PrognosisAmplification Predicts Poor SurvivalKaplan-MeierOutcomesOutcomeBiomarkersMedian overall survivalTumor progressionProgressionChemotherapyExpressionIndependent predictorsColorectal cancerPredictor of poorMultivariate analysisDiagnosisFactorsLong-term survivalLungBaselineBoneMetastaticMortality in patientsShort-term survivalAnalysisWorseSeverityImmunoTherapyDependentIncidenceCancersRatesTreatmentRateResultsConclusionResearchers
Prognosis15
- While all three types carry a poor prognosis, epithelioid mesothelioma, which accounts for 50 to 70 percent of cases, usually responds better to treatment than the other two types. (survivingmesothelioma.com)
- Doctors at the University of Zagreb School of Medicine in Croatia say there is a subtype of epithelioid mesothelioma that carries as poor a prognosis as the sarcomatoid and biphasic types. (survivingmesothelioma.com)
- Our results indicate that pleomorphic subtype is a predictor of poor prognosis and support classifying it with sarcomatoid or biphasic malignant pleural mesothelioma," the researchers conclude in Virchows Archiv, an international pathology journal. (survivingmesothelioma.com)
- The results showed patients with ≥4 copies of chromosome 1q had the worst prognosis (28.3 months survival). (doctorsnewshubb.com)
- ASBMR 2020 Low Vitamin D in COVID-19 Predicts ICU Admission, Poor Survival A study from Italy reports that patients who had severe COVID-19 had lower levels of vitamin D than patients with mild infections, and low vitamin D was an independent predictor of worse prognosis. (medscape.com)
- The positive SDF-1or NF-κB expression is significantly correlated with poor prognosis. (medscimonit.com)
- RUNX1/AML1 is one of the most frequently mutated leukaemias associated with a poor prognosis in AML. (mdpi.com)
- The presence of EGFR-positive myeloid cells in these tumors produced a poorer prognosis for survival. (pharmacytimes.com)
- Length of survival was significantly dependent on age, weaning success and main diagnosis (i.e., prognosis in COPD is worse compared to thoracic restriction, neuromuscular disease and others) in the multivariate analysis. (nih.gov)
- Difficult-to-wean patients have a high hospital mortality rate and poor long-term prognosis. (nih.gov)
- Therefore, the identification of new biomarkers can help to predict the prognosis risk of CN-AML. (biomedcentral.com)
- Treatment with erlotinib attempts to kill cancer cells by inhibiting EGFR signaling, a cellular mechanism that is hyperactive in most cases of glioblastoma multiforme and associated with poor prognosis," said senior author Dr. Chonghui Cheng, associate professor of molecular and human genetics and of molecular and cellular biology at Baylor College of Medicine. (neurosciencenews.com)
- We present novel data that show HNF4A protein expression does not confer favourable prognosis in papillary RCC, confirming our survival analysis with publicly available HNF4A RNA expression data. (lu.se)
- In addition, we have demonstrated that that high expression of CysLT1R in colorectal adenocarcinomas predicts poor prognosis in patients. (lu.se)
- The risk of distant recurrence in breast cancer patients is difficult to prognostic indices, such as the Nottingham Prognostic Index (6, 7), assess with current clinical and histopathological parameters, and have proven valuable in identifying patients with poor prognosis. (lu.se)
Amplification Predicts Poor Survival1
- HER-2/neu amplification predicts poor survival in node-positive breast cancer. (thieme-connect.de)
Kaplan-Meier7
- The Kaplan-Meier survival model and Cox proportional hazards models for both univariate and multivariate analyzes were used. (bmj.com)
- We computed overall survival of the cohort by using Kaplan-Meier estimators. (cdc.gov)
- Kaplan-Meier survival analysis was performed, along with univariate and multivariate cox regression analysis to test the effect of obesity and diabetes on overall survival . (bvsalud.org)
- Kaplan-Meier and Cox regression models showed that patients with low-TIMP-3/high-IL-6 tumors had shorter overall survival and relapse-free survival periods when compared with patients with high-TIMP-3/low-IL-6 tumors. (tmu.edu.tw)
- The overall survival times (OS) were collected by follow-up and analyzed by Kaplan-Meier analysis. (medscimonit.com)
- Kaplan-Meier and Cox regression analyses were used to compare progression free survival (PFS) and overall survival (OS) between the groups. (springer.com)
- Cumulative survival rates were compared using Kaplan-Meier analysis, and the log-rank test was used to test for significant differences between two groups. (frontiersin.org)
Outcomes7
- The mitochondrial markers we identified here could also be used as companion diagnostics, to predict clinical outcomes, as well as the patient response to therapy. (oncotarget.com)
- The incorporation of targeted therapies has modestly improved clinical outcomes, but the identification of new targets could further improve clinical outcomes by guiding stratification of poor-risk early stage patients and individualizing therapeutic choices. (johnshopkins.edu)
- The short-term outcomes after discharge are poor and remarkably worse in patients with underlying CTD or renal impairment. (ersjournals.com)
- Generally, it is rapidly lethal, and survival outcomes for adults with AML are very poor despite intensive chemotherapy and/or targeted therapies together with supportive care [ 4 ]. (researchsquare.com)
- A growing body of evidence suggests that anemia reflects poor health and increases risks of adverse outcomes. (ispub.com)
- Clinical outcomes of interest included mortality and survival rates. (ispub.com)
- Malnutrition is significantly associated with poor clinical outcomes and reduced quality of life among can- cer patients. (who.int)
Outcome6
- In particular, we directly assessed whether nuclear-derived mRNA species encoding proteins involved in mitochondrial protein translation and OXPHOS are able to successfully predict clinical outcome in gastric cancer. (oncotarget.com)
- CONCLUSIONS: HIF-1alpha expression in patients with breast cancer is a marker of poor therapy response and outcome, especially in ER-positive patients. (ox.ac.uk)
- Marginal change in FVC in IPF denotes a poor outcome. (ersjournals.com)
- Researchers use multiple independent variables (eg, age, injury severity) to predict the dependent variable (or outcome). (medscape.com)
- Articles met our inclusion criteria if they were (1) randomized clinical trials, (2) observational or epidemiological studies, (3) assessments of the prevalence of IDA in selected disease populations, and (4) studies that correlated IDA with quantitative outcome measures, including morbidity, mortality, survival rate, healthcare utilization, or cost. (ispub.com)
- Furthermore, even when standardized treatment is used and tumors are at the same stage and have similar histologic features, it is difficult to predict the outcome. (cdc.gov)
Biomarkers1
- The authors have evaluated whether patients' overall survival (OS) could be predicted by biomarkers such as demographic or clinical ( n = 4), biologic ( n = 1), pathologic ( n = 1), and imaging variables extracted from baseline and on treatment 18 F-FDG PET/CT ( n = 6). (snmjournals.org)
Median overall survival4
- Median overall survival for the patients with epithelioid mesothelioma was 10.5 months. (survivingmesothelioma.com)
- Patients with biphasic mesothelioma had a median overall survival of 6.5 months, while those with sarcomatoid mesothelioma survived for a median of 4 months. (survivingmesothelioma.com)
- Median overall survival for these patients, if untreated, is approximately 3 months. (medscape.com)
- [ 1 ] Because this is typically a late complication of systemic disease, melanoma-related brain metastases have been associated with significant neurologic morbidity and a poor median overall survival, with treatment, of approximately 9 months. (medscape.com)
Tumor progression1
- Increased expression of EGFR-positive myeloid cells associated with tumor progression and reduced survival in bowel cancer. (pharmacytimes.com)
Progression1
- High baseline BLR mean predicted a significantly poor progression-free survival and OS. (snmjournals.org)
Chemotherapy7
- A team of medical researchers in Italy have achieved what they are calling "excellent" tumor control and survival results in malignant pleural mesothelioma patients using a combination of surgery, chemotherapy, and radiotherapy. (survivingmesothelioma.com)
- Although CDK1 was highly expressed in tumor tissues, its loss from the cytoplasm unexpectedly predicted poor survival and conferred resistance to chemotherapy in multiple cell lines, especially microtubule-directed agents. (johnshopkins.edu)
- 5, elevated Alanine aminotransferase and patients without chemotherapy were correlated with poor survival. (scirp.org)
- 5 and patients who could not be treated with chemotherapy remained independent predictors of worse survival. (scirp.org)
- The number of colorectal cancer (CRC) patients has been increasing rapidly worldwide in recent decades, and the survival rates of CRC patients have increased in the past few years, possibly as a result of progress in diagnostic faculty and improved chemotherapy. (scirp.org)
- The method was not prognostic - it did not predict a survival benefit in three different control groups of patients treated with either chemotherapy or surgery alone. (eurekalert.org)
- Malnutrition is prevalent among Palestinian cancer patients receiving chemotherapy, and it is associated with poor quality of life. (who.int)
Expression6
- Hypoxia-inducible factor-1alpha expression predicts a poor response to primary chemoendocrine therapy and disease-free survival in primary human breast cancer. (ox.ac.uk)
- PURPOSE: To investigate the relationship of hypoxia-inducible factor-1alpha (HIF-1alpha) tumor expression in predicting the response to epirubicin and disease-free survival (DFS) in patients with breast cancer enrolled in a single institution trial of primary anthracycline and tamoxifen therapy. (ox.ac.uk)
- Expression analyses of epidermal growth factor receptor and HER-2/neu: no advantage of prediction of recurrence or survival in breast cancer patients. (thieme-connect.de)
- In multivariate analysis, high NCALD expression was an independent prognostic factor that predicts shorter EFS and OS (EFS, P = 3.84E−05, OS, P = 8.53E−05) of CN-AML. (biomedcentral.com)
- Our results indicate that high expression of NCALD gene is a poor prognostic factor for CN-AML. (biomedcentral.com)
- We have shown that LTD4 via its receptor CysLT1 induces expression of proteins associated with colorectal cancer and promotes proliferation, survival and migration in intestinal epithelial cells. (lu.se)
Independent predictors1
Colorectal cancer3
- The association between being diagnosed with a cardiometabolic disease before cancer and survival in patients with breast cancer and in patients with colorectal cancer was independent of body mass index (BMI). (who.int)
- Participants who developed colorectal cancer or breast cancer after age 50 years were included in the survival analysis to study how well knowing their average BMI and presence of cardiometabolic diseases before the development of cancer could predict their risk of death. (who.int)
- Having a higher BMI at ages 20-50 years was associated with poorer survival in patients with breast cancer and in patients with colorectal cancer. (who.int)
Predictor of poor1
Multivariate analysis2
- In multivariate analysis, only four copies of chromosome 1q were significant for survival. (doctorsnewshubb.com)
- The influence of various extensively studied prognostic factors on survival was assessed by multivariate analysis. (springer.com)
Diagnosis4
- Age, main diagnosis, severity of illness, weaning success and institution of NIV predict survival. (nih.gov)
- In this population, the authors confirmed that noninvasive measurement of glucose metabolism on nontumoral bone marrow can be used to predict OS in patients with a diagnosis of advanced melanoma treated with ICIs ( 4 ). (snmjournals.org)
- Parametric survival models have not previously been applied to survival following a diagnosis of HIV/AIDS in Australia. (who.int)
- Using likelihood based goodness-of-fit criteria the Weibull model was found to be the best-fitted model for predicting survival following a diagnosis of HIV infection without and with a diagnosis of AIDS. (who.int)
Factors5
- Our results suggested that high expressions of FHL2 and iASPP were poor prognostic factors for AML, but the prognostic effect might be overcome by allo-HSCT. (nature.com)
- Despite methodological differences, findings evidence that although IBC presents particular features (lower survival rate and worse prognostics than most types of breast cancer), very few studies examine its epidemiology and specific risk factors in depth and use any other therapeutic approaches than those commonly used for other breast cancer subtypes. (bvsalud.org)
- Several covariates-age, sex, combined HIV exposure category, CD4 cell counts, antiretroviral treatment and AIDS-defining illnesses-were included in the parametric model to predict factors associated with future mortality. (who.int)
- Survival analyses were conducted adjusting for demographic, psychosocial, and work organizational factors, with the SI as time-dependent variable. (cdc.gov)
- [ 2 ] Factors that predict survival include age, performance status, and the number of brain metastases, which are summarized as the melanoma-specific graded prognostic assessment. (medscape.com)
Long-term survival1
Lung6
- therefore, we expected that TIMP-3 loss might induce chronic inflammation, thereby promoting tumor malignancy as well as poor survival and relapse in patients with HPV-infected non-small cell lung cancer. (tmu.edu.tw)
- In summary, loss of TIMP-3 may increase IL-6 production via the tumor necrosis factor α/nuclear factor κB axis, thereby promoting tumor malignancy and subsequent relapse and poor survival in patients with HPV-infected non-small cell lung cancer. (tmu.edu.tw)
- Our hypothesis was that a marginal change in lung function parameters would predict survival and allow a more sensitive signal to be used in clinical decision-making and therapeutic trials. (ersjournals.com)
- A multi-center team, led by Vanderbilt-Ingram Cancer Center investigators, has discovered a "signature" of proteins in the blood that predicts which non-small-cell lung cancer patients will live longer when they are treated with certain targeted cancer therapies. (eurekalert.org)
- In the case of the EGF receptor tyrosine kinase inhibitors (TKIs) gefitinib (Iressa) and erlotinib (Tarceva), studies have demonstrated a survival benefit for 30 to 40 percent of lung cancer patients, but there has been no method for identifying these patients prior to treatment, Carbone said. (eurekalert.org)
- In particular, interstitial lung disease (ILD) is one of the major manifestations associated with poor mortality in patients with polymyositis (PM)/dermatomyositis (DM) ( 2 ). (frontiersin.org)
Baseline1
- Low pIL6 at baseline in mccRCC patients treated with sunitinib predicts improved treatment response, and might represent a candidate predictive marker. (urotoday.com)
Bone1
- The finding that bone marrow glucose metabolism is an imaging biomarker correlated with survival is of interest and aligns with findings in existing literature ( 4 , 5 ). (snmjournals.org)
Metastatic1
- Elevated plasma interleukin 6 predicts poor response in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. (urotoday.com)
Mortality in patients1
- In one recent report, the presence of ID predicted a six-fold increase in in-hospital mortality in patients undergoing carotid endarterectomy(7). (ispub.com)
Short-term survival2
- Methods We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. (bmj.com)
- 32, improvement of short-term survival rate may be the only benefit. (wjgnet.com)
Analysis2
- At the time of the mass spectrometry analysis and classification, the researchers were "blind" to the survival status of the patients. (eurekalert.org)
- We validate our findings using immunohistochemical staining and analysis of a 363-patient tissue microarray (TMA), showing for the first time that NFIA can independently predict poor cancer-specific survival in clear cell RCC (ccRCC) patients (hazard ratio = 0.46, 95% CI = 0.24-0.85, p value = 0.014). (lu.se)
Worse1
Severity1
- The ability to predict survival after trauma is perhaps the most fundamental use of injury severity scoring, Furthermore, injury severity scoring can provide objective correlations with resource utiliziation such as length of stay and costs of treatment, as well as inform clinical decisions regarding management of injuries of specific severity. (medscape.com)
ImmunoTherapy1
- They concluded patients with four chromosome 1q gain require immunotherapy for survival in the patient population, despite novel agents and transplantation. (doctorsnewshubb.com)
Dependent1
- Cancer staging and survival in colon cancer is dependent on the quality of the pathologists' specimen examination. (cancercentrum.se)
Incidence4
- Brain Tumor Registry of the United States analytic data set and primary malignant ependymal tumours from the SEER 13 registries research data file were used to evaluate incidence and survival, respectively. (cdc.gov)
- Predicting work-related incidence of lateral and medial epicondylitis using the strain index. (cdc.gov)
- The objective of this study is to determine if the SI predicts incidence cases of work-related lateral, medial, or any epicondylities (LEPI, MEPI, and EPI). (cdc.gov)
- 5), older age, and self-perceived poor general health were associated with incidence of LEPI and EPI, but not MEPI. (cdc.gov)
Cancers1
- And, despite years of research, brain cancer survival rates have remained little-changed in recent years, even while survival rates for many other cancers have been significantly improved. (braintumor.org)
Rates4
- Hospital mortality and survival rates of long-term ventilated patients.DESIGN. (nih.gov)
- Post-discharge survival rates were 67.6% at 3 months, 49.4% at 1 year and 38.1% at 3 years. (nih.gov)
- Similar to HNSCC, in general, survival rates for patients with OSCC are poor. (cdc.gov)
- However, children and adolescents, the oldest adult age group, cases diagnosed with anaplastic ependymoma and/or tumour location in a brain site had lowest survival rates. (cdc.gov)
Treatment4
- Studies addressing the effect of timing of RT on survival suffer from considerable bias, such as inhomogeneous patient populations, inhomogenous treatment protocols or disregard for tumor location, EOR, and RTV. (springer.com)
- Immune profiles can be used to predict treatment responses. (helsinki.fi)
- The IFIGENIA (Idiopathic Pulmonary Fibrosis International Group Exploring N -acetylcysteine I Annual) group, investigating N -acetylcysteine in IPF, found a difference of 8% predicted in FVC and 14% pred in D L,CO at 12 months between the treatment and placebo groups 7 . (ersjournals.com)
- Using mass spectrometry, the researchers analyzed pre-treatment blood samples from 139 patients who had been treated with gefitinib (three patient cohorts in Italy and Japan), identified a pattern of eight proteins that was correlated with survival, and developed a prediction algorithm. (eurekalert.org)
Rate1
- In the specific case of the House Finch, the higher escape ability of redder individuals could be the reason for their higher overwinter survival rate. (researchgate.net)
Results1
Conclusion1
- To reach that conclusion, the team analyzed biopsy specimens and survival data from 108 mesothelioma patients diagnosed between 2000 and 2010 at the University's Institute of Pathology. (survivingmesothelioma.com)
Researchers2
- SAN ANTONIO - Indiana University School of Medicine researchers have discovered how to predict whether triple negative breast cancer will recur, and which women are likely to remain disease-free. (iu.edu)
- In the case of glioblastoma multiforme, the deadliest type of brain cancer, researchers have discovered that the molecule CD44s seems to give cancer cells a survival advantage. (neurosciencenews.com)