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  • METHODS
  • Bootstrap methods were used to identify factors for the final model. (nih.gov)
  • His research interests have covered evaluating more effective treatments for cancer and cardiovascular disease as well as developing improved methods in clinical trials design, quality-of-life assessment and integrating evidence from several trials to improve clinical decision making. (edu.au)
  • My laboratory utilizes human population-based approaches, large electronic health record data analysis and health services research methods to define and characterize cardiovascular disease (CVD) risk prediction, prevention and treatment approaches in patients with chronic liver disease. (northwestern.edu)
  • While redevelopment approaches resulted in models that were miscalibrated for local datasets of less than 500 observations, model aggregation methods were well calibrated across all simulation scenarios. (biomedcentral.com)
  • Methods and Results- Of 5888 participants in the Cardiovascular Health Study, an observational study of adults aged ≥65 years, 5020 without baseline CVD were included in the analysis. (ahajournals.org)
  • predictors
  • Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
  • Indeed, their data show that adding CRP did not greatly improve these statistics, but they point out that neither did adding total, low-density lipoprotein, or high-density lipoprotein cholesterol to models lacking these predictors. (annals.org)
  • These models share some common predictors, for example gender, arterial disease outside the heart and recent heart attack, but some predictors appear only in a subset of the CPMs. (biomedcentral.com)
  • algorithms
  • In these analyses, large proportions of women with 10-year risk estimates of 5 percent to less than 10 percent or of 10 percent to less than 20 percent based on current ATP-III (Adult Treatment Panel III) risk scores were reclassified at either higher or lower risk of total cardiovascular disease when either of the new algorithms was used," the researchers found. (bio-medicine.org)
  • We developed, validated and demonstrated highly improved accuracy of two clinical algorithms for global cardiovascular risk prediction that reclassified 40 percent to 50 percent of women at intermediate risk into higher- or lower-risk categories," the authors write. (bio-medicine.org)
  • discrimination
  • Model performance was heterogeneous and measures such as discrimination and calibration were reported for only 65% and 58% of the external validations, respectively. (bmj.com)
  • Discrimination was assessed for all models and calibration for the SCORE models. (um.edu.my)
  • The WHO/ISH model showed poor discrimination, AUC=0.613. (um.edu.my)
  • Discrimination was moderate for all 10 prediction models, with c-statistics ranging from 0.54 (95% CI 0.46 to 0.63) to 0.76 (95% CI 0.67 to 0.84). (bmj.com)
  • The addition of 6MWD to the clinical prediction model improves model discrimination compared with the original model. (ersjournals.com)
  • When the size of local data was less than 1000 observations and between-population-heterogeneity was small, aggregating existing CPMs gave better discrimination and had the lowest mean square error in the predicted risks compared with deriving a new model. (biomedcentral.com)
  • Risk discrimination was only slightly better in a model containing HbA1c than in a model with conventional cardiovascular risk factors alone, as indicated by a change in the C-index of only 0.0018, according to a report in JAMA from the Emerging Risk Factors Collaboration . (medpagetoday.com)
  • Sattar and colleagues found only slight changes in the C-index and integrated discrimination index -- measures of cardiovascular risk discrimination -- after including HbA1c levels with traditional heart risk factors, but this did not yield significant improvements in net reclassification. (medpagetoday.com)
  • outcome
  • Substantial heterogeneity in predictor and outcome definitions was observed between models, and important clinical and methodological information were often missing. (bmj.com)
  • Clinical prediction models (CPMs), which compute the risk of an outcome for a given set of patient characteristics, are fundamental to clinical decision support systems. (biomedcentral.com)
  • However, this framework is undesirable because the dataset used to derive the new CPM is often smaller than previous derivation datasets and can lead to multiple models for the same outcome. (biomedcentral.com)
  • CPMs
  • For patients with cardiovascular disease, there are numerous CPMs available although the extent of this literature is not well described. (nih.gov)
  • This database contains CPMs for 31 index conditions, including 215 CPMs for patients with coronary artery disease, 168 CPMs for population samples, and 79 models for patients with heart failure. (nih.gov)
  • There is an abundance of CPMs available for a wide assortment of cardiovascular disease conditions, with substantial redundancy in the literature. (nih.gov)
  • Clinical prediction models (CPMs) are increasingly deployed to support healthcare decisions but they are derived inconsistently, in part due to limited data. (biomedcentral.com)
  • This simulation study aimed to investigate the impact of between-population-heterogeneity and sample size on aggregating existing CPMs in a defined population, compared with developing a model de novo. (biomedcentral.com)
  • When aiming to develop models in defined populations, modellers should consider existing CPMs, with aggregation approaches being a suitable modelling strategy particularly with sparse data on the local population. (biomedcentral.com)
  • While differences in variable definitions between existing CPMs add complexity, the prior information encapsulated by each model can be exploited. (biomedcentral.com)
  • summarise
  • In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism. (springer.com)
  • although
  • Although they reach different conclusions, these 2 papers (5, 6) actually discuss similar data, and the discrepancy between them relates to their assessment of the value of the small improvement in risk prediction provided by CRP. (annals.org)
  • prospective
  • This model may provide additional information for targeting and tailoring interventions and requires future prospective evaluation. (nih.gov)
  • Results
  • Results 9965 references were screened, of which 212 articles were included in the review, describing the development of 363 prediction models and 473 external validations. (bmj.com)
  • validation
  • The usefulness of most of the models remains unclear owing to methodological shortcomings, incomplete presentation, and lack of external validation and model impact studies. (bmj.com)