AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceNamed GroupsHealth Care
Hydrops FetalisPrenatal DiagnosisFetal DiseasesEndolymphatic HydropsUltrasonography, PrenatalPregnancyParvovirus B19, HumanParvoviridae InfectionsAbortion, Eugenicalpha-ThalassemiaBlood Transfusion, IntrauterineFetal DeathErythroblastosis, FetalRh IsoimmunizationAmniocentesisHemoglobins, AbnormalErythema InfectiosumInfant, NewbornPolyhydramniosCystic Adenomatoid Malformation of Lung, CongenitalHydrothoraxThalassemiaalpha-GlobinsGestational AgeHeterozygote DetectionHemoglobin HEdemaPrenatal Exposure Delayed EffectsChorionic Villi SamplingMucopolysaccharidosis VIIPrenatal CarePhosphotransferases (Phosphomutases)Abnormalities, MultipleFatal OutcomePregnancy OutcomeHypoalbuminemiaHeart Defects, CongenitalPregnancy Complications, InfectiousMeniere DiseaseAmniotic FluidGenetic CounselingPericardial EffusionAbortion, TherapeuticPregnancy Trimester, Second
UltrasoundNonimmune Hydrops FetalisSigns of hydrops fetalisErythroblastosisAssociated with fetalFetusFetusesEarly prenatal diagnosisHemolyticAscitesSyndromeInterstitial fluidClinicalNeonatalExomePlacentalMother's immune systemEdemaSymptomsAnomaliesInfectionDetectionNewbornUteroFluidAccumulationThalassemiaMaternalSevereIncompatibilityCardiacGenesIncidenceCongenitalFindingsAntigenGlobulinPostnatalAbnormallyPregnancyDiseasesPregnanciesDifferential diagnosisPatientPregnantUncommonCitationOccursGeneticCases
Ultrasound12
  • Prenatal ultrasound findings of rasopathies in a cohort of 424 fetuses: update on genetic testing in the NGS era. (cdc.gov)
  • She oversees the prenatal diagnosis program at UCSF, and is an expert in high-risk obstetrical ultrasound and prenatal diagnosis procedures such as amniocentesis and CVS. (ucsf.edu)
  • The prenatal diagnosis of hydrops fetalis is achieved by ultrasound, which demonstrates the skin edema and/or fluid accumulations in serous cavities of the fetus (abdominal ascites, pleural and/or pericardial effusion). (taylorfrancis.com)
  • Prenatal diagnosis of thrombocytopenia absent radius syndrome by ultrasound and cordocentesis. (radiopaedia.org)
  • Ultrasound Diagnosis of Fetal Anomalies. (radiopaedia.org)
  • Accordingly, this chapter provides a detailed overview of the important anatomic aspects of some of the ventricular inflow anomalies, focusing on currently available information, to enable the prenatal diagnosis of such CHDs by ultrasound or echocardiography. (benthamscience.com)
  • During an ultrasound examination, the crossed AV valves produce false images of the mitral valve or tricuspid atresia in a standard 4-chamber view, which makes the diagnosis difficult. (benthamscience.com)
  • The October issue of Ultrasound in Obstetrics & Gynecology includes a systematic review evaluating the incidence and predictive factors of obstetric anal sphincter injury in primiparous women, a study providing preliminary evidence supporting the feasibility and efficacy of prenatal open spina bifida repair in twin pregnancy and two studies assessing the utility of glycosylated fibronectin as a new biomarker for pre-eclampsia screening in mixed and Asian populations. (isuog.org)
  • The July issue of Ultrasound in Obstetrics & Gynecology includes a systematic review investigating the prevalence of adenomyosis in women with subfertility, a review focusing on the definition of the uterine junctional zone and its appearance in adenomyosis, a study proposing sonographic descriptors for instant diagnosis of 20 major fetal anomalies and a population-level study evaluating the incidence, risk factors and timing of pregnancy loss in major congenital heart disease. (isuog.org)
  • A baby girl was born at 37 weeks by urgent cesarean delivery due to concerns for hydrops fetalis on prenatal ultrasound. (longdom.org)
  • Diagnosis of hydrops fetalis is usually made during an ultrasound. (healthline.com)
  • A doctor might notice hydrops fetalis on an ultrasound during a routine pregnancy checkup. (healthline.com)
Nonimmune Hydrops Fetalis3
  • Exome Sequencing for Prenatal Diagnosis in Nonimmune Hydrops Fetalis. (cdc.gov)
  • Nonimmune Hydrops Fetalis-Prenatal Diagnosis, Genetic Investigation, Outcomes and Literature Review. (cdc.gov)
  • Definition The Greek-Latin term hydrops fetalis is issued for pathologically increased fluid accumulations in fetal soft tissues and serous cavities.1 Immune hydrops fetalis refers to those cases of hydrops that are caused by alloimmune hemolytic anemia in the presence of circulating maternal antibodies against fetal erythrocytes.2 If there is no evidence of blood group incompatibility (isoimmunization), the hydrops is characterized as being nonimmune hydrops fetalis. (taylorfrancis.com)
Signs of hydrops fetalis2
Erythroblastosis4
Associated with fetal2
  • More recent recognition of factors other than isoimmune hemolytic disease that can cause or be associated with fetal hydrops led to the use of the term nonimmune hydrops to identify those cases in which the fetal disorder was caused by factors other than isoimmunization. (medscape.com)
  • Enzymatic studies in chorionic villous sample or amniotic cultured cells, once the most common conditions associated with fetal ascites or hydrops have been ruled out, are important. (biomedcentral.com)
Fetus7
  • Hydrops has been produced in the ovine fetus by anemia, tachyarrhythmia, occlusion of lymphatic drainage, and obstruction of cardiac venous return. (medscape.com)
  • Hydrops fetalis or hydrops foetalis is a condition in the fetus characterized by an accumulation of fluid, or edema, in at least two fetal compartments. (wikipedia.org)
  • In the event of a pregnancy where the fetus has the Rh-D blood antigen and the mother does not, the mother's immune system will respond to the red blood cells as foreign and create antibodies against the Rh-D antigen on the fetal blood cells. (wikipedia.org)
  • Fetalis means fetus. (cedars-sinai.org)
  • If there is a family history of thalassemia or if both parents are carriers, prenatal testing may be recommended to check for thalassemia in the developing fetus. (asianhomeocare.com)
  • Hydrops fetalis is a serious, life-threatening condition in which a fetus or newborn has an abnormal buildup of fluids in the tissue around the lungs, heart, or abdomen, or under the skin. (healthline.com)
  • Immune hydrops fetalis usually occurs when the blood types of the mother and the fetus aren't compatible with each other. (healthline.com)
Fetuses4
  • [ 2 ] Furthermore, a study in humans showed that, despite a significant negative correlation between the fetal serum albumin level and the degree of fetal hydrops, most fetuses with hydrops had albumin levels within the reference range. (medscape.com)
  • Prenatal diagnosis and early childhood outcome of fetuses with extremely large nuchal translucency. (cdc.gov)
  • Furthermore, hydrops may even be associated with oligohydramnios, for example, in some preterminal fetuses with Turner syndrome or in cases with intrauterine cytomegaloviral infection. (taylorfrancis.com)
  • Prenatal treatment with fluorinated glucocorticoids beginning as soon after detection has favourable outcome for mothers of fetuses with second degree heart block, is of no value for mothers of fetuses with third degree heart block, and controversial for mothers of fetuses with first degree heart block. (heraldopenaccess.us)
Early prenatal diagnosis1
  • Although the TAR syndrome is not uniformly fatal, early prenatal diagnosis is important as the morbidity and mortality associated with this condition may be high. (radiopaedia.org)
Hemolytic2
  • More recent recognition of factors other than isoimmune hemolytic disease that can cause or be associated with hydrops fetalis led to the use of the term non-immunological hydrops fetalis (NIHF). (biomedcentral.com)
  • Evaluation of relatives at risk: Presymptomatic diagnosis is warranted in relatives at risk for initiation of early intervention (no phototherapy, strict sun protection) and future monitoring for signs of hemolytic anemia. (porphyriafoundation.org)
Ascites5
  • Hydrops fetalis (fetal hydrops) is a serious fetal condition defined as abnormal accumulation of fluid in two or more fetal compartments, including ascites , pleural effusion , pericardial effusion , and skin edema. (medscape.com)
  • Some series of nonimmune hydrops also include cases of isolated pleural effusion, abdominal ascites, or generalized skin edema, because fluid accumulation in one site may represent an early stage of a disease that may lead to fluid accumulation in several sites at a more advanced stage, especially in diseases known to result in generalized hydrops fetalis. (taylorfrancis.com)
  • Lysosomal storage disorders (LSD) are a rare cause of non immunological hydrops fetalis (NIHF) and congenital ascites. (biomedcentral.com)
  • We report four cases with transient hydrops fetalis resulting from LSD and performed a literature review on LSD with NIHF and congenital ascites in combination. (biomedcentral.com)
  • Isolated congenital ascites is usually considered as part of the clinical picture of hydrops fetalis, in which the severity of peripheral edema is of a mild degree and ascites is the dominant clinical sign[ 1 , 2 ]. (biomedcentral.com)
Syndrome8
  • thalassemia to control Hb Bart's hydrops fetalis syndrome: 15 years of experience. (cdc.gov)
  • Prenatal diagnosis of thrombocytopenia absent radius (TAR) syndrome and vaginal delivery. (radiopaedia.org)
  • Prenatal diagnosis of thrombocytopenia-absent radius syndrome. (radiopaedia.org)
  • Twin-twin transfusion syndrome (TTTS) in pregnancies in which twins share a single placenta (hydrops affects the recipient twin) Twin anemia-polycythemia sequence (TAPS) Twin reversed arterial perfusion sequence (TRAPS) Maternal hyperthyroidism Fetal cardiac defects and skeletal defects Noonan syndrome Mirror syndrome, in which fetal and placental hydrops develops in association with maternal preeclampsia, edema and hypertension Down syndrome Hydrops fetalis can be diagnosed and monitored by ultrasound scans. (wikipedia.org)
  • Hemophagocytic Lymphohistiocytosis (HLH) is a rare, hyperinflammatory syndrome due to pathologic immune activation. (longdom.org)
  • Women whose babies have hydrops fetalis are at a risk of another condition known as mirror syndrome. (healthline.com)
  • Bloom syndrome (BSyn) is characterized by severe pre- and postnatal growth deficiency, immune abnormalities, sensitivity to sunlight, insulin resistance, and a high risk for many cancers that occur at an early age. (beds.ac.uk)
  • 1. AIDS: Acquired immune deficiency syndrome Acquired immunodeficiency syndrome 2. (cdc.gov)
Interstitial fluid2
  • The basic mechanism for the formation of fetal hydrops is an imbalance of interstitial fluid production and the lymphatic return. (medscape.com)
  • Although polyhydramnios defined by an amniotic fluid index above 24 cm is associated in 30%-75% of cases with nonimmune hydrops,4,5 the amniotic sac should not be considered as one of the compartments for the diagnosis of hydrops, because the pathophysiological mechanisms of the occurrence of polyhydramnios can differ from those leading to an increased rate of interstitial fluid accumulation causing hydrops fetalis and placentae. (taylorfrancis.com)
Clinical2
  • Diagnostic yield using whole-genome sequencing and in-silico gene panel of 281 genes associated with non-immune hydrops fetalis in clinical setting. (cdc.gov)
  • Genomic sequencing to aid diagnosis in pediatric and prenatal practice: Examining clinical utility, ethical implications, payer coverage, and data integration in a diverse population. (ucsf.edu)
Neonatal4
  • Hydrops fetalis has been a well-recognized fetal and neonatal condition throughout history. (medscape.com)
  • Prenatal glucocorticoids can be used also in presence of cardiomyopathy associated with neonatal lupus. (heraldopenaccess.us)
  • Neonatal lupus erythematosus presents group of autoimmune disorders that results from either congenital trans-placental passage of antinuclear and ribonuclear autoantibodies targeting fetal and neonatal tissues (Neonatal Lupus Syndromes( or to less extent from infant's intrinsic deregulated immune system (Primary infantile SLE). (heraldopenaccess.us)
  • Neonatal lupus syndromes (NLS) occurs in infants born to mother with rheumatic conditions including systemic lupus erythematous (SLE), Sjögren's disease, mixed connective tissue disease, leukocytoclastic vasculitis, various forms of arthritis, immune-mediated thrombocytopenia, thyroiditis, autoimmune hepatitis, and undifferentiated autoimmune syndromes. (heraldopenaccess.us)
Exome2
  • Author Correction: Diagnostic yield of pediatric and prenatal exome sequencing in a diverse population. (ucsf.edu)
  • Corrigendum to 'Prenatal Exome and Genome Sequencing for Fetal Structural Abnormalities': [American Journal of Obstetrics and Gynecology 228 (2023) 140-149]. (ucsf.edu)
Placental1
  • Placentomegaly indicating hydrops placentae can be diagnosed if the placental thickness, from chorionic plate to base, increases by 4 cm or more in the second trimester and by 6 cm or more in the third trimester. (taylorfrancis.com)
Mother's immune system3
  • Rh disease develops in the event of a second pregnancy where the mother's immune system launches an attack, via IgG, against the infant's Rh-D positive blood cells. (wikipedia.org)
  • The Rh negative mother's immune system sees the baby's Rh positive red blood cells as foreign. (cedars-sinai.org)
  • The mother's immune system may then attack and destroy the baby's red blood cells. (healthline.com)
Edema2
  • La hidropesía fetal es una afección fetal letal definida como la acumulación anormal de líquido en dos o más compartimentos fetales que se presenta como ascitis, derrame pleural, derrame pericárdico y edema cutáneo. (igenomix.com)
  • La hidropesía fetal o hidropesía fetal es una condición fetal letal definida como la acumulación anormal de líquido en dos o más compartimentos fetales que se presenta como ascitis, derrame pleural, derrame pericárdico y edema cutáneo. (igenomix.com)
Symptoms2
  • Think of secondary syphilis as a diffuse spirochete infection causing immune complex deposition that manifests as a multitude of symptoms. (tomwademd.net)
  • What are the symptoms of hydrops fetalis? (healthline.com)
Anomalies2
  • Currently, the accuracy of fetal echocardiography enables the detailed diagnosis of a significant variety of congenital cardiac anomalies, and it has also been demonstrated that prenatal outcomes may improve in critical CHDs. (benthamscience.com)
  • Information regarding prenatal management, delivery plan strategies, and differential diagnosis of such anomalies is presented. (benthamscience.com)
Infection2
  • Congenital disorders of glycosylation Parvovirus B19 (fifth disease) infection of the pregnant woman (most common cause) Cytomegalovirus in mother Congenital pulmonary airway malformation (formerly called congenital cystic adenomatoid malformation) Maternal syphilis and maternal diabetes mellitus Alpha-thalassemia can also cause hydrops fetalis when all four of the genetic loci for α globin are deleted or affected by mutation. (wikipedia.org)
  • Cryptococcosis is a well-recognised infection in immunocompromised patients, although its prevalence varies with the type of immune defect. (annals.edu.sg)
Detection2
  • She is also studying novel ways to use machine learning to improve prenatal detection of heart disease as early as the first trimester. (ucsf.edu)
  • The diagnosis is usually made in utero by detection of a slow fetal heart rate and subsequent fetal echocardiographic confirmation of heart block and/or cardiomyopathy. (heraldopenaccess.us)
Newborn2
Utero4
  • With the introduction of widespread immunoprophylaxis for red blood cell alloimmunization and the use of in-utero transfusions for immune hydrops therapy, nonimmune causes have become responsible for at least 85% of all cases of fetal hydrops. (medscape.com)
  • The precise incidence of hydrops fetalis is difficult to elucidate, because many cases are not detected prior to intrauterine fetal death and some cases may resolve spontaneously in utero. (biomedcentral.com)
  • The phenotypic spectrum, however, is broad and ranges from non-immune hydrops fetalis in utero to late-onset disease with only mild cutaneous manifestations in adulthood. (porphyriafoundation.org)
  • This podcast covers congenital syphilis, including epidemiology, pathophysiology, impacts on mothers and infants, prenatal screening, bloodwork and follow-up for infants exposed in utero. (tomwademd.net)
Fluid3
  • Fetal hydrops is defined by the demonstration of fluid accumulations in at least two of these four fluid compartments.3 But the placenta and the amniotic sac have sometimes been included as additional "fetal compartments. (taylorfrancis.com)
  • By comparison, hydrops allantois or hydrops amnion is an accumulation of excessive fluid in the allantoic or amniotic space, respectively. (wikipedia.org)
  • A baby born with hydrops fetalis may need a blood transfusion and other treatments to remove the excess fluid. (healthline.com)
Accumulation1
  • The mechanism contributing to the development of hydrops fetalis in storage diseases may involve the obstruction of venous blood return resulting from visceromegaly secondary to accumulation of storage material[ 13 ]. (biomedcentral.com)
Thalassemia2
  • Ten years' experience in prenatal diagnosis of α-thalassemia in a municipal hospital and retrospective analysis of ultrasonic abnormalities. (cdc.gov)
  • Genetic testing can confirm the diagnosis of thalassemia and determine the specific mutations in the HBA1, HBA2, and HBB genes. (asianhomeocare.com)
Maternal1
  • Prenatal labs were significant for positive Group B Streptococcus and maternal blood type is B+. (longdom.org)
Severe2
Incompatibility1
  • Special immune globulins, called RhoGAM, are now used to prevent RH incompatibility in mothers who are Rh-negative. (medlineplus.gov)
Cardiac1
  • A subset of these cases with more sustained periods of tachycardia is clinically relevant for enhanced risk of cardiac failure, non-immune hydrops, and fetal death [ 5 ]. (biomedcentral.com)
Genes1
  • Proporciona un análisis completo de los genes involucrados en esta enfermedad utilizando secuenciación de próxima generación (NGS) para comprender completamente el espectro de genes relevantes involucrados. (igenomix.com)
Incidence1
  • Nevertheless, in developing countries, the incidence of immune fetal hydrops is still high. (medscape.com)
Congenital2
  • Non-immune hydrops can also be unrelated to anemia, for example if a fetal tumor or congenital cystic adenomatoid malformation increases the demand for blood flow. (wikipedia.org)
  • I continue to work on a variety of infectious diseases and immune disorders (e.g., inflammatory bowel disease, AIDS, Kaposi sarcoma, tuberculosis, filariasis, congenital/hereditary lymphatic system syndromes, opportunistic infections/neoplasms) and direct an internationally recognized Lymphedema-Angiodysplasia clinic. (arizona.edu)
Findings1
  • The diagnosis of CEP is supported by the biochemical findings of markedly decreased uroporphyrinogen (URO)-synthase activity in erythrocytes and/or markedly increased levels of urinary uroporphyrin I and coproporphyrin I isomers. (porphyriafoundation.org)
Antigen1
  • In the 1970s, the major cause of immune hydrops (ie, RhD antigen) was conquered with the use of immunoglobulin (Ig) prophylaxis in at-risk mothers. (medscape.com)
Globulin3
  • Rh disease can be prevented by administration of anti-D IgG (Rho(D) Immune Globulin) injections to RhD-negative mothers during pregnancy and/or within 72 hours of the delivery. (wikipedia.org)
  • However, a small percentage of pregnant mothers are still susceptible to Rh disease even after receiving anti-D IgG (Rho(D) Immune Globulin). (wikipedia.org)
  • IV immune globulin may also be used. (medlineplus.gov)
Postnatal1
  • The purpose of this work is to report four cases, which have in common a transient hydrops fetalis, normal appearance in the postnatal period and progressive deterioration with time. (biomedcentral.com)
Abnormally1
  • It is a prenatal form of heart failure, in which the heart is unable to satisfy demand (in most cases abnormally high) for blood flow. (wikipedia.org)
Pregnancy3
  • The May issue also features a randomized controlled trial evaluating the impact of predictive information regarding the likely outcome of pregnancy on psychological wellbeing of women with a pregnancy of uncertain viability during the waiting period to final diagnosis. (isuog.org)
  • Sometimes, this diagnosis is made during pregnancy. (cedars-sinai.org)
  • Hydrops fetalis usually can't be treated during the pregnancy. (healthline.com)
Diseases1
  • Writing Group For Practice Guidelines For Diagnosis And Treatment Of Genetic Diseases Medical Genetics Branch Of Chinese Medical Association et al. (cdc.gov)
Pregnancies1
  • Carrier testing for at-risk family members and prenatal testing for pregnancies at increased risk are possible if the pathogenic variants in the family have been identified. (porphyriafoundation.org)
Differential diagnosis1
  • Acneiform Eruptions in Dermatology is a practical, full-color guide to the differential diagnosis of acne vulgaris and the treatment of acne-like conditions. (nshealth.ca)
Patient1
  • She also has a particular interest in patient attitudes and preferences regarding prenatal testing. (ucsf.edu)
Pregnant1
Uncommon1
Citation1
  • citation needed] Hydrops fetalis usually stems from fetal anemia, when the heart needs to pump a much greater volume of blood to deliver the same amount of oxygen. (wikipedia.org)
Occurs1
  • Hydrops fetalis only occurs in 1 out of every 1,000 births. (healthline.com)
Genetic1
Cases1