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  • development
  • Recently, state-of-the-art methods for single-cell genomics have flourished, which may overcome the limitations associated with classical PGD, and these underpin the development of generic assays for PGD that enable selection of embryos not only for the familial genetic disorder in question, but also for various other genetic aberrations and traits at once. (springer.com)
  • bovine
  • In vitro production of embryos alters levels of insulin-like growth factor-II messenger ribonucleic acid in bovine fetuses 63 days after transfer. (publish.csiro.au)
  • placenta
  • It is proposed that human decidua contains a population of stem cells that are responsible for the proliferation ability during the process of embryo implantation and placenta formation and that factors in the crosstalk between the decidua and chorion may mediate decidual stem cell. (ebscohost.com)
  • However, Ms van den Berg and her colleagues have now found the first evidence that XCI does occur in pre-implantation embryos, indicating that this mechanism of compensating for gene dosages has remained basically unchanged throughout evolution and is probably the same in all mammals that have their young attached to a placenta in the womb "" from mice to humans. (redorbit.com)
  • Reproductive Technologies
  • What is IVF - IVF treatment - Low Cost IVF - Europe Turkey Istanbul #ivf #ivftreatment https://www.turkey-ivf.com P: + 90 212 867 79 38 /Mrs. Yelda Sertbas - International Patient Coordinator We offer a wide range of Assisted Reproductive Technologies including IVF and ICSI (Intracytoplasmic Sperm Injection), Embryo and Sperm Cryopresevation, Intrauterine inseminations (IUI), ovulation induction, Co-Culture (Artificial Uterus). (whatclinic.com)
  • blastocysts
  • Results obtained provide evidence that myo-Ins induces cellular pathways involving Akt and show that (a) exposure of preimplantation embryos to myo-Ins increases the number of blastocysts available for uterine transfer and of delivered animals and (b) the developmental patterns of mice obtained from embryos cultured in the presence or absence of myo-Ins, up to three weeks of age, overlap. (hindawi.com)
  • A total of 465 women undergoing 571 frozen-embryo transfers with the use of cryopreserved blastocysts in a single academic institution from 2007 through 2014. (readbyqxmd.com)
  • They constitute a category of primary cells isolated from the inner cell mass (ICM) of blastocysts, which are early-stage pre-implantation embryos, and these cells can form tightly aggregated, three-dimensional colonies in culture. (biomedcentral.com)
  • pronuclear
  • In rabbit DNA demethylation of the paternal chromosomes occurs at slightly advanced pronuclear stages. (biomedcentral.com)
  • The reactivity of the α-5meC antibody starts to diminish around the early pronuclear stage 2 (PN2) when the protamine-histone exchange is completed (approximately three hours post fertilization). (biomedcentral.com)
  • mouse
  • Indeed, antisense-mediated inhibition of expression of a highly expressed LINE-1 family in mouse zygotes caused developmental arrest at the two- or four-cell embryo stages. (mdpi.com)
  • The 3.5-day-old blastocyst-stage mouse embryo consists of two tissues and contains approximately 60 cells. (biomedcentral.com)
  • This was first observed 30 years ago, when it was noticed that 50% of eight-cell-stage mouse embryos expressed the histocompatibility Y (Hya) antigen. (biomedcentral.com)
  • In addition, the wealth of essential information on mouse laboratory strains, mouse housing and breeding, surgical procedures, assisted reproduction, handling of embryos, and micromanipulation setups has been entirely updated. (cshlpress.com)
  • The first edition of Manipulating the Mouse Embryo appeared in 1986 as an outgrowth of Cold Spring Harbor Laboratory courses on the molecular embryology of the mouse held in the early 1980s, and authors of the first two editions included Brigid Hogan, Rosa Beddington, Frank Costantini, and Liz Lacy. (cshlpress.com)
  • More recently this technique has been applied to the microinjection of CRISPR/Cas9 reagents into two-cell stage mouse embryos.7 The authors demonstrated significant increase in the knock-in efficiency and high viability of embryos using their method. (wpiinc.com)
  • The IMCB researchers used laser imaging technologies to study live mouse embryos, which develop extremely similarly to humans during early embryonic stages of life. (biospace.com)
  • uterus
  • The mucosa which had thickened for the implantation of the fertilized egg degenerates and is expelled from the uterus in the form of bleeding. (cpma.ch)
  • endometrium
  • The endometrium responds differently to cloned versus fertilized embryos. (publish.csiro.au)
  • The receptors of both TH and TSH increase in the receptive endometrium, suggesting that they are important for implantation, possible by influencing inflammatory mediators such as leukemia inhibitory factor. (frontiersin.org)
  • occur
  • Few interspecies differences do occur, such as time spent at each stage, timing of zygotic genome activation (ZGA) and cell lineage commitment initiation. (biomedcentral.com)
  • early
  • On the whole these findings suggest that reverse transcription is strictly required in early embryos as a key component of a novel RT-dependent mechanism that regulated the proper unfolding of the developmental program. (mdpi.com)
  • Using wildtype or engineered stem cell lines, researchers may use this technique to uncover the various mechanisms or treatments that may affect early brain infection and resulting microcephaly in Zika virus-infected embryos. (jove.com)
  • Early failure to perform correct XCI is likely to lead to the demise of the embryo. (redorbit.com)
  • 2016). A catalog of Xenopus tropicalis transcription factors and their regional expression in the early gastrula stage embryo. (kencho-lab.org)
  • CRISPR
  • MICRO-ePORE™ was designed for a range of applications including generation of CRISPR/Cas9 mediated knock-in mice with large insertions by microinjection into two-cell stage embryos with high viability.7 The MICRO-ePORE™ has delivered accurate microinjection of morpholino oligomers (anti-sense "knockdown") in zebrafish tails. (wpiinc.com)
  • survival
  • As a result of our finding that XCI occurs at the pre-implantation stage, further research should be able to clarify whether culture conditions in the laboratory influence the growth rate and survival of female embryos and whether this can be improved. (redorbit.com)
  • earliest stages
  • SINGAPORE, 1 SEPT 2017 - Scientists at Singapore's Agency for Science, Technology and Research (A*STAR) have discovered how mammalian cells build their internal skeletons during the earliest stages of life. (biospace.com)
  • therefore it has long been a mystery how cells begin to build their skeletons during the earliest stages of life. (biospace.com)