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  • induce
  • demonstrate that increasing hepcidin expression to induce iron deficiency in murine β-thalassemia not only mitigates the iron overload, but also the severity of the anemia. (jci.org)
  • Mice
  • Here we demonstrate that a moderate increase in expression of hepcidin in β-thalassemic mice limits iron overload, decreases formation of insoluble membrane-bound globins and reactive oxygen species, and improves anemia. (jci.org)
  • Hepcidin-mediated transcription in mice also suppressed toxicity and morbidity due to single doses of LPS, poly(I:C), and turpentine, which is used to model chronic inflammatory disease. (pubmedcentralcanada.ca)
  • Most notably, we demonstrated that hepcidin pretreatment protected mice from a lethal dose of LPS and that hepcidin-knockout mice could be rescued from LPS toxicity by injection of hepcidin. (pubmedcentralcanada.ca)
  • toxicity
  • Hepcidin/Fpn-mediated transcription is anti-inflammatory and can reduce toxicity due to activation of TLR by agonists such as LPS, turpentine, and poly(I:C). (pubmedcentralcanada.ca)
  • protein
  • In the liver, Zip14 protein was highly localized in the hepatocyte membrane along with sinusoids by 2% carbonyl iron. (ufl.edu)
  • To determine whether hepcidin interacts with Fpn, we generated a stable cell line (HEK293-Fpn) expressing mouse Fpn with a C-terminal green fluorescent protein (GFP) under the control of the ecdysone-inducible promoter. (sciencemag.org)
  • In addition to these transcription factors, activator protein-1 may also be activated in hepatocytes due to its association with resolution of increased ROS. (mdpi.com)
  • proteins
  • In addition, the metabolic product, acetaldehyde, modifies the proteins in hepatocyte, which become antigens inviting auto-immune response. (mdpi.com)
  • leads
  • Hepcidin binding to Fpn leads to the binding and activation of Jak2, which phosphorylates Fpn, resulting in its internalization through clathrin-coated pits ( 5 ). (pubmedcentralcanada.ca)