• Triweekly XELOX or capecitabine concurrent with neoadjuvant radiotherapy leads to similar long-term survival outcomes, acute toxicities and surgical complications in LARC patients. (biomedcentral.com)
  • The investigators randomly assigned patients with resectable cancers to undergo surgery alone or receive weekly carboplatin (area under the curve, 2) and paclitaxel (50 mg/m 2 ) for 5 weeks and concurrent radiotherapy, followed by surgery. (medscape.com)
  • Current options for resectable esophageal cancer include preoperative cisplatin-based radiotherapy and preoperative or perioperative chemotherapy alone (either 5-fluorouracil/cisplatin, as in the UK Medical Research Council study, [ 1 ] or epirubicin, cisplatin and fluorouracil, as in the MAGIC study [ 2 ] ). (medscape.com)
  • This study therefore offers a new option of weekly chemotherapy with concurrent radiotherapy for patients with resectable esophageal (but not gastric) cancers. (medscape.com)
  • Other clinical studies from the United States, Europe, and Asia have also influenced the treatment strategies for operable rectal cancer, as various approaches using preoperative or postoperative radiotherapy, with or without chemotherapy, have been examined. (biomedcentral.com)
  • Between January 2009 and December 2014, 90 patients underwent preoperative RCT at the radiotherapy department at University Hospital Mohamed VI, Oujda, Morocco. (waocp.com)
  • A Bayesian network meta-analysis comparing concurrent chemoradiotherapy followed by adjuvant chemotherapy, concurrent chemoradiotherapy alone and radiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma. (srobf.cz)
  • Among the other studies chosen to be highlighted at the scientific session on breast cancer was a phase Ib trial to assess safety and toxicity and establish the maximum tolerated dose of concurrent cisplatin with adjuvant radiotherapy for women with stage II and II triple-negative breast cancer. (ascopost.com)
  • High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy. (genscript.com)
  • Title: The prognostic impact of lipid biosynthesis-associated markers, HSD17B2 and HMGCS2, in rectal cancer treated with neoadjuvant concurrent chemoradiotherapy. (genscript.com)
  • Methods: Between 2007 and 2017, patients with clinically staged II-III rectal cancer who were treated with preoperative chemoradiotherapy using either triweekly XELOX (oxaliplatin 130 mg/m 2 plus capecitabine 825 mg/m 2 ) or capecitabine were included. (biomedcentral.com)
  • Background: To evaluate the prognostic value of neutrophil-lymphocyte ratio (NLR) in rectal cancer patients treated with preoperative chemoradiotherapy (CRT) and curative surgery. (ewha.ac.kr)
  • Methods: A comprehensive search of the EMBASE and PubMed databases was performed to screen studies that compared treatment outcomes according to the pre-CRT and/or post-CRT NLR in patients receiving preoperative CRT and curative surgery for locally advanced rectal cancer. (ewha.ac.kr)
  • Further studies are needed to confirm the prognostic value of NLR in rectal cancer patients receiving preoperative CRT. (ewha.ac.kr)
  • To study the pattern and treatment outcome of rectal cancer (RC) with concurrent locoregional recurrence (LR) and distant metastasis (DM) after total mesorectal excision (TME) and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after concurrent LR and DM. (biomedcentral.com)
  • In 2004, a randomized trial from Germany was published establishing a regimen of preoperative chemoradiotherapy and surgery followed by additional cycles of chemotherapy alone as the standard of care for clinical stages T3 or T4, or for node-positive rectal cancer [ 3 ]. (biomedcentral.com)
  • The aim of this study was to investigate the effect of preoperative chemoradiotherapy (CRT) on nodal disease in locally advanced rectal adenocarcinoma.Thirty-two patients staged uT3N0 and 27 patients staged uT3N1 rectal adenocarcinoma who underwent pre-CRT staging using endoscopic ultrasound or rectal protocol CT were included. (stanfordhealthcare.org)
  • These dramatic changes reflected the results of 2 prospective randomized clinical trials, i.e., the RAPIDO (Rectal Cancer and Preoperative Induction Therapy Followed by Dedicated Operation) trial [ 8 ] and PRODIGE (Partenariat de Recherche en Oncologie Digestive) 23 trial [ 9 ] in 2021. (coloproctol.org)
  • This study was designed to explore whether an intensified chemoradiotherapy (CRT) led to a better clinical outcome in locally advanced rectal cancer. (biomedcentral.com)
  • Predictive value of genetic variants XRCC1 rs1799782, APEX1 rs1760944, and MUTYH rs3219489 for adjuvant concurrent chemoradiotherapy outcomes in oral squamous cell carcinoma patients. (cdc.gov)
  • The survival advantage associated with the addition of surgical therapy in esophageal squamous cell carcinoma (ESCC) patients who demonstrate a complete clinical response to chemoradiotherapy is unclear, and many institutions have adopted an organ-preserving strategy of selective surgery in this population. (shengsci.com)
  • The German Esophageal Study Group performed a phase III trial comparing definitive CRT to preoperative CRT followed by resection in locally advanced squamous cell carcinoma of the esophagus. (appliedradiationoncology.com)
  • A Novel RNA-Seq-Based Model for Preoperative Prediction of Lymph Node Metastasis in Oral Squamous Cell Carcinoma. (cdc.gov)
  • This trial confirms that preoperative chemoradiation for resectable esophageal cancer is safe and, compared with surgery alone, is associated with pathological complete responses, higher rates of R0 resection, and prolonged survival. (medscape.com)
  • Only 30% to 40% of patients with Pancoast tumors are eligible to receive preoperative concurrent chemoradiotherapy followed by complete resection. (oncnursingnews.com)
  • However, smokers newly diagnosed with non-small cell lung cancer and scheduled for curative resection are frequently discouraged from stopping smoking in the immediate preoperative period. (thieme-connect.de)
  • The CROSS trial compared weekly paclitaxel/carboplatin with the standard of surgery alone rather than other established preoperative regimens. (medscape.com)
  • Preoperative CRT was administered with concurrent chemotherapy (mostly fluoropyrimidine-based regimens). (ewha.ac.kr)
  • The present study aimed to compare the survival outcomes, acute toxicities and surgical complications in LARC patients who received preoperative chemoradiotherapy with triweekly oxaliplatin and capecitabine (triweekly XELOX) or capecitabine. (biomedcentral.com)
  • Although the prognosis remains poor, pursuing NED status through comprehensive treatments may improve the survival of RC patients with concurrent LR and DM after TME. (biomedcentral.com)
  • The combination of concurrent fluorouracil (5-FU)and ionizing radiation therapy for patients with unresectable disease hasresulted in a twofold increase in median survival: approximately 10 months vs 5months. (cancernetwork.com)
  • To compare patient survival outcomes between completion hysterectomy and conventional surveillance in locally advanced adenocarcinoma of the cervix after concurrent chemoradiotherapy (CCRT). (koreamed.org)
  • 2. Albert A, Allbright R, Lee A, Vijayakumar S. Preoperative chemoradiation followed by hysterectomy for cervical cancer: patterns of care and survival in a large, hospital database. (koreamed.org)
  • 2 In the 1990s, improvements in survival were made with the addition of concurrent chemotherapy to RT, 3,4 with no patients alive at 3 years in the RT-alone arm. (appliedradiationoncology.com)
  • The FFCD 9102 trial randomized 444 patients with resectable esophageal cancer (majority squamous histology) to induction CRT consisting of either 46 Gy in 23 fractions with concurrent cisplatin and 5-FU or split course 30 Gy in 10 fractions RT given over 4 weeks (5 days on, 10 days off, 5 days on). (appliedradiationoncology.com)
  • 9 Similarly, the European Organization for Research and Treatment of Cancer (EORTC) trial 8 randomized SCC patients to surgery alone or neoadjuvant CRT consisting of two 1-week courses of RT, separated by a 2-week break, to a total dose of 37 Gy in 10 fractions with concurrent cisplatin. (appliedradiationoncology.com)
  • 2023. Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial . (cardiff.ac.uk)
  • The study compared the perioperative morbidity and mortality of patients aged 70 years or older with those of patients younger than 70 years who underwent chemoradiotherapy followed by esophagectomy. (medscape.com)
  • We sought to characterize our institutional experience of salvage esophagectomy (for failure of definitive bimodality therapy) and planned esophagectomy (as a component of trimodality therapy) by retrospectively analyzing patients with ESCC of the thoracic esophagus and GEJ who underwent esophagectomy following chemoradiotherapy between 2004 and 2016. (shengsci.com)
  • In summary, esophagectomy following chemoradiotherapy for ESCC at our institution has been associated with frequent postoperative morbidity and considerable rates of mortality in both planned and salvage settings. (shengsci.com)
  • A study by Fogh et al of induction chemoradiotherapy followed by surgery, a strategy that is widely used in treating esophageal cancer, found that perioperative morbidity and mortality with this approach was not significantly different in patients aged 70 years or older compared with younger patients. (medscape.com)
  • During the past 12 years, numerous observational studies have investigated the impact of preoperative smoking cessation on perioperative risk for thoracic and non-thoracic surgery. (thieme-connect.de)
  • In view of the post-cessation recovery time-course of pathophysiological alterations relevant to the occurrence of perioperative complications, a smoke-free preoperative interval of 2 - 6 weeks appears most favourable. (thieme-connect.de)
  • All other patients received a preoperative chemoradiotherapy (CRT) with 50.4 Gy and concomitant 5-fluorouracil (5-FU) or 5-FU+oxaliplatin followed by postoperative chemotherapy with 5-FU or 5-FU+oxaliplatin. (jcancer.org)
  • A concomitant boost to oxalipatin-combined preoperative chemoradiotherapy demonstrated a slightly higher pCR rate but delayed incision healing after surgery. (biomedcentral.com)
  • Therefore, we designed this randomized trial to explore whether a combined regimen of oxaliplatin-added chemoradiotherapy and a concomitant boost to the primary tumor would further lead to a better clinical outcome. (biomedcentral.com)
  • In the absence of similar research, we endeavored to investigate the prognostic usefulness of posttreatment neutrophil-to-lymphocyte ratio (NLR) in patients treated with definitive concurrent chemoradiotherapy (CCRT) for locally advanced pancreatic adenocarcinoma (LAPAC). (hindawi.com)
  • The preoperative clinical stage was determined by CT scan, MRI, physical examination, or a combination of these. (waocp.com)
  • Ongoing efforts to improve response rates and identify the ideal preoperative regimen will clarify matters in the next few years. (medscape.com)
  • however, chemotherapy (CT), concurrent chemoradiotherapy (CCRT), and induction CT followed by CCRT are the most often utilized alternatives [ 6 ]. (hindawi.com)
  • In addition, preoperative chemotherapy allows the oncologist toidentify those patients with aggressive disease who are destined to progressquickly specifically, patients with micrometastatic disease who are lesslikely to benefit from a course of locoregional chemoradiotherapy. (cancernetwork.com)
  • Since there is no scientific evidence demonstrating a negative impact of preoperative smoking cessation on prognosis, patients newly diagnosed with lung cancer should be encouraged to make an attempt to quit while waiting for thoracic surgery. (thieme-connect.de)
  • Here, our study was designed to study the pattern and treatment outcome of RC with concurrent LR and DM after TME and to identify patient-, disease-, and treatment-related factors associated with differences in prognosis after concurrent LR and DM. (biomedcentral.com)
  • A study by Fogh et al examined the use of induction chemoradiotherapy followed by surgery a strategy that is widely used in treating esophageal cancer. (medscape.com)
  • Special interest radiology improves the perceived preoperative stage of gastric cancer. (helsedirektoratet.no)
  • Owing to methodological limitations and considerable heterogeneity of the included patient groups, the existing data are insufficient to support or refuse any recommendation regarding cessation advice for patients during the immediate preoperative phase. (thieme-connect.de)
  • Is Intermediate Radiation Dose Escalation With Concurrent Chemotherapy for Stage III Non-Small-Cell Lung Cancer Beneficial? (srobf.cz)
  • The median radiation dose was 50.4 Gy (range: 45-50.4 Gy) at 1.8 Gy per fraction and all patients received concurrent 5-FU or capecitabine-based chemotherapy. (stanfordhealthcare.org)
  • Ninety-five percent patients completed a full-dose chemoradiotherapy as planning. (biomedcentral.com)
  • 10-12] Despite these limited benefits, many consider external beamradiation and concurrent 5-FU as the standard therapy for locally advancedpancreatic cancer. (cancernetwork.com)
  • Compared to patients without BOFJ, those with BOFJ had a higher preoperative body mass index (23.3 kg/m 2 versus 20.9 kg/m 2 , P = 0.022), and greater postoperative body weight loss rate: 3 month, decrease to 84.2% of initial body weight versus 89.3% ( P = 0.002). (biomedcentral.com)
  • RC patients who were diagnosed with concurrent LR and DM after TME from May 2015 to June 2019 were included in our study. (biomedcentral.com)
  • Results of surgery after concurrent chemoradiotherapy in advanced cervical cancer: comparison of extended hysterectomy and extrafascial hysterectomy. (koreamed.org)
  • Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy. (uchicago.edu)
  • For early and locally advanced RC, normative guidelines can be adopted for standardized treatment [ 7 ], while no consensus of treatment has been reached for concurrent LR and DM after TME. (biomedcentral.com)
  • Thus, the individualized and comprehensive treatment of concurrent LR and DM still needs to be intensively studied. (biomedcentral.com)