Thioamides function as antithyroid agents mainly by inhibiting iodide organification and coupling processes, thereby preventing synthesis of thyroid hormones. (medscape.com)
Liver function test results should be obtained to monitor for liver toxicity caused by thioamides (antithyroid medications). (medscape.com)
Amides1
Thioamides are typically prepared by treating amides with phosphorus sulfides such as phosphorus pentasulfide, a reaction first described in the 1870s. (wikipedia.org)
Synthesis4
Thioamides inhibit the enzyme thyroid peroxidase in the thyroid, reducing the synthesis of triiodothyronine (T3) and thyroxine (T4), thereby blocking uptake of iodotyrosines from the colloid. (wikipedia.org)
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. (nih.gov)
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. (nih.gov)
The most widely applied strategies for their synthesis rely on cross-coupling reactions but the preparation of structurally diverse and nonsymmetrical tetraarylmethanes remains challenging. (thieme.de)
Compounds1
Fifth chapter includes the preparation of few important bio-active compounds. (journaltocs.ac.uk)
Rarely2
A thioamide (rarely, thionamide, but also known as thiourylenes) is a functional group with the general structure R1−C(=S)−NR2R3, where R1, R2 and R3 are any groups (typically organyl groups or hydrogen). (wikipedia.org)
Thioamides may rarely cause severe hematologic side effects, but routine screening for these rare events is not cost-effective. (medscape.com)
Reaction1
The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary amines, and elemental sulfur in a single synthetic operation. (nih.gov)
Chemistry1
One of the best-known thioamides is thioacetamide, which is used as a source of the sulfide ion and is a building block in heterocyclic chemistry. (wikipedia.org)
Oral1
Only oral preparations are available, but they have been used as retention enemas in patients in whom oral intake is not possible or is contraindicated. (medscape.com)
Process1
The present invention relates to new 1-aralkylpyrazoles, a process for their preparation and their use as agents for combating pests. (justia.com)