• To determine in a randomized study design whether the incidence and/or severity of acute vincristine-induced peripheral neuropathy can be reduced by decreasing the dosage of vincristine in patients with the high-risk CEP72 TT genotype or by shortening the duration of vincristine therapy in standard/high-risk patients with the CEP72 CC or CT genotype. (centerwatch.com)
  • Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
  • We treated 33 patients with LL with the intensive chemotherapy regimens hyper-CVAD (fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone) or modified hyper-CVAD used for ALL at our institution. (ashpublications.org)
  • However, reliance upon PURINETHOL alone is not justified for initial remission induction of acute lymphatic leukemia since combination chemotherapy with vincristine, prednisone, and L-asparaginase results in more frequent complete remission induction than with PURINETHOL alone or in combination. (druglib.com)
  • Randomized trial to compare LSA2L2-type maintenance therapy to daily 6-mercaptopurine and weekly methotrexate with vincristine and dexamethasone pulse for children with acute lymphoblastic leukemia. (druglib.com)
  • Dogs initially treated with COP protocol for induction (combination protocol with cyclophosphamide, vincristine and prednisone) or COAP (same as COP plus cytosine arabinoside) for a period of 8 weeks, are followed with LMP protocol for maintenance (methotrexate, chlorambucil and prednisone) for the period where the remission time is sustained. (vin.com)
  • When the patients did not achieve a complete remission at the end of the induction of the COAP protocol or when a loss of remission happens during the LMP, generally the addition of vincristine every two weeks to the LMP protocol in a dose of 0.5 mg/m 2 alternated with the chlorambucil is enough to reinduce and maintain a remission. (vin.com)
  • Determine whether intensification with anthracycline and cyclophosphamide improves disease-free survival in these patients. (knowcancer.com)
  • Efficacy and safety of CTD (cyclophosphamide/thalidomide/dexamethasone) regimen in patients with multiple myeloma - a preliminary report of Polish Myeloma Group. (edu.pl)
  • The Capizzi regimen, which involves the administration of escalating-dose methotrexate and L-asparaginase, has been the standard treatment for ALL for the past 20 years. (medscape.com)
  • In their study, Dr. Larsen and colleagues randomized 2426 patients to receive dexamethasone or prednisone during induction, and then to receive high-dose methotrexate (5 g/m 2 biweekly for 4 weeks) or escalating-dose methotrexate plus PEG-L-asparaginase during interim maintenance. (medscape.com)
  • Determine whether treatment with a regimen without methotrexate maintains the same disease-free survival as NHL/BFM 90 in these patients. (knowcancer.com)
  • Patients also receive methotrexate intrathecally (IT) on days 7 and 28 and cytarabine IT on day 0. (knowcancer.com)
  • Maintenance (84 day course): Patients receive same therapy as localized lymphoblastic lymphoma patients, except methotrexate IT is administered on day 0 and 28 (for first 4 courses). (knowcancer.com)
  • While reviewing charts in a general medicine cl inic you see that a patient, 55-year-old and with no history of cancer at all, i s taking methotrexate (MTX). (medquizzes.net)
  • To determine the incidence of osteonecrosis (ON), defined by magnetic resonance (MR) imaging, and to characterize the natural history of clinically silent ON in children, adolescents, and young adults 10 years of age and greater and to assess the role of drugs (i.e., asparaginase and methotrexate) in addition to corticosteroids, in the risk for development of ON. (uchicagomedicine.org)
  • and methotrexate IT on days 8 and 29 (plus days 15 and 22 for CNS3 patients). (clinicaltrialsgps.com)
  • other asparaginase products include asparaginase Erwinia chrysanthemi , asparaginase Erwinia chrysanthemi recombinant , calaspargase pegol , or pegaspargase . (medscape.com)
  • Oncaspar (pegaspargase) is a pegylated version of L-asparaginase, which converts L-asparagine to ammonia and L-aspartic acid, reducing available asparagine resulting in decreased protein synthesis, inhibition of tumor cell proliferation, and increased apoptosis (NCI Drug Dictionary). (jax.org)
  • Secondary acute myelogenous leukemia and myelodysplastic syndrome occur at a higher incidence in patients treated with anthracyclines, including doxorubicin. (medilib.ir)
  • In dogs initially treated with an induction protocol containing doxorubicin (for example the Wisconsin-Madison 19 weeks protocol) and if the patient is in complete remission when the protocol is finished, no maintenance therapy is given. (vin.com)
  • In cases where: a second remission is not obtained, a second loss of remission is present or when the patients did not respond to the first induction, a rescue protocol without doxorubicin is started. (vin.com)
  • This phase III trial compares standard chemotherapy to therapy with liposome-encapsulated daunorubicin-cytarabine (CPX-351) and/or gilteritinib for patients with newly diagnosed acute myeloid leukemia with or without FLT3 mutations. (vicc.org)
  • In a planned interim analysis, 5-year event-free survival for patients who received the high-dose regimen was 82%, compared with 75% for those receiving the escalation protocol. (medscape.com)
  • Outcomes were better for patients who received the high-dose regimen than for those who received the dose-escalating Capizzi regimen, he explained. (medscape.com)
  • Enrollment was stopped early because the survival difference crossed a predefined boundary, explained Dr. Larsen, and patients receiving the escalating-dose regimen were permitted to cross over to the high-dose regimen when feasible. (medscape.com)
  • The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
  • Indicated as part of a multiagent chemotherapeutic regimen as a substitute for asparaginase (Elspar), which was discontinued by the manufacturer in August 2012. (medscape.com)
  • To estimate overall survival (OS) rates both overall and by regimen a) for HR B-ALL and b) VHR B-ALL patients. (uchicagomedicine.org)
  • To determine the tolerability of combination therapy with ruxolitinib and Early Intensification therapy in patients with activation of JAK-STAT signaling that can be inhibited by ruxolitinib and Day 15 or Day 22 MRD ≥5%, Day 42 MRD ≥1%, or LLy patients without complete response at the End of Induction and all patients with early T cell precursor leukemia. (centerwatch.com)
  • If a complete remission is achieved when a rescue protocol is started, the dose of the asparaginase may be "saved" for the future, but if only a partial remission is obtained, intensification with asparaginase may be necessary). (vin.com)
  • Relapsed Multiple Myeloma Randomized Study of Bortezomib vs DexamethasoneThe safety data described below and in Table 10 reflect exposure to either bortezomib (n=331) or dexamethasone (n=332) in study of patients with relapsed multiple myeloma. (drugcentral.org)
  • Among the 332 patients in the dexamethasone group, the most commonly reported adverse reactions leading to treatment discontinuation were psychotic disorder and hyperglycemia (2% each).Four deaths were considered to be bortezomib-related in this relapsed multiple myeloma study: one case each of cardiogenic shock, respiratory insufficiency, congestive heart failure and cardiac arrest. (drugcentral.org)
  • AALL0232 was a phase 3 randomized trial for patients 1 to 30 years of age with newly diagnosed National Cancer Institute high-risk B-precursor ALL that evaluated the safety and efficacy of interventions targeted to enhance CNS control. (medscape.com)
  • Simultaneously, it is prednisone controlled trials have vitamin d, sepsis, the cardiac tamponade here are rested but is safe and efficacy, dexamethasone. (myjuicecup.com)
  • It is also used to induce remission in ALL with dexamethasone and L-asparaginase, and in combination with prednisone to treat childhood leukemia. (wikipedia.org)
  • As a single agent, PURINETHOL will induce complete remission in approximately 10% of pediatric patients and adults with acute myelogenous leukemia or its subclassifications. (druglib.com)
  • Given as a single agent for remission induction, PURINETHOL induces complete remission in approximately 25% of pediatric patients and 10% of adults. (druglib.com)
  • Asparaginase as a single agent induces in the majority of the cases a complete remission, but because this time is usually short, the administration of other chemotherapy agents is needed. (vin.com)
  • Antineoplastic agents are used for induction, consolidation, and maintenance therapy and central nervous system (CNS) prophylaxis in patients with acute lymphoblastic leukemia (ALL). (medscape.com)
  • This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. (uchicagomedicine.org)
  • This randomized phase III trial is studying how well combination chemotherapy works in treating young patients with newly diagnosed acute lymphoblastic leukemia that is likely to come back or spread. (clinicaltrialsgps.com)
  • The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric patient or adult). (druglib.com)
  • The relapse rate remains high after chemotherapy for adult patients with acute lymphoblastic leukemia (ALL). (biomedcentral.com)
  • Some acute myeloid leukemia patients have an abnormality in the structure of a gene called FLT3. (vicc.org)
  • Giving CPX-351 and/or gilteritinib with standard chemotherapy may work better in treating patients with acute myeloid leukemia compared to standard chemotherapy alone. (vicc.org)
  • When leukemic blasts replace the bone marrow, patients present with signs of bone marrow failure, including anemia, thrombocytopenia, and neutropenia. (medscape.com)
  • Analyses of larger patient cohorts treated with more contemporary regimens, however, have shown minimal survival differences between ETP and Not-ETP. (bvsalud.org)
  • A large intergroup trial has demonstrated that AHFRT over standard fractionation TRT seems to further benefit patients with limited disease SCLCa.4 Most of the literature to date has not demonstrated an advantage in treating extensive disease with TRT in regards to response or survival. (oncolink.org)
  • The 5-year survival rates of patients in arms 1 and 2 were 9.1% and 3.7%, respectively. (oncolink.org)
  • Survival for the other patients was 0% by 4 years. (oncolink.org)
  • The results of this trial suggest that a certain subset of extensive stage patients may benefit from TRT in regards to survival, as is the case in limited stage SCLCa. (oncolink.org)
  • The study is being conducted to evaluate the pharmacokinetic parameters (Cmax, Tmax and AUC) of the new delayed release, lowered dose, 40 mg 6MP test formulation as compared to standard 6MP (100 mg Purinethol) in 12 patients with Crohn's Disease. (druglib.com)
  • and asparaginase intramuscularly (IM) on days 3, 5, and 7 and then 3 times a week for 9 doses (during days 8-21). (knowcancer.com)
  • The disadvantage is that the high doses of prednisone that are required generally create side effects like panting, extreme appetite, and thirst. (naturalpet.health)
  • One patient treated with the gamma secretase inhibitor, BMS906024, achieved a complete hematologic response with a deep molecular response after two cycles, and one patient with R/R T-ALL treated with the NOTCH inhibitor CB-103 achieved a complete response (CR) within 1 week and progressed to allogeneic stem cell transplantation (allo-HSCT). (lymphoblastic-hub.com)
  • Furthermore, more intensive therapy of ≥6 total cycles of CT yielded significantly superior 5-year OS for patients with initial non-CR (76.7% vs. 54.7%, P = 0.026) rather than patients with initial CR. (aging-us.com)
  • After eight, 21 day cycles patients continued therapy for three, 35 day cycles on weekly schedule. (drugcentral.org)
  • PE chemotherapy x 4 more cycles alone.Only 109 patients met criteria to be randomized. (oncolink.org)
  • Most patients were definitely diagnosed only after surgical resection following complications, resulting in a poor prognosis. (frontiersin.org)
  • Only clinicians familiar with these methods of administration and with management of potential complications should administer dexamethasone by these routes. (pdr.net)
  • Arm I (closed to accrual as of 4/2006): Patients receive same induction, consolidation, and interim maintenance therapy schedule as localized lymphoblastic lymphoma patients. (knowcancer.com)
  • No prior therapy for this malignancy (patients with secondary AML following treatment of primary malignancy are eligible) except for one dose of intrathecal therapy. (stanford.edu)
  • Evaluate neuropsychologic outcome upon completion of protocol therapy in patients who have reached the ages of 3 and 7 years, with special attention to the outcome in infants who received total-body irradiation. (knowcancer.com)
  • Like prednisone, this agent is used in induction and reinduction therapy and is also given as intermittent pulses during continuation therapy. (medscape.com)
  • Consolidative radiation therapy was given to patients with mediastinal disease at presentation. (ashpublications.org)
  • CONSOLIDATION THERAPY: Patients are randomized to 1 of 2 treatment arms. (clinicaltrialsgps.com)
  • however, grade IV liver toxicity occurred more often in the patients receiving 6-MP/MTX with VCR and DEX therapy than in patients receiving LSA2L2. (druglib.com)
  • Adverse events were more common among patients on active therapy. (druglib.com)
  • Please understand that prednisone therapy may interfere with the effectiveness of rotational chemotherapy, so don't start it if you are still deciding about the best alternative for your pet. (naturalpet.health)
  • Drug-induced hypoglycemic coma occurred in patients undergoing treatment with insulin, glyburide, and combined therapy with insulin and glyburide, insulin and metformin, or glyburide and metformin. (diabetestalk.net)
  • This goal is achieved reliability, reproducibility, clinical applicability, clinical flex- for many patients receiving chemotherapy or radiation ibility, clarity, multidisciplinary process, review of evidence, therapy, and is based on clinical and basic research that has and documentation.4 steadily improved the control of emesis over the last 20 In formulating recommendations for antiemetic usage, years. (marysfamilymedicine.org)
  • This phase III trial studies iobenguane I-131 or lorlatinib and standard therapy in treating younger patients with newly-diagnosed high-risk neuroblastoma or ganglioneuroblastoma. (vicc.org)
  • Giving iobenguane I-131 or lorlatinib and standard therapy may work better compared to lorlatinib and standard therapy alone in treating younger patients with neuroblastoma or ganglioneuroblastoma. (vicc.org)
  • The main complaints, colonoscopy and imaging findings of patients with ENKTL involving the colon are non-specific, and may be similar to many other benign and malignant lesions. (frontiersin.org)
  • Dexamethasone sodium phosphate solution for injection 4 mg/mL may be administered into joints, soft tissues, or lesions, but administration of dexamethasone via these routes requires specialized techniques. (pdr.net)
  • OUTLINE: Patients are stratified by disease characteristics (disseminated lymphoblastic lymphoma vs localized lymphoblastic lymphoma [localized lymphoblastic lymphoma is closed to accrual as of 10/2005]) and age. (knowcancer.com)
  • Patients with localized lymphoblastic lymphoma (closed to accrual as of 10/2005) are not randomized. (knowcancer.com)
  • Patients with Burkitt leukemia/lymphoma are treated with regimens specific for this diagnosis. (medscape.com)
  • Because of the poor long term prognosis associated with lymphoma in dogs, regardless of treatment, some pet lovers opt to keep things simple by treating their dog with prednisone alone. (naturalpet.health)
  • Because lymphoma is a cancer of the immune system and prednisone suppresses that immune system, patients generally respond for a variable period of time before the lymphoma progresses. (naturalpet.health)
  • Chemotherapy is the choice of treatment for multicentric lymphoma, approximately 70% to 95% of the cases achieve remission, period in which the patients do not present signs of disease, and because in most of the cases chemotherapy is well tolerated, a good quality of life is maintained during the remission time. (vin.com)
  • Many protocols have been developed for the treatment of canine lymphoma, but independently of the protocol used, eventually, the majority of the patients will present loss of remission in approximately 6 to 9 months after the treatment is initiated. (vin.com)
  • This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (ucsf.edu)
  • Determine the clinical significance of bone marrow and peripheral blood involvement in these patients. (knowcancer.com)
  • Patients can also be admitted into clinical trials, which is strongly recommended. (medscape.com)
  • not intended to supplant physician judgment with respect to As antiemetic usage has grown, the classes of agents available particular patients or special clinical situations. (marysfamilymedicine.org)
  • appreciates these issues and their applicability to the manage- to interventions performed in the context of clinical ment of patients with cancer. (marysfamilymedicine.org)
  • Nine percent (9%) of dexamethasone-treated patients experienced Grade adverse reaction. (drugcentral.org)
  • Reinfusion of CTL019/tisagenlecleucel or huCART19 is safe, may reduce relapse risk in a subset of patients, and can reinduce remission in CD19-positive relapse. (bvsalud.org)
  • Indicated for treatment of Ph-negative ALL for patients in second or greater relapse or whose disease has progressed following 2 or more antileukemia therapies. (medscape.com)
  • It is indicated for the treatment of adult and pediatric patients with metastatic microsatellite instability-high(MSI-H). (magicinepharma.com)
  • Determine whether rapid reduction in tumor volume by chest radiography and CT scan is predictive of improved outcome in patients treated with these regimens. (knowcancer.com)
  • Patients aged 15-39 years are referred to as "AYA" (adolescent and young adult) and are eligible for more intensive pediatric-style treatment regimens. (medscape.com)
  • The following regimens can be used for patients diagnosed with ALL. (medscape.com)
  • This trial also assigns patients into different chemotherapy treatment regimens based on risk (the chance of cancer returning after treatment). (ucsf.edu)
  • Treating patients with chemotherapy based on risk may help doctors decide which patients can best benefit from which chemotherapy treatment regimens. (ucsf.edu)
  • Patients with Philadelphia chromosome-positive (Ph+) ALL receive a tyrosine kinase inhibitor (TKI) in combination with chemotherapy. (medscape.com)
  • Keytruda, in combination with axitinib, is indicated for the first-line treatment of patients with advanced renal cell carcinoma RCC. (magicinepharma.com)
  • Giving blinatumomab and combination chemotherapy may work better than combination chemotherapy alone in treating patients with B-ALL. (ucsf.edu)
  • Prednisone is a steroid that works in a similar way to cortisol, which is the hormone normally made by the body's adrenal glands. (diabetestalk.net)
  • The goals of this study are to help make chemotherapy more effective in treating the patient's leukemia as demonstrated by fewer patients with leukemia minimal residual disease (MRD) while also trying to reduce the amount of body fat that chemotherapy causes the patient to gain in the first month. (ucsf.edu)
  • The chlorine dioxide compositions are injected directly into the cancerous tumor and the resulting tumor is effectively eliminated from the patient or subject over a period of one to several days to a few weeks, often after a single injection, or multiple injections at one session into the tumor. (justia.com)
  • Dexamethasone sodium phosphate solution for injection 4 mg/mL or 10 mg/mL may be given directly from the vial. (pdr.net)
  • Dexamethasone sodium phosphate solution for injection 4 mg/mL or 10 mg/mL may be added to 5% Dextrose injection or 0.9% Sodium Chloride injection, USP and given by IV infusion. (pdr.net)
  • Dexamethasone sodium phosphate injection is particularly recommended for use in conjunction with one of the less soluble, longer-acting steroids for intra-articular and soft tissue injection. (pdr.net)
  • Ninety-three patients had at least 1 of the following risk factors: age older than 60 years, renal dysfunction, decreased intake of energy, and infection. (diabetestalk.net)
  • Determine the prevalence of bone marrow involvement at presentation in these patients. (knowcancer.com)
  • Determine whether peripheral blood can replace bone marrow in the initial staging of these patients. (knowcancer.com)
  • A phase I/II multicenter trial is currently investigating CB-103 in adult patients with advanced hematological malignancies ( NCT03422679 ). (lymphoblastic-hub.com)
  • Receive email alerts when trials open to patients. (stanford.edu)
  • The future trials may utilize AHFRT for good performance status patients and standardized fractionation for others. (oncolink.org)
  • PROJECTED ACCRUAL: 100 patients per year will be entered over approximately 3 years. (knowcancer.com)
  • During the hospitalization, the patient developed intestinal perforation and an emergency surgery was performed. (frontiersin.org)
  • Drug-induced hypoglycemic coma occurred in 99 patients out of the hospital, while 3 patients developed it during hospitalization. (diabetestalk.net)
  • 4,5 Among the latter, drugs are very important, contributing in more than a quarter of cases and being associated with other risk factors in at least a third of patients. (pharmaco-vigilance.eu)
  • These interventions include placing the patient in high Fowler's position and administering oxygen, diuretics, and positive inotropic drugs as prescribed. (rnpedia.com)
  • A patient who is experiencing digoxin toxicity may report nausea, vomiting, diplopia, blurred vision, light flashes, and yellow-green halos around images. (rnpedia.com)
  • Several patients have survived after aggressive and immediate intervention. (wikipedia.org)
  • This phase II trial studies how well avelumab with or without cetuximab work in treating patients with skin squamous cell cancer that has spread to other places in the body. (marshfieldresearch.org)
  • In recent times, the number of cancer patients is multiplying rapidly across the globe. (pharmika.co.in)
  • Two hundred ten patients with extensive stage small cell lung cancer (SCLCa) were enrolled onto this prospective trial, which was partially randomized. (oncolink.org)
  • A total of three colonoscopes and biopsies were performed for the patient, and the results showed multiple irregular ulcers in the whole colon ( Figure 1 ). (frontiersin.org)
  • Results The study consisted of 102 patients and included 61 females and 41 males. (diabetestalk.net)