Predicts shorter disease free survival. Medical search. Frequent questions

The median overall survival (OS) and progression-free survival (PFS) were calculated using Kaplan-Meier and Cox regression methods, respectively. (cancerindex.org)
Median progression-free survival for all patients was 18.8 months but had not been reached for the 19 responders. (sciencedaily.com)
Gene expression analysis of tumor samples from 18 patients before treatment showed that progression-free survival increased for patients when their gene signature included genes that are highly active during T cell response or repressed in regulatory T cells that dampen T cell activation," said Eric Davis, M.D., associate professor of Lymphoma/Myeloma and co-senior author of the paper. (sciencedaily.com)
In a new study published in the journal Clinical Cancer Research , researchers from the University of Pennsylvania are the first to demonstrate that glioblastoma (GBM) patients with a higher concentration of cell-free DNA (cfDNA) have a shorter progression-free survival after they are diagnosed compared to patients with less cfDNA, and that cfDNA concentrations increase in patients at the time of, or just before, their disease progresses. (technologynetworks.com)
We performed a pooled analysis of European Organization for Research and Treatment of Cancer (EORTC) trials on recurrent glioblastoma to validate existing clinical prognostic factors, identify new markers, and derive new predictions for overall survival (OS) and progression free survival (PFS). (eur.nl)
There was no statistically significant difference between the arms for progression-free survival. (aacr.org)
In addition, results presented earlier this week at the AACR Annual Meeting 2018 , which were simultaneously published in The New England Journal of Medicine and highlighted on this blog , showed that a combination of ipilimumab and nivolumab significantly improved the overall response rate and median progression-free survival among certain patients with non-small cell lung carcinoma, compared with standard-of-care chemotherapy. (aacr.org)
The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. (snmjournals.org)
A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. (snmjournals.org)
The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). (snmjournals.org)
In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
Estimates of cancer-specific (CSS) and progression-free survival (PFS) were calculated according to the Kaplan-Meier method. (unicatt.it)
001). The achievement of either a 2-log molecular response at the time of CCR or a 3-log response anytime thereafter is a significant and independent prognostic marker of subsequent progression-free survival. (elsevierpure.com)
imRECIST progression-free survival (PFS) did not count initial PD as an event if the subsequent scan showed disease control. (medscape.com)
[ 9 ] Experience with immune checkpoint inhibitors has shown that the overall survival (OS) benefit with CIT is often not fully reflected in RECIST v1.1-based progression-free survival (PFS) or overall response rate (ORR). (medscape.com)

The presence of residual ctDNA after treatment of patients with non-small cell lung cancer (NSCLC) is associated with a shorter recurrence-free survival and overall survival. (hospitalhealthcare.com)
Among those where ctDNA was found before treatment, there was also a reduced overall survival (HR = 2.97, p = 0.01) and recurrence free survival (HR = 3.14, p = 0.003) compared to samples where ctDNA was not detected prior to treatment. (hospitalhealthcare.com)
In the subgroup of regions, TOP2A amplification was associated with longer overall survival (HR= 0.66, 95%CI= 0.46-0.96, P= 0.029) in Australia. (jcancer.org)
The median progression-free and overall survival periods were 11.8 and 38.7 months, respectively, and sustained stable disease was obtained in some selected patients. (cancerindex.org)
Precise diagnosis is crucial for the disease management since prognosis and overall survival differ substantially between metastatic endometrial cancer (EC) or OC. (bvsalud.org)
Through Cox proportional hazard regression analysis, smoking, tumor number, tumor size, liver cirrhosis, total operative blood loss and pulmonary function were independent risk factors for overall survival (OS) and disease-free survival (DFS). (oncotarget.com)
We observed that the expression of miR-650 in tumor tissues had a positive association with overall survival. (oncotarget.com)
In short, patients randomized to the combination had significantly improved overall survival rates compared with those randomized to sunitinib. (aacr.org)
In addition, at that time, it was not possible to estimate the median overall survival among those receiving the immunotherapy combination, whereas it was estimated to be 25.9 months among those who received sunitinib. (aacr.org)
On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. (snmjournals.org)
Despite a significant increase in overall survival, most treated patients do not show durable clinical responses. (aacrjournals.org)
They allow researchers to measure short-term outcomes such as tumour shrinkage or changes in biomarkers, rather than more long-term impacts of treatment, such as overall survival or improved quality of life. (massbio.org)
This can shorten the time it takes make new treatments available to patients, though it's worth noting that full approval may be conditional on the longer-term follow-up of clinical endpoints such as event-free or overall survival. (massbio.org)
Surrogate endpoints are critical in chronic and long-term conditions where clinical endpoints such as overall survival can take years to measure. (massbio.org)
Most recently, a team of IDDI experts worked with Roche to validate disease-free survival as a surrogate for overall survival in trials in HER-2-positive, early breast cancer. (massbio.org)
TNBCs exhibit a high level of molecular heterogeneity, and are biologically aggressive: a poor prognostic factor for disease-free and overall survival in the adjuvant and neoadjuvant setting, a more aggressive clinical course in the metastatic setting, and no effective specific targeted therapy [ 1 , 2 ]. (biomedcentral.com)
It's often poorly correlated with overall survival. (mightynatural.com)
The median overall survival (OS) from the first dose of inpatient therapy was only 47 days, suggesting that those who received inpatient ICIs were not living long enough to reap the benefits of these drugs. (medpagetoday.com)
How do you plan to determine predictors of overall survival and discharge to home? (medpagetoday.com)
Purpose Treating solid tumors with cancer immunotherapy (CIT) can result in unconventional responses and overall survival (OS) benefits that are not adequately captured by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. (medscape.com)

Background: This study aimed to determine the relationship between the pre-operative metabolic tumor volume (MTV) and the disease-free survival (DFS) of patients with stage I non-small cell lung cancer (NSCLC) using F-18 2-fluoro-2-deoxy-D-glucose (FDG) positron-emission tomography-computed tomography (PET-CT) scanning. (iiarjournals.org)
PURPOSE: To investigate the relationship of hypoxia-inducible factor-1alpha (HIF-1alpha) tumor expression in predicting the response to epirubicin and disease-free survival (DFS) in patients with breast cancer enrolled in a single institution trial of primary anthracycline and tamoxifen therapy. (ox.ac.uk)
The research team examined blood samples and tumor biopsies to identify possible risk factors and genes that might indicate response to treatment and survival. (sciencedaily.com)
Carpenter says: "Since the tumor cells of cancer patients also shed cell-free DNA, a cancer patient will often have a portion of their cell-free DNA that originated in the tumor. (technologynetworks.com)
This cell-free tumor DNA provides us with a non-invasively accessible "liquid biopsy" that molecularly represents the genetic signature of the tumor. (technologynetworks.com)
Currently, circulating tumor DNA(ctDNA) is being recognised as a molecular biomarker of minimal residual disease(MRD) in predicting postoperative recurrence of NSCLC in clinical trials and has not been confirmed. (researchsquare.com)
Early diagnosis and treatment of tumor recurrence may prolong the survival time of patients and improve clinical efficacy. (researchsquare.com)
The novel MRI-based model considering regular shape of primary tumor and short axis of largest lymph node in the regional area can accurately predict lymph node metastases preoperatively in NF-PNETs patients, which might facilitate the surgeons' decision on risk stratification. (springeropen.com)

For the present study, the researchers set out to assess ctDNA levels in patients with stage 1 to 3 NSCLC to determine whether detection of this DNA tumour fragment post-therapy could predict patient outcomes. (hospitalhealthcare.com)
Of most importance, AML is a heterogenous disease and improved molecular understanding is increasing clinicians' abilities to predict outcomes and improve treatment. (pharmacytimes.com)
Mutations in this particular gene are associated with a shorter duration of remission, decreased disease-free survival, and poor outcomes. (pharmacytimes.com)
PIVKA-II is clinically useful for monitoring curative and intra-arterial locoregional treatments, outcomes, and recurrence, and could potentially predict microvascular invasion risk and facilitate patient selection for liver transplant. (e-cmh.org)
Primary Sclerosing Cholangitis: Clinical Outcomes Studies focused on pediatric patients and factors predicting posttransplant survival. (medscape.com)
New Insights Into Liver Disease and Transplantation Findings on new therapeutic options, long-term outcomes, and diagnostic tools were on view at the recent Liver Meeting. (medscape.com)
New Drugs Seek to Further Improve Outcomes in Hepatitis C At the recent Liver Meeting, the spotlight was on next-generation interferon- and ribavirin-free regimens. (medscape.com)
The clinical outcomes are variable with the 5-year survival rates ranging from 30 to 66% [ 7 ]. (springeropen.com)
However, there is no consensus regarding the extent of the surgical approach, partly due to the challenge of preoperatively predicting Lymph node metastasis (LNM), which has been clearly proved as a significant prognostic factor associated with outcomes. (springeropen.com)
In vivo work showed that the outcomes of disease (erythroid, myeloid, or both) depend on the driving oncogene and the hematopoietic target cell in which it is aberrantly expressed. (medscape.com)
Approval of new cancer drugs is often based on short-term health outcomes, referred to as "surrogate outcomes", such as shrinking or slower growth of tumours. (mightynatural.com)
The hope is these surrogate outcomes predict longer-term benefits. (mightynatural.com)

We also have a hard time predicting which patients with newly diagnosed brain tumors, such as glioblastoma, will do well with standard of care treatment and which patients will do poorly. (technologynetworks.com)
Background: Prognostic models have been developed to predict survival of patients with newly diagnosed glioblastoma (GBM). (eur.nl)

For NSCLC patients, ctDNA is a promising biomarker for predicting postoperative recurrence, which can be used as a supplement to the current monitoring of radiation and blood biomarkers to better guide the treatment selection and prognosis of patients after surgery. (researchsquare.com)
In this clinical context, the likely prognosis of patients can be predicted depending on the presence of certain risk factors, such as anemia, hypercalcemia, neutrophilia, and thrombocytosis. (aacr.org)

One emerging potential biomarker is circulating tumour DNA (ctDNA), which is a component of cell-free DNA shed by malignant tumours into the bloodstream and other bodily fluids. (hospitalhealthcare.com)
Currently, there is no effective biomarker for predicting the prognosis of non-metastatic CRC in clinical practice. (oncotarget.com)
Though various studies have demonstrated the utility of protein induced by vitamin K absence II (PIVKA-II) in surveillance, treatment monitoring, and predicting recurrence, it is still not recommended as a routine biomarker test. (e-cmh.org)

Conclusion: For patients with stage I NSCLC treated with surgery, preoperative MTV parameters have a limited prognostic value for predicting DFS. (iiarjournals.org)
With these data prognostic calculators with confidence intervals for both medians and fixed time probabilities of survival were derived. (eur.nl)

The relative ratio (RR) and 95 % confidence interval (CI) were determined as comparative measures of postoperative recurrence-free survival (RFS). (researchsquare.com)
In order to evaluate the value of ctDNA in predicting postoperative recurrence of NSCLC patients, we systematically collected relevant studies and conducted a comprehensive meta-analysis to evaluate the effect of ctDNA on postoperative recurrence-free survival ( RFS ) of NSCLC patients. (researchsquare.com)

The authors concluded that their data supported the clinical utility of ctDNA testing to identify residual disease and recurrence and that this was a potentially sensitive tool to determine which patients were at high risk of relapse and who could benefit from additional adjuvant therapy. (hospitalhealthcare.com)
The oncology team needs to analyze the patient's specific mutation, his or her allelic ratio, the presence of co-mutations (with the presence of an NPM1 mutation a good sign), and an assessment of FLT3-ITD at relapse associated with very short survival. (pharmacytimes.com)
Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma. (cdc.gov)

Patients with large tumours measured by the maximum diameter of the largest lesion (≥42 mm) and treated with steroids at baseline had shorter OS. (eur.nl)
Tumours with predominant frontal location had better survival. (eur.nl)
indeed, it has been reported that 5-12 months survival rate is usually 50% when tumours are 2 cm [30], and close to 100% for tumours 1 cm [31]. (ipa2014.org)
The effectiveness of a drug may be evaluated based on its potential to shrink tumours - but this doesn't necessarily equate to improved survival rates. (mightynatural.com)

Furthermore, CAIX positivity conferred a significantly shorter DFS (P = 0.02) compared with CAIX-negative tumors in patients with HIF-1alpha-negative tumors. (ox.ac.uk)
CSS and PFS were significantly shorter in patients with lower levels of Klotho (P<0.0001 and P = 0.0004, respectively). (unicatt.it)

10% predicted was associated with an increased risk of death in the INBUILD trial (hazard ratio 3.64) and the INPULSIS trials (hazard ratio 3.95). (ersjournals.com)

In fact, highly precise ctDNA detection and quantification methods have the potential to transform clinical practice via non-invasive monitoring of solid tumour malignancies, residual disease detection at earlier timepoints than standard clinical and/or imaging surveillance . (hospitalhealthcare.com)
Prior to therapy, ctDNA was detected in 24%, 77% and 87% of patients with stage I, II and III disease respectively. (hospitalhealthcare.com)
Interestingly, ctDNA was also detected 1 - 3 days after surgery in 25% of patients but not associated with disease recurrence. (hospitalhealthcare.com)
The goal of our study is to evaluate the value of ctDNA in predicting postoperative recurrence in NSCLC patients. (researchsquare.com)
A comprehensive systematic literature research was performed for studies exploring the value of ctDNA in predicting postoperative recurrence in NSCLC patients up to February 2022. (researchsquare.com)
A total of 10 studies including 799 patients were summarized for meta-analysis of ctDNA in predicting recurrence in NSCLC. (researchsquare.com)

Results: During a median follow-up duration of 24 months, two patients died of disease progression, and 11 experienced recurrent tumors (eight intrathoracic tumors, two distant metastasis, and one both types of recurrences). (iiarjournals.org)
Breast cancer is the leading cancer that affects women around the world, where the majority of deaths due to this dreaded disease could be attributed to metastasis. (biomedcentral.com)

Multivariate analysis was performed to identify the most significant variables for predicting CSS and PFS. (unicatt.it)
Multivariate logistic regression model for predicting LNM in NF-PNETs was constructed using the training group and further tested using validation group. (springeropen.com)

Biochemical response and positive octreotide scintigraphy predicted objective response. (cancerindex.org)
10% and the absence of biochemical or objective response by imaging as independent risk factors for shorter PFS. (cancerindex.org)
Positive octreotide scintigraphy and biochemical response predict objective response. (cancerindex.org)

Treatment options for NSCLC depend upon disease stage and range from surgical resection or radiotherapy (stage 1) through to surgery and adjuvant chemotherapy or chemo-radiotherapy for those with stage 3. (hospitalhealthcare.com)
Although 5-year survival rate of non-metastatic colorectal cancer (CRC) is high, about 10% of patients in stage I and II still develop into metastatic CRC and eventually die after resection. (oncotarget.com)
Concerning micro-RNAs, the overexpression of miR-21 was associated with a shorter disease-free survival in patients who received adjuvant gemcitabine after surgical resection [24], and miR-21 overexpression predicts resistance to 5-fluorouracil [25]. (ipa2014.org)
Surgical resection is currently the best option to improve survival [32]. (ipa2014.org)
WP13: Does CRP monitoring help for the postoperative management of patients after ileocolonic resection for Crohn's disease? (eu.com)

We used data from the INBUILD and INPULSIS trials to investigate the natural history of progressive fibrosing interstitial lung diseases (ILDs). (ersjournals.com)
Idiopathic pulmonary fibrosis (IPF) is, by definition, a progressive fibrosing interstitial lung disease (ILD) [ 1 ]. (ersjournals.com)
Few data are available on the long-term effect of pulmonary rehabilitation (PR) and on long PR programs in interstitial lung diseases (ILD). (biomedcentral.com)
18 F-FDG PET has recently been applied for assessing disease activity in interstitial pneumonia patients ( 11 - 14 ). (snmjournals.org)

However, an important consideration for any of the different forms of treatment, is the ability to detect the presence of post-therapy residual disease. (hospitalhealthcare.com)
Historically, patients with this debilitating disease have had limited treatment options, and disease-modifying agents were not available. (cancernetwork.com)
Due to the lack of clear symptoms and specific biomarkers, most HCC patients are diagnosed in the late stage of disease, and patients with advanced HCC are generally not eligible for surgical treatment and have short survival periods, usually only 6 months [ 2 ]. (jcancer.org)
FDG-PET or PET/CT seems to be helpful in assessing the response to treatment in patients with MM and in the evaluation of possible sites of recurrent or progressive disease. (hindawi.com)
Disease control in patients with two or more comorbidities was better with fludarabine plus cyclophosphamide than with fludarabine treatment, but not with fludarabine compared to chlorambucil treatment. (haematologica.org)
9 , 10 The underlying causes of the shorter survival of these patients have remained unclear so far, resulting in uncertainty whether treatment approaches in patients with CLL and comorbidity should focus on the prevention of therapy-related morbidity and mortality or whether the potential loss of disease control associated with such a strategy will offset its net benefits by increasing disease-related morbidity and mortality. (haematologica.org)
A good surrogate endpoint is one that is statistically validated and can be relied upon to predict if the experimental treatment will reach the stated clinical endpoint. (massbio.org)
Previous exposure to chemotherapy drugs (eg, alkylating agents) - These agents may be used in the treatment of Hodgkin lymphoma , multiple myeloma , bone marrow transplant , ovarian cancer , breast cancer , and nonneoplastic disorders (eg, collagen-vascular disease ). (medscape.com)
Hydroxyurea has proven clinical efficacy for SCA - treatment significantly reduces disease manifestations and prolongs survival. (cdc.gov)
It is hoped that the results of SAMS will contribute to fewer patients with indolent, low-risk prostate cancer receiving unnecessary treatment and more patients on active surveillance who need treatment receiving it when the disease is still curable. (cancercentrum.se)

Ren L, Liu J, Gou K, Xing C. Copy number variation and high expression of DNA topoisomerase II alpha predict worse prognosis of cancer: a meta-analysis. (jcancer.org)
Notably, we also found that HCC with liver cirrhosis predicted worse prognosis. (oncotarget.com)
Niacinamide might make gallbladder disease worse. (medlineplus.gov)

In which disease areas could surrogate endpoints be a critical factor in clinical trials and research? (massbio.org)
A surrogate endpoint can only be used if there is extensive evidence that it can be relied upon to predict clinical benefit in the context of the trial. (massbio.org)

Klotho protein levels were significantly decreased in RCC tissues compared with normal tissues (P<0.01) and the more advanced the disease, the more evident the down-regulation. (unicatt.it)
0.01) and the more advanced the disease, the more evident the down-regulation. (unicatt.it)

PDAC diagnosis is usually late because the disease is usually often asymptomatic in early stages, and the first symptoms, such as abdominal pain and nausea, are usually managed in outpatient care. (ipa2014.org)
Patients with idiopathic pulmonary fibrosis (IPF) experience progressive respiratory failure and have a median survival of less than 3 y after diagnosis ( 1 ). (snmjournals.org)
The Kaplan-Meier product limit method was used to compare survival between persons who were homeless at AIDS diagnosis and those who were housed. (cdc.gov)
Proportional hazards models were used to estimate the independent effects of homelessness and supportive housing on survival after AIDS diagnosis. (cdc.gov)

Ongoing Trials Put Focus Back on Fatty Liver Disease Researchers at this year's Liver Meeting offered promising insights into nonalcoholic steatohepatitis and fatty liver disease. (medscape.com)

The goals of therapy for AML include complete remission, restoration of normal hematopoietic functions, and no evidence of measurable residual disease. (pharmacytimes.com)

Median response duration for responders was 20.2 months, with only seven having disease progression as of May 2013. (sciencedaily.com)
To determine the potential of real-time quantitative BCR-ABL reverse transcriptase-polymerase chain reaction (RT-PCR) to predict the duration of continued CCR, we monitored 85 patients treated with imatinib mesylate who achieved a CCR. (elsevierpure.com)
There appears to be a threshold effect above which the amount and duration of alcohol use increases the risk of the development of liver disease. (merckmanuals.com)

We examined the effect of homelessness on the mortality of persons with AIDS and measured the effect of supportive housing on AIDS survival. (cdc.gov)
More recently, a clinic-based, case-control study of HIV patients [ 24 ] and an analysis of data from two cohort studies of HIV infection and alcohol use found that homelessness independently predicted mortality [ 25 ]. (cdc.gov)

IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas. (cdc.gov)
IDH1/2 Mutations Predict Shorter Survival in Chondrosarcoma. (cdc.gov)

Although PSC is thought to be caused by autoimmune disease, it does not demonstrate a clear response to immunosuppressants. (wikipedia.org)
Objective response rate (ORR) and disease control rate (DCR) were 34% and 72%, respectively. (cancerindex.org)
Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. (ox.ac.uk)
In both cases-incomplete response or complete remission—if the disease eventually relapses, clinicians will move to salvage therapy. (pharmacytimes.com)
Modifications to imRECIST versus RECIST v1.1 included allowance for best overall response after progressive disease (PD) and changes in PD definitions per new lesions (NLs) and nontarget lesions. (medscape.com)
Results The best overall response was 1% to 2% greater, the disease control rate was 8% to 13% greater, and the median PFS was 0.5 to 1.5 months longer per imRECIST versus RECIST v1.1. (medscape.com)

Alteration (amplification or deletion) of TOP2A gene was also significantly related to shorter survival of cancer patients. (jcancer.org)
0 SCCM/E insignificant 0.801 0.674 0.794 Gene promoters 0.793 0.556 0.733 Gene bodies 0.507 0.606 0.477 Repetitive elements 0.095 0.095 0.128 Conserved regions 0.203 0.210 0.198 SNP 0.008 0.009 0.010 DNase sensitivity regions 0.926 0.829 0.a significant overrepresentation of CpG "traffic lights" within the predicted TFBSs. (glucagon-receptor.com)

In addition, poor pulmonary function was independently associated with shorter survival and increased HCC recurrence in patients. (oncotarget.com)
Prognosis is usually poor, with a 5-12 months survival of only 8% [29]. (ipa2014.org)
Several physiologic and radiologic parameters that predict poor survival in patients with IPF have been identified, including lower forced vital capacity (FVC), diffusion capacity for carbon monoxide (DL CO ), and extent of fibrosis shown by high-resolution CT (HRCT) ( 8 - 10 ). (snmjournals.org)
For many cancers, however, they have been found to do a poor job of predicting improved survival . (mightynatural.com)

Seeking Less-Invasive Care in Obesity-Related Liver Disease At DDW 2017, the focus was on finding better ways to detect disease and encourage weight loss. (medscape.com)
However, a US study concluded that post-approval studies found a survival advantage for only 19 of 93 new cancer drugs approved from 1992 to 2017. (mightynatural.com)

This is further suggested by the observation that around 75% of individuals with PSC also have inflammatory bowel disease (IBD), most often ulcerative colitis. (wikipedia.org)

The aim of this prospective study was to clarify whether dual-time-point 18 F-FDG PET imaging results are useful to predict long-term survival of idiopathic pulmonary fibrosis (IPF) patients. (snmjournals.org)
Sleep hypoventilation has been proposed as a cause of progressive hypercapnic respiratory failure and death in patients with severe chronic obstructive pulmonary disease (COPD). (bmj.com)

Nocturnal NIV in stable oxygen-dependent patients with hypercapnic COPD may improve survival, but this appears to be at the cost of worsening quality of life. (bmj.com)

The aim of this meta-analysis was to elucidate whether TOP2A could predict prognosis of cancer. (jcancer.org)
Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Doctors have begun using liquid biopsies more frequently to monitor certain cancers - particularly lung cancer - in recent years as research has shown their effectiveness in other disease sites. (technologynetworks.com)
In the shorter term, immunotherapies have maintained their buzz among researchers, with a spotlight on the role of Programmed Death-1 (PD1) as a way to cut off one important safe harbor for cancer cells looking to protect themselves from warring T cells. (pharmexec.com)
They also play an important role in life-threatening diseases such as cancer, by helping to ensure timely access to innovative new treatments. (massbio.org)
People who haven't had cancer themselves will likely have a close friend or family member who has been diagnosed with the disease. (mightynatural.com)

Methods: Data from 300 patients with recurrent GBM recruited in eight phase I or II trials conducted by the EORTC Brain Tumour Group were used to evaluate patient's age, sex, World Health Organisation (WHO) performance status (PS), presence of neurological deficits, disease history, use of steroids or anti-epileptics and disease characteristics to predict PFS and OS. (eur.nl)

A study was undertaken to determine the effects of nocturnal non-invasive bi-level pressure support ventilation (NIV) on survival, lung function and quality of life in patients with severe hypercapnic COPD. (bmj.com)

Although there are no definitive treatments for IPF, clinical trials of some agents have suggested possible benefits ( 3 , 4 ), especially when given early in the course of the disease before an irreversible condition develops ( 5 ). (snmjournals.org)
Hepatitis C Therapies Perform Well in Challenging Patients This year's Digestive Disease Week focused on shorter, simpler treatments, and new ways to predict outcome. (medscape.com)

This review describes current considerations in the use of hydroxyurea for the management of sickle cell disease in the context of clinical severity. (cdc.gov)

Primary sclerosing cholangitis (PSC) is a long-term progressive disease of the liver and gallbladder characterized by inflammation and scarring of the bile ducts, which normally allow bile to drain from the gallbladder. (wikipedia.org)

Information is lacking about the benefits and risks of genetic testing, the efficacy of early interventions, and the population distribution of genotypes and other risk factors associated with disease conditions. (cdc.gov)

A blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream -- called a liquid biopsy -- correlates with how patients will progress after they are diagnosed with glioblastoma. (technologynetworks.com)

After a median follow-up of 25.2 months, the 18-month survival rate was 77 percent for the immunotherapy combination arm compared with 60 percent for the sunitinib arm. (aacr.org)

This study proposed to develop and validate the value of MRI features for predicting LNM in NF-PNETs. (springeropen.com)

Previous studies have suggested that several factors are associated with recurrence or reduced survival, such as carcinoembryonic antigen, epithelial growth factor receptor, and cytokeratin-19 fragment ( 3 , 4 ). (iiarjournals.org)
However, few studies focused on the performance of MR in predicting LNM of PNETs. (springeropen.com)
Predicted values should be obtained from studies of "normal" or "healthy" subjects with the same anthropometric ( e.g. sex, age and height) and, where relevant, ethnic characteristics of the patient being tested. (ersjournals.com)
One of the arguments for earlier approvals is the required studies can be carried out later on, and sick patients can be given an increased chance of survival before it's too late. (mightynatural.com)
To date, however, no studies have examined the effect of homelessness on AIDS survival in a population-based sample or the effect of providing supportive housing on survival in the era of effective antiretroviral therapy. (cdc.gov)

The five-year survival rate for GBM patients is between five and 10 percent. (technologynetworks.com)
the five-year relative survival rate for this form of the disease is just 11.6 percent. (aacr.org)
The 5-y survival rate for patients with negative RI-SUV was better than that for those with positive RI-SUV (76.8% vs. 14.3%, P = 0.00001). (snmjournals.org)

Even though the combined use of ultrasound (US) and alpha-fetoprotein (AFP) is recommended for the surveillance of hepatocellular carcinoma (HCC), the utilization of AFP has its challenges, including accuracy dependent on its cut-off levels, degree of liver necroinflammation, and etiology of liver disease. (e-cmh.org)

Anatomy10

Organisms6

Diseases56

Chemicals and Drugs59

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Phenomena and Processes38

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science11

Named Groups3

Health Care35

Geographicals2

Progression-free sur15

Overall survival20

Tumor8

Outcomes12

Patients with newly diagnosed2

Prognosis of patients2

Biomarker3

Prognostic2

Recurrence free survival2

Relapse3

Tumours4

Significantly shorter2

Hazard ratio1

CtDNA6

Metastasis2

Multivariate2

Biochemical3

Resection5

Interstitial4

Treatment10

Worse3

Surrogate2

0.012

Diagnosis4

Fatty Liver Disease1

Residual1

Duration3

Mortality2

Mutations2

Response6

Gene2

Poor4

20172

Inflammatory bowel d1

Pulmonary2

Improve survival1

Cancer7

Methods1

COPD1

Treatments2

Context1

Gallbladder1

Risk factors1

Glioblastoma1

Immunotherapy1

Validate1

Studies5

Rate3

Surveillance1