Other studies revealed mean serum concentrations of approximately 70 to 80 mcg/mL 1 to 2 hours after a dose in patients with normal renal function receiving a 6-week regimen of flucytosine (150 mg/kg/day given in divided doses every 6 hours) in combination with amphotericin B. The half-life in the majority of healthy subjects ranged between 2.4 and 4.8 hours. (nih.gov)
flucytosine increases effects of amphotericin B deoxycholate by pharmacodynamic synergism. (medscape.com)
amphotericin B deoxycholate increases levels of flucytosine by decreasing elimination. (medscape.com)
Flucytosine must not be used as a sole agent in life-threatening fungal infections due to relatively weak antifungal effects and fast development of resistance, but rather in combination with amphotericin B and/or azole antifungals such as fluconazole or itraconazole. (wikipedia.org)
These people benefit from combination therapy including flucytosine, but the incidence of side-effects of a combination therapy, particular with amphotericin B, may be higher. (wikipedia.org)
How does one treat a patient whose CSF still grows C neoformans after 8 weeks of amphotericin plus flucytosine? (medscape.com)
The flucytosine/amphotericin B combination is synergistic: in some cases, it allows a dose reduction and reduces the risk of the emergence of secondary resistance to flucytosine. (who.int)
Cryptococcal meningitis is a severe infection and initial treatment consists of a combination of amphotericin B (0.7-1.5 mg/kg/day) plus flucytosine (100 mg/kg/day in 4 divided doses) for a minimum of 2 weeks. (hivinchildren.org)
Flucytosine Capsules, an antifungal agent, are available as 250 mg and 500 mg capsules for oral administration. (nih.gov)
Flucytosine, also known as 5-fluorocytosine (5-FC), is an antifungal medication. (wikipedia.org)
The type, dose, and duration of antifungal treatment may differ for certain groups, such as pregnant women, children, and people in resource-limited settings. (cdc.gov)
Doses3
Median serum flucytosine concentrations at steady state were calculated to be 57 ± 10 mcg/mL (doses of 50 to 125 mg/kg/day, normalized to 25 mg/kg per dose for comparison). (nih.gov)
In three infants receiving flucytosine 25 mg/kg/day (four divided doses), a median flucytosine half-life of 7.4 hours was observed, approximately double that seen in adult patients. (nih.gov)
Patients with renal disease should receive flucytosine cautiously and in reduced doses. (wikipedia.org)
Pharmacokinetics2
Limited data are available regarding the pharmacokinetics of Flucytosine Capsules administered to neonatal patients being treated for systemic candidiasis. (nih.gov)
Although hepatic impairment is not expected to have a significant effect on the pharmacokinetics of flucytosine, strict monitoring is necessary when treating with [HA753 trade name] in patients with hepatic impairment (see Sections 4.4 and 5.2). (who.int)
A linear correlation was found between the elimination rate constant of flucytosine and creatinine clearance. (nih.gov)
Combination1
Flucytosine must be used in combination, to avoid as much as possible the selection of resistant organisms, especially in the treatment of candidiasis and cryptococcosis. (who.int)
Patients2
The use of flucytosine has not been studied in patients with hepatic impairment. (who.int)
Since clinical data on the use of flucytosine in elderly patients are limited, [HA753 trade name] should only be used in these patients if the expected benefit outweighs the potential risks. (who.int)
Women5
Pregnant women should be given flucytosine only if the potential benefits exceed the potential harm to the fetus. (wikipedia.org)
We aimed to study the Candida prevalence and strain distribution in pregnant Chinese women with a molecular beacon assay. (nih.gov)
From March 2016 to February 2017, a total of 993 pregnant women attending routine antenatal visits at the Beijing Obstetrics and Gynecology Hospital were enrolled. (nih.gov)
Bacterial vaginosis is common in pregnant women and is associated with preterm birth. (medscape.com)
In pregnant women with symptomatic bacterial vaginosis who have a history of preterm birth, administration of treatment early in pregnancy has been shown to decrease the incidence of preterm birth. (medscape.com)
Pregnancy2
A 32 years old HIV infected pregnant female (G2P2L1) presented at 36 weeks of pregnancy for deciding neonatal antiretroviral (ARV) prophylaxis. (hivinchildren.org)
Pregnant (confirmed by a highly sensitive urinary pregnancy test) or breastfeeding. (who.int)
Minor infections such as candidal cystitis may be treated with flucytosine alone. (wikipedia.org)
Injection1
Flucytosine is used by mouth and by injection into a vein. (wikipedia.org)
Treatment4
Given the potential risk to the child, the patient should not breastfeed during treatment with flucytosine. (wikipedia.org)
Is it really necessary to use a third agent in a treatment-naive pregnant woman with a low baseline viral load? (medscape.com)
Treatment with [HA753 trade name] should be started after identification of the strain and an assessment for flucytosine susceptibility has been done, due to possible primary resistance. (who.int)
You may be asked to continue with this treatment for a period after becoming pregnant. (whitelotushealthline.com)
Found3
In vitro studies have shown that 2.9% to 4% of flucytosine is protein-bound over the range of therapeutic concentrations found in the blood. (nih.gov)
citation needed] In animal models (rats), flucytosine has been found to be teratogenic. (wikipedia.org)
The issue has been raised because traces of 5-fluorouracil, which is a known carcinogen, are found in the colon resulting from the metabolization of flucytosine. (wikipedia.org)
Blood1
Flucytosine readily penetrates the blood-brain barrier, achieving clinically significant concentrations in cerebrospinal fluid. (nih.gov)
Administration2
Flucytosine is rapidly and virtually completely absorbed following oral administration. (nih.gov)
Administration of flucytosine must be repeated after each dialysis session. (who.int)
Levels2
flucytosine increases levels of peramivir by decreasing renal clearance. (medscape.com)
flucytosine increases levels of tenofovir DF by decreasing renal clearance. (medscape.com)
Medical1
Inform your doctor of all medical conditions, including if you are pregnant, plan to breastfeed, or breastfeed while using this medicine because it is not known whether it can harm a fetus or nursing infant. (doctorsolve.com)
Plan1
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. (medlineplus.gov)
Woman1
ZDV/3TC for Pregnant Woman With Low HIV Viral Load? (medscape.com)
Significant1
Flucytosine is excreted via the kidneys by means of glomerular filtration without significant tubular reabsorption. (nih.gov)