• RESULTS: Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. (lu.se)
  • INTRODUCTION: The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. (lu.se)
  • BACKGROUND: Preoperative radiotherapy (PRT) has become part of standard practice offered to improve treatment outcomes in patients with rectal cancer. (mcmaster.ca)
  • OBJECTIVES: To determine if PRT improves outcome for patients with localized resectable rectal cancer and how it compared with other adjuvant or neoadjuvant strategies. (mcmaster.ca)
  • SEARCH STRATEGY: A computerized search was performed December 2006 on MEDLINE (from 1966 to December 2006) and the Cochrane Central Register of Controlled Trials (CENTRAL), conference proceedings, using MeSH and textwords where appropriate to identify randomized trials in PRT and rectal cancer. (mcmaster.ca)
  • SELECTION CRITERIA: Randomized trials with a PRT arm versus surgery alone, or other neoadjuvant or adjuvant (NA/A) strategies, targeted patients with localized rectal cancer planned for radical surgery were included. (mcmaster.ca)
  • Because of the high incidence of local tumor recurrence in patients with rectal cancer, sigmoidoscopy should be performed every 3-6 months for 3 years. (health.am)
  • Combined modality therapy for rectal cancer. (health.am)
  • Imaging studies are a major component in the evaluation of patients for the screening, staging, treatment and surveillance of rectal cancer. (medscape.com)
  • It is difficult to separate epidemiological considerations of rectal cancer from those of colon cancer because studies often consider colon and rectal cancer together (i.e., colorectal cancer). (cancer.gov)
  • New cases of rectal cancer: 46,050. (cancer.gov)
  • Evidence supports screening for rectal cancer as a part of routine care for all adults aged 50 years and older, especially for those with first-degree relatives with colorectal cancer. (cancer.gov)
  • 20 - 25 ] A major pooled analysis evaluating the impact of T and N stage and treatment on survival and relapse in patients with rectal cancer who are treated with adjuvant therapy confirmed these findings. (cancer.gov)
  • Preoperative chemoradiotherapy changes the size criterion for predicting lateral lymph node metastasis in lower rectal cancer. (shengsci.com)
  • abstract: PURPOSE:The purpose of this study was to identify the size criteria of lateral lymph node metastasis in lower rectal cancer both in patients who underwent preoperative CRT and those who did not. (shengsci.com)
  • Robotic rectal cancer surgery in obese patients may lead to better short-term outcomes when compared to laparoscopy: a comparative propensity scored match study. (shengsci.com)
  • BACKGROUND: Adding modified FOLFOX6 (folinic acid, fluorouracil, and oxaliplatin) after chemoradiotherapy and lengthening the chemoradiotherapy-to-surgery interval is associated with an increase in the proportion of rectal cancer patients with a pathological complete response. (elsevierpure.com)
  • PATIENTS: Four sequential study groups with stage II or III rectal cancer were included. (elsevierpure.com)
  • CONCLUSIONS: Adding modified FOLFOX6 after chemoradiotherapy and before total mesorectal excision increases compliance with systemic chemotherapy and disease-free survival in patients with locally advanced rectal cancer. (elsevierpure.com)
  • Looking at the literature and analyzing recent data collected at the Department of Surgery of the University of Torino, neither pit-pattern classification, nor EUS, nor biopsy histology, nor lifting sign verification, nor digital examination allow a specificity of more than 75% of suspected adenomas or early rectal cancer. (albertoarezzo.it)
  • WP24: C-reactive protein monitoring reduce length of stay after stoma reversal in patients with laparoscopic sphincter-saving surgery for rectal cancer. (eu.com)
  • CHICAGO - Many patients with locally advanced rectal cancer who do not have high-risk disease can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy alone and then surgery, say researchers reporting results from the PROSPECT trial. (medscape.com)
  • This study establishes preoperative therapy with FOLFOX and only selective use of chemoradiation for patients with locally advanced rectal cancer," commented principal investigator Deborah Schrag, MD, MPH, gastrointestinal oncologist at Memorial Sloan Kettering Cancer Center, New York City. (medscape.com)
  • Reacting to the findings, Pamela Kunz, MD, leader of the Gastrointestinal Cancers Program at Yale Cancer Center, New Haven, Connecticut, commented: "What's important here is that radiation can be safely omitted in many patients with clinically advanced rectal cancer - this is really 'less is more. (medscape.com)
  • Marijnen also pointed out that the definition of "locally advanced" in rectal cancer varies by region, and that in Europe many of the patients in the current trial would be defined as early and intermediate stage, and so would not qualify for neoadjuvant therapy. (medscape.com)
  • Presenting the findings, Schrag began by noting that approximately half of all new rectal cancer diagnoses have locally advanced disease, which in the US represents 48,000 cases per year. (medscape.com)
  • Surgery remains the standard of care for most rectal cancer as it offers the best chance of cure. (wustl.edu)
  • In this way a personalised approach can be offered for patients with rectal cancer using novel radiotherapy techniques. (wustl.edu)
  • Aside from the detection of occult blood on a digital rectal exam, the physical examination is usually not helpful in the diagnosis of colon cancer. (jomi.com)
  • Background: The treatment of rectal cancer has changed significantly over the last few decades. (tau.ac.il)
  • The use of laparoscopy for rectal resection is the most recent addition to this series of improvements, but in contrast to the use of laparoscopy in colon cancer its role is not yet well defined. (tau.ac.il)
  • Results: Of 750 laparoscopic colorectal procedures performed over a 13 year period, 67 were for rectal cancer. (tau.ac.il)
  • Rectal cancer is a common malignancy of the gastrointestinal tract. (bvsalud.org)
  • Extramural vascular invasion (EMVI) is a key indicator of risk stratification for rectal cancer and an important reference factor in determining individualised treatment options, so it is important to accurately assess whether extramural vessels are infiltrated by the tumour before surgery. (bvsalud.org)
  • The main imaging methods for rectal cancer include magnetic resonance imaging (MRI), computed tomography (CT) and transrectal ultrasound (TRUS). (bvsalud.org)
  • This article focuses on the performance and diagnostic efficacy of these imaging methods in the diagnosis of EMVI in rectal cancer, and provides clinical reference. (bvsalud.org)
  • The Kappa values used for assessing agreement in staging diagnosis of stage I-III rectal cancer between dual contrast-enhanced ultrasonography and interventional biopsy and postoperative tissue pathological examination results were 0.923, 0.912, and 0.927, respectively. (bvsalud.org)
  • The areas under the curve plotted for staging diagnosis of rectal cancer were 0.961, 0.955, and 0.970, respectively.Conclusion:Dual contrast-enhanced ultrasonography and interventional biopsy have a high efficacy in the localization, qualitative diagnosis, and staging diagnosis of rectal tumors. (bvsalud.org)
  • Disparities in Rectal Cancer Care-What Are We Missing? (umassmed.edu)
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Rectal Cancer 2023 Supplement. (umassmed.edu)
  • She is a member of ASCO program committee and the American College of Surgeons Rectal Cancer Standards Operative Workgroup. (rochester.edu)
  • Hospital and surgeon variation in positive circumferential resection margin among rectal cancer patients. (rochester.edu)
  • Recent advances in the management of rectal cancer have dramatically changed the clinical practice of colorectal surgeons because the main focus of rectal cancer treatment has changed from sphincter-saving to an organ-preserving strategies. (coloproctol.org)
  • TNT poses limitations or obstacles, such as overtreatment issues in patients with stage I rectal cancer. (coloproctol.org)
  • However, considering the quality-of-life issues in patients with low-lying rectal cancer necessitating a permanent colostomy, the indication for TNT will be expanded. (coloproctol.org)
  • The current rectal cancer management should be extended to achieve more pCR and apply the organ-preserving strategy beyond the sphincter-preserving surgery because it harbored many disadvantages, such as low anterior resection syndrome, sexual and voiding difficulties, and permanent colostomy [ 5 , 6 ]. (coloproctol.org)
  • Various approaches have been tested to improve the survival of rectal cancer patients and have resulted in promising outcomes. (coloproctol.org)
  • The year 2022 will be a landmark year for the treatment of rectal cancer because the mainstream of rectal cancer management has been changed from nCRT to TNT. (coloproctol.org)
  • These dramatic changes reflected the results of 2 prospective randomized clinical trials, i.e., the RAPIDO (Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation) trial [ 8 ] and PRODIGE (Partenariat de Recherche en Oncologie Digestive) 23 trial [ 9 ] in 2021. (coloproctol.org)
  • p class=\'abstract\'>The NCCN Guidelines for Rectal Cancer provide recommendations for the diagnosis, evaluation, treatment, and follow-up of patients with rectal cancer. (stanford.edu)
  • Rectal Cancer, Version 6.2020 Featured Updates to the NCCN Guidelines. (stanford.edu)
  • We performed robot-assisted TME and lateral lymph node dissection for rectal cancer using the da Vinci ® Si™ system (Intuitive Surgical Inc., Sunnyvale, CA, USA). (spandidos-publications.com)
  • Predicting pathological response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer using 18FDG-PET/CT. (uci.edu)
  • An easy-to-use artificial intelligence preoperative lymph node metastasis predictor (LN-MASTER) in rectal cancer based on a privacy-preserving computing platform: multicenter retrospective cohort study. (cdc.gov)
  • Herein, we report a case of a large Pub in which the symptoms were masked by oral medication, precise preoperative diagnosis was difficult, and intraoperative confirmation of tumoral adhesion to the rectum resulted in hypertensive attacks during surgery. (biomedcentral.com)
  • Herein, we report a case of a large Pub in which a precise preoperative diagnosis and intraoperative confirmation of tumor adhesion to the rectum were difficult, resulting in hypertensive attacks during surgery. (biomedcentral.com)
  • The ASCRS Manual of Colon and Rectal Surgery, Second Edition is designed to provide a rapid access pocket reference for residents, fellows, private clinicians, and allied health professionals caring for patients with colorectal surgical diseases. (nshealth.ca)
  • The Manual, abstracted from the ASCRS Textbook of Colon and Rectal Surgery, Second Edition, is intended to impart succinct, clinically relevant information for daily patient care. (nshealth.ca)
  • Concise yet comprehensive, The ASCRS Manual of Colon and Rectal Surgery, Second Edition is very useful for physicians and researchers dealing with diseases of the colon and rectum. (nshealth.ca)
  • On the other hand, the treatment of rectal lesions may benefit from a further therapeutic option (i.e. transanal surgery). (albertoarezzo.it)
  • WP01: What is the functional result of a delayed colo-anal anastomosis in rectal redo-surgery? (eu.com)
  • Objectives: To present our experience with laparoscopic surgery for upper and lower rectal tumors. (tau.ac.il)
  • Methods: A database was used to prospectively collect all data on laparoscopic rectal surgery in our department since we started performing these procedures in 1997. (tau.ac.il)
  • Dr. Temple chairs the Quality Assessment Committee for the American Society of Colon and Rectal Surgery. (rochester.edu)
  • Fellowship, Colon & Rectal Surgery, St Luke's-Roosevelt Hospital Center-St Luke's Divi. (rochester.edu)
  • CT scan for early diagnosis of anastomotic leak after colorectal surgery: is rectal contrast useful? (canceropole-est.org)
  • However, the incidence of metastasis of rectal carcinoid tumors increases when they are larger than 10 mm, have muscular invasion, poorly differentiated histology, and lymphatic or vascular involvement. (spg.pt)
  • Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms . (lookformedical.com)
  • Malignant cells were of glandular structure, consistent with a neoplasm. (ispub.com)
  • In general colonic carcinosarcomas constitute a rare category of malignant neoplasms whose nature is still incompletely understood. (klinikitsekoura.gr)
  • The term carcinosarcoma implies a mixed malignant tumor that is composed of an epithelial element, typically the common form of carcinoma seen in the tissue harboring the neoplasm, close to or intermixed with a sarcomatous component. (klinikitsekoura.gr)
  • Although magnetic resonance imaging (MRI) is slightly more accurate than CT in staging primary rectal tumors, CT is much more widely available. (medscape.com)
  • Most institutions and departments have more extensive experience using CT than MRI and continue to use CT for staging rectal tumors. (medscape.com)
  • The incidence of rectal neuroendocrine tumors has been rising largely due to an increased number of screening colonoscopies, allowing for identification of smaller lesions amenable to endoscopic treatment 1 . (spg.pt)
  • Therefore, EUS has shown to be useful during preoperative evolution for measuring the size and depth of rectal carcinoid tumors. (spg.pt)
  • Endoscopic submucosal dissection and preoperative assessment with endoscopic ultrasonography for the treatment of rectal carcinoid tumors. (spg.pt)
  • Carcinoid tumors of the colon are rare, comprising less than 11% of all carcinoid tumors and only 1% of colonic neoplasms. (jomi.com)
  • Tumors less than 1 cm can often be excised locally either by endoscopy or for rectal lesions via a transanal approach. (jomi.com)
  • Advanced surgical techniques have led to an increase in the rate of sphincterpreserving operations, even for low rectal tumors. (tau.ac.il)
  • Objective:To investigate the clinical efficacy of qualitative and staging diagnosis of rectal tumors with dual contrast-enhanced ultrasonography and interventional biopsy.Methods:A total of 300 patients with rectal tumors who received treatment in The First People's Hospital of Huzhou from December 2019 to March 2022 were included in this study. (bvsalud.org)
  • The sensitivity, specificity, and accuracy of the dual contrast-enhanced ultrasonography and interventional biopsy for qualitative diagnosis of rectal tumors were 94.8%, 97.8%, and 96.7%, respectively. (bvsalud.org)
  • The Kappa value used for assessing agreement in the qualitative diagnosis of rectal tumors between dual contrast-enhanced ultrasonography and interventional biopsy and postoperative tissue pathological examination results was 0.947. (bvsalud.org)
  • The area under the curve plotted for qualitative diagnosis of rectal tumors was 0.974. (bvsalud.org)
  • For each stage, rectal cancers have a worse prognosis. (health.am)
  • Rectal cancers are, after colon cancers , the second most common gastrointestinal (GI) carcinoma, and have the best prognosis. (medscape.com)
  • Almost all rectal cancers are primary adenocarcinomas (see the images below). (medscape.com)
  • Deaths: 52,550 (rectal and colon cancers combined). (cancer.gov)
  • However, for patients with early stage low rectal cancers there are several treatment options available using novel radiotherapy techniques. (wustl.edu)
  • Patient selection is important and careful assessment after preoperative chemoradiotherapy can identify good responders, even with advanced rectal cancers. (wustl.edu)
  • His clinical practice is focused on the surgical treatment of colon and rectal cancers, inflammatory bowel disease (ulcerative colitis and Crohn's disease), and benign colon and anorectal diseases (diverticulitis, hemorrhoids, fistulas, fissures). (stanford.edu)
  • Advanced rectal cancers were traditionally treated with neoadjuvant chemoradiation therapy (nCRT) followed by total mesorectal excision (TME) and postoperative adjuvant chemotherapy [ 1 , 2 ]. (coloproctol.org)
  • Results: A significant percentage of intra-abdominal cancers prove to be inoperable because of metastatic or locally advanced disease despite a preoperative workup suggesting a potentially resectable disease. (bvsalud.org)
  • A CT scan of the abdomen and pelvis was subsequently performed revealing the lower rectal mass and distortion of adjacent perirectal fat. (klinikitsekoura.gr)
  • Patients treated by elective rectal resection were included. (lu.se)
  • Patients who had a complete preoperative colonoscopy should undergo another colonoscopy 1 year after surgical resection. (health.am)
  • ESD was conceived in Japan with the aim to avoid this problem, allowing en bloc resection of larger colorectal lesions. (albertoarezzo.it)
  • Despite its longer procedure time and higher complication rate, ESD result in a higher en bloc resection rate compared to that seen with conventional or piecemeal EMR [12-14]. (albertoarezzo.it)
  • A recent comparative study [20] demonstrated that the higher en bloc resection rate of 83.5% with colorectal ESD compared with 48.1% for lesions removed by EMR. (albertoarezzo.it)
  • The cause proved to be a rectal carcinosarcoma that was treated by abdominoperineal resection and postoperative chemo-radiotherapy. (klinikitsekoura.gr)
  • This was facilitated by preoperative oncologic treatment and the use of chemoradiation to downstage the tumor before resection. (tau.ac.il)
  • Conclusions: Laparoscopic rectal resection is a demanding procedure. (tau.ac.il)
  • Systematic preoperative radiochemotherapy and total mesorectal excision are the standard of care for locally advanced rectal carcinoma. (medscape.com)
  • A precise diagnosis about the presence, location and extent of rectosigmoid endometriosis is required during the preoperative workup because this information is necessary in the discussion with both the colorectal surgeon and the patient. (blogspot.com)
  • Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system. (lookformedical.com)
  • CT scan for low rectal carcinoma preoperative staging. (medscape.com)
  • Argani, P. Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. (hopkinsmedicine.org)
  • Failing to Prepare Is Preparing to Fail: A Single-Blinded, Randomized Controlled Trial to Determine the Impact of a Preoperative Instructional Video on the Ability of Residents to Perform Laparoscopic Right Colectomy. (uci.edu)
  • Evaluation begins with a history and physical examination, including a digital rectal examination. (medscape.com)
  • The patient's abdomen was soft and flat on physical examination, and the tumor was not palpable on digital rectal examination. (biomedcentral.com)
  • Conclusion: In the patient with a new diagnosis of localized CaP, clinical tumor stage as determined by digital rectal examination, diagnostic biopsy tumor (Gleason primary) grade, and pretherapy serum prostate-specific antigen value were significant factors for development of a model that estimated the likelihood of SVI. (elsevierpure.com)
  • Note circumferential thickening of the rectal wall. (medscape.com)
  • Can preoperative CA19-9 and CEA levels predict the resectability of patients with pancreatic adenocarcinoma? (kbsmc.co.kr)
  • The CAO/ARO/AIO-12 trial [ 10 , 11 ] and OPRA (Organ Preservation of the Rectal Adenocarcinoma) trial [ 12 ] comparing the induction and consolidation chemotherapy as a TNT have been reported. (coloproctol.org)
  • Patients who did not undergo full colonoscopy preoperatively should undergo colonoscopy within 3-6 months postoperatively to exclude other synchronous colorectal neoplasms and 1 year thereafter. (health.am)
  • Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
  • ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms. (spg.pt)
  • The mean number of total chemotherapy cycles differed among the 4 groups (p = 0.002), because one third of patients in the group assigned to no preoperative FOLFOX did not receive any adjuvant chemotherapy. (elsevierpure.com)
  • The purpose of our study was to develop modern epidemiological data for adult patients completing an appendectomy for UA secondary to an appendiceal neoplasm (AN). (cancerindex.org)
  • Her abdomen was soft, mildly distended, and there was no evidence of masses and a negative occult blood test at rectal examination. (ispub.com)
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Anal Fissures. (umassmed.edu)
  • The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Anorectal Abscess, Fistula-in-Ano, and Rectovaginal Fistula. (umassmed.edu)
  • This Clinical Policy Bulletin addresses treatment approaches for liver and other neoplasms. (aetna.com)
  • Endoscopic ultrasonography-guided fine-needle aspiration revealed CD34-positive spindle-shaped cells in the fibrous tissue, suggestive of a mesenchymal neoplasm. (biomedcentral.com)
  • Gastric gastrointestinal stromal tumor (GIST) en face. (medscape.com)
  • The finding of a neoplasm in a hernia sac is extremely rare and is reported to occur in less than 0.5% of examined hernia sacs. (ispub.com)
  • Figure 1: Preoperative CT scan showing left inguinal hernia. (ispub.com)
  • However, some cases without typical symptoms have been found incidentally, making preoperative diagnosis difficult. (biomedcentral.com)
  • The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause. (lookformedical.com)
  • 1. Scherübl H., Rectal carcinoids are on the rise: early detection by screening endoscopy. (spg.pt)
  • Methods which attempt to express in replicable terms the extent of the neoplasm in the patient. (lookformedical.com)
  • There was significantly more pelvic or perineal wound infection, late rectal and sexual dysfunction. (mcmaster.ca)