AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaInformation ScienceNamed GroupsHealth CareGeographicals
Risk FactorsCardiovascular DiseasesRisk AssessmentCardiac Imaging TechniquesPredictive Value of TestsModels, StatisticalROC CurveBiological MarkersProspective StudiesCohort StudiesArea Under CurveLogistic ModelsModels, TheoreticalReproducibility of ResultsPrognosisRiskAge FactorsAlgorithmsHypertensionCase-Control StudiesProportional Hazards ModelsBlood PressureCross-Sectional StudiesPrevalenceBody Mass IndexFollow-Up StudiesGenetic Predisposition to DiseaseSmokingRegression AnalysisC-Reactive ProteinMultivariate AnalysisForecastingObesityUnited StatesDyslipidemiasDiabetes Mellitus, Type 2Data Interpretation, StatisticalSex FactorsLinear ModelsLipidsAtherosclerosisCholesterol, HDLIncidenceDiabetes MellitusCoronary DiseaseBreast NeoplasmsModels, BiologicalCholesterolDecision Support TechniquesTreatment OutcomeTime FactorsMetabolic Syndrome XRetrospective StudiesHypercholesterolemiaSensitivity and SpecificityOdds RatioSeverity of Illness IndexTunica MediaCarotid Intima-Media ThicknessBlood GlucoseStrokeCholesterol, LDLCoronary Artery DiseaseCarotid ArteriesNomogramsDiscriminant AnalysisDiabetes ComplicationsBrachial ArteryWaist CircumferenceAnthropometryComorbidityTriglyceridesCarotid Artery DiseasesLife StyleChi-Square DistributionTunica IntimaProbabilityMyocardial InfarctionNeural Networks (Computer)CalcinosisHyperlipidemiasDiabetic AngiopathiesEpidemiologic MethodsJapanLongitudinal StudiesComputer SimulationPolymorphism, Single NucleotideSupport Vector MachinesEuropean Continental Ancestry GroupInsulin ResistanceNetherlandsArtificial IntelligenceCalibrationGenotypeVascular StiffnessSex DistributionDiagnostic Techniques, CardiovascularFinlandAntihypertensive AgentsFibrinogen
Coronary arteryBiomarkersStratificationMajor cardiovascular eventsCohort studyOutcomesPrognosisConclusionsInterventionsAtrial fibrillationPrevalenceFuture cardiovascular riskComputed tomographyIncreased cardiovascular diseaseDiagnosisDiseasesOccurrenceMorbidityCardiacIncrementalPrognosticAssessmentToxicityDisease mortalityPreventionMyocardial infarctionEventsAtheroscleroticPredictorsAtherosclerosisPopulationsMetabolic RiskPredictAdverseOutcomePracticePrevalentSignificantlyTumorDatasetsImprovesSeverityCohortsVariantsHospitalisationAcute exacerbationsDiabetesEpidemiologyMetSMachine learning and compSurvivalUtilityDiabeticDisordersBurdenHypertensionSubgroupHighEquationsGenetic riskMethodsDiagnosticStrokeInsightsEstimates
Coronary artery12
Biomarkers7
  • Furthermore, identifying new biomarkers of cardiovascular risk has the potential to refine early-life prevention strategies, before atherosclerosis becomes established. (bmj.com)
  • The expanding list of nontraditional biomarkers is outweighed by the standard risk factors for predicting future cardiovascular events and adds only moderately to standard risk factors. (medscape.com)
  • The aim of this narrative review is to summarize contemporary evidence on the use of circulating cardiac biomarkers of heart failure (HF) and to identify a promising biomarker model for clinical use in personalized point-of-care HF management. (annlabmed.org)
  • In addition, we provide clear information on the role of alternative biomarkers and future directions with the aim of improving the predictive ability and reproducibility of multiple biomarker models and advancing genomic, transcriptomic, proteomic, and metabolomic evaluations. (annlabmed.org)
  • They found that of the three evaluated biomarkers, NT-proBNP was most strongly associated with cardiovascular events. (libsyn.com)
  • The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)
  • We will review several projects based on the use of panels of biomarkers for a better understanding of risk of disease and prognosis. (lu.se)
Stratification7
  • The AHA/ACC and US Preventive Services Task Force (USPSTF) use the above as their recommendations for current risk stratification. (medscape.com)
  • However, subanalyses of the SYNTAX trial and results from different studies have implied that the purely anatomy-based risk stratification of the SxS score made it prone to misclassification of patient's true risk, particularly for all-cause mortality and cardiac death in patients with stable CAD or ACS treated by PCI [ 7 , 8 ]. (hindawi.com)
  • The addition of clinical variables was a promising step in improving risk stratification by reclassifying patients into more accurate risk categories. (hindawi.com)
  • In this regard, non-invasive stress imaging tests were shown to be excellent tools for properly selecting patients who would further benefit from an invasive procedure, thus providing both precise diagnostic classification and risk stratification [ 1 ] [ 2 ] . (encyclopedia.pub)
  • Prenatal diagnosis and risk stratification are relevant to assure the prompt referral to a tertiary Center, proper counseling, and the correct selection of candidates for prenatal treatment (4, 5). (researchsquare.com)
  • In today's episode, we are discussing very important new data regarding stroke risk stratification in patients with atrial fibrillation. (libsyn.com)
  • Risk stratification and early preventive measures can reduce major cardiovascular events given the long latent asymptomatic period. (bvsalud.org)
Major cardiovascular events1
  • Coronary atherosclerotic disease is a leading cause of mortality and morbidity due to major cardiovascular events in the United States and abroad. (bvsalud.org)
Cohort study2
  • In a prospective population-based cohort study, conventional CV risk factors were documented in 403 independently living elderly men. (nih.gov)
  • Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. (mja.com.au)
Outcomes9
  • Such predictive knowledge is often of great utility to physicians, counsellors, health education specialists, policymakers or other professionals, who may then advice course correction or interventions to prevent adverse health outcomes from occurring. (cdc.gov)
  • Therefore, in order to account for the variability of clinical parameters affecting long-term outcomes and hence better classification of patients' risk, the SYNTAX score II (SxSII) was developed by complementing SxS with 7 prognostic variables including age, creatinine clearance, left ventricular ejection fraction (LVEF), presence of unprotected left main coronary artery (ULMCA) disease, peripheral vascular disease (PVD), female gender, and chronic obstructive pulmonary disease (COPD) [ 9 ]. (hindawi.com)
  • Familial Hypercholesterolemia in the Electronic Medical Records and Genomics Network: Prevalence, Penetrance, Cardiovascular Risk, and Outcomes After Return of Results. (cdc.gov)
  • Health disparities are due largely to differences in social and environmental factors (e.g. equitable access to healthy foods, education, employment, health care, and safe environments), resulting in poorer health outcomes, across many disease conditions throughout the lifespan. (cdc.gov)
  • Conventional risk factors and other markers of arterial compliance, inflammation and autonomic function have limited value for prediction of outcomes in risk-modified patients assessed for coronary disease. (biomedcentral.com)
  • Risk assessment was performed prior to angiography, clinicians were blinded to results to avoid any impact on treatment over the 5 years of follow-up, and outcomes were independently adjudicated. (biomedcentral.com)
  • Long-Term Survival, Cardiovascular, and Functional Outcomes after Minimally Invasive Coronary Artery Bypass Grafting in 566 Patients. (ottawaheart.ca)
  • Self-expanding Transcatheter vs Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 5-Year Outcomes of the SURTAVI Randomized Clinical Trial. (uzh.ch)
  • Am J outcomes associated with treatment of cervical the risk of cancer: a multisite case-control study in Clin Nutr 2008;88:1567-75. (who.int)
Prognosis5
  • The establishment of this model may promote the use of precision medicine and targeted therapy in EC and has the potential to improve the prognosis of patients affected by EC. (spandidos-publications.com)
  • However, current data about associations between TyG index and critically ill patients are limited, whether TyG index was an independent factor of prognosis in ICU patients has not been determined yet. (biomedcentral.com)
  • Conversely, high-sensitivity C-reactive protein, pulse wave analysis and heart rate variability were unrelated to prognosis at 5 years after risk modification and treatment of coronary disease. (biomedcentral.com)
  • BODE Index for COPD Survival Prediction Estimates prognosis in patients with COPD based on body mass index, airflow obstruction, dyspnea, and exercise. (bmj.com)
  • The follow-up time of breast cancer data with diagnosis in 2019 in the SEER database is less than two years, this study also used 1-year survival as the study outcome, to establish a predictive model to identify people with better and worse prognosis, especially people with a poorer prognosis, and to assist physicians in taking the best interventional treatment for patients promptly. (biomedcentral.com)
Conclusions2
  • Conclusions: Predictive analysis offers tools that could aid the decision making of policymakers, physicians, and environmental health practitioners to improve public health. (cdc.gov)
  • Conventional tests of statistical significance are based on the probability that a particular result would arise if chance alone were at work, and necessarily accept some risk of mistaken conclusions of a certain type (mistaken rejections of the null hypothesis). (wikipedia.org)
Interventions3
  • In an effort to overcome the first barrier, BP interventions have been implemented to increase the range of BPs upon which estimation models are trained. (nature.com)
  • Cardiovascular Interventions, 16(8), e012527. (ottawaheart.ca)
  • Percutaneous treatment options for acute pulmonary embolism: a clinical consensus statement by the ESC Working Group on Pulmonary Circulation and Right Ventricular Function and the European Association of Percutaneous Cardiovascular Interventions. (uzh.ch)
Atrial fibrillation2
Prevalence6
  • We sought to determine the prevalence and factors associated with retinopathy among women with hypertensive disorders of pregnancy in southwestern Uganda. (bvsalud.org)
  • The prevalence of retinopathy was determined and multivariable logistic regression was used to determine the independent factors associated with retinopathy. (bvsalud.org)
  • Prevalence of various cardiovascular disorders coupled with a well-established healthcare sector can drive the market growth in the region. (medgadget.com)
  • Metabolic syndrome (MetS) represents a cluster of cardiovascular risk factors, including elevated blood pressure, obesity, high circulating triglyceride (TG), dysglycemia and low circulating high-density lipoprotein cholesterol (HDL-C). One study indicated that EC is a form of cancer that has associations with metabolic diseases, and that EC incidence increases with metabolic disease prevalence ( 8 ). (spandidos-publications.com)
  • Conversely, African Americans have a lower prevalence of other diseases, such as melanoma and acute lymphoblastic leukemia, due to protective genetic factors. (cdc.gov)
  • A questionnaire was used for the dietary survey Data thus obtained revealed the widespread prevalence of malnutrition among children the target population and allowed examination of the relationships between the various factors affecting the nutritional status of the children. (who.int)
Future cardiovascular risk2
  • In this review, we argue that a woman's pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowledge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. (bvsalud.org)
  • Impact of providing genetics-based future cardiovascular risk on LDL-C in patients with familial hypercholesterolemia. (cdc.gov)
Computed tomography3
  • In nondiabetic patients, a number of factors may be used to stratify the level of risk of coronary disease, including clinical history, resting ventricular function, exercise capacity, the presence and extent of ischemia at single-photon emission-computed tomography (SPECT), or stress echo. (diabetesjournals.org)
  • Cardiovascular Computed Tomography. (bvsalud.org)
  • Cardiovascular Imaging, Naval Medical Center Portsmouth, Board of Di- go to the ACR website at www.acr.org/ac to confirm that you are accessing rectors, Society of Cardiovascular Computed Tomography. (bvsalud.org)
Increased cardiovascular disease1
  • Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. (bmj.com)
Diagnosis9
  • In Medicare aged subjects with clinically identified risk factors for OSA, how does the diagnostic accuracy of tests other than PSG or Type II, III & IV HST, such as oximetry, peripheral arterial tone and actigraphy, alone or in combination, compare with PSG and Type II, III & IV HST in confirming a diagnosis of CPAP-responsive OSA? (cms.gov)
  • Does a diagnosis of the metabolic syndrome provide additional prediction of cardiovascular disease and total mortality in the elderly? (mja.com.au)
  • To assess whether a diagnosis of the metabolic syndrome (MetS) improves the prediction of cardiovascular disease or total mortality beyond that already provided by conventional risk factors. (mja.com.au)
  • A diagnosis of MetS provides additional prediction of CHD events, stroke events, and total mortality beyond that provided by other conventional risk factors. (mja.com.au)
  • Europe has similar growth factors to the Americas due to increasing diagnosis of endovascular diseases and a large geriatric populace. (medgadget.com)
  • Our PI estimator offers an effective uncertainty metric to quantify the quality of BP estimates and can minimize the risk of false diagnosis. (nature.com)
  • Originally the cohort was implemented as a screening programme to attain more insights into the set of risk factors and their relation to and their predictive value to the diagnosis and severity of CAD of consecutive patients referred for elective cardiac catheterisation to the Department of Cardiology at the University Hospital of Innsbruck, Austria. (bmj.com)
  • Also, the ADDITION-Europe Simulation Model Study shows early diagnosis reduces the risk of suffering cardiovascular events and mortality ( 2 ), which also spurs research associated with early diagnosis. (frontiersin.org)
  • Data with a diagnosis time of 2018(n = 23,384) were distributed randomly as training and testing sets in the ratio of 7:3 using the leave-out method for model construction and internal validation. (biomedcentral.com)
Diseases11
  • Increasing evidence shows genetic scores to offer predictive potential that is similar or, in some cases, even better than conventional clinical risk factors in diseases such as cardiovascular diseases and common cancers and for many diseases we are currently lacking tools to identify high-risk individuals. (helsinki.fi)
  • For three diseases with tremendous public health burden - cardiovascular disease, type 2 diabetes and breast cancer - the utility of AI-empowered tools will be tested in clinical settings in Finland, Estonia and Italy. (helsinki.fi)
  • Despite the fast accumulating scientific evidence, the predictive value of genetic risk scores has not been tested in clinical practice for many preventable diseases. (helsinki.fi)
  • The results of the project will hopefully provide unprecedented precision in personalized prediction models and thus more effective prevention and better treatment options for patients suffering from a variety of complex and rare diseases. (helsinki.fi)
  • Cardiovascular diseases are prevalent worldwide, and is the leading cause of death both in men and women in Austria. (bmj.com)
  • This research project aims to improve our understanding and ability to predict many different diseases through the analysis of CanPath questionnaire data using conventional and advanced machine learning models. (canpath.ca)
  • Some of the advanced models in this platform have been previously applied to predicting prostate cancer and have shown significantly better predictive accuracy than the best publicly available prostate cancer predictive models which illustrates the potential value of this platform for predicting many other diseases. (canpath.ca)
  • The standardized data analysis platform does not require any functionality changes for creating predictive models for different diseases which is why this platform can be efficiently applied to the prediction of dozens of diseases such as cancers, cardiovascular diseases, pulmonary diseases, diabetes, and neurological disorders using CanPath questionnaire data. (canpath.ca)
  • Once all predictive models have been created for each disease, the models will be analyzed to understand the global risk factors of diseases as well as how different risk factors change in risk for different subpopulations such as over different ages and genders. (canpath.ca)
  • Yet, those who develop these diseases experience poorer survival due to social factors and differential access to healthcare. (cdc.gov)
  • The use of risk calculators that facilitate management of chronic diseases has increased considerably since the first cardiovascular risk assessment equations were developed in the 1970s ( 1 ). (silverchair.com)
Occurrence3
  • We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease. (bvsalud.org)
  • Obesity is a risk factor for both susceptibility to infections including postoperative infections and other nosocomial infections and the occurrence of a more severe disease course. (hrb.ie)
  • Patients were prospectively followed over a median of 42 months for the occurrence of cardiovascular events including death, heart failure, hospitalization, arrhythmia, thromboembolic events and reintervention. (libsyn.com)
Morbidity3
  • Cardiovascular morbidity and mortality associated with the metabolic syndrome. (mja.com.au)
  • In congenital diaphragmatic hernia, the lung size, liver position, and defect side are the most common prenatal prognostic parameters used in clinical practice for morbidity and mortality prediction. (researchsquare.com)
  • However, the assessment of the total fetal lung volume (TFLV) at fetal magnetic resonance imaging (MRI) was demonstrated to be more accurate than 2D US examination in predicting postnatal mortality and morbidity, representing an independent prognostic factor (5, 9-12). (researchsquare.com)
Cardiac4
  • New cardiac CT techniques can assess coronary artery inflammation by imaging perivascular fat, and this may represent an important step forward in identifying the 'residual risk' that is not detected by plaque or ischaemia imaging. (bmj.com)
  • Notwithstanding a reduction in the general cardiovascular disease mortality in recent decades, the global burden of sudden cardiac death (SCD) has not greatly diminished [1]. (escardio.org)
  • The investment of nearly 2 decades of clinical investigation into cardiac cell therapy has yet to change cardiovascular practice. (go.jp)
  • asymptomatic individuals with heart failure risk factors, but no cardiac structural or functional abnormalities. (libsyn.com)
Incremental4
  • We set out to estimate the incremental prognostic utility of inflammation and atherosclerosis markers in the prediction of all-cause and CV mortality in elderly men. (nih.gov)
  • To assess the incremental prognostic value of SYNTAX score II (SxSII) as compared to anatomical SYNTAX Score (SxS) and GRACE risk score in patients with acute coronary syndromes who underwent percutaneous coronary intervention. (hindawi.com)
  • Incremental validity analyses combined hierarchical regression and structural equation models (SEM). (biomedcentral.com)
  • Ischemia adds risk that is incremental to clinical risks and LV dysfunction. (diabetesjournals.org)
Prognostic4
  • Future plans Various diagnostic and prognostic studies are planned, also concerning complications, competing risks and cost-effectiveness. (bmj.com)
  • Prognostic Modelling Studies of Coronary Heart Disease-A Systematic Review of Conventional and Genetic Risk Factor Studies. (cdc.gov)
  • While most studies currently predict five-year survival in breast cancer, some studies have focused on developing 1-year survival prediction models or Comprehensive Prognostic Index (CPI) for breast cancer patients with multiple comorbidities [ 8 ]. (biomedcentral.com)
  • However, due to the extreme variability of the disease, the prognostic prediction remains challenging (2). (researchsquare.com)
Assessment7
  • For example, doctors directed HIV patients at high cardiovascular risk to a particular HIV treatment, abacavir, and lower-risk patients to other drugs, preventing a simple assessment of abacavir compared to other treatments. (wikipedia.org)
  • Is a picture worth a thousand words in cardiovascular risk assessment? (revespcardiol.org)
  • Currently, cardiovascular risk assessment uses different scales adapted to each region or country, according to their own cohort data. (revespcardiol.org)
  • The Framingham general CVD profile is the most common risk assessment tool used worldwide. (revespcardiol.org)
  • Most of these tools have, however, not been externally validated in a population-based setting ( 2 ), with a few exceptions, including the relatively well-evaluated Fracture Risk Assessment calculator (FRAX) and QFracture ( 3 ). (silverchair.com)
  • All patients underwent clinical assessment, electrocardiography, echocardiography and biomarker measurement, including NT-proBNP, high-sensitivity troponin T and growth differentiation factor 15. (libsyn.com)
  • It is not surprising that expert opinion in that regard is conflicted as well, While opinions may differ current US guidelines recommend oral anticoagulation( OAC) for PAF patients based on their risk assessment score. (blogspot.com)
Toxicity1
  • Algorithms such as Support Vector Machines (SVMs), Artificial Neural Networks (ANNs), and Self Organizing Maps (SOMs), as well as the difficulties they present, the potential ties they may one day forge, and the web-based toxicity prediction tools have been discussed in this article. (anveshika.org)
Disease mortality1
  • The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. (mja.com.au)
Prevention4
  • European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). (acpjournals.org)
  • The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). (acpjournals.org)
  • The understanding of such factors is critical to the prevention of cardiovascular morbidities and mortality. (medscape.com)
  • Fruits, vegetables and endometrial cancer risk in women in the European forces in synthesizing evidence on new methods for the risk of cancer: a multisite case-control study in Prospective Investigation into Cancer and Nutrition cervical cancer prevention. (who.int)
Myocardial infarction2
Events8
  • Background: The goal of predictive modelling is to identify the likelihood of future events, such as the predictive modelling used in climate science to forecast weather patterns and significant weather occurrences. (cdc.gov)
  • In public health, increasingly sophisticated predictive models are used to predict health events in patients and to screen high risk individuals, such as for cardiovascular disease and breast cancer. (cdc.gov)
  • Ways to predict the risk of cardiovascular (CV) events or all-cause mortality have largely been derived from populations in which old and very old subjects were underrepresented. (nih.gov)
  • The aim of the present study was to assess the predictive performance of SxSII in patients presenting with ACS undergoing PCI and to compare it to the previously validated SxS and the commonly used Global Registry of Acute Coronary Events (GRACE) risk score [ 13 ]. (hindawi.com)
  • Cardiovascular disease (CVD) events are responsible for more than 4 million deaths in Europe each year. (revespcardiol.org)
  • The next study is the first large and prospective study showing that NT-proBNP is associated with cardiovascular events in patients with adult congenital heart disease independent of multiple clinical and echocardiographic variables. (libsyn.com)
  • In patients with elevated NT-proBNP, elevations of high sensitivity troponin T and growth differentiation factor 15 identified those patients at highest risk of cardiovascular events. (libsyn.com)
  • In population- levels results in similar benefits in older and younger based epidemiological studies, atherosclerotic risk fac- subjects, as well as in a reduction in cerebrovascular tors such as age, hypertension, systolic blood pressure, events The lack of a consistent association between diabetes mellitus, and smoking, but not lipids and lipids and CAA is therefore puzzling. (pdfmedfinder.com)
Atherosclerotic2
  • 3 Although these recommendations work for the general population, more intensive lifestyle efforts and the use of evidence-based preventive pharmacotherapy (ie, statins) should be prescribed for persons at high risk of atherosclerotic CVD, since, in this case, the benefits of medical therapy outweigh the risk of any adverse effects. (revespcardiol.org)
  • 1 In this setting, to select persons who merit inclusion in special preventive cardiovascular programs, criteria are currently based on absolute predicted risk for atherosclerotic CVD (typically, a 10-year estimated risk). (revespcardiol.org)
Predictors3
  • In the old and very old, IL-6 and number of carotid plaques are powerful predictors of mortality risk in the years to come. (nih.gov)
  • In hierarchical regression models, a set of variables are regressed on an outcome variable looking for those predictors that remain significant after controlling for the others in successive steps. (biomedcentral.com)
  • Competing risk regression modeling determined independent predictors of time to first fracture over 10 years and the coefficients incorporated in a risk model. (silverchair.com)
Atherosclerosis3
  • Dr. Shah and colleagues from the Brigham and Women's Hospital in Boston Massachusets classified more than 6,000 participants in the atherosclerosis risk and community study into heart failure stages. (libsyn.com)
  • Risk factors progressively attenuated with age, the absolute riskattributable to blood lipids is greater among the elderly Extracranial carotid artery atherosclerosis (CAA) is a Further, intervention studies have shown that major cause of cerebral infarction and transient ischemic lowering of low density lipoprotein (LDL) cholesterol attacks, a disease primarily of the elderly. (pdfmedfinder.com)
  • Imaging tests can detect subclinical coronary atherosclerosis and aid initiation of targeted preventative efforts based on patient risk. (bvsalud.org)
Populations6
  • Large studies with long-term follow-up confirmed the utility of CACS as a predictor of cardiovascular risk in populations. (bmj.com)
  • Selection, optimization, and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse populations. (cdc.gov)
  • Use of Polygenic Risk Scores for Coronary Heart Disease in Ancestrally Diverse Populations. (cdc.gov)
  • The need for validation across different populations is exemplified by the observation that fracture rates are higher in Northern and Eastern Europe compared with Anglo-Celt and Southern European countries, paralleling regional differences in osteoporosis risk factors such as calcium intake, sunlight exposure, smoking, alcohol use, and physical activity ( 4 ). (silverchair.com)
  • accepted 10 June 2002 The association of apolipoproteins A-I and B (apo A-I and apo B) with cardiovascular disease has been studied in younger populations, but there is sparse information in the elderly. (pdfmedfinder.com)
  • However, most of adapted from the Behavioral Risk Factor Surveillance these studies were performed in younger and middle- System by the Centers for Disease Control and Preven- aged populations. (pdfmedfinder.com)
Metabolic Risk1
Predict4
  • AIM: To determine whether serum testosterone levels predict hospitalised acute exacerbations of COPD (H-AECOPD), cardiovascular disease outcome, and mortality in people with COPD. (bvsalud.org)
  • A nomogram was generated to predict a patient's probability of MI based on the four independent risk factors. (spandidos-publications.com)
  • A standardized data analysis platform will be used to create different types of disease predictive models and these models will contain insights about the risk factors for the disease they predict. (canpath.ca)
  • ABCD2 Score to Predict Stroke Risk after TIA Estimates the risk of stroke following transient ischemic attack. (bmj.com)
Adverse1
  • With the continuous development of machine learning and data mining techniques, more and more researchers have tried to use machine learning models such as Random Forest (RF), Artificial Neural Network (ANN), Decision Tree (DT), and Support Vector Machine (SVM) to build adverse event prediction models. (biomedcentral.com)
Outcome1
  • For outcome prediction, the absolute value of the TFLV is converted to a percentage of what is expected for a normal fetus of the same gestational age, based on normative data (O/E TFLV) (13). (researchsquare.com)
Practice1
  • Two longstanding limitations hamper effective suicide risk management in clinical practice. (hrb.ie)
Prevalent1
  • Very low or zero CACS is reassuring and clinically valuable, but age and other prevalent risk factors are major drivers of CACS, 1 such that most middle-aged or older patients in higher cardiovascular risk groups have elevated CACS. (bmj.com)
Significantly4
  • ROC curve analysis showed that, compared with the clinical model (model 1), the combined model with MRS (model 2) significantly improved the diagnostic accuracy of MI in patients with EC (area under the curve in model 1 vs. model 2: 0.737 vs. 0.828 in the training cohort and 0.713 vs. 0.759 in the validation cohort). (spandidos-publications.com)
  • Kaplan-Meier analysis showed that the risk of all-cause mortality was significantly higher in patients with higher TyG index (log-rank P = 0.021). (biomedcentral.com)
  • model χ 2 = 104.8) was significantly enhanced by addition of stress echo data (model χ 2 = 122.9). (diabetesjournals.org)
  • So the correlation between risk score and stroke risk varies with the cohort studied.The numbers from the Northern European studies formed the basis of the alleged relationship between the CHA2DS2-VASc score and annual stroke risk and the North American Cohort analyses indicate significantly lower ( about 1/3 of the European rate) stroke rates for untreated AF. (blogspot.com)
Tumor4
  • We observed that DHT convincingly inhibits tumor necrosis factor-alpha (TNF-α) induced Janus Kinase-1 (JNK-1) activation and apoptosis in breast cancer cells, MCF-7 in p21 dependent manner. (anveshika.org)
  • AndrogenAR induces expression of p21 that in turn inhibits tumor necrosis factor-α induced JNK activation and apoptosis. (anveshika.org)
  • Breast Cancer Recurrence Risk After Mastectomy (simple) Assesses risk of breast cancer recurrence after mastectomy based on tumor grade and lymphatic involvement. (bmj.com)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
Datasets3
  • Results: Using data from 7094 farm crashes that occurred between 2005 and 2010 in nine mid-western states, we demonstrate and discuss predictive model fitting approaches, model validation techniques using external datasets, and the calculation and interpretation of predicted probabilities. (cdc.gov)
  • We discuss best practices and common limitations associated with predictive models built from observational datasets. (cdc.gov)
  • Moreover, for the second strategy, we show other critical miRNAs can be made apparent through the disease's comorbidities, and in this case, overall, the hsa-mir-103a-3p models work well for all the datasets, especially in T2D, while the hsa-mir-124-3p models achieved the best scores for the AD datasets. (frontiersin.org)
Improves1
  • A linear weighted combination of polygenic scores for a broad range of traits improves prediction of coronary heart disease. (cdc.gov)
Severity2
  • Bedside Index of Severity in Acute Pancreatitis (BISAP) Score Predicts risk of mortality in acute pancreatitis. (bmj.com)
  • Postnatal clinical severity, considered as a postnatal cardiovascular and respiratory impairment that indirectly reflects lung hypoplasia, is associated with an increased mediastinal shift angle calculation. (researchsquare.com)
Cohorts4
  • METHODS: Separate analyses were carried out on two observational, multicentre COPD cohorts, Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE) and Evaluation of the Role of Inflammation in Chronic Airways Disease (ERICA), both of which had serum testosterone measured using a validated liquid chromatography assay at the same laboratory. (bvsalud.org)
  • Multivariate analysis indicated that MRS was an independent risk factor for MI in both cohorts. (spandidos-publications.com)
  • 4 In Europe, the most commonly used scale is the European Systematic Coronary Risk Evaluation (SCORE), because it is based on analysis of large representative European cohorts, 1 in which risk estimates have been differentiated into high- and low-risk regions. (revespcardiol.org)
  • For example, with a risk score of 2, 27% of the cohorts reported a stroke risk of less than 1% and 33% reported stroke risk greater than 2% per year. (blogspot.com)
Variants2
  • Association of Rare Protein-Truncating DNA Variants in APOB or PCSK9 With Low-density Lipoprotein Cholesterol Level and Risk of Coronary Heart Disease. (cdc.gov)
  • For example, APOL1 gene variants contribute to increased kidney disease risk among African Americans, adding to social factors (such as, institutional racism, poverty, and barriers to high quality health care) that contribute to this health disparity. (cdc.gov)
Hospitalisation3
  • Multivariate logistic regression was used to determine associations with H-AECOPD during follow-up (3 years ECLIPSE, 4.5 years ERICA), a composite endpoint of cardiovascular hospitalisation and cardiovascular death, and all-cause mortality. (bvsalud.org)
  • Testosterone was not associated with H-AECOPD (ECLIPSE: OR: 0.76, p=0.329, ERICA males: OR (95% CI): 1.06 (0.73 to 1.56), p=0.779, ERICA females: OR: 0.77 (0.52 to 1.12), p=0.178) or cardiovascular hospitalisation and death. (bvsalud.org)
  • Frequent episodes of ICD appropriate therapy warrant a clinical reassessment, as it has been demonstrated that ICD shocks correlate with increased risk of heart failure hospitalisation and mortality [2]. (escardio.org)
Acute exacerbations1
  • BAP-65 prediction of in-hospital mortality and need for mechanical ventilation in COPD Predicts risk of mortality and need for mechanical ventilation in acute exacerbations of COPD. (bmj.com)
Diabetes4
  • To develop a type 2 diabetes hip fracture risk tool in community-based patients, to validate it in an independent cohort, and to compare its performance against the only published prediction equation to include type 2 diabetes as a risk factor (QFracture). (silverchair.com)
  • The model was validated in 286 participants with type 2 diabetes from the Busselton Health Study (BHS). (silverchair.com)
  • The FDS1 hip fracture risk equation is a simple validated adjunct to type 2 diabetes management that uses variables that are readily available in routine care. (silverchair.com)
  • Type 2 diabetes is associated with an increased fracture risk ( 5 - 7 ). (silverchair.com)
Epidemiology3
  • Although causal modelling is frequently used in epidemiology to identify risk factors, predictive modelling provides highly useful information for individual risk prediction and for informing courses of treatment. (cdc.gov)
  • In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)
  • The paucity of information on some aspects of these factors prompted me to under this study In this project the epidemiology of protein energy malnutrition :was studied. (who.int)
MetS1
Machine learning and comp2
  • CARL pioneered computational mapping of 'chaotic' heart rhythm disturbances (arrhythmias), targeting mechanistic drivers for atrial and ventricular fibrillation (AF, VF) using machine learning and computational models. (stanford.edu)
  • 1 To accomplish that goal, they used machine learning and computational modeling to segment patients into different "bins'' based on health status, medication intake, and chronic disease. (blogspot.com)
Survival1
  • Beside established primary reproductive functions, the male hormone androgen act as a growth and survival factor for most of its target tissues. (anveshika.org)
Utility1
  • Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults. (cdc.gov)
Diabetic3
  • Metabolic syndrome: connecting and reconciling cardiovascular and diabetic worlds. (mja.com.au)
  • This increased risk in the diabetic population is equivalent to the risk of nondiabetic patients after infarction ( 3 ), a finding that has engendered calls for more aggressive risk factor intervention in this group. (diabetesjournals.org)
  • sex and lipids levels are less predictive in diabetic than nondiabetic patients ( 4 ), and silent ischemia is more common ( 5 ). (diabetesjournals.org)
Disorders2
  • Transcatheter are used in the treatment of aortic valve stenosis, which is one of the common cardiovascular disorders which warrant surgical intervention. (medgadget.com)
  • used their new algorithms to evaluate the risk of specific disorders amongst healthy individuals. (blogspot.com)
Burden1
  • Combined use of only IL-6 and plaque burden allowed identification of subjects with low and high mortality risk. (nih.gov)
Hypertension2
  • The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother later in life. (bvsalud.org)
  • Maternal lupus nephritis will increase the risk of hypertension and preeclampsia/eclampsia. (ehd.org)
Subgroup2
  • the AUCs for the external validation of the two models on the subgroup population were 0.601 and 0.813. (biomedcentral.com)
  • The predictive efficacy of both models decreased and the difference was greater in advanced HER2 + patients, which means the HBN model had higher robustness and more stable predictive performance in the subgroup. (biomedcentral.com)
High8
  • In the INTERVENE project, life-long clinical and laboratory measurement data will be integrated with the genetic scores to create powerful predictive tools and to identify individuals at high risk of getting the disease. (helsinki.fi)
  • This finding indicates that the TyG index might be useful in identifying people at high risk of ICU death and hospital death. (biomedcentral.com)
  • When they looked at anemia cut offs like hemoglobin and mean corpuscular volume, a measurement of red blood cell size, their newly created risk calculators were able to separate anemic patients into groups at high risk for microcytic and macrocytic anemia from those with a risk no higher than the average nonanemic population. (blogspot.com)
  • Clinicians were blinded to all risk assessments, consisting of conventional factors, radial artery pulse wave analysis, 5-minute heart rate variability, high-sensitivity C-reactive protein and B-type natriuretic peptide (BNP). (biomedcentral.com)
  • This leaves limited scope for identifying patients at high risk that might benefit from more intensive management. (biomedcentral.com)
  • Importantly, patients with a low-risk of death and heart failure could be accurately identified with a high negative predictive value. (libsyn.com)
  • A summary of available imaging tests for low-, intermediate-, and high-risk asymptomatic patients is outlined in this document. (bvsalud.org)
  • Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)
Equations1
  • Then, with according to the structures, we study the laser equations first in the conventional state, then we propagate the spin state to better gain. (anveshika.org)
Genetic risk4
  • This study explores the use of a genetic risk score (GRS) for CAD risk prediction, compares it to established clinical markers, and investigates its performance according to the age and pharmacological treatment. (diabetesjournals.org)
  • The project focuses on developing improved genetic risk scores and testing their clinical validity. (helsinki.fi)
  • Genetic risk scores are statistical tools generated based on genome-wide profiling of individuals and the effects of each genetic variant on a risk of each disease. (helsinki.fi)
  • INTERVENE will also build a new European platform that will allow researchers and clinicians to easily calculate genetic scores with the goal to enable a wide adoption of genetic risk scores as a gold standard in clinical research. (helsinki.fi)
Methods4
  • In this manuscript, we use an example dataset that documents farm vehicle crashes and conventional statistical methods to forecast the risk of an injury or death in a farm vehicle crash for a specific individual or a scenario. (cdc.gov)
  • This can be due to low hospital stay time and less pain felt during surgical procedures as compared to conventional methods. (medgadget.com)
  • A systematic approach toward presenting NRI analysis is proposed: Detail and motivate the methods used for computation of the NRI, use clinically meaningful risk cutoffs for the category-based NRI, report both NRI components, address issues of calibration, and do not interpret the overall NRI as a percentage of the study population reclassified. (acpjournals.org)
  • To the best of our knowledge, this is the first study that used predicted miRNAs to determine the features that can separate the diseased samples (T2D or AD) from the normal ones, instead of using conventional non-biology-based feature selection methods. (frontiersin.org)
Diagnostic1
  • In Medicare aged subjects with clinically identified risk factors for OSA, how does the diagnostic accuracy of a clinical trial of CPAP compare with PSG and Type II, III & IV HST in identifying subjects with OSA who will respond to CPAP? (cms.gov)
Stroke3
  • current guidelines discrepancies also reflect the fact that the level of stroke risk among men with a score on 1 and women with a score of 2 is on the borderline of where the impact of anticoagulation treatment shifts from beneficial to harmful. (blogspot.com)
  • A 2014 report by Vanassche which analyzed data from 6563 AF patients not treated with oral anticoagulants (OAC) determined that stroke risk in permanent AF was roughly twice that of PAF. (blogspot.com)
  • Even though the risk of stroke is lower, still the stroke risk may overwhelm the risk of serious bleeding from OAC leading to a positive clinical benefit or trade-off and a reasonable recommendation for OAC. (blogspot.com)
Insights2
  • The Feops HEARTguide is a predictive planning guide which can provide insights on size of the device as well as positioning during surgery to reduce the probability of injuries. (medgadget.com)
  • The predictive models will be made available for public use and new insights about disease risk factors will be published to improve humanity's understanding of disease. (canpath.ca)
Estimates1
  • Bleeding Risk (any bleeding complication) on Warfarin Therapy Estimates risk of any bleeding complications for patients on warfarin. (bmj.com)