• Causes of obesity are multifactorial and include genetic predisposition and behavioral, metabolic, and hormonal influences. (msdmanuals.com)
  • We have previously showed that genetic polymorphisms in glucose transporter 10 (GLUT10) gene are associated with a T2DM intermediate phenotype in non-diabetic population, and GLUT10 G128E mice (carrying human orthologous GLUT10 G128E variant) are highly sensitive to HFD-induced metabolic dysregulation. (researchsquare.com)
  • A genetic predisposition associated to excessive caloric intake and a lack of physical excercise can lead to obesity and central adiposity. (biomedcentral.com)
  • Attempts to find a genetic predisposition have been unsuccessful. (medscape.com)
  • Therefore, research assumes that genetic predispositions favor type 1 diabetes mellitus. (usz.ch)
  • However, many people have a genetic predisposition and still do not get diabetes. (usz.ch)
  • The genetic predisposition to IR (family history). (youaremom.com)
  • In addition, genetic factors play an important role in predisposition to obesity. (pcrm.org)
  • Rare genetic disorders may contribute to obesity, and patients should be referred to a geneticist if such conditions are suspected. (pcrm.org)
  • The aetiology of hypertension involves the complex interplay of environmental and pathophysiological factors that affect multiple systems, as well as genetic predisposition. (nature.com)
  • Beyond genetic screening-functionality-based precision medicine in monogenic obesity. (cdc.gov)
  • Individuals with a genetic predisposition to high cholesterol can be especially vulnerable to metabolic syndrome, but researchers have now found that blocking the enzyme stearoyl-CoA desaturase-1, which helps synthesize unsaturated fatty acids, greatly improves the profile of FH-mice affected by metabolic syndrome. (sciencedaily.com)
  • The causes involve a mix of factors like fat accumulating inside liver cells, the body becoming resistant to insulin's effects, genetic predisposition, excessive alcohol consumption and changes in the gut microbiome . (drvaesthetics.com)
  • Genetic predisposition also likely influences susceptibility. (drvaesthetics.com)
  • This heterogeneity of NAFLD is in turn influenced by various factors primarily demographic/dietary factors, metabolic status, gut microbiome, genetic predisposition together with epigenetic factors. (wjgnet.com)
  • Evidence from genome-wide association studies highlight the importance of genetic and epigenetic factors in the development of obesity and how they in turn affect the transcriptome, metabolites, microbiomes, and proteomes. (springermedizin.at)
  • Obesity is commonly characterized as the accumulation of body fat that results when energy intake exceeds energy expenditure, although individuals respond differently to this imbalance due to genetic predisposition. (springermedizin.at)
  • Obesity is recognized as a multifactorial, chronic, inflammatory disease whereby excess body fat is accumulated through complex interactions between the environment, genetic predisposition, human metabolism, neuroendocrine and behavioral factors. (continuingeducation.net)
  • Thus, this conference has been designed with the overall objective to equip healthcare providers with the most current scientific clinical research examining the magnitude of the problem, genetic and environmental causes, pathophysiology, and complications related to the obesity epidemic. (continuingeducation.net)
  • Characterized as a chronic disease with a multifactorial etiology, environmental factors and a genetic predisposition appear to be the main cofactors 1 . (bvsalud.org)
  • We hypothesized that a respiratory quotient might predict metabolic syndrome and type 2 diabetes onset. (frontiersin.org)
  • Two individuals developed type 2 diabetes and 10 metabolic syndrome after 1 year. (frontiersin.org)
  • A high percentage of children with obesity carry their adiposity into adulthood increasing their predisposition to the metabolic syndrome and severe co morbidities including coronary heart disease, stroke, type 2 diabetes, and certain forms of cancer. (nationalchildrensresearchcentre.ie)
  • Moreover, in this common female patient population, there is markedly high prevalence of multiple cardio-metabolic conditions, such as type 2 diabetes, obesity, and hypertension, which may significantly increase the risk for adverse COVID-19-related outcomes. (beds.ac.uk)
  • Type 2 diabetes is very common in Europe due to frequent obesity. (usz.ch)
  • Studies show that in addition to stabilizing blood sugar, semaglutide can promote weight loss, improve glucose control for people with obesity and type 2 diabetes, and reduce markers of inflammation. (drvaesthetics.com)
  • Morbid obesity is defined as a BMI ≥ 40 kg/m 2 or ≥ 35 kg/m 2 when obesity-related comorbidities are present. (pcrm.org)
  • The aetiology of obesity and its comorbidities is multifactorial, but despite the evidence of traditional contributing factors, the role of environmental toxicants with endocrine disrupting activity has been recently highlighted. (openbiotechnologyjournal.com)
  • Current NASH management focuses on identifying and treating metabolic comorbidities like obesity, hypertension and diabetes . (drvaesthetics.com)
  • The purpose of this mini-review is to discuss the implications sarcopenia has for the development of obesity and comorbidities that occur with aging. (hindawi.com)
  • This understanding will be translated into the clinical setting throughout the conference with current evidence-based strategies for the practical treatment of obesity and its related comorbidities. (continuingeducation.net)
  • In his NCRC funded research project, Pat and postdoctoral researcher Dr. Eirini Giannoudaki are expanding on these adult focussed studies and trying to uncover how IL-36 cytokines control the development of obesity and metabolic dysfunction in children. (nationalchildrensresearchcentre.ie)
  • However, in addition to adulthood exposure, the perinatal effects are very important, since it may allow a change in the metabolic programming, promoting the further development of obesity and MetS. (openbiotechnologyjournal.com)
  • Both NAFLD and its progression into NASH are seen almost simultaneously, with at least some of the components of metabolic syndrome. (nursingcenter.com)
  • Dietary factors are central to both the cause and the treatment of obesity and will be discussed in Nutrition Considerations below. (pcrm.org)
  • Integrating multi-omics approaches will enable a paradigm shift from the one size fits all approach towards precision obesity management, i.e. (1) precision prevention of the onset of obesity, (2) precision medicine and tailored treatment of obesity, and (3) precision risk reduction and prevention of secondary diseases related to obesity. (springermedizin.at)
  • The Intra-oral Alimentary Satiety Device can be considered a safe and effective method which, together with a hypocaloric diet, shows satisfactory results, thus proving to be an important auxiliary option in the treatment of obesity. (bvsalud.org)
  • In the Western countries, cutoff points of 25 and 30 kg/m2 are used for describing overweight and obesity. (benthamscience.com)
  • The number of people with overweight and obesity in the US increased by one-third between 1990 and 2000, and the rise in incidence of obesity since the 1970s has been attributed to larger portion sizes and increased availability of high-calorie foods such as meat, cheese, and soft drinks. (pcrm.org)
  • The results of CASPIAN-V (Childhood and Adolescence Surveillance and Prevention of Adult Non-Communicable Disease) study of 14,118 subjects aged 7 to 18 years of 30 provinces in Iran, showed that the prevalence of overweight and obesity were 9.4 and 11.4% respectively [ 7 ]. (biomedcentral.com)
  • Alveolar hypoventilation is caused by several disorders that are collectively referred as hypoventilation syndromes. (medscape.com)
  • The central respiratory drive is maintained in patients with neuromuscular disorders. (medscape.com)
  • However, common disorders in the general population such as obesity and depression can mimic Cushing's syndrome. (pulmonologyadvisor.com)
  • Other risk factors include heart disease, obesity, a family history of CKD, inherited kidney disorders, past damage to the kidneys, and older age. (cdc.gov)
  • Persons with metabolic disorders (extreme obesity). (wealthfits.com)
  • The International Classification of Sleep Disorders, third edition, recognizes insufficient sleep syndrome as a disorder characterized by excessive daytime sleepiness caused by curtailed sleep almost every day for at least three months ( table 2 ) [ 1 ]. (medilib.ir)
  • Assess how selected obesity-related complications, such as mood disorders, eating disorders, and sleep apnea impact management strategies. (continuingeducation.net)
  • We investigated the impacts of AA on high-fat diet (HFD)-induced metabolic dysregulation in wild type (WT) and GLUT10 G128E mice. (researchsquare.com)
  • Furthermore, AA attenuates the predisposition of GLUT10 G128E mice to HFD-triggered eWAT inflammation, adipokine dysregulation, ectopic fatty acid accumulation, metabolic dysregulation and body weight gain, as compared with WT mice. (researchsquare.com)
  • AA plays an important role in improving WAT development and HFD-induced metabolic dysregulation in GLUT10 G128E mice. (researchsquare.com)
  • The significance of the male influence on TEI is further emphasised by the experimental injection of sperm RNA into zygotes, which resulted in metabolic dysregulation [3]. (biocertica.com)
  • Mechanisms linking excess adiposity to metabolic dysregulation. (continuingeducation.net)
  • Describe how excess adiposity is linked to metabolic dysregulation. (continuingeducation.net)
  • However, many other factors appear to increase a person's predisposition to obesity, including endocrine disruptors (eg, bisphenol A [BPA]), gut microbiome, sleep/wake cycles, and environmental factors. (msdmanuals.com)
  • In preliminary studies that were further developed and subsequently published , Pat found that serum levels of IL-36 cytokines are altered in adults with obesity and that mice lacking the IL-36 receptor antagonist have an altered gut microbiome (e.g. increased levels of protective Akkermansia muciniphila bacteria) and exhibit reduced weight gain and metabolic dysfunction. (nationalchildrensresearchcentre.ie)
  • Causes of central alveolar hypoventilation include drugs and central nervous system (CNS) diseases such as cerebrovascular accidents, trauma, and neoplasms. (medscape.com)
  • Neuromuscular diseases that can cause alveolar hypoventilation include myasthenia gravis, amyotrophic lateral sclerosis, Guillain-Barré syndrome, and muscular dystrophy. (medscape.com)
  • Disturbance of circadian rhythms underlies various metabolic diseases. (researchgate.net)
  • In Asian populations, the risk for weight-related diseases begins to increase at lower BMI ranges, compared with other populations, so overweight among Asians is commonly defined as a BMI of 23 to 24.9, and obesity is defined as BMI ≥ 25. (pcrm.org)
  • Childhood and adolescent obesity (CAO) is one of the most serious risk factors for cardiovascular and metabolic diseases [ 1 ]. (biomedcentral.com)
  • Diet is a major environmental factor that influences the functioning of the epigenome, and ancestral diet exposure may lead to diseases such as cardiovascular disease, obesity and fetal alcohol syndrome (FAS). (biocertica.com)
  • Obesity is frequently associated with WAT inflammation, which contributes to further ectopic fat accumulation and finally T2DM 5 . (researchsquare.com)
  • This suggests that improving glycemic control might reduce the inflammatory response supporting the link between inflammation and glucose metabolic disturbance. (biomedcentral.com)
  • Emerging data link the risk of severe COVID-19 with certain factors such as hyper-inflammation, ethnicity predisposition, low vitamin D levels, and hyperandrogenism, all of which have known direct associations with PCOS. (beds.ac.uk)
  • is acknowledged as exerting a profound influence over the development of adiposity and metabolic dysfunction. (nationalchildrensresearchcentre.ie)
  • On the other hand, the distinct distribution pattern observed between two metabolically distinct AT depots (visceral and subcutaneous) and subsequent repercussion in the aggravation of metabolic dysfunction in a context of obesity, provides accumulating evidence to hypothesise that EDCs might have an important "environmental dysmetabolism" effect. (openbiotechnologyjournal.com)
  • In the literature, there is a link that NAFLD is the hepatic component of the metabolic syndrome diagnosis ( Takahashi & Fukosato, 2014 ). (nursingcenter.com)
  • In the United States, obesity and its complications cause as many as 300,000 premature deaths each year, making it second only to cigarette smoking as a preventable cause of death. (msdmanuals.com)
  • Metabolic syndrome in children is one of the most serious complications derived from childhood obesity. (youaremom.com)
  • However, ART is restricted by adverse drug reactions, resulting in medication non-ad- treatment barriers such as complex dosing, drug-drug in- herence, treatment failure and poor response rate of pa- teractions, toxicities and metabolic complications. (bvsalud.org)
  • Predisposition to hypertension and diabetes and the adverse metabolic profile in Cushing's disease are major contributors to long-term morbidity and mortality. (pulmonologyadvisor.com)
  • The global outbreak of the new disease (COVID-19) caused by the novel severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV-2) has reached pandemic status in March 2020 [ 1 , 2 ]. (beds.ac.uk)
  • Dec. 8, 2020 Researchers have identified a novel mechanism by which periodontal disease may cause metabolic syndrome. (sciencedaily.com)
  • 2020) found that obesity is associated with Western diet and the paternal line. (biocertica.com)
  • Obesity of central or abdominal predominance. (youaremom.com)
  • It always requires the presence of abdominal obesity in addition to two of the other four parameters. (youaremom.com)
  • From the abstract: ' In our study, all of the 203 young adults with abdominal obesity had some rare variant in the genes associated with obesity. (cdc.gov)
  • The use of targeted sequencing and clinical criteria makes it possible to identify carriers of rare clinically significant variants in a wide range of obesity-associated genes and to investigate their influence on phenotypic manifestations of abdominal obesity. (cdc.gov)
  • Ultimately, obesity results from a long-standing imbalance between energy intake and energy expenditure, including energy utilization for basic metabolic processes and energy expenditure from physical activity. (msdmanuals.com)
  • [ 1 ] Tripodi et al reported that in nonalcoholic fatty liver disease (NAFLD), a procoagulant imbalance progresses from steatosis to metabolic cirrhosis, which may be caused by an increase in factor VIII and a reduction of protein C. (medscape.com)
  • During his session "Helping Kids Thrive In A Metabolical World," Dr. Lustig explored metabolic syndrome as a primary threat to population health, the impact of poor metabolic health on pediatric immunity and development, and the paramount role of proper nutrition. (worldhealth.net)
  • Figure 1 outlines our concept of how sarcopenia increases the risk of obesity and poor metabolic health. (hindawi.com)
  • Patients who hypoventilate may develop clinically significant hypoxemia, and the presence of hypoxemia along with hypercapnia aggravates the clinical manifestations seen with hypoventilation syndromes. (medscape.com)
  • This strong overlap of risk factors for both worse PCOS cardio-metabolic manifestations and severe COVID-19 should be highlighted for the clinical practice, particularly since women with PCOS often receive fragmented care from multiple healthcare services. (beds.ac.uk)
  • A qualitative study was conducted using in-depth interviews with 39 key informants and document review from different stages of the policymaking process of childhood and adolescent obesity prevention programs in Iran. (biomedcentral.com)
  • The important factors of the problem stream were the high prevalence of childhood and adolescent obesity and its risk factors in Iran. (biomedcentral.com)
  • Now that a window of opportunity for childhood and adolescent obesity prevention policymaking has been created, the problems such as the therapeutic approach in the health system, the existence of sanctions against Iran and outbreak of coronavirus disease-19 (COVID-19), have hindered the successful implementation of this policy and the opportunity window has not been well used. (biomedcentral.com)
  • These findings also add further evidence to a critical window, that of early life, at which to intervene to prevent childhood and adolescent obesity. (cdc.gov)
  • Here, we assessed the combined effect of diet composition and feeding time on (1) body composition, (2) energy balance, and (3) circadian expression of hepatic clock and metabolic genes. (researchgate.net)
  • Most genes causing monogenic obesity are implicated in the central energy regulatory circuits of the leptin-melanocortin pathway. (cdc.gov)
  • Medicine Central , im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/116169/all/Dementia. (unboundmedicine.com)
  • Consensus for obesity treatment is that clinical therapy should begin with lifestyle changes focusing on behavioral modification, diet, and exercise. (benthamscience.com)
  • Because many of the signs and symptoms of Cushing's syndrome are common in the general population, it may be difficult to establish the diagnosis based on the clinical presentation. (pulmonologyadvisor.com)
  • Childhood obesity is a challenging clinical condition. (cdc.gov)
  • Moreover, clinical trials show semaglutide can help patients with obesity achieve significant weight loss and glycemic control. (drvaesthetics.com)
  • Pediatric obesity is one of the most important health challenges of the twenty-first century. (biomedcentral.com)
  • From the paper: 'a recent study indicates that salivary epigenetics, an easy measure to obtain in field or clinic, can be used to further explore the questions of pediatric obesity and related outcomes. (cdc.gov)
  • Renowned pediatric neuroendocrinologist with decades of experience treating childhood obesity, Robert Lustig, MD, brought his expertise in pediatric metabolic health to the stage. (worldhealth.net)
  • Understand the current scientific literature about the association between periodontal health and metabolic syndrome (MetS). (cdeworld.com)
  • 1,2 In parallel with obesity rates, prevalence of MetS has increased in the US over time. (cdeworld.com)
  • In this revision, we focused our attention on the mechanisms of action and impact of EDCs exposure as a contributor to the present epidemics of obesity and MetS. (openbiotechnologyjournal.com)
  • Obesity in Adolescents Obesity is now twice as common among adolescents than it was 30 years ago and is one of the most common reasons for visits to adolescent clinics. (msdmanuals.com)
  • In women of reproductive age, polycystic ovary syndrome (PCOS) constitutes the most frequent endocrine disorder. (beds.ac.uk)
  • Familial AN, drug-induced AN, AN occurring in hyperinsulinemic states (eg, diabetes, obesity), AN associated with polycystic ovary disease, and AN associated with a spectrum of autoimmune disease in women should be considered before AN is determined to represent a paraneoplastic syndrome. (medscape.com)
  • Finally, we propose a vision for the future of precision obesity management. (cdc.gov)
  • The purpose of this review is to provide an overview of the different types of omics data: genomics, epigenomics, transcriptomics, proteomics, metabolomics and illustrate how a multi-omics approach can be fundamental for the implementation of precision obesity management. (springermedizin.at)
  • If attacks of suffocation occur frequently, the quality of rest suffers, as a result of which obstructive inspire sleep apnea syndrome develops. (wealthfits.com)
  • In the Southern region the prevalence of excess weight was 56.8% for males and 51.6% in females as well as being the region with the highest percentage of obesity: 15.9% of men and 19.6% of women. (bvsalud.org)
  • Chronically elevated serum triglyceride levels are a component of metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), both of which typically involve obesity and contribute significantly to cardiovascular mortality in industrialised countries as of 2021. (wikipedia.org)
  • Metabolic syndrome in children (MS) is one of the afflictions that can occur in obese children. (youaremom.com)
  • This group tends to develop the other criteria of metabolic syndrome and run a much greater risk of developing NASH. (nursingcenter.com)
  • A body mass index of 30 or higher is considered the most important risk factor for the development of this metabolic disease. (usz.ch)
  • [8] Additionally, lifestyle factors that disrupt circadian rhythm such as night and shift work are associated with significant risk for developing obesity. (pcrm.org)
  • The drug has also demonstrated cardiovascular benefits in high-risk diabetic patients, on top of its metabolic effects. (drvaesthetics.com)
  • Conclusions: Our results suggest a potential harmful association between low serum 25(OH)D concentration and the risk of obesity among children. (vitamindwiki.com)
  • When applied to obesity prevention and management, each omics type could potentially help to detect specific biomarkers in people with risk profiles and guide healthcare professionals and decision makers in developing individualized treatment plans according to the needs of the individual before the onset of obesity. (springermedizin.at)
  • Research has demonstrated that successful management of obesity and overweight requires both sustained lifestyle changes with frequent follow-up as well as the simultaneous medical management of cardiovascular risk factors. (continuingeducation.net)
  • [ 2 ] This may indicate that long periods of excessive alcohol intake are required for the full syndrome to develop. (medscape.com)
  • Centrilobular localization of steatosis results from decreased energy stores caused by relative hypoxia and a shift in lipid metabolism, along with a shift in the redox reaction as a result of preferential oxidation of alcohol in the central zone. (medscape.com)
  • In contrast to ADH, the alcohol-metabolizing enzyme cytochrome P450-also called microsomal ethanol oxidizing system -plays a central role in alcohol-medication interactions. (analizatuwebgratis.com)
  • This syndrome typically occurs due to mothers consuming alcohol while pregnant, and children present with physiological, neurobiological and cognitive deficits [5]. (biocertica.com)
  • Atta-ur-Rahman, M. Iqbal Choudhary , " Anti-Obesity Drug Discovery and Development ", Bentham Science Publishers (2011). (benthamscience.com)
  • The use of anti-obesity drug has become increasingly common in the last 30 years. (benthamscience.com)
  • Of the current anti-obesity therapies, orlistat and sibutramine do not raise plasma HDL levels, while rimonabant does directly increase HDL concentrations. (benthamscience.com)
  • Here we show that AA has greater metabolic impacts on HFD-fed GLUT10 G128E mice than HFD-fed WT mice. (researchsquare.com)
  • This growing rate of childhood obesity will likely have long term negative health impacts. (nationalchildrensresearchcentre.ie)
  • "There is pressing need to greater understand how obesity impacts children's health, and in particular to identify strategies which can be exploited to therapeutically intervene and successfully treat this disease " explains Pat. (nationalchildrensresearchcentre.ie)
  • Abnormal central ventilatory drive and obesity contribute to the development of OHS. (medscape.com)
  • The abnormal structure of the lower jaw, anatomical features of the nasopharynx and larynx can influence the development of the syndrome. (wealthfits.com)
  • Intermittent fasting is one of the ways to boost your metabolism and keep your metabolic health. (healthifyme.com)
  • in rats with metabolic syndrome and hyperinsulinemia, plasma levels are much higher than in controls. (bvsalud.org)
  • There are several factors that act and interact in the regulation of food intake and energy deposition, contributing to the development and maintenance of obesity, including: endocrinal, adipose, intestinal and neuronal factors 2 . (bvsalud.org)
  • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. (nature.com)