• Background The pathogenetic mechanisms behind placental dysfunction-related complications like preeclampsia and intrauterine growth restriction have remained perplexing till now, in part because of lack of well-defined structural and functional molecular characterisation. (bl.uk)
  • Methods Placental samples were obtained from normal term pregnancies, preterm controls, as well as from pregnancies complicated by preeclampsia (PET), intrauterine growth restriction (IUGR) and PET-IUGR. (bl.uk)
  • These findings indicate that sFLT1 plays an essential role in maintaining vascular integrity in the placenta by sequestering excess maternal VEGF and suggest that a local increase in VEGF can trigger placental overexpression of sFLT1, potentially contributing to the development of preeclampsia and other pregnancy complications. (jci.org)
  • Vascular disease in systemic sclerosis is a major cause of morbidity and mortality among nonpregnant patients with SSc and is even a bigger concern in the pregnant SSc patient, as the underlying vasculopathy may prevent the required hemodynamic changes necessary to support a growing pregnancy. (hindawi.com)
  • Although not definitive, it has been suggested that an initial fall in systemic vascular resistance leads to the other well-established vascular and hemodynamic changes of pregnancies [ 3 ]. (hindawi.com)
  • A total of five independent longitudinal studies have demonstrated that DM individuals with Hp 2-2 genotype have a two to five-fold increased risk of CVD as compared to DM individuals without the Hp 2-2 genotype We sought to determine whether HP genotype plays important role in development of vascular complications in pregastational pregnancies. (clinicaltrials.gov)
  • Last week, the National Institute for Health and Clinical Excellence (NICE) closed a consultation on its draft medical technology guidance on the use of a device to assess the potentially serious complication of unexplained vaginal wetness in pregnancy. (prweb.com)
  • Cardiac output increases by 50% over the course of pregnancy, with the majority of increase occurring within the first 8 weeks, followed by a gradual increase until plateau mid-third trimester [ 5 ]. (hindawi.com)
  • The study was part of the Thyroid Screening in Urban Ludhiana Pregnancy Study (TULIPS), which is a prospective study on thyroid function screening during the first trimester. (endocrineweb.com)
  • When a woman contracts rubella during the first trimester of pregnancy, the baby has an 85 percent chance of contracting congenital rubella syndrome. (reference.com)
  • Most often, jaundice in pregnancy is due to hepatitis or a condition known as cholestasis of pregnancy, which is characterized by extreme itching during the third pregnancy trimester. (wisegeek.com)
  • No increase in risk with up to two first trimester surgical terminations of pregnancy has been found. (womens-health.co.uk)
  • Maximum systolic blood pressure in pregnancy was increased in stone formers vs. controls despite similar first trimester blood pressure. (newkerala.com)
  • A recent study compared pretreatment with mifepristone followed by treatment with misoprostol against treating with misoprostol alone for the management of first-trimester pregnancy loss. (contemporaryobgyn.net)
  • TUESDAY, July 11, 2017 (HealthDay News) -- Preeclampsia , a serious pregnancy complication, continues to increase in the United States, exacting a significant economic toll, a new study shows. (medicinenet.com)
  • Bariatric surgery has both a positive and negative influence on the risk of complications during subsequent pregnancy and delivery, concludes a new study from Karolinska Institutet in Sweden. (eurekalert.org)
  • Participating mothers-to-be were recruited for a larger long-term study between 1999 and 2008, and followed through pregnancy and beyond. (reuters.com)
  • Moms-to-be with inflammatory bowel disease (IBD) carry certain risks during pregnancy, reports a new study. (medindia.net)
  • The investigators analyzed 207 pregnancies reported prior the study period and 174 pregnancies reported in the 3 years following the initial survey. (thyroid.org)
  • Future studies, Lin's team writes, should try to determine the roles of RA severity and medication use in the pregnancy complications seen in this study. (lifescript.com)
  • One limitation of the study was that it was not possible to differentiate whether weight gain between pregnancies could have been due to lack of weight loss after the first pregnancy, excessive weight gain during that initial pregnancy or a weight increase between the time after the first delivery and the next conception. (emaxhealth.com)
  • But, the effects of weight-loss procedures on pregnancies haven't been clear, the study authors said. (health24.com)
  • We all know that we should watch our diets carefully during pregnancy, but the results of a frightening new study show just how important nutrition can be and. (pregnancydiary.org)
  • These findings don't prove that chlamydia and gonorrhea infections actually cause pregnancy complications, but do suggest that such infections may be important in predicting pregnancy complications, the study authors concluded. (aarpmedicareplans.com)
  • Given that pregnancy is a 'window' into future cardiovascular and metabolic health, OSA is a diagnosis worthy of investigation in pregnancy," said lead study author Ghada Bourjeily, MD, associate professor of medicine at Brown University. (brightsurf.com)