment. (axios.com)
  • In theory, the extent of fitness costs determines the long-term stability of resistance, and consequently, the rate by which the frequency of resistant bacteria decreases in an antibiotic-free environment. (elifesciences.org)
  • Antimicrobial resistance is a global challenge and food animal production, including cattle production, is increasingly singled‐out as a significant contributor to emergence, amplification, persistence and dissemination of antimicrobial‐resistant bacteria. (beefresearch.org)
  • This is likely to happen eventually, but the rate of decline is a function of the fitness cost that is incurred by the bacteria for carrying resistance traits. (beefresearch.org)
  • The fitness cost will make the bacteria less competitive so that the bacteria will rapidly diminish in prevalence, or they will shed the resistance trait. (beefresearch.org)
  • Since tetracycline has been in wide use since the mid-1900s for treatment of many human and animal infections and as growth promoters in agriculture, many bacteria have since developed sophisticated mechanisms to prevent the harmful effects of tetracycline (Greer 2006). (kenyon.edu)
  • Specifically, tetracycline-speicific efflux pumps and ribosomal protection proteins are commonly employed by bacteria. (kenyon.edu)
  • Derived from tetracycline, glycylcyclines have added substituents that interfere with the mechanisms bacteria employ to resist tetracycline, including both the efflux pumps and ribosomal protection proteins. (kenyon.edu)
  • Whether these phenotype and resistances that had no fitness cost to the bacterium could significantly affect the virulence of the bacteria in vivo remains to be investigated. (scirp.org)
  • Out of 100 poultry excreta samples tested, 93 showed the presence disaggregated by the WHO AWaRe* classification for E.coli isolated from of E.coli and 8 showed salmonella bacteria. (who.int)
  • The presence of antibiotic resistant bacteria on lettuce from wastewater irrigated fileds in the town of Yaounde was investigated. (researchbib.com)
  • To evaluate the presence of these nuisance bacteria, a total of 61 samples comprising 39 raw milk and 22 brand milk samples were collected, using convenience sampling from different points/markets of Dhaka and the local farms at Mohakhali, Hemayetpur, and BLRI. (ac.bd)
  • The presence of antibiotic-resistant bacteria in sewage can exacerbate this problem. (mcmaster.ca)
  • Tetracyclines are used principally in the treatment of infections caused by susceptible Rickettsia, Chlamydia, Mycoplasma, and a variety of uncommon gram-negative and gram-positive bacteria. (antiinfectivemeds.com)
  • Because of the development of resistance, tetracyclines are rarely used for the treatment of infections caused by common gram-negative or gram-positive bacteria unless other appropriate anti-infectives are contraindicated or are ineffective and in vitro susceptibility tests indicate that the causative organisms are susceptible to the drugs. (antiinfectivemeds.com)
  • How to cite (IEEE): A. Andriani, and W. Suwito, "The prevalence of pathogenic bacteria and antimicrobial resistance in milk of Ettawa Grade goat," Journal of the Indonesian Tropical Animal Agriculture , vol. 43, no. 2, pp. 140-148, May. (undip.ac.id)
  • How to cite (Vancouver): Andriani A, Suwito W. The prevalence of pathogenic bacteria and antimicrobial resistance in milk of Ettawa Grade goat. (undip.ac.id)
Ciprofloxacin3
  • The percentage of isolates resistant to tetracycline, ciprofloxacin, penicillin, or all three antimicrobials, was greater in isolates from MSM than from MSW. (cdc.gov)
  • Ten of 21 isolates were resistant to penicillin, ciprofloxacin and tetracycline, due mainly to the presence of the bla TEM gene, the S91F mutation in the gyrA gene and the tetM gene, respectively. (who.int)
  • Gonococcal Antimicrobial Surveil ance Programme has antimicrobials representing four different classes, namely operated in the Western Pacific and South-East Asian penicil in (PEN), ciprofloxacin (CIP), tetracycline (TCY), regions since 1992, but surveil ance of gonococcal anti- ceftriaxone (CRO) and cefixime (CFX), by disc diffusion microbial resistance (AMR) remains limited in the Asia- and gradient diffusion (Etest, BioMerieux). (who.int)
Streptomycin2
Penicillin3
Antimicrobials3
  • The antimicrobial resistance of Salmonella isolates was determined using a minimal inhibitory concentration assay with 14 antimicrobials. (frontiersin.org)
  • Salmonella of turkey origin (n=38) exhibited the highest rates of resistance, with 92% of isolates resistant to least one antimicrobial, and 60% resistant to greater than or equal to 10 antimicrobials. (usda.gov)
  • Wound infections and mastitis in camels associated with GBS are widespread and should ideally be treated with antimicrobials other than tetracycline in East Africa. (slu.se)
Erythromycin1
  • No virulence factors were detected for any strain and only the non-transferable erm(49) gene, which confers resistance to erythromycin and clindamycin, was identified in the genome of B. longum KABP042. (frontiersin.org)
Gene9
  • The mcr-1 gene exists on a plasmid, a small piece of DNA that is capable of moving from one bacterium to another, potentially spreading antibiotic resistance to other bacterial species. (cdc.gov)
  • In November 2015, a report from China first described plasmid-mediated colistin-resistance caused by the mcr-1 gene. (cdc.gov)
  • They added a resistance gene to the transferred DNA to look at how quickly resistance was established. (axios.com)
  • The isolate also contains a plasmid with a chromate resistance gene ( chrA ) adjacent to an arsenic resistance operon. (confex.com)
  • This arrangement of the chromate resistance ( chrA ) gene and arsenic resistance operon has been described in the plasmids of three other isolates, one of which was isolated clinically in Virginia, U.S.A. while the other two samples were isolated environmentally in a Citrobacter amalonaticus in South Korea and in a Pluralibacter gergoviae in Malaysia. (confex.com)
  • Widespread resistance (34%) to tetracycline was associated with acquisition of the tetM gene that is carried on a Tn916-like element, and observed primarily among GBS isolated from mastitis. (slu.se)
  • This analysis does not include mutations that may result in antibiotic resistance or resistance determinants added to newer versions of used database or other antimicrobial resistance gene databases. (cdc.gov)
  • Genomic DNA extraction was done by use of chloroform-phenol-isoamyl alcohol method and for the presence of tetA gene, PCR method was used. (congressapp.ir)
  • Pathogens' inhibition was mostly mediated by the production of organic acids, but neutralization experiments strongly suggested the presence of additional antimicrobial compounds in probiotic culture supernatants such as the bacteriocin Lantibiotic B, whose gene was detected in the genome of B. longum KABP042. (frontiersin.org)
Determinants3
  • This research is one of the first studies documenting the genetic determinants of antibiotic resistance in wildlife of the United States. (vin.com)
  • The antibiotic minimum inhibitory concentration (MIC) was determined for ten antimicrobial compounds, along with the minimum biofilm inhibitory concentration (MBIC) and minimum biofilm eradication concentration (MBEC), followed by PCR identification of genetic determinants of biofilm production and antimicrobial resistance. (biomedcentral.com)
  • The multilocus sequence type, multiantigen sequence type, presence of determinants of antimicrobial resistance and relatedness among the isolates were all derived from the sequence data. (who.int)
Tigecycline2
  • Furthermore, the main difference between tigecycline and minocycline is the addition of an N,N-dimethylglycylamido group which actually causes the molecule to bind to the ribosome up to five times more tightly and decreases the probability that resistance will develop. (kenyon.edu)
  • Biochemical experiments have shown that the tigecycline molecule binds to the same site on 16S rRNA as tetracycline but in a different orientation and with greater affinity. (kenyon.edu)
Proportion of tetracycline2
Susceptible2
Salmonella11
  • The prevalence of antimicrobial resistance in zoonotic Salmonella is a significant ongoing concern over the world. (frontiersin.org)
  • In conclusion, there is widespread presence of E. coli (93%) in poultry excreta, with some excreta showing Salmonella as well. (who.int)
  • 0%). Furthermore, there was no correlation between faecal coliform and the presence of Salmonella species. (banglajol.info)
  • Stool samples were also colle cted and all specimens analyzed for the presence of Salmonella by routine microbiological procedures. (jidc.org)
  • Onyango D, Machioni F, Kakai R, Waindi EN (2008) Multidrug resistance of Salmonella enterica serovars Typhi and Typhimurium isolated from clinical samples at two rural hospitals in Western Kenya. (jidc.org)
  • In conclusion, the high bacterial load beyond the permissible level in the milk samples, the presence of Salmonella spp. (ac.bd)
  • Resistencia a múltiples antibióticos en serovariedades de Salmonella aisladas de muestra. (bvsalud.org)
  • Salmonella enterica es un patógeno transmitido por alimentos y agente etiológico de brotes alimentarios de gran impacto en la salud humana. (bvsalud.org)
  • El objetivo de este trabajo fue generar información sobre los serotipos circulantes, resistencia a los antibióticos y presencia de resistencia simultánea a múltiples fármacos en Salmonella provenientes de muestras clínicas humanas y muestras de alimentos en el periodo desde 2017 a 2019. (bvsalud.org)
  • Fueron analizadas un total de 668 cepas de Salmonella aisladas en los años 2017, 2018 y 2019 a partir de muestras clínicas humanas y de alimentos, en el Laboratorio Central de Salud Pública y/o remitidas por Laboratorios de la Red de Enteropatógenos. (bvsalud.org)
  • The target of this work was to generate information on circulating serotypes, antibiotic resistance and the presence of simultaneous resistance to multiple drugs in Salmonella from human clinical samples and food samples in the period from 2017 to 2019. (bvsalud.org)
Coli4
  • have identified the binding sites of tetracycline and tegecycline through probing 70S E. coli ribosomes with dimethylsulphate (DMS) and Fe 2+ -mediated cleavage. (kenyon.edu)
  • So, only antibiotic resistance pattern of E. coli was determined. (banglajol.info)
  • ABSTRACT We investigated antimicrobial resistance patterns and plasmid profiles of uropathogenic Escher- ichia coli isolates from inpatients and outpatients at Jordan University Hospital in 2000 and 2001. (who.int)
  • RESUME Nous avons étudié la résistance aux antimicrobiens et les profils plasmidiques des isolats d' Escherichia coli uropathogénique chez des malades hospitalisés et des malades externes à l'Hôpital universitaire jordanien en 2000 et 2001. (who.int)
Efflux pumps2
  • Tetracycline efflux pumps are of particular interest because of their broad global distribution and because they are regulated so that their expression only occurs in the presence of tetracycline or a tetracycline analogue. (beefresearch.org)
  • For the current proposal we developed a means to induce expression of tetracycline efflux pumps. (beefresearch.org)
Bacterial4
  • Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. (elifesciences.org)
  • Such strategies implicitly presume that resistance leads to reduced bacterial fitness in an antibiotic-free environment, and therefore these resistant populations should be rapidly outcompeted by antibiotic-sensitive variants. (elifesciences.org)
  • The increase in bacterial resistance constitutes a threat to public health. (bvsalud.org)
  • it exposes patients to drug complications without any benefit and contributes to bacterial resistance. (msdmanuals.com)
Infections10
  • Antibiotic resistance may limit treatment options and may be associated with increased risk of hospitalization, bloodstream infections, and treatment failures in patients. (cdc.gov)
  • In vitro susceptibility testing and molecular resistance testing may be useful to guide therapy, especially for disseminated infections if available. (medscape.com)
  • The physiopathology of diabetic foot infections (DFI) is complex, but its severity and prevalence are a consequence of host-related disorders and pathogens-factors, as virulence and antibiotic resistance traits [ 1 ]. (biomedcentral.com)
  • Because minocycline and, to a lesser extent, doxycycline penetrate most body tissues and fluids better than do other currently available tetracyclines, some clinicians prefer these derivatives in the treatment of infections of the CNS, eye, or prostate. (antiinfectivemeds.com)
  • Because of its low renal clearance, doxycycline may not be as effective as other currently available tetracyclines for the treatment of urinary tract infections in patients with normal or impaired renal function. (antiinfectivemeds.com)
  • Tetracyclines are used for the treatment of rickettsial infections and are considered drugs of choice for Rocky Mountain spotted fever, epidemic (louse-borne) typhus, Brill-Zinsser disease, endemic (murine) typhus, scrub typhus, Q fever, and rickettsialpox. (antiinfectivemeds.com)
  • Tetracyclines are highly effective in the treatment of most chlamydial infections, including urogenital infections caused by Chlamydia trachomatis, respiratory tract infections caused by C. pneumoniae, respiratory tract infections caused by C. psittaci (psittacosis), and lymphogranuloma venereum caused by invasive serovars of C. trachomatis. (antiinfectivemeds.com)
  • Prolonged exposure to zinc in livestock feeds and fertilizers could propagate resistance to the metal ion, thereby hindering use of zinc-based topical agents in treating S. aureus infections. (cdc.gov)
  • Nous avons analysé les infections des plaies après un acte chirurgical chez 1200 patients blessés pendant le conflit libyen en 2011 et admis au service des urgences du centre médical de Tripoli. (who.int)
  • Les bacilles à Gram-négatif multirésistants représentaient un facteur de complication important pour les infections de plaies associées à des blessures de guerre chez des patients blessés en Libye. (who.int)
Antibacterial1
  • ETH Zurich's Vanessa R. Povolo and Martin Ackermann write in an accompanying perspective piece that the findings offer what could be an 'important element' in the fight against antibacterial resistance - that the development of pump inhibitors will be key. (axios.com)
Penicillins2
Plasmid2
  • At present all laboratories also test isolates for the presence of high level (plasmid-mediated) resistance to the tetracyclines, known as TRNG. (health.gov.au)
  • This R-plasmid reservoir may contribute to the spread of multiple antibiotic resistance in our Region. (who.int)
Susceptibility2
  • This is the first report to present comprehensive surveillance data from GISP and summarize gonococcal susceptibility over time, as well as underscore the history and public health implications of emerging cephalosporin resistance. (cdc.gov)
  • Copenhagen) isolates obtained from either animal diagnostic specimens (n=199) or food animals after slaughter/processing (n=389) were examined for antimicrobial susceptibility, presence of class-1 integrons, and characterized using pulsed-field gel electrophoresis and phage typing. (usda.gov)
Resistant to at least1
  • Of the 49 wastewater isolates 59.2% percent were resistant to at least one antibiotic, and 40.8% demonstrated multi-drug resistance. (vin.com)
Mechanisms1
  • Gonococci develop their antibiotic resistance through plasmidmediated and chromosomal mechanisms. (pediagenosis.com)
Widespread3
  • Conclusions: Results indicate that integron-mediated antibiotic resistance is common among S. Typhimurium isolates, and that multi-drug resistant clones are widespread among diagnostic and slaughter/processing samples. (usda.gov)
  • If compensatory mutations are indeed widespread, pathogens can reach both high level of resistance and high fitness. (elifesciences.org)
  • In addition, resistance to both chloroquine and FansidarR (*) is widespread in Thailand, Myanmar (formerly Burma), Cambodia, and the Amazon basin area of South America, and resistance has also been reported in sub-Saharan Africa. (cdc.gov)
TetM1
  • The presence of tetM within different MLST clades suggests acquisition on multiple occasions. (slu.se)
Pulsed-field gel elect1
  • Altogether 156 P. larvae isolates from honey or brood samples supplied by 114 beekeepers were analysed by Not I pulsed-field gel electrophoresis (PFGE) and biotyping, as well as for tetracycline resistance. (apidologie.org)
Drug-resistance3
  • Of the 115 gull isolates, 15.6% were resistant to one antibiotic, and 0.9% demonstrated multi-drug resistance. (vin.com)
  • We have demonstrated that drug-resistance frequently declines within 480 generations during exposure to an antibiotic-free environment. (elifesciences.org)
  • Surviving cells of all isolates demonstrated multiple drug-resistance post exposure to UV radiation. (bvsalud.org)
Gonorrhoeae1
  • Such a GASP network is useful not only for the individual contributing countries and the Regions, but also has wider application as an indicator of emerging global resistance in Neisseria gonorrhoeae . (health.gov.au)
Staphylococcus2
Urinary1
  • Background and Objective: Urinary tract infection (UTI) is the presence of pathogens in the urinary tract. (congressapp.ir)
Mutations6
  • However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of resistance may proceed too slowly to be of practical importance. (elifesciences.org)
  • The extent of resistance loss was found to be generally antibiotic-specific, driven by mutations that reduce both resistance level and fitness costs of antibiotic-resistance mutations. (elifesciences.org)
  • We conclude that phenotypic reversion to the antibiotic-sensitive state can be mediated by the acquisition of additional mutations, while maintaining the original resistance mutations. (elifesciences.org)
  • However, in other cases, such deleterious side effects of resistance mutations are undetectable, and resistance can even confer benefits in specific, antibiotic-free environmental settings ( Maharjan and Ferenci, 2017 ). (elifesciences.org)
  • It is frequently assumed that such compensatory mutations mitigate the fitness costs of resistance mutations without affecting the level of resistance. (elifesciences.org)
  • As the range of targets for compensation is much broader, compensatory mutations are more likely than the reversion of resistance mutations. (elifesciences.org)
Prevalence2
  • Once the prevalence of resistance has increased to a clinically relevant level, however, it is unclear how effective prudent use and regulatory control practices will be in the short‐term. (beefresearch.org)
  • This study was conducted to determine the prevalence of zinc and cadmium resistance in S. aureus isolated in the United States. (cdc.gov)
Derivative1
Aureus2
  • This novel phenomenon is generic, occurring with methicillin-resistant S. aureus (MRSA) in the presence of β-lactams and with the unrelated human pathogen Pseudomonas aeruginosa. (whiterose.ac.uk)
  • The odds of being czrC positive were observed to be significantly high in tetracycline-resistant S. aureus isolated from noninfection samples (P = .009) and swine (P (cdc.gov)
Colistin1
  • If laboratories are testing to determine whether colistin can be used clinically, Enterobacteriaceae isolates with a minimum inhibitory concentration (MIC) to colistin of 4 µg/ml or higher should be tested for confirmation and the presence of mcr-1 . (cdc.gov)
High4
  • High level tetracycline resistance was concentrated in a number of centres including Singapore, Malaysia, the Philippines and Vietnam. (health.gov.au)
  • Umar, U. , Anagor, S. , Aliyu, A. and Suleiman, A. (2016) Hypermucoviscosity in Clinical Isolates of Klebsiella pneumoniae Correlates with High Multiple Antibiotic Resistance (MAR) Index. (scirp.org)
  • High levels of resistance (AMR) from livestock to humans. (who.int)
  • S. typhi displayed a high resistance pattern to most antibiotic screened than S. typhimurium . (jidc.org)
Genotypic4
  • Assessment of genotypic macrolide resistance was done as previously described. (annals.edu.sg)
  • thus, the results of genotypic macrolide resistance were not known at the time of treatment. (annals.edu.sg)
  • Demographic and clinical data were collected and matched to the results of genotypic macrolide-resistance testing. (annals.edu.sg)
  • The concordance between phenotypic and genotypic resistance was also determined. (who.int)
Monitor antibiotic2
  • The WHO has sought to establish a global surveillance network to monitor antibiotic resistance in the gonococcus - the Gonococcal Antimicrobial Surveillance Programme (GASP). (health.gov.au)
  • Establish and expand the routine surveillance to monitor antibiotic resistance in poultry. (who.int)