Premature aging phenotypes. Medical search. Frequent questions

Therefore, it is urgent to uncover the molecular mechanism(s) underlying the physiological changes, so that certain actions could prevent or postpone the non-optimal modifications that occur during aging. (elifesciences.org)
Accumulating mitochondrial DNA mutations drive premature hematopoietic aging phenotypes distinct from physiological stem cell aging. (rug.nl)
Since the phenotype of aged VDR knockout mice is similar to mouse models with hypervitaminosis D(3), our study suggests that VDR genetic ablation promotes premature aging in mice, and that vitamin D(3) homeostasis regulates physiological aging. (anti-agingfirewalls.com)
Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modulation of biological age with interventions track with cardiovascular health. (oaepublish.com)

Cellular aging or cellular senescence is the critical factor for the process of aging. (hindawi.com)
Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
Unlike aged somatic cells, which exhibit a decline in molecular fidelity and eventually reach a state of replicative senescence, pluripotent stem cells can indefinitely replenish themselves while retaining full homeostatic capacity. (biorxiv.org)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
Calcium channel ITPR2 and mitochondria-ER contacts promote cellular senescence and aging. (ens-lyon.fr)
By the time that the SENS rejuvenation research proposals were first formalized, more than three decades later, a little after the turn of the century, the research community had a much better understanding of cellular senescence as a phenomenon, as well as a good deal of indirect evidence to show that (a) senescent cells accumulated with age, and (b) their presence contributed to age-related disease and dysfunction. (fightaging.org)
Senescent cells cause harm through what is known as the senescence-associated secretory phenotype (SASP) , the secretion of signals that spur inflammation, tissue modeling, and alterations in cellular behavior. (fightaging.org)
It is an interesting point to consider that a range of diseases, age-related and otherwise, may provoke greater cellular senescence as a part of the progression of pathology, even though cellular senescence is not one of the main root causes of these condition. (fightaging.org)
His research has shown that as people age, mitochondria become dysfunctional and produce excessive reactive oxygen species that can accelerate telomere damage, inducing premature senescence. (mayo.edu)
His team is currently investigating the mechanisms by which mitochondria drive senescence with the hope of finding new therapies to increase healthspan as adults age. (mayo.edu)
Dr. Passos' research has shown a role for telomere-induced senescence in multiple tissues with aging and age-related diseases. (mayo.edu)
Preservation of mitochondrial integrity and function antagonizes aging as myocardial senescence is usually associated in part with decreased mitochondrial content and altered metabolic function 7-9. (gasyblog.com)
Limited studies in the aging cardiovascular system of murine models or human patient samples have identified strong correlations between the epigenome, age, and senescence. (oaepublish.com)
These include premature replicative senescence (in a subset of cell types), chromosomal instability, a distinct mutator phenotype, and hypersensitivity to a limited number of DNA damaging agents. (brighton.ac.uk)

For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
In turn, myeloid cells are less active in old age due to phagocytosis and antigen presentation, and they get more mutations. (medscape.com)
Cockayne syndrome (CS) is an accelerated aging disorder characterized by progressive neurodegeneration caused by mutations in genes encoding the DNA repair proteins CS group A or B (CSA or CSB). (johnshopkins.edu)
Overlap exists with Congenital Muscular Dystrophy (CMD) as several gene mutations can cause both a LGMD and CMD phenotype. (medscape.com)
Some mutations can cause both a myofibrillar myopathy and a muscular dystrophy phenotype. (medscape.com)
These diseases are discussed here in part because mutations in 2 genes can present with either an LGMD or a myofibrillar myopathy phenotype. (medscape.com)
Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)

introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)

PheWAS of LTL identified 67 distinct clinical phenotypes associated with both short and long LTL. (cdc.gov)
DNA repair defects are heterogenous conditions characterized by a wide spectrum of clinical phenotypes. (mdpi.com)

Previous reports indicate that the mechanisms of DN involve a multifactorial interaction of metabolic and hemodynamic factors such as high blood glucose, advanced glycation end-products (AGEs), and the renin-angiotensin system (RAS). (hindawi.com)
We learned how the T-cell aging process translates into metabolic reprogramming of the T-cells - how a good, strong, and protective T-cell transforms into a disease-inducing T-cell. (medscape.com)
High-fat feeding rescued the metabolic, transcriptomic, and behavioral phenotypes of Csb m/m mice. (johnshopkins.edu)
This suggests that certain metabolic processes and the production of reactive oxygen species, are increased in the knockout worms, which speeds up the aging process. (elifesciences.org)
Reversal of the dysregulated metabolic phenotype was observed by overexpressing c-Myc a downstream target of Pim kinases. (gasyblog.com)
In addition, the incidence of metabolic diseases such as diabetes also increases significantly with age and contributes greatly to CVD morbidities and mortalities [ 8 ] . (oaepublish.com)
Interestingly, many metabolic disorders are associated with premature aging, suggesting that there are mechanisms we can unravel to potentially intervene and prevent the deterioration of the cardiovascular system independent of natural aging. (oaepublish.com)

SIRT7 knockout mice display features of premature aging. (wikipedia.org)
The publication Premature aging in vitamin D receptor mutant mice (vitamin D receptor (VDR) knockout mice) states "Overall, VDR KO mice showed several aging related phenotypes, including poorer survival, early alopecia, thickened skin, enlarged sebaceous glands and development of epidermal cysts. (anti-agingfirewalls.com)
Brain and muscle Arnt-like protein-1 ( BMAL1 ) knockout mice exhibit accelerated aging, abnormal glucose metabolism, and impaired adipocyte differentiation, among other phenotypes, which are effects associated with the BMAL1 gene. (go.jp)
BMAL1 knockout mice exhibited premature aging of the mandibular condyle, which suggests that circadian rhythms affect mandibular condyle morphology. (go.jp)

Accession H0023 Systematic name Allele 1 and 2: g.1035C>T, c.7C>T, r.7c>u, p.Gln3X Original code Patient 1 ref [1] Description Allele 1 and 2: A point mutation in the exon 1 leading to a Description premature stop codon Date 30-Jul-2002 (Rel. (lu.se)

Male worms in which the gene for this protein has been 'knocked out' have a normal lifespan, but show signs of aging earlier than normal males. (elifesciences.org)
The blog post Klotho anti-aging gene in the news describes how " Klotho expression is also important for averting premature aging due to overexpression of Vitamin D," citing a number of papers relevant to that topic. (anti-agingfirewalls.com)
And the post Hypervitaminosis D and premature aging indicates, among other topics, how mice with their VDR gene knocked out age prematurely. (anti-agingfirewalls.com)
Unfortunately, most of these phenotypes are not suitable for the rapid assessment of loss of function of the wrn gene product. (brighton.ac.uk)
This research looked at women without a faulty BRCA gene but who had either one first-degree relative under 50 with breast cancer plus at least one other relative with the disease, or simply three relatives of any age with breast cancer. (canceractive.com)
Recognition of a single-gene disorder as causal for a patient's 'multiple sclerosis-like' phenotype is critically important for accurate direction of patient management, and evokes broader genetic counselling implications for affected families. (medscape.com)

SIRT6 deficiency in mice leads to a degenerative aging-like phenotype. (wikipedia.org)
No significant alteration of hematopoietic homeostasis and HSC function is observed in young Pus10-/- mice, while aged Pus10-/- mice exhibit mild alteration of hematopoietic homeostasis and HSC function. (haematologica.org)
LT-HSCs from young and aged mice have differential responses to acute inflammatory challenge. (biorxiv.org)
One of the LT-HSC subsets is more prevalent in young and the other in aged mice. (biorxiv.org)
Physiologic aging in both humans and mice leads to permanent changes in LT-HSC function, such as myeloid-biased hematopoietic output ( Akunuru and Geiger, 2016 ). (biorxiv.org)
Furthermore, premature aging in CS mice, nematodes, and human cells results from aberrant PARP activation due to deficient DNA repair leading to decreased SIRT1 activity and mitochondrial dysfunction. (johnshopkins.edu)

In this study, we observed that the expression of pseudouridine (Ψ) synthase 10 is increased in aged hematopoietic stem and progenitor cells (HSPC) and enforced protein of Ψ synthase 10 (PUS10) recapitulates the phenotype of aged HSC, which is not achieved by its Ψ synthase activity. (haematologica.org)
To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. (frontiersin.org)
While SIRT6 expression declines significantly with age acetylated H3K9 protein expression is increased throughout the brain. (frontiersin.org)
Now, Guo and García have revealed that a protein called SIR-2.1, which regulates metabolism in worms, also helps to protect the animals from the effects of aging. (elifesciences.org)
The ATPase motif II point mutation (E646Q) abolished the function of the CSB protein to complement the UV-sensitive phenotypes of survival, RNA synthesis recovery and apoptosis. (hacettepe.edu.tr)

From in vitro studies, sirtuins are implicated in influencing cellular processes like aging, transcription, apoptosis, inflammation and stress resistance, as well as energy efficiency and alertness during low-calorie situations. (wikipedia.org)
PHENOTYPE: Homozygous mutant embryos undergo extensive apoptosis and die during early gestation. (utsouthwestern.edu)

The conferment of beneficial-pluripotency related traits via in vivo partial cellular reprogramming (IVPR) significantly extends lifespan and restores aging phenotypes in mouse models. (biorxiv.org)

The pathological consequences associated with normal cardiovascular aging include hypertrophy, altered left ventricular (LV) diastolic and systolic function, heart failure, enhanced arterial stiffness, and endothelial dysfunction, all of which can alter the structure and function of the heart and arterial system [ 5 , 6 ] . (oaepublish.com)

At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)
In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
Our data suggests that systemic mitochondrial dysfunction plays important roles in age-related muscle wasting by preferentially affecting the myosatellite cell pool. (nih.gov)
The goal of Dr. Passos' current work is to develop new therapies that target mitochondrial dysfunction to counteract the detrimental impact of senescent cells with aging and age-related diseases. (mayo.edu)
Despite the strong link between aging and CVD, surprisingly few studies have directly investigated heart failure and vascular dysfunction in aged models and subjects. (oaepublish.com)

Loss of the wrn helicase imposes a distinct set of phenotypes at the cellular level. (brighton.ac.uk)

Dr. Passos' research aims to find new ways to target the aging process, thereby delaying the onset of multiple age-related diseases and increase healthspan. (mayo.edu)
Dr. Passos subscribes to the idea that decelerating the aging process can delay the onset of multiple diseases and significantly improve the quality of life of older people. (mayo.edu)
The onset of ventricular hypertrophy at the cellular and organ level is usually a hallmark of cardiac aging which compensates for losses in cellular density and concomitant diminution of functional hemodynamic output. (gasyblog.com)

Using a novel transgenic mouse model of mitochondrial DNA (mtDNA) double-strand breaks (DSBs) that presents a premature aging-like phenotype, we studied the role of mtDNA damage in muscle wasting. (nih.gov)
Rationale The senescent cardiac phenotype is accompanied by changes in mitochondrial function and biogenesis causing impairment in energy provision. (gasyblog.com)

Aged hematopoietic stem cells (HSC) exhibit compromised reconstitution capacity and differentiation-bias towards myeloid lineage, however, the molecular mechanism behind it remains not fully understood. (haematologica.org)
1 , 2 During aging, the function of HSC declines, featured as compromised reconstitution capacity and differentiation skewing towards myeloid line-age. (haematologica.org)

There is this phenomenon of premature aging of the immune system," said Cornelia Weyand, PhD, director of the Center for Translational Medicine at Stanford University, Stanford, California, at the German Rheumatology Congress 2023 in Leipzig, Germany. (medscape.com)

Additional studies are warranted to confirm the association and to more fully characterize the phenotype. (cdc.gov)

Short telomere syndromes are the most prevalent premature aging disorders, with prominent phenotypes affecting the lung and hematopoietic system. (cdc.gov)
In humans, Mendelian defects in several of these factors can result in abnormally short or dysfunctional telomeres, causing a group of rare heterogeneous premature-ageing diseases, termed telomeropathies, short-telomere syndromes or telomere biology disorders (TBDs). (cdc.gov)

The understanding that senescent cells existed and were important in human health and aging started sometime around the discovery and subsequent exploration of the Hayflick limit to cellular replication, in the 1960s. (fightaging.org)
Now, however, we're going to be seeing a whole lot more work in the years ahead on the characterization of senescent cells, improved methods of detection and targeting, and better understanding how and where these unwanted cells are contributing to specific age-related conditions. (fightaging.org)
Joao Passos, Ph.D., investigates the role of senescent cells in aging and age-related disease, with a particular focus on the role of mitochondria and telomeres in the process. (mayo.edu)
Additionally, his research has shown that mitochondria are key regulators of the pro-inflammatory phenotype characteristic of senescent cells. (mayo.edu)
His team is investigating the impact of therapies targeting the negative impact of senescent cells in multiple organs and age-related diseases. (mayo.edu)

Aging strongly correlates with the development and incidence of chronic respiratory diseases, including cancer and idiopathic pulmonary fibrosis, but is most strongly linked with development of chronic obstructive pulmonary disease. (karger.com)
LEIPZIG, GERMANY - With age comes illness: Cancer, cardiovascular and neurodegenerative diseases, increased infections, and autoimmune diseases such as rheumatism become more common. (medscape.com)
In the case of autoimmune diseases, this aging happens particularly quickly. (medscape.com)
Dr. Passos' research has shown that telomeres can sense stress and become irreparably damaged during aging in a variety of tissues and age-related diseases. (mayo.edu)
Aging is characterized by multimorbidities and is the major risk factor for all age-related diseases. (mayo.edu)
After adjusting for the other major risk factors for CVD, one study found the odds of vascular diseases increased with every decade of life, demonstrating a strong increase in peripheral arterial disease (PAD), carotid artery stenosis, and abdominal aortic aneurysm (AAA) with advanced age [ 4 ] . (oaepublish.com)
Ageing increases the risk of human diseases: of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related causesiv.More than 70% of people over 65 have two or more chronic conditions such as arthritis, diabetes, cancer, heart disease and strokev. (politicalanthropologist.com)
Ageing increases the risk of human diseases: of the roughly 150,000 people who die each day across the globe, about two-thirds die from age-related cause. (politicalanthropologist.com)

Defective development of the embryonic radial ray (eg, aplasia, hypoplasia, fusion, other anomalous development) results in a wide spectrum of phenotypes, including triphalangeal or absent thumbs, foreshortened arms, and phocomelia. (medscape.com)

Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. (frontiersin.org)

This study identifies previously unknown roles for sirtuins in regulating cellular homeostasis and healthy aging. (frontiersin.org)

One sentence summary Murine hematopoietic stem cells display transcriptional heterogeneity that is quantitatively altered with age and leads to the age-dependent myeloid bias evident after inflammatory challenge. (biorxiv.org)

Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
Lung failure due to aging can be traced to loss of lung stem cell regenerative capacity within the distinctive stem cell niches found within each compartment of the lung. (karger.com)
While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
Current and past research has focused on aging of the lung, heart, liver and skin. (mayo.edu)

Cockayne syndrome (CS) is a rare inherited human genetic disorder characterized by UV sensitivity, developmental abnormalities and premature aging. (hacettepe.edu.tr)
The CSB mutant allele was tested for genetic complementation of UV-sensitive phenotypes in the human CS-B cell line CS1AN.S3.G2. (hacettepe.edu.tr)
Werner syndrome (WS) is an inherited genetic disease in which individuals display the premature aging of a selected subset of tissues. (brighton.ac.uk)

With the B-cells, functional germinal centers in the lymphoid organs and protective antibodies become rarer, and age-associated B-cells accumulate. (medscape.com)
The common presentations of DNA repair defects include increased risk of cancer, accelerated aging, and defects in the development of various organs and systems. (mdpi.com)

Recently our group documented the remarkable ability of Pim-1 overexpression to "rejuvenate" aged human cardiac stem cells by decreasing senescent markers promoting proliferation and survival 24. (gasyblog.com)

Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. (frontiersin.org)
Our data shows that SIRT1 expression increases with age, concurrently with increased acetylated p53 levels in all brain regions investigated. (frontiersin.org)
Notably, β-hydroxybutyrate levels are increased by the high-fat diet, and β-hydroxybutyrate, PARP inhibition, or NAD + supplementation can activate SIRT1 and rescue CS-associated phenotypes. (johnshopkins.edu)

Consistently, we observed no difference of transcribed RNA pseudouridylation profile between young and aged HSPC. (haematologica.org)
Here, we show that young and aged LT-HSCs respond differently to inflammatory stress, such that aged LT-HSCs produce a cell-intrinsic, myeloid-biased expression program. (biorxiv.org)
Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. (rug.nl)

In her cellular and microbiological investigations, Weyand has devoted a lot of time to studying why T-cells age prematurely in patients with RA. (medscape.com)

Although lifespan is well studied in the model organism Caenorhabditis elegans ( Kenyon, 2010 ), the aging process per se is still under intense research ( Jin, 2010 ). (elifesciences.org)
In other words, extending lifespan also seems to increase "health-span", or the time lived without chronic age-related conditions. (politicalanthropologist.com)

Introduction: Polycystic ovary syndrome (PCOS) is associated with known cardiovascular risk factors, consequently predisposing to premature cardiovascular disease. (endocrine-abstracts.org)
In agreement, senotherapeutics have had success in reducing the detrimental effects in experimental models of cardiovascular aging and disease. (oaepublish.com)

In the periphery, we have identified a process we call inflamm-aging, where the cytokines interferon-γ, interleukin (IL)-10, and IL-17 play a predominant role. (medscape.com)
They are released more often from the bone marrow, produce more cytokines, and essentially contribute to inflamm-aging. (medscape.com)

In the vasculature specifically, aging contributes to decreasing vascular compliance. (oaepublish.com)

May 16, 2003 - Fri 12:30PM - Dr. Vilhelm Bohr, NIA - Human Premature Aging Proteins: Werner and Cockayne, Links Between DNA Repair and Aging 3. (bio.net)

The aging kidneys undergo a wide range of macrostructural changes, such as decreased cortical volume, increased surface roughness, and augmented numbers and sizes of cysts [ 11 ], which correspond to the typical microstructural features of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and nephron loss [ 12 ]. (hindawi.com)

Conclusion Pim kinases prevent premature BMN673 cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics. (gasyblog.com)

Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)
During aging, a decline in organ function can be traced to a loss of stem cell function due to increased cell turnover, depletion of stem cells, and alterations to the stem cell niche. (karger.com)
We found a significant decline in muscle satellite cells, which decreases the muscle's capacity to regenerate and repair during aging. (nih.gov)
What's good about this is that the T- and B-cells age together, but all a little differently, each system by itself," said Thomas Dörner, MD, PhD, head of consultation hours for clinical hemostaseology at the Charité University Hospitals in Berlin, Germany. (medscape.com)
While the reduced formation of naïve T-cells can be attributed to the regression of the thymus gland, the naïve B-cells are a consequence of age-related, fatty bone marrow degeneration. (medscape.com)
This means that age-associated B-cells develop more frequently, such as with rheumatoid arthritis (RA), scleroderma, and systemic lupus erythematosus . (medscape.com)
There are good data that show that they are triggered by infections and that they are specialized to form autoantibodies," Weyand also said about the age-associated B-cells. (medscape.com)
His premature death at the age of 53 (in March 1997) cut short a remarkably creative career that included seminal contributions to understanding the physiology of smooth muscle, and the pioneering development of digital imaging fluorescence microscopy that permitted observation of dynamic movement of molecules in living cells in real time. (umassmed.edu)
Establishment of the freshly isolated single smooth muscle cell system was ground-breaking because smooth muscle cells rapidly lose their differentiated contractile phenotype in culture. (umassmed.edu)
According to recent data, Ras-transformed cells require autophagy to survive and maintain malignant phenotype [ 5 - 10 ]. (aging-us.com)

In a sample of post-menopausal premutation carrier mothers of children with the full mutation of fragile X syndrome (n = 88), this study examined the co-occurrence of the reproductive and psychiatric phenotypes associated with FMR1 premutations. (wisc.edu)

3 , 4 Although previous studies have identified various molecular signaling pathways promoting HSC aging, 5-8 the exact molecular mechanism is still not fully understood. (haematologica.org)

Current knowledge about the identity and function of these stem cell compartments has been largely drawn from a variety of transgenic and spontaneously mutated mouse models that are characterized by rapid rates of aging or have been used to examine regeneration from injury in the context of natural or accelerated aging. (karger.com)
Lnk deficiency partially mitigates hematopoietic stem cell aging. (rug.nl)
An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state. (rug.nl)

This phenotype was associated with impairment in acetylcholinesterase (AChE) activity and assembly at the neuromuscular junction (NMJ), also associated with muscle aging. (nih.gov)

Pending direct investigation of these general mechanisms in aged tissues, this review predicts that future work will establish epigenetic rejuvenation as a potent method to delay CVD. (oaepublish.com)

CVD prevalence continues to increase as human life expectancy also continues to rise, likely due to greater exposure to the traditional external risk factors and intrinsic pathways of aging [ 3 ] . (oaepublish.com)

Notably, LGMD subtypes are phenotypically highly variable, limb-girdle weakness may not be the predominant presentation, and mutation in genes assigned to LGMD subtypes may cause allelic conditions with a different phenotype. (medscape.com)

We hope readers will understand this phenomenon better and perhaps can be involved in adopting measures and respective lifestyles to slow down the process of premature aging. (politicalanthropologist.com)

However, although the primary defect in many LGMDs is known, the precise mechanism leading to the dystrophic phenotype has not always been elucidated. (medscape.com)

Among these, we show that Klf5 , Ikzf1 and Stat3 play important roles in age-related inflammatory myeloid bias. (biorxiv.org)

01). Neither maternal education nor smoking history was significantly associated with age at menopause. (wisc.edu)
We analyzed twenty fecal samples taken from four premature infants (4-6 time points from each infant), and found significantly higher diametric ratios of genes associated with low oxygen levels in samples of infants later diagnosed with NEC than in samples without NEC. (osti.gov)

As of 2018, there was no clinical evidence that sirtuins affect human aging. (wikipedia.org)
A large body of new data from Mendelian genetics and epidemiology now provides an opportunity to reconsider paradigms related to the role of telomeres in human aging and cancer. (cdc.gov)
Simply stated, aging in humans represents the accumulation of changes in a human being over time and can encompass physical, psychological, and social changes. (politicalanthropologist.com)
Maternal uniparental disomy of chromosome 14, paternal deletions and loss of methylation at the intergenic differentially methylated region (IG-DMR) result in a human phenotype of low birth weight, hypotonia, early puberty and markedly short adult stature. (bmj.com)

With age, your hormones shift and your metabolism slows. (sharecare.com)
While the link between metabolism and aging is well known, the work of Guo and García offers insights into some of the molecular mechanisms that may form the basis of this relationship. (elifesciences.org)

Prevalence, incidence, and mortality rates increase with age. (msdmanuals.com)
Among men, Canadian Community Health Survey, the prevalence of factors were age, apolipoprotein A1 level, apolipoprotein B obesity among people who self-identified as Aboriginal level, and insulin resistance. (cdc.gov)
The overall prevalence rate of disabled children was 2.7% and age-specific prevalence rates showed an increase with age [5]. (who.int)

With age, however, they produce a myeloid-biased output that may lead to poor immune responses to infectious challenge and the development of myeloid leukemias. (biorxiv.org)
Using single-cell RNA-seq, we identify a myeloid-biased subset within the LT-HSC population (mLT-HSCs) that is much more common amongst aged LT-HSCs and is uniquely primed to respond to acute inflammatory challenge. (biorxiv.org)
These factors may regulate myeloid versus lymphoid balance with age, and can potentially mitigate the long-term deleterious effects of inflammation that lead to hematopoietic pathologies. (biorxiv.org)
Aged LT-HSCs demonstrate a cell-intrinsic myeloid bias during inflammatory challenge. (biorxiv.org)
Klf5 , Ikzf1 and Stat3 regulate age‐ and inflammation-related LT-HSC myeloid-bias. (biorxiv.org)

Temple syndrome (TS) is an imprinting disorder that was first described by Temple et al in 1991 in a report of a male aged 18 years with maternal uniparental disomy of chromosome 14. (bmj.com)

The key question is whether sirtuins regulate healthier aging in mammals. (frontiersin.org)

Anatomy29

Organisms19

Diseases13

Chemicals and Drugs51

Analytical, Diagnostic and Therapeutic Techniques and Equipment44

Psychiatry and Psychology2

Phenomena and Processes104

Disciplines and Occupations1

Information Science4

Health Care6

Physiological4

Senescence16

Mutations7

Secretory phenotype1

Clinical phenotypes2

Metabolic7

Knockout4

Stop codon1

Gene6

Mice6

Protein5

Apoptosis2

Restores1

Pathological1

Dysfunction5

Distinct1

Onset3

Mitochondrial2

Differentiation2

20231

Characterize1

Telomere2

Senescent cells5

Diseases8

Wide spectrum1

Prevalent1

Homeostasis1

Hematopoietic stem1

Lung7

Genetic3

Organs2

Overexpression1

SIRT13

Young and aged3

Prematurely1

Lifespan2

Cardiovascular2

Cytokines2

Contributes1

Proteins1

Fibrosis1

Cardiac1

Cells10

Reproductive1

Molecular signalin1

Stem cell3

Impairment1

Tissues1

Pathways1

LGMD1

Phenomenon1

Mechanism1

Important roles in age-related1

Significantly2

Human4

Metabolism2

Prevalence3

Myeloid5

Disorder1

Sirtuins1