Predictors of disease progression. Medical search. Frequent questions

They analyzed data from the Alzheimer's Disease Neuroimaging Initiative, a multicenter study designed to identify biomarkers for the detection and tracking of AD. (medscape.com)
Cyhoeddir y papur 'Complement Biomarkers as predictors of disease progression in Alzheimer's disease' yn Journal of Alzheimer's Disease . (cardiff.ac.uk)
This knowledge will help identify novel blood-based biomarkers for early detection of Alzheimer's disease, and inform development of novel treatments. (cdc.gov)
6 ] aim to tackle the more general problem of the lack of disease activity measures, such as biomarkers. (ersjournals.com)
It was set up to identify clinically relevant COPD subtypes and find predictors, including biomarkers, of disease progression [ 7 ]. (ersjournals.com)
DNA damage signatures in peripheral blood cells as biomarkers in prodromal huntington disease. (cdc.gov)
Introduction: Our objective was determining the optimal combinations of cerebrospinal fluid (CSF) biomarkers for predicting disease progression in Alzheimer's disease (AD) and other neurodegenerative diseases. (lu.se)

World Trade Center (WTC) responders are showing signs of mild cognitive impairment (MCI), a symptom consistent with neurodegenerative diseases earlier than general population. (cdc.gov)
Clinical Predictors of Progression in Amnestic Mild Cognitive Impairment. (bvsalud.org)

In conclusion, hypergammaglobulinemia before starting DAA therapy represents a strong predictor of hepatic decompensation, HCC and death in cirrhotic patients even after HCV clearance. (unime.it)
Depression also is recognized as strong predictor of non-adherence to medical treatment plans. (harvard.edu)
Viral load is a strong predictor of disease progression in untreated patients. (health.am)
Prior acute COPD exacerbation is well known to be a strong predictor of later events [ 5 ]. (ersjournals.com)

Plasma levels of phosphorylated tau at threonine 181 (p-tau181) may provide a means of monitoring disease progression for patients with Alzheimer's disease (AD), new research suggests. (medscape.com)
Cognitively unimpaired participants responded to the Preclinical Alzheimer Cognitive Composite, a measure designed to detect early cognitive changes in cognitively normal patients with Alzheimer's disease pathology. (medscape.com)
64 ms were independent predictors of progression to AVB in patients with BFB. (revespcardiol.org)
Patients with SSc from the EUSTAR database with a disease duration from the onset of the first non-Raynaud sign/symptom ≤5 years and a baseline visit between 2003 and 2014 were first extracted. (nih.gov)
The majority of HIV-infected patients in developing countries commences combination antiretroviral therapy (cART) with advanced disease. (tmu.edu.tw)
We examined predictors of disease progression in patients initiating cART with CD4 count ≤200 cells/mm3 in the TREAT Asia HIV Observational Database. (tmu.edu.tw)
The aim of this study was to identify any predictors of liver failure, hepatocellular carcinoma (HCC) and/or death in patients with compensated liver cirrhosis who achieved the sustained virological response (SVR). (unime.it)
Most (86.4%) of the 2,182 initial ARF patients did not experience disease progression by the end of 2015. (cdc.gov)
Progression was more rapid and ≈2 times more likely for indigenous Māori or Pacific Islander patients. (cdc.gov)
Thrombosis and thromboembolic events are recognized complications in patients with atrial flutter, particularly in the setting of repaired congenital heart disease, such as the Fontan procedure. (medscape.com)
He serves on the editorial board of numerous national and international journals, and is a frequent lecturer and presenter at national and international pediatric cardiac conferences on complex cardiovascular disease in both fetal and pediatric patients. (chop.edu)
Describes the development, pilot testing, and fine-tuning of a Web-based digital health solution to help PCPs manage patients with cardiometabolic diseases. (sutterhealth.org)
Interstitial lung disease (ILD) is an extra-articular manifestation of RA, which occurs frequently in up to 80% of patients with RA. (hindawi.com)
Currently, ILD is the second leading cause of death in patients with RA after cardiovascular disease [ 8 ]. (hindawi.com)
The median progression-free survival for patients with negative RI-SUV was better than that for those with positive RI-SUV (27.9 vs. 13.3 mo, P = 0.0002). (snmjournals.org)
However, even though the natural history of affected patients is unpredictable, most patients demonstrate a slow gradual progression over several years, whereas some may experience an accelerated decline ( 2 ). (snmjournals.org)
18 F-FDG PET has recently been applied for assessing disease activity in interstitial pneumonia patients ( 11 - 14 ). (snmjournals.org)
Also, pulmonary 18 F-FDG uptake was recently reported to be a predictor of global health score and lung physiology in patients with IPF ( 11 ). (snmjournals.org)
Patients with BCR have a greater risk of disease progression and mortality. (spandidos-publications.com)
Venclovas Z, Stanionis M, Matjosaitis AJ and Milonas D: Significance of time until PSA recurrence on clinical progression of surgically treated high-risk prostate cancer patients. (spandidos-publications.com)
The program implements and develops novel treatment strategies for patients affected with peritoneal malignancies and oligometastatic disease to the liver. (stanford.edu)
Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) improves drug distribution and tissue penetration, allowing for a minimally invasive application for patients who are not CRS/HIPEC candidates based on high disease burden. (stanford.edu)
Clinical studies have shown that cortical and hippocampal hyperactivity are a feature shared by patients in the early stages of disease, progressing to hypoactivity during later stages of neurodegeneration. (nature.com)
ECLIPSE was a multicentre observational study in which hospitalised COPD patients with Global Initiative for Chronic Obstructive Lung Disease grades II-IV, plus smoking and nonsmoking controls, were evaluated regularly for 3 years. (ersjournals.com)
Objective To evaluate in a referral cohort of patients with ALS the prevalence of hypometabolic state as compared with normometabolic and hypermetabolic states, and to correlate it with clinical phenotype, rate of progression and survival. (bmj.com)
Unrecognized disease progression is associated with higher health care costs both for patients with end-stage kidney disease and late-stage (stages G4-G5) chronic kidney disease. (ajmc.com)
Past studies report higher health care costs among patients with delayed nephrology care and suboptimal dialysis initiation, but they are limited because they focused on patients undergoing dialysis and did not evaluate costs associated with unrecognized disease for patients "upstream," or patients with late-stage CKD. (ajmc.com)
We compared costs for patients with unrecognized progression to late-stage (stages G4 and G5) CKD and end-stage kidney disease (ESKD) with costs for individuals with prior CKD recognition. (ajmc.com)
Total costs were higher both for unrecognized patients with ESKD and unrecognized patients with late-stage disease. (ajmc.com)
Our findings indicate that costs associated with undiagnosed CKD extend to patients not yet requiring dialysis and highlight potential savings from earlier disease detection and management. (ajmc.com)
Based on a large sample of commercial and Medicare enrollees, total all-cause health care costs were higher for patients with late-stage chronic kidney disease (CKD) or end-stage kidney disease who lacked prior diagnosis compared with those with prior recognition. (ajmc.com)
Using a large, deidentified commercial and Medicare claims database, we calculated health care costs for patients with unrecognized progression to late-stage CKD or ESKD immediately before and after late-stage diagnosis and compared them with costs for individuals with late-stage CKD or ESKD who had prior CKD recognition. (ajmc.com)
This prospective, longitudinal study of radiographic progression and clinical predictors of RA involved 256 patients with RA who were seen within the first 2 years of disease (mean 0.77 years) and were followed up for up to 19 years. (nih.gov)
Objective: This study was to investigate the relationship between the progression of Diabetic nephropathy (DN) and Coronary artery calcification score (CACS) in Japanese patients with Type 2 Diabetes mellitus (T2DM) at baseline and over 5 years of follow-up. (ijmrhs.com)
In male patients without diabetic retinopathy (DR), those in the high CACS group also had significantly higher DN progression than those in the low CACS group. (ijmrhs.com)
Patients with DR in the high and low CACS groups did not have a significantly different rate of DN progression. (ijmrhs.com)
2) Agar et al, in a study of 1,502 patients with MF/SS (mean age 54 years, 71% with early-stage disease), using univariate and multivariate models, found disease progression in 34%, with 26% of patients dying due to MF/SS. (aad.org)
A significant difference in survival and progression was noted for patients with early-stage disease having patches alone (T1a/T2a) compared with those having patches and plaques (T1b/T2b). (aad.org)
Originally approved for administration in hospitalized patients, remdesivir leads to improved outcomes in patients with moderate to severe coronavirus disease 2019 (COVID‑19). (spandidos-publications.com)
After proving to be effective in hospitalized patients, its use gained approval in early‑stage disease for symptomatic outpatients who are at a high risk of progression to severe disease. (spandidos-publications.com)
All patients enrolled completed the 3‑day course, with a total of 6 out of 143 patients (4.2%) having a COVID‑19‑related hospitalization by day 28, and 5 patients (3.5%) succumbing to the disease within the study period. (spandidos-publications.com)
Long-term follow-up data illustrated that some patients with IgA nephropathy progress to end-stage renal disease (ESRD). (medscape.com)
Serum IgA levels are elevated in approximately half of patients with IgA nephropathy, but that increase is unlikely to play a role in the pathogenesis of the disease, as markedly elevated IgA levels are observed in patients with AIDS who do not have IgA nephropathy. (medscape.com)
It is hoped that the results of SAMS will contribute to fewer patients with indolent, low-risk prostate cancer receiving unnecessary treatment and more patients on active surveillance who need treatment receiving it when the disease is still curable. (cancercentrum.se)
Pre-existing comorbid conditions in COVID-19 patients are risk factors for Conclusion developing severe disease and death. (cdc.gov)
Pre-existing comorbid conditions in COVID-19 patients are risk atory syndrome coronavirus 2 (SARS-CoV-2) (2019) that belong factors for developing severe disease and death. (cdc.gov)
Chronic liver disease (CLD) is marked by the gradual destruction monly found in COVID-19 patients included in our review were of liver parenchyma over time. (cdc.gov)
Le nombre de patients en surpoids ou obèses s'est fortement accru. (who.int)
A study of Huntington disease-like syndromes in black South African patients reveals a single SCA2 mutation and a unique distribution of normal alleles across five repeat loci. (cdc.gov)
Multiple system atrophy and CAG repeat length: A genetic screening of polyglutamine disease genes in Italian patients. (cdc.gov)
Association Between Body Mass Index and Disease Severity in Chinese Spinocerebellar Ataxia Type 3 Patients. (cdc.gov)
C9orf72 Repeat Expansion Frequency among Patients with Huntington Disease Genetic Testing. (cdc.gov)
HTT haplogroups in Finnish patients with Huntington disease. (cdc.gov)
Of the patients reporting good adherence, a greater proportion of those with severe OSA (27%) than with mild or moderate disease (0%-12%) reported an excellent response to treatment. (cdc.gov)
Patients with adult-onset glycogen-storage disease type II typically present with proximal muscle weakness between the second and sixth decades of life. (medscape.com)
Importantly, this implies that up to 78% of the variation in HIV disease progression rate between patients remains to be explained. (lu.se)

Body weight is a robust predictor of clinical progression in Huntington disease. (cdc.gov)

Cognitively impaired participants underwent the Alzheimer Disease Assessment Scale-Cognitive Subscale with 13 tasks to assess the severity of cognitive impairment. (medscape.com)
To assess the predictive value for short-term disease severity accrual of the EUSTAR-AI, as compared with those of the EScSG-AI and of known adverse prognostic factors. (nih.gov)
The primary outcome was disease progression defined as a Δ≥1 in the Medsger's severity score and in distinct items at the 2-year follow-up visit. (nih.gov)
At multivariate analysis, the EUSTAR-AI adjusted mean was the only predictor of any severity accrual and of that of lung and heart, skin and peripheral vascular disease over 2 years. (nih.gov)
Non-alcoholic fatty liver disease (NAFLD) is a heterogeneous condition with a wide spectrum of clinical presentations and natural history and disease severity. (wjgnet.com)
When pharmacotherapy is warranted, selection of treatment agent(s) should be made based on the patient's medical history, cancer type, and disease severity. (cancernetwork.com)
6 ] explored the relationship between disease severity measures "as surrogate markers of disease activity" (and changes in those measures over time) and mortality. (ersjournals.com)
Our literature review indicated that chronic liver disease (CLD) is associ- ated with increased adverse clinical outcomes in terms of severity of dis- tality. (cdc.gov)
There were no significant effects of age, sex, disease severity, viral load or educational status on BMI changes. (who.int)
Body mass index (BMI) and tonsil size are predictors of OSA severity (2,3). (cdc.gov)
The World Health Organization declared the outbreak of cal risk prediction score for COVID-19 mortality, severity coronavirus disease 2019 (COVID-19) caused by severe and complications and triage recommendations can be acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 1 determined from current signs and symptoms, comorbidi- to be a public health emergency of international concern ties, medical history and demographics. (who.int)

Persons infected with human immunodeficiency virus (HIV) are at risk for having active tuberculosis (TB) disease (1-3) because of either reactivation of latent infection with Mycobacterium tuberculosis (4) or rapid progression of newly acquired infection (5). (cdc.gov)
Where adults on average progress to AIDS over 8-10 years if untreated, infants experience extremely rapid progression, with 50% of African infants dying before they are two years old. (lu.se)

A multivariate Cox proportional hazards model showed higher RI-SUV and higher extent of fibrosis score as independent predictors of shorter progression-free survival. (snmjournals.org)
On the other hand, multivariate Cox analysis showed higher RI-SUV and lower forced vital capacity to be independent predictors of shorter overall survival. (snmjournals.org)
In multivariate models, the mean ESR, mean grip strength, rheumatoid factor positivity, and tender joint count were independent predictors of radiographic progression. (nih.gov)

The present study investigates 5-year data of a 2-year methotrexate (MTX) based tight control treatment (TC) strategy compared to conventional MTX-based treatment (CT) strategy, and the (added) predictive value of an early response (at 6 months) to treatment for 5-year outcome with respect to disease activity and radiographic progression. (bmj.com)
To describe the longitudinal radiographic course of rheumatoid arthritis (RA), and to identify and quantitate predictors of radiographic progression. (nih.gov)
Overall, radiographic progression rates, as measured by the summary Sharp scores, appeared constant over the course of RA. (nih.gov)

Centers for Disease Control and Prevention. (cdc.gov)
The MMWR series of publications is published by the Epidemiology Program Office, Centers for Disease Control and Prevention (CDC), Public Health Service, U.S. Depart- ment of Health and Human Services, Atlanta, GA 30333. (cdc.gov)
Single copies of this document are available from the Centers for Disease Control and Prevention, National AIDS Clearinghouse, P.O. Box 6003, Rockville, MD 20850. (cdc.gov)
The opinions expressed by authors contributing to this journal do not necessarily reflect the opinions of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
I'm Commander Ibad Khan, and I'm representing the Clinician Outreach and Communication Activity (COCA) with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)

Parkinson's disease dementia becomes common in advanced stages of the disease. (wikipedia.org)
For the first time, we will compare the monocyte transcriptome and plasma markers of cerebral neuropathology of Stony Brook WTC Health Program responders within a longitudinal study design to identify molecular mechanisms underlying monocyte dynamics and the biological processes involved in the progression of MCI to dementia. (cdc.gov)
Alzheimer's disease (AD) is the most common cause of dementia, accounting for 60-80% of all cases [ 2 ]. (nature.com)
Alzheimer disease (AD) is the most common progressive degenerative form of dementia, strongly associated with advancing age. (medscape.com)
Article: Multiclassifier learning for the early prediction of dementia disease progression from MCI Journal: International Journal of Intelligent Engineering Informatics (IJIEI) 2021 Vol.9 No.5 pp.455 - 469 Abstract: Recently many machine learning and deep learning prediction models have been proposed for the early detection and classification of Alzheimer's disease (AD). (inderscience.com)
This study utilised mini-mental state exam (MMSE), clinical dementia rating (CDR), estimated total intracranial volume, normalise whole brain volume, and Atlas scaling factor for constructing randomised trees and thus predicting the progression of disease stages from MCI to Alzheimer's disease that causes Dementia. (inderscience.com)
P-tau/Aβ42 (AUC ≥ 0.87) and p-tau/Aβ42 together with NfL (AUC ≥ 0.75) were the best predictors of conversion to AD and all-cause dementia, respectively. (lu.se)

Conclusions: In men with T2DM, CACS is a good predictor of DN progression. (ijmrhs.com)

This review examines the evidence linking acute kidney injury (AKI) with the risk of subsequently developing chronic kidney disease (CKD). (karger.com)
Amongst the survivors of an episode of AKI, there is an increasing understanding of long-term consequences that may include an increased mortality risk, the development of chronic kidney disease (CKD), and the progression from CKD to end-stage renal disease (ESRD) [ 2,3 ]. (karger.com)
Many individuals with chronic kidney disease (CKD) are undiagnosed or unaware of the disease and at risk of not receiving services to manage their condition and of "crashing" into dialysis. (ajmc.com)
More than 37 million US adults have chronic kidney disease (CKD), and approximately 800,000 live with end-stage kidney disease (ESKD). (ajmc.com)
The condition can sometimes lead to chronic kidney disease as well. (medscape.com)
Sleep apnea, chronic kidney disease, obesity, or renal artery stenosis are other causes of secondary hypertension. (msdmanuals.com)

Depression is associated with worse HIV outcomes, including immunologic decline, progression to AIDS, and AIDS-related mortality, Tsai said. (harvard.edu)

The standardized uptake value (SUV) at each point and retention index value (RI-SUV) calculated from those were evaluated, and then the results were compared with overall and progression-free survival. (snmjournals.org)
PIPAC is an emerging treatment that may convert the patient to resectable disease, and may increase survival without major morbidity, as indicated by many small studies. (stanford.edu)
Considering that such practice of consumption of iron tablets by the donors was not based on any physiological consideration to the quantum of blood loss through donation, it was of interest to find out if any alteration in the serum iron status could be related to disease progression and survival of the HIV-1 infected blood donors. (scirp.org)
Conclusion Hypometabolism in ALS is not uncommon and is associated with slower disease progression and better survival than normometabolic and hypermetabolic subjects. (bmj.com)
Advanced age was associated with poor overall survival, but not with disease-specific survival (DSS) or progression free survival (PFS). (aad.org)
Gender, increasing clinical stage, T and B classifications, elevated LDH levels, and development of large cell transformation were significant predictors of poor survival or disease progression. (aad.org)
Univariate analysis established that advanced skin and overall clinical stage, increased age, male sex, increased LDH, and large-cell transformation were associated with reduced survival and increased risk of disease progression. (aad.org)
5.7-7.4 years of follow-up the disease-specific survival was 99% in all four cohorts. (cancercentrum.se)

The main outcome measure was progression to either an AIDS-defining illness or death occurring 6 months after initiation of cART. (tmu.edu.tw)
We linked ARF progression outcome data (recurrent hospitalization for ARF, hospitalization for rheumatic heart disease [RHD], and death from circulatory causes) for 1989-2015. (cdc.gov)
For those on antiretroviral therapy, CD4 T cell counts are the stronger predictor of clinical outcome and are useful in monitoring clinical response to therapy (O'Brien et al. (health.am)
Multiple regression analysis showed that early response to treatment is an independent predictor of 5-year outcome, irrespective of treatment strategy. (bmj.com)
1 , - , 4 Next to known predictors of long-term outcome of RA, which are assessed at baseline, 5 , - , 8 early response to treatment also could be predictive. (bmj.com)
9 Disease activity during the first 3 months of treatment has been related to clinical and radiographic outcome after the first year of treatment, 6 10 11 and an early treatment response can predict the long-term work disability outcome. (bmj.com)

In conclusion, measurements of CD4 count and hemoglobin at month 6 may be useful for early identification of disease progression in resource-limited settings. (tmu.edu.tw)
Postoperatively detectable PSA was associated with pathologic stage (T3bN0M0 and any N1) In conclusion, preoperative MRI imaging stage and PSA density are predictors for short‑term BCR after prostatectomy. (spandidos-publications.com)

A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
A deep understanding of disease mechanisms will be needed to deliver etiology-based strategies to reverse this vexing trend. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
We drew mainly on MS and T1D research because intensive investigation has generated detailed insights into vitamin D mechanisms in these diseases and provided valuable guidance for research on other autoimmune diseases. (frontiersin.org)
A recent chapter ( 6 ) and a review ( 7 ) have summarized vitamin D mechanisms in autoimmune diseases more generally. (frontiersin.org)
Active TB, in turn, may hasten the evolution of HIV-related disease, possibly through mechanisms involving increased cytokine production and accelerated HIV replication (6,7). (cdc.gov)
Preclinical models provide evidence for a causal link between AKI and CKD while also proposing some of the potential mechanisms for this progression. (karger.com)
In this review, we summarize the evidence for neuronal excitability changes over the course of AD onset and progression and the molecular mechanisms underpinning these differences. (nature.com)
Despite decades of research into the genetic basis and pathological mechanisms of AD, there is no treatment available to halt or reverse its progression, leading to an urgency for the development of new treatment options. (nature.com)
The detailed underlying mechanisms that determine differences in disease progression and clinical presentation of acute HIV infection (AHI) are largely unknown. (lu.se)

The rate of progression to the combined end point was 3.0 per 100 person years. (tmu.edu.tw)

www.cdc.gov/pcd/issues/2022/21_0228.htm Preventing Chronic Disease. (cdc.gov)

Methods Prevalence of AMD-associated genetic risk variants, complement factor H (CFH) rs1061170, age-related maculopathy susceptibility 2 (ARMS2) rs10490924, component 3 (C3) rs2230199, complement factor B (CFB) rs641153 and superkiller viralicidic activity 2-like (SKIV2L) rs429608 and 4-year progression data in a population-representative cohort (The Irish Longitudinal study on Ageing (TILDA)) were assessed. (bmj.com)

The concept of "active" disease in COPD has been around for a while, but it is not known whether this should be defined by frequent acute exacerbations, inflammation by one or other biomarker, or "fast" decline of forced expiratory volume in 1 s (FEV 1 ). (ersjournals.com)
While FEV 1 is considered the standard measure of this, its limitations include the fact that people with the same FEV 1 can have different functional status and that it can take quite a long time for decline to be usable as a measure of progression: a point to which we will return. (ersjournals.com)

The prognostic value of early response to treatment in addition to established predictors was analysed by multiple linear regression analyses. (bmj.com)
Progression and regression from early to late AMD were measured. (bmj.com)
Genetic association as indicators of disease and as predictors of progression were assessed by multinomial logistic regression. (bmj.com)
Regression analyses utilized time-integrated predictors. (nih.gov)
In the univariate Cox regression analysis, the neutrophil‑to‑lymphocyte ratio and haematological malignancy were identified as predictors of progression to severe disease, and albumin levels, the C‑reactive protein‑to‑albumin ratio (CAR) and haematological malignancy were identified as predictors of 28‑day mortality. (spandidos-publications.com)

Other studies use p-values to rank predictors, which is also a poor choice, as p-values are heavily dependent on the prevalence of the risk factor in the dataset. (ersjournals.com)
Prevalence of AMD-associated genetic risk factors and rate of disease progression are unknown in Ireland. (bmj.com)
Conclusions The prevalence of risk-associated genes and 4-year progression rates of AMD in this Ireland cohort are comparable with other Caucasian populations. (bmj.com)
Molecular analysis and prevalence of Huntington disease in northwestern Iran. (cdc.gov)
Prevalence of Carriers of Intermediate and Pathological Polyglutamine Disease-Associated Alleles Among Large Population-Based Cohorts. (cdc.gov)
Veterans may be at an elevated risk for OSA because of increased prevalence of factors associated with the development and progression of OSA. (cdc.gov)

The prognosis is poor as no treatment is available for the primary disease. (medscape.com)

We are very pleased to have with us Dr. Laura Adams and Dr. Liliana Sanchez-Gonzales, both of whom are epidemiologists in the Dengue Branch in the Division of Vector-Borne Diseases at CDC's National Center for Emerging and Zoonotic Infectious Diseases. (cdc.gov)

The factors significantly associated with a higher risk of disease progression were Indian ethnicity, infection through intravenous drug use, lower CD4 count, and hemoglobin ≤130 g/dL at 6 months. (tmu.edu.tw)
Those with an affected family member are at an increased risk of getting the disease, with certain genes known to be inheritable risk factors. (wikipedia.org)
Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
The majority of cases are sporadic AD or late-onset Alzheimer's disease (LOAD), where the disease is driven by a combination of genetic and other risk factors. (nature.com)
With any risk model, a key question is: how much better is the new set of predictors than the existing ones? (ersjournals.com)
Carriers of CFH risk allele showed a strong association for disease progression. (bmj.com)
Heterozygosity for ARMS2 risk allele predicted progression to late AMD. (bmj.com)
CFH Y402H is associated with disease progression, with soft drusen and hyperpigmentation as high-risk features. (bmj.com)
1 The majority of individuals with CKD are unaware they have the disease, 1 and half or more of adults at increased risk of CKD go untested or undiagnosed, 2,3 putting them at risk of receiving inappropriate care, not receiving services and treatments intended to help delay or slow CKD progression, and having little or no nephrologist care prior to dialysis (or "crashing" into dialysis). (ajmc.com)
As a NLM fellow of Biomedical Informatics and Data Science, Dr. Chander led projects investigating the molecular causes of rare diseases and also the relationship between somatic mosaicism in blood and cardiovascular disease risk. (stanford.edu)
Clinical characteristics that predict risk of development and progression of OSA include a large neck circumference and male sex. (cdc.gov)
However, it can be difficult to ascertain the role of virus-specific factors, as additional factors such as age and the time between infections, has also been shown to play an important role in the risk for severe disease. (cdc.gov)

Dr. Hirotaka Ieki is a physician-scientist specializing in cardiovascular disease. (stanford.edu)

We observed groups of metabolites associated with CMV infection, but also to related clinical factors including graft-versus-host disease (GvHD) and the pre-transplantation conditioning regimen. (mdpi.com)
Because of the complications associated with TB disease in HIV-infected persons, these persons must be screened for tuberculin infection. (cdc.gov)
It was of interest to find out if disease course in HIV type-1 infection could have any relation with alteration in body iron status among individuals with history of oral iron intake. (scirp.org)
The present prospective study, carried out over fifteen years, describes the pattern of natural course of disease progression in a group of ART naive male professional blood donors with asymptomatic HIV-1 infection in relation to serum iron status, viral load, peripheral CD4 + T lymphocyte count, serum levels of cytokines and immune activation markers viz. (scirp.org)
Chagas disease, also known as American trypanosomiasis, is caused by infection with the protozoan parasite Trypanosoma cruzi . (medscape.com)
A minority of persons with long-standing T cruzi infection develop the serious cardiac and gastrointestinal problems that characterize chronic symptomatic Chagas disease. (medscape.com)
It has been suggested that different virological and immunological events during the very early stages of HIV infection may determine the rate of the future disease course of the individual patient. (lu.se)
The main goal of this project is to dissect the relationship between HIV-1 viral diversity, evolutionary dynamics, innate immune responses, and acute retroviral syndrome during acute HIV-1 infection, and how they contribute to disease pathogenesis during the acute and chronic stages of infection. (lu.se)
Interestingly, the disease progression rate can vary considerably between individuals (with time to AIDS ranging between months to decades), and the immune specificity against HIV infection has been suggested to only explain about 22% of the most reliable predictor of when AIDS will develop? (lu.se)

The decision tree model prioritized age and history of hospital admission as predictors of mortality. (who.int)

ARF may permanently damage cardiac valves, producing chronic rheumatic heart disease (RHD), a serious, sometimes fatal, condition that may require surgery ( 2 ). (cdc.gov)
The journal "Annals of the Rheumatic Diseases" published most with 93 articles and received 338 citations. (hindawi.com)

1 Centre for AIDS and Related Diseases, National Centre for Disease Control 22-Sham Nath Marg, Delhi, India . (scirp.org)

These findings demonstrate that p-tau181 and NfL in blood have individual and complementary potential roles in the diagnosis and the monitoring of neurodegenerative disease," coinvestigator Michael Schöll, PhD, senior lecturer in psychiatry and neurochemistry at the University of Gothenburg, Gothenburg, Sweden, told Medscape Medical News . (medscape.com)
The study findings also may relate to other diseases as depression is known to adversely affect the management and course of conditions such as heart disease and diabetes. (harvard.edu)
Our findings highlight potential savings from earlier disease detection and management. (ajmc.com)
4] The characteristic pathologic findings by immunofluorescence microscopy of granular deposits of IgA and complement 3 (C3) in the glomerular mesangium suggest that this disease is the result of the deposition of circulating immune complexes leading to the activation of the complement cascade. (medscape.com)
The images below are photomicrographs documenting liver findings in glycogen-storage disease type II. (medscape.com)

Journal of Alzheimer's Disease. (ed.ac.uk)

Dr. Yan develops predictive models to predict early onset of disease (e.g., heart failure), and applies machine learning models and natural language processing (NLP) models to identify disease phenotypes. (sutterhealth.org)

Although IgA nephropathy is a limited nonsystemic renal disease, many systemic diseases are sporadically associated with mesangial IgA deposition. (medscape.com)

A follow-up study of immunologic and virologic markers in relation to disease progression was undertaken on asymptomatic HIV-1 positive blood donors with history of oral iron intake (subgroup I) compared to those without such history (subgroup II). (scirp.org)

4] Depressive syndromes are highly correlated with a reduced quality of life, increased difficulty managing the course of disease, decreased adherence to treatment, and earlier admission to inpatient or hospice care. (cancernetwork.com)

The global burden has risen with the near tripling in the last half-century of multiple sclerosis (MS) ( 2 , 3 ), type 1 diabetes (T1D) ( 4 ), and other autoimmune diseases. (frontiersin.org)
This review highlights recent advances in vitamin D and T-lymphocyte biology in an effort to harness vitamin D's potential to reduce the impact of autoimmune diseases. (frontiersin.org)
Autoimmune diseases represent a failure of self-identification leading to an immune-mediated assault on host tissues. (frontiersin.org)
Other autoimmune diseases are included where robust mechanistic data exist. (frontiersin.org)

The retrieval steps and strategies were as follows: Title = rheumatoid arthritis AND Title = (interstitial lung disease OR interstitial pneumonia) AND Language = English AND Document type = (review OR article) AND Time span =1980 to 2021. (hindawi.com)

The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population. (cdc.gov)
Clinical manifestations of homozygote allele carriers in Huntington disease. (cdc.gov)

The adjusted mean EUSTAR-AI has the best predictive value for disease progression and development of severe organ involvement over time in SSc. (nih.gov)

Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype? (nature.com)

This hypothesis is supported by the high recurrence rate of IgA nephropathy in renal transplant recipients who have IgA nephropathy and, conversely, by the disappearance of the deposits from donor kidneys with IgA nephropathy when transplanted into donors without the disease. (medscape.com)

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by articular and extra-articular manifestations affecting approximately 1-2% of the general population [ 1 ]. (hindawi.com)
Other systemic diseases in which mesangial deposits of IgA are regularly observed include systemic lupus erythematosus, hepatitis, dermatitis herpetiformis, and ankylosing spondylitis. (medscape.com)

Results: Over a 5-year follow-up, men in the high CACS group demonstrated more DN progression compared with those in the low CACS group. (ijmrhs.com)
Glycogen-storage disease type II (GSDII), also referred to as Pompe disease, is an autosomal recessive disorder that results from the deficiency of acid alpha-glucosidase, a lysosomal hydrolase. (medscape.com)

Clinical, electrocardiographic and electrophysiologic variables were analyzed to identify predictors of progression to significant AVB (i.e. second or third grade). (revespcardiol.org)
In addition, we will discuss potential opportunities to identify the predictors of progression to CKD after AKI. (karger.com)

One poster suggested in HCV monodisease a follow-up biopsy should be done 3-5 years after the first to evaluate progression. (natap.org)

The strongest correlate of progression was the time-integrated ESR (rho=0.53). (nih.gov)

Conclusions The difference in disease activity between treatment strategies disappeared over the years. (bmj.com)

In the current study, investigators examined whether baseline and longitudinal levels of p-tau181 in plasma were associated with progressive neurodegeneration related to the disease. (medscape.com)
The proposed study intends to develop a machine learning model that utilises a relevant subset of predictors to diagnose the progression of the disease. (inderscience.com)

Kaplan-Meier analyses were performed to examine whether the relationship between CACS and DN progression was different between the sexes. (ijmrhs.com)

Amyloid plaque deposition and neurofibrillary tangles (NFT) in the brain are the main pathological hallmarks of this disease. (nature.com)

Objectives To examine links between clinical and other characteristics of people with Alzheimer's disease living in the community, likelihood of care home or hospital admission, and associated costs. (bmj.com)
Participants Every individual with diagnosis of Alzheimer's disease seen and treated by mental health services in the catchment area, with at least one rating of cognition, not resident in care home at time of assessment (n=3075). (bmj.com)
We analysed detailed, electronic clinical records of more than 3000 individuals with Alzheimer's disease using natural language processing to generate some of the data. (bmj.com)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of cognitive abilities and ultimately, death. (nature.com)
The gut-brain axis has been implicated in a range of neurological conditions, including Parkinson's disease and Alzheimer's disease. (qualitycounts.com)
Recently many machine learning and deep learning prediction models have been proposed for the early detection and classification of Alzheimer's disease (AD). (inderscience.com)
Research and Pratice in Alzheimer's Disease , 13. (bvsalud.org)

In recent years, the number of studies on rheumatoid arthritis-related interstitial lung disease (RA-ILD) has been increasing, which has led to many publications on this topic. (hindawi.com)

However, familial inherited genetic cases of the disease (familial AD, FAD) represent only around 2% of total cases [ 6 ]. (nature.com)
Alongside, she also led collaborative projects employing the role of structural variation in genetic diseases. (stanford.edu)
Studies reporting common are alcoholic liver disease, nonalcoholic fatty liver dis- the diagnosis of CLD based on previous medical records were also ease (NAFLD), chronic viral hepatitis, and genetic and autoim- included in the review. (cdc.gov)
Genetic Modification of Huntington Disease Acts Early in the Prediagnosis Phase. (cdc.gov)

She specializes in methodology development and the application of advanced analytics using Electronic Health Records (EHR) and other clinical data in evaluation, disease prediction, and population health management. (sutterhealth.org)

This review summarizes and integrates research on vitamin D and CD4 + T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. (frontiersin.org)
Indeed, "functional and mechanistic work on the molecular etiology of disease remains one of the major challenges in modern biology" ( 5 ). (frontiersin.org)

Acute-phase reactants are, by far, the strongest determinants of progression. (nih.gov)

Periodontal diseases are inflammatory diseases affecting the periodontium, causing progressive loss of the bone around the teeth. (bvsalud.org)

Anatomy10

Organisms10

Diseases63

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology4

Phenomena and Processes44

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena2

Humanities1

Information Science8

Named Groups2

Health Care44

Geographicals1

Biomarkers7

Mild cognitive2

Strong predictor4

Patients56

Clinical progression1

Severity11

Rapid progression2

Independent predictors3

Radiographic progression3

Centers for Diseas5

Dementia7

Good predictor1

Chronic kidney6

Outcomes1

Survival8

Outcome6

Conclusion2

Mechanisms11

Rate of progression1

20221

Longitudinal Study1

Decline2

Regression5

Prevalence6

Prognosis1

Infectious Diseases1

Risk14

Cardiovascular disease1

Infection9

Mortality1

Rheumatic2

AIDS1

Findings5

Journal of Alzh1

Onset1

Renal disease1

Immunologic1

Inpatient1

Autoimmune diseases4

20211

Allele2

Predictive1

Phenotype1

Recurrence1

Systemic2

Results2

Identify2

Biopsy1

Correlate1

Conclusions1

Study2

Analyses1

Amyloid1

Alzheimer's disease7

Rheumatoid1

Genetic4

Prediction1

Molecular2

Acute1

Inflammatory1