JNK is expressed as ten different isoforms due to differential mRNA splicing. (thermofisher.com)
To this end, primary human hepatocytes were treated with estradiol and progesterone, and mRNA expression and activity levels of 10 different P450 isoforms were determined. (aspetjournals.org)
Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
Isoform 9 is faintly expressed in fetal brain, heart, lung, skeletal muscle and spleen. (affbiotech.cn)
Cytochrome2
Fipronil was incubated with human liver microsomes (HLM) and several recombinant cytochrome P450 (CYP) isoforms obtained from BD Biosciences. (cdc.gov)
Results from clinical studies suggest that pregnancy alters hepatic drug metabolism in a cytochrome P450 (P450) isoform-specific manner, and rising concentrations of female hormones are potentially responsible for the changes. (aspetjournals.org)
Kinase2
Here we found that the germinal ablation of the MAPK c-Jun N-Terminal Kinase isoform 1 (JNK1) results in a significant reduction of myelin in the cerebral cortex and corpus callosum at both postnatal and adult stages. (nature.com)
C-Jun N-terminal kinase (JNK) regulation of iNOS expression in glial cells: predominant role of JNK1 isoform. (musc.edu)
Metabolism1
This holds true also to delineate genes and their isoform regulation of enzymes responsible for the metabolism of many commonly prescribed cancer drugs so to calculate, foresee and ideally prevent major side effects of a given compound. (techscience.com)
Protein3
The encoded protein is the predominant aquaporin found in brain. (antibodies-online.com)
Tau is present in the adult human CNS as multiple protein isoforms generated by alternative splicing, with either 0, 1 or 2 N-terminal inserts (0N, 1N, 2N) and either 3 or 4 C-terminal repeats (3R, 4R)(4). (researchsquare.com)
Distinct2
New exonic regions, splice sites and UTRs are described, confirming the presence of four distinct transcript isoforms. (nih.gov)
This work has shown that distinct tauopathies are characterised by unique structures, which are (in part) a result of the deposition of specific tau isoforms. (researchsquare.com)
Transcript variants2
At least two transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. (nih.gov)
Highly expressed1
The predominant isoform in the brain, which we name rCdkl5_1, is orthologous to the human hCDKL5_1 and mouse mCdkl5_1 isoforms and is the most highly expressed isoform across all brain regions tested. (nih.gov)
Deposition1
Pathological tau aggregates can be composed of all tau isoforms - for example in Alzheimer's Disease - or a subset of tau isoforms, such as progressive supranuclear palsy (PSP), corticobasal degeneration (CBD) and FTD with splice-site mutations in MAPT , all of which show a predominant deposition of 4R isoforms(1). (researchsquare.com)
Mutations6
The presence of tau splicing mutations results in disease-associated alterations in tau expression, specifically a dose-dependent increase in 4R tau isoforms in the presence of the MAPT 10+16 variant. (researchsquare.com)
The precise stoichiometry of tau isoforms is tightly regulated: the levels of 3R and 4R in the adult human CNS are approximately equal, and this appears to have a direct influence on neuronal viability, as mutations in MAPT that disrupt tau splicing are causative of frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP17T) (5,6). (researchsquare.com)
Although splice-site mutations in MAPT were discovered in 1998(5), we know little about the mechanism by which relative increases in certain isoforms can drive neurodegeneration. (researchsquare.com)
Spectrum of MAP3K1 mutations in breast cancer is luminal subtype-predominant and related to prognosis. (cdc.gov)
Comparative analysis and isoform-specific therapeutic vulnerabilities of KRAS mutations in non-small cell lung cancer. (cdc.gov)
UNC13D is the predominant causative gene with recurrent splicing mutations in Korean patients with familial hemophagocytic lymphohistiocytosis. (lu.se)
Kinetics1
In the July 25 Journal of Biological Chemistry , Steven Rosenfeld and colleagues at the University of Alabama report the biochemical analysis of the kinetics and enzymology of the myosin IIB isoform. (the-scientist.com)
Adult1
Isoform 7, isoform 9 and isoform 10 are not expressed in adult tissues, with the exception of adult retina expressing isoform 10. (affbiotech.cn)
Found4
The IIB isoform constitutes most of the myosin found in the central nervous system and all of the nonmuscle myosin in the heart. (the-scientist.com)
Latent TGF beta 2 is the predominant isoform found in bodily fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye. (caslab.com)
predominant isoform of phosphodiesterase found in the. (heinkel115.com)
Isoform 8 is found at low frequency. (affbiotech.cn)
Gene1
In this study we characterise, both bioinformatically and experimentally, the rat Cdkl5 gene structure and its associated transcript isoforms. (nih.gov)
Identification1
Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction. (nih.gov)
Human4
Among the OAT isoforms, rOAT3, as well as rOAT1, exhibits a markedly wide substrate selectivity, and its human homolog is considered a key molecule in the renal handling of organic anions. (aspetjournals.org)
The predominant human CDKL5 brain isoform is a 9.7kb transcript comprised of 18 exons with a large 6.6kb 3'-untranslated region (UTR). (nih.gov)
Other human CYP isoforms have minimal or no activity toward fipronil. (cdc.gov)
To further explore the role of PZR, we assessed the expression of PZR and its ITIM-less isoform, PZRb, in human bone marrow mesenchymal stromal cells (hBM MSC), and its ability to facilitate adhesion to and spreading and migration on various ECM molecules. (ox.ac.uk)
Liver2
To address this issue, we characterized the substrate specificity of all isoforms of the Ugt2b subfamily expressed in the mouse liver. (elsevierpure.com)
The cDNAs of Ugt1a1, Ugt2a3, and all the Ugt2b isoforms expressed in the liver were reverse-transcribed from the total RNA of male FVB-mouse livers and then amplified. (elsevierpure.com)
Brain1
Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. (ca.gov)
Mice1
The mouse is an important animal for its use in investigations, but the substrate specificities of Ugt isoforms belonging to the 2b subfamily in mice remain largely unknown. (elsevierpure.com)
Humans1
CYP3A4 is the major isoform responsible for fipronil oxidation in humans while CYP2C19 is considerably less active. (cdc.gov)
Levels2
Transcript levels of SREBP1c, the most abundant isoform in adipose tissue, were significantly decreased in the subcutaneous adipose tissue of obese normoglycemic and type 2 diabetic subjects compared with that of nonobese normoglycemic control subjects. (diabetesjournals.org)
Fetal thymus expresses isoforms 1, 7, 9 and 10 at similar levels. (affbiotech.cn)
Role1
TGF-β, especially TGF-β1 as an uppermost isoform of TGF-β superfamily, may play a very essential role in the development of insulin resistance and obesity and finally, diabetes. (frontiersin.org)
Region1
Subsequent mobility shift assays confirmed that HNF-1alpha isoform was the predominant factor interacting with this region of the promoter. (xenbase.org)