• A conceptual model of patients outcomes. (medscape.org)
  • Therefore, in this study, we evaluated the effect of BMI on the outcomes of patients with COVID-19. (medsci.org)
  • To investigate these outcomes, the researchers used data from the Surgical Replacement and Transcatheter Aortic Valve Implantation (SURTAVI) trial that compared the safety and efficacy of TAVR performed with a self-expanding bioprosthesis with surgical aortic-valve replacement in patients who were deemed to be at intermediate risk for surgery. (medscape.com)
  • QOL was evaluated using the Medical Outcomes Study Short-Form 36 (SF-36) questionnaire, which assesses eight dimensions of health status and provides a physical and mental component summary scale, with higher scores representing better health status. (medscape.com)
  • The main flaw with most studies to date is they do not take into account the social determinants of health that more strongly predict our health outcomes, compared to body weight. (nursinginpractice.com)
  • Co-first author Marcos Restrepo, MD, MSc, PhD, professor of medicine at the health science center and director of the medical intensive care unit in the South Texas Veterans Health Care System, said the immune health grades and overall concept of immunologic resilience accurately predicted most patient outcomes, which in addition to mortality included hospitalization, need for advanced respiratory support, and levels of SARS-CoV-2 in the nasopharynx. (globalhealthnewswire.com)
  • We compared AEs and clinical outcomes in mRCC patients treated with full vs. reduced starting cabozantinib dose. (emory.edu)
  • Overall survival (OS), progression-free survival (PFS), and objective response (OR) rate measured clinical outcomes. (emory.edu)
  • The presence of all three taxa, as well as the species Bacillus Clausii, predicted better outcomes for patients in both MD Anderson and Johns Hopkins cohorts. (justbalancinghealth.com)
  • Methods We evaluated the prognostic value of preoperative, postoperative and change in plasma ePD-L1, as well as plasma soluble PD-L1, in short-term survival of GC patients after surgery. (bmj.com)
  • Methods: Using the Duke Database for Cardiovascular Disease, we selected 22,877 patients who underwent cardiac catheterization from January 1986 to August 2004 and were found to have significant coronary artery disease. (elsevierpure.com)
  • Patients and Methods: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. (aacrjournals.org)
  • OBJECTIVES:Predicting body mass is a frequent objective of several anthropological subdisciplines, but there are few published methods for predicting body mass in immature humans. (duke.edu)
  • Methods: We performed a retrospective analysis of 87 mRCC patients treated with cabozantinib at Winship Cancer Institute from 2016 to 2019. (emory.edu)
  • 1983. Mass spectrometric methods in structural analysis of some vesicants. (cdc.gov)
  • The "obesity paradox" has been described as the paradoxical decrease in morbidity and mortality in overweight patients compared to patients that are underweight [ 1 ]. (medsci.org)
  • As many developing countries, including Malaysia, have disproportionately high rates of breast cancer morbidity and mortality, a comprehensive assessment of lifestyle behaviors after breast cancer is essential as these behaviors may potentially affect prognosis, cancer recurrence, long-term survival and risk of other chronic diseases such as cardiovascular, hypertension and diabetes [ 11 ]. (biomedcentral.com)
  • The investigators recommend that management of hypertension in patients being treated with VEGFIs should be aimed at reducing the risk of short-term morbidity associated with hypertension while maintaining effective dosing of antiangiogenic therapy for optimal cancer treatment. (science20.com)
  • Investigators from several large studies examined the performance characteristics of BNP testing in the acute care setting to assist in diagnosing CHF and in predicting long-term morbidity and mortality. (medscape.com)
  • Creatine kinase is a muscle enzyme that has been reported at various levels in different studies involving patients with amyotrophic lateral sclerosis. (lww.com)
  • In the present retrospective case-control study, we included 582 patients with amyotrophic lateral sclerosis and 582 age- and sex-matched healthy controls. (lww.com)
  • Serum creatine kinase levels in patients with amyotrophic lateral sclerosis were significantly higher than those in healthy controls. (lww.com)
  • Subgroup analysis revealed that serum creatine kinase levels in men were higher than those in women in both amyotrophic lateral sclerosis patients and healthy controls. (lww.com)
  • Compared with patients with bulbar-onset amyotrophic lateral sclerosis, patients with limb-onset amyotrophic lateral sclerosis had higher creatine kinase levels. (lww.com)
  • Spearman's correlation analysis revealed that serum creatine kinase levels were not correlated with body mass index, Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised score, or progression rate. (lww.com)
  • After adjusting for prognostic covariates, higher log creatine kinase values were correlated with higher overall survival in the amyotrophic lateral sclerosis patients. (lww.com)
  • Together, our results suggest that serum creatine kinase levels can be used as an independent factor for predicting the prognosis of amyotrophic lateral sclerosis patients. (lww.com)
  • Vitamin D deficiency and its supplementation in patients with amyotrophic lateral sclerosis. (vitad.org)
  • We studied 25-hydroxyvitamin D (vitamin D) levels in patients with amyotrophic lateral sclerosis (ALS) and the effect of vitamin D supplementation. (vitad.org)
  • Survival in COPD is related to the severity of airflow limitation and the frequency of exacerbations. (msdmanuals.com)
  • Reduced survival time has been associated with various factors such as advanced age, severe physiological impairment, low body-mass index, radiological extent and severity of fibrosis determined by chest high-resolution computed tomography (HRCT), presence of comorbidities including pulmonary hypertension (PH), emphysema and bronchogenic cancer. (unicatt.it)
  • Bedside Index of Severity in Acute Pancreatitis (BISAP) Score Predicts risk of mortality in acute pancreatitis. (bmj.com)
  • The concept is a useful way to assess the severity levels of patients and understand their potential rate of progression and need for advanced therapies and longer hospitalizations," said co-author Sandra Sanchez-Reilly, MD, professor of medicine at the health science center and associate chief of service for geriatrics and extended care in the South Texas Veterans Health Care System. (globalhealthnewswire.com)
  • There are many factors that are used to calculate the lung allocation score:[citation needed] diagnosis of the patient (e.g. emphysema, cystic fibrosis Pulmonary Fibrosis, etc. (wikipedia.org)
  • Given BA, Given C, Azzouz F, Stommel M. Physical functioning of elderly cancer patients prior to diagnosis and following initial treatment. (medscape.org)
  • In an earlier study, a 25-hydroxyvitamin D(3) (25(OH)D) score calculated from known predictors of vitamin D status significantly predicted plasma levels of 25(OH)D and the risk of colorectal cancer, but the influence of the 25(OH)D score on survival after diagnosis is unknown. (nih.gov)
  • We prospectively examined the influence of post-diagnosis predicted 25(OH)D levels on mortality among 1017 participants in the Nurses' Health Study and Health Professionals Follow-Up Study who were diagnosed with colorectal cancer from 1986 to 2004. (nih.gov)
  • Higher predicted 25(OH)D levels after a diagnosis of colorectal cancer may be associated with improved survival. (nih.gov)
  • Published in the October 15, 2006 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study found that obese and overweight women who had higher levels of moderate or vigorous recreational physical activity within one year before diagnosis tended to have better five-year survival patterns compared to other groups. (sciencedaily.com)
  • Page E. Abrahamson, Ph.D. now at the Fred Hutchinson Cancer Research Center in Seattle, led researchers while at the University of North Carolina, Chapel Hill to investigate the relationship between pre-diagnosis physical activity and survival in 1264 women with breast cancer. (sciencedaily.com)
  • Survival modestly increased among women with body mass index (BMI) greater than 25 who reported highest levels of physical activity within one year of diagnosis. (sciencedaily.com)
  • The estimation of survival depends on which time-point is used as the starting point: onset of symptoms, time of diagnosis or later time-points. (ersjournals.com)
  • Consequently, mean survival rates reported in different studies are highly variable, being estimated at between 2 and 4 yrs from the time of diagnosis [ 1 , 3 , 9 , 10 ]. (ersjournals.com)
  • The prospective studies published recently have been generated from clinical trial data, and enrolment criteria usually exclude advanced patients, irrelevant of the symptom starting point, while they include patients with variable time lags from diagnosis [ 1 , 10 , 13 - 17 ]. (ersjournals.com)
  • The aim of our study was to determine whether 3-yr survival could be predicted on the basis of clinical indicators collected at the time of diagnosis and re-evaluated at 6 months in a homogenous cohort of patients with a rigorous diagnosis of IPF. (ersjournals.com)
  • They stress the importance of patient history and physical examination for predicting airflow obstruction, spirometry for screening or diagnosis of COPD, and assessing management strategies including inhaled medications, pulmonary rehabilitation and supplemental oxygen. (adam.com)
  • We carried out an electronic health records- (EHR-) based retrospective cohort study that included patients with cardiological clinical evaluation and no previous diagnosis of HF. (units.it)
  • According to the optimal model results, cancer stage, tumor size, diagnosis age, surgery, and body mass index were the most critical factors for predicting breast cancer survival. (tmu.edu.tw)
  • While ovarian cancer is the leading cause of death in the UK from gynaecological malignancies, there have been improvements in survival in the past two decades, which might reflect earlier diagnosis and more effective treatments. (bmj.com)
  • Information on magnitude of weight change after breast cancer diagnosis and lifestyle behaviors of breast cancer survivors with varying degrees of weight change could facilitate the development and targeting of effective intervention strategies to achieve healthy weight and optimal health for better survival. (biomedcentral.com)
  • However, weight gain rather than weight loss has been frequently reported in patients after diagnosis of breast cancer. (biomedcentral.com)
  • With a focus on early diagnosis and improved treatment strategies, investigative studies and clinical trials over the past two decades have improved the recurrence-free and overall survival rates in breast cancer patients. (biomedcentral.com)
  • A total of 824 patients with a diagnosis of myocardial infarction or unstable angina were analyzed. (hindawi.com)
  • A total of 853 patients were initially admitted during the period studied with a discharge diagnosis of unstable angina or myocardial infarction. (hindawi.com)
  • Given that obesity is relatively well established as a poor prognostic factor in breast cancer," conclude the authors, "it is hopeful that activity may provide an opportunity to improve survival in this sub-population. (sciencedaily.com)
  • Yoshida J, Setoguchi K, Shiraishi K, Kikuchi T, Tanaka M. The obesity paradox in Japanese COVID-19 patients. (medsci.org)
  • To investigate the effect of obesity on mortality and invasive respiratory care (IRC) in patients with COVID-19. (medsci.org)
  • In Japanese COVID-19 patients, the risk of mortality and the IRC rate decreased in underweight patients and remained low in overweight patients, suggesting the importance of the obesity paradox. (medsci.org)
  • Given the conventional wisdom that obesity is harmful, assuming a higher body weight increases the risks with Covid-19 could be viewed as taking steps to protect the public. (nursinginpractice.com)
  • 1 The actual evidence around the virus, however, remains inconsistent and it is possible an obesity survival paradox may exist, as is the case with other conditions. (nursinginpractice.com)
  • When social determinants and co-morbidities are accounted for, death rates appear lower in higher BMI groups 8 - hence the obesity survival paradox referred to earlier. (nursinginpractice.com)
  • Metabolic syndrome (MetS) represents a cluster of cardiovascular risk factors, including elevated blood pressure, obesity, high circulating triglyceride (TG), dysglycemia and low circulating high-density lipoprotein cholesterol (HDL-C). One study indicated that EC is a form of cancer that has associations with metabolic diseases, and that EC incidence increases with metabolic disease prevalence ( 8 ). (spandidos-publications.com)
  • Although obesity is a well-established cardiovascular risk factor, some controversy has arisen with regard to its effect on hospital mortality in patients admitted for acute coronary syndrome. (hindawi.com)
  • It would therefore be logical to expect obesity to have a lethal effect on patients who have suffered a coronary event. (hindawi.com)
  • This situation, in which obesity seems to protect patients with acute coronary syndrome (ACS), has been called "the obesity paradox" and has been described in other facilities. (hindawi.com)
  • Pediatric overweight and obesity impacts more than one in three children in the U.S.. Nationwide Mississippi has the highest rate of obesity in youth. (umc.edu)
  • The NO participants displayed a comparatively unhealthier profile, having a higher proportion of participants diagnosed with hypertension, coronary artery disease, obesity, and dyslipidemia. (news-medical.net)
  • Obesity, defined as having a body-mass index of 30 or greater, sets the stage for diabetes and killer conditions such as heart disease, stroke and cancer. (popsci.com)
  • Female students, although they exercised less than men, had higher scores for healthy eating, had a lower rate of overweight/obesity and a lower rate of alcohol consumption. (who.int)
  • The Kaplan-Meier survival model and Cox proportional hazards models for both univariate and multivariate analyzes were used. (bmj.com)
  • When separately determining the Cox proportional hazard models and Kaplan-Meier survival curves by liver transplantation status, higher adiponectin was significantly associated with an increased hazard ratio (HR) of death of 1.72 (95% confidence interval (CI)=1.12-2.64), i.e. poor survival among patients without liver transplantation. (tmu.edu.tw)
  • Moreover, Kaplan-Meier survival curves differed remarkably between the YES and the NO cohorts. (news-medical.net)
  • The aim of this study was to emphasize the impact of the aspartate aminotransferase-to-alanine aminotransferase ratio (De Ritis ratio) on the prognosis of patients with stable coronary artery disease (SCAD) undergoing percutaneous coronary intervention (PCI). (medscimonit.com)
  • Dual antiplatelet therapy with aspirin and clopidogrel is commonly used in patients with coronary artery disease or post intra-arterial stenting. (bmj.com)
  • Objective: We examined the effect of body mass index on the association between revascularization strategy and survival in patients with coronary artery disease. (elsevierpure.com)
  • The clinical course is highly variable, with many patients remaining stable for a prolonged period of time, even in the absence of effective medical treatment, while others experience a rapid and relentless progression [ 1 - 3 ]. (ersjournals.com)
  • The heterogeneity of the clinical course in IPF makes it difficult to predict the disease outcome, and hence the timing of lung transplantation (LTx), and patients with IPF present the highest waiting list mortality among LTx candidates [ 11 ]. (ersjournals.com)
  • Patients' opinions, beliefs and values hold an important place in clinical decision making in modern medicine. (bmj.com)
  • The present study is aimed to build an artificial intelligence (AI) prognostic model that takes in account a large and heterogeneous set of clinical factors and investigates the risk of developing HF in diabetic patients. (units.it)
  • The AI approach led to the identification of 20 predictors of different domains (age, body mass index, echocardiographic and electrocardiographic features, laboratory measurements, comorbidities, therapies) whose relationship with the predicted risk correspond to known trends in the clinical practice. (units.it)
  • The study used clinical data to develop a prediction model for breast cancer survival. (tmu.edu.tw)
  • The relationship between body mass index, coronary disease treatment, and survival was assessed via Cox multivariable models adjusting for baseline demographic, clinical, and angiographic characteristics. (elsevierpure.com)
  • The present study evaluated the clinical relevance of an integrative preoperative assessment of inflammation-, nutrition-, and muscle-based markers for patients with muscle-invasive bladder cancer (MIBC) undergoing curative radical cystectomy (RC). (karger.com)
  • ROC curve analysis showed that, compared with the clinical model (model 1), the combined model with MRS (model 2) significantly improved the diagnostic accuracy of MI in patients with EC (area under the curve in model 1 vs. model 2: 0.737 vs. 0.828 in the training cohort and 0.713 vs. 0.759 in the validation cohort). (spandidos-publications.com)
  • Clinical and anthropometric variables were analyzed in patients consecutively admitted for acute coronary syndrome to a university hospital between 2009 and 2010, and the correlation of those variables with hospital mortality was examined. (hindawi.com)
  • The Moon Shots Program™ is a collaborative effort to accelerate the development of scientific discoveries into clinical advances that save patients' lives. (justbalancinghealth.com)
  • High plasma level of postoperative ePD-L1 correlates significantly with poor survival, while high change in ePD-L1 level brings the significant survival benefit. (bmj.com)
  • Results: Gender, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, high body mass index (BMI), diabetes mellitus (DM) history and Child-Pugh (CP) class were associated with leptin and adiponectin levels, while fetoprotein (AFP) and presence of metastasis, being outside the Milan criteria and Barcelona clinic liver cancer (BCLC) stage, were significantly associated with liver transplantation and HCC survival. (tmu.edu.tw)
  • After adjustment for age and baseline vitamin D levels in a linear regression model, the ALSFRS-R score decline was smaller in patients taking vitamin D at 9 months (p=0.02) but was not significantly different at 3 or 6 months. (vitad.org)
  • What's worse, it is predicted that its mortality will increase significantly by 2040 [ 7 ]. (hindawi.com)
  • Body mass index, renal function, race, a family history of hypertension, or cardiovascular disease do not seem to predict development of hypertension with VEGFI treatment. (science20.com)
  • Therefore, the renal clearance of NT-proBNP confounds its diagnostic utility in patients with renal insufficiency. (medscape.com)
  • New cancer therapies, particularly agents that block vascular endothelial growth factor (VEGF) signaling, have been successful and are now used as a first line therapy for some tumors, but almost 100% of patients who take VEGF inhibitors (VEGFIs) develop high blood pressure, and a subset develops severe hypertension. (science20.com)
  • By finely balancing the protective effects of immunosuppression against lung allograft rejection with the significant toxic effects of these therapies, excellent long-term survival can be achieved. (ersjournals.com)
  • The diversity results were independent of other factors, such as previous therapies, body mass index, and antibiotics use, making it a predictor of survival for surgical patients and indicating the potential importance of the tumor microbiome in cancer progression. (justbalancinghealth.com)
  • We review the current literature on mitochondrial-targeted therapies, which have the potential to open new therapeutic avenues in the management of patients with chronic liver disease. (imperial.ac.uk)
  • Multifactorial Cox regression analysis revealed that a high De Ritis ratio was an independent risk factor for MACCE (HR=2.96, 95% CI: 1.29-6.78, P =0.01) and all-cause mortality (HR=3.61, 95% Cl: 1.31-9.86, P =0.012). (medscimonit.com)
  • A high De Ritis ratio was an independent and valuable risk stratification factor for MACCE and all-cause mortality in patients with SCAD after PCI. (medscimonit.com)
  • Effective surgical adjuvant therapy for high-risk rectal carcinoma. (medscape.org)
  • Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival. (nih.gov)
  • The purpose of the multifactorial ROSE is to risk-stratify patients in order to predict survival and detect rapid disease progression. (ersjournals.com)
  • Resource utilization and toxicities after carboplatin/etoposide/melphalan and busulfan/melphalan for autologous stem cell rescue in high-risk neuroblastoma using a national administrative database. (chop.edu)
  • Whole chromosome 7 gain predicts high risk of recurrence in pilocytic astrocytomas independently from BRAF-KIAA1549 fusion status. (chop.edu)
  • Scientists from the International Agency for Research on Cancer (IARC), in collaboration with researchers from Ludwig Maximilian University of Munich (Germany), have found that every extra kilogram per square metre (kg/m 2 ) of body weight that an individual carries is associated with a significant increase in the risk of dying from breast cancer and from colorectal cancer. (who.int)
  • Participants who developed colorectal cancer or breast cancer after age 50 years were included in the survival analysis to study how well knowing their average BMI and presence of cardiometabolic diseases before the development of cancer could predict their risk of death. (who.int)
  • In patients with colorectal cancer, the risk of death increased by 6% for every 1 kg/m 2 higher BMI compared with their peers. (who.int)
  • In patients with breast cancer, a higher BMI was associated with a 4% increase in the risk of death for each 1 kg/m 2 above the mean BMI of the cohort. (who.int)
  • Nutritional risk index (NRI) has been shown to better predict survival than body mass index (BMI) or albumin after several cardiovascular interventions. (viamedica.pl)
  • Three-month mortality in patients with no nutritional risk was 6.8% (9/132) vs. 25% (5/20) in patients with malnutrition (p = 0.022). (viamedica.pl)
  • The geriatric nutritional risk index predicts short-term mortality after TAVR and has a higher discriminating ability than other commonly used nutritional variables. (viamedica.pl)
  • Aim The aim of this study was to explore the difference between haemorrhagic events among those patients on either aspirin or aspirin plus clopidogrel who were enrolled in the Clopidogrel in High-Risk Patients with Acute Non-disabling Ischemic Cerebrovascular Events (CHANCE) trial. (bmj.com)
  • However, patients enrolled with minor strokes had an increased risk of haemorrhagic events regardless of treatment group, not seen in patients with high-risk transient ischaemic attacks. (bmj.com)
  • Patients with higher body mass index had lower risk of haemorrhagic events. (bmj.com)
  • Patients with type 2 diabetes mellitus (T2DM) have more than twice the risk of developing heart failure (HF) compared to patients without diabetes. (units.it)
  • We developed two prognostic models using (1) elastic net regularization for Cox proportional hazard model (COX) and (2) a deep neural network survival method (PHNN), in which a neural network was used to represent a non-linear hazard function and explainability strategies are applied to estimate the influence of predictors on the risk function. (units.it)
  • An inverted U-shaped survival function was noted across all time points after 30 days, with the lowest risk of death at a body mass index of approximately 26 kg/m 2 (independent of revascularization strategy). (elsevierpure.com)
  • Independent predictors were age, family history of ovarian cancer (9.8-fold higher risk), anaemia (2.3-fold higher), abdominal pain (sevenfold higher), abdominal distension (23-fold higher), rectal bleeding (twofold higher), postmenopausal bleeding (6.6-fold higher), appetite loss (5.2-fold higher), and weight loss (twofold higher). (bmj.com)
  • Conclusion The algorithm has good discrimination and calibration and, after independent validation in an external cohort, could potentially be used to identify those at highest risk of ovarian cancer to facilitate early referral and investigation. (bmj.com)
  • As there are few established risk factors, targeted screening of asymptomatic patients at risk of developing ovarian cancer is unlikely to be cost effective at present (although further information is likely to become available when the UK ovarian cancer screening trial reports in 2015-6). (bmj.com)
  • Prevention of the disease avoids these problems but requires an ability to predict risk. (biomedcentral.com)
  • The measurement of these hormones was then examined in women who were otherwise at high risk for breast cancer based on other epidemiological factors. (biomedcentral.com)
  • However, risk factors that have been associated with VEGFI-induced hypertension include a previous history of hypertension, combination therapy with more than one anti-VEGFI, over 65 years of age, smoking, and possibly high cholesterol. (science20.com)
  • As VEGF inhibitors become more widely used and the number of older patients with cardiovascular risk factors and pre-existing hypertension are treated with these drugs, the need to better understand the molecular mechanisms underlying VEGF inhibitor-induced hypertension and the risk factors predisposing to this condition are imperative, so that clear guidelines and improved management can be instituted," concludes Dr.Touyz. (science20.com)
  • ABCD2 Score to Predict Stroke Risk after TIA Estimates the risk of stroke following transient ischemic attack. (bmj.com)
  • Atrial Fibrillation CHA(2)DS(2)-VASc Score for Stroke Risk Estimates risk of stroke in patients with atrial fibrillation. (bmj.com)
  • Atrial fibrillation CHADS(2) score for stroke risk Estimates risk of stroke in patients with atrial fibrillation. (bmj.com)
  • BAP-65 prediction of in-hospital mortality and need for mechanical ventilation in COPD Predicts risk of mortality and need for mechanical ventilation in acute exacerbations of COPD. (bmj.com)
  • Bleeding Risk (any bleeding complication) on Warfarin Therapy Estimates risk of any bleeding complications for patients on warfarin. (bmj.com)
  • We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
  • The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio. (aacrjournals.org)
  • A nomogram was generated to predict a patient's probability of MI based on the four independent risk factors. (spandidos-publications.com)
  • An 18-year-old could have inferior immunologic resilience, resulting in a high risk of severe COVID-19, whereas an 80-year-old with robust resilience could manifest less severe COVID-19. (globalhealthnewswire.com)
  • Metrics tracking inferior immunologic resilience predicted up to 19-times higher risk of dying within 30 days, which was the primary outcome of the study. (globalhealthnewswire.com)
  • Results Across all the 1 267 159 patients in the validation dataset, the 50th, 75th, 90th, and 95th centile values for lifetime risk were 31%, 39%, 50%, and 57% respectively. (bmj.com)
  • Of the 10% of patients in the validation cohort classified at highest risk with either the lifetime risk model or the 10 year risk model, only 18 385(14.5%) were at high risk on both measures. (bmj.com)
  • Patients identified as high risk with the lifetime risk approach were more likely to be younger, male, from ethnic minority groups, and have a positive family history of premature coronary heart disease than those identified with the 10 year QRISK2 score. (bmj.com)
  • Conclusions Compared with using a 10 year QRISK2 score, a lifetime risk score will tend to identify patients for intervention at a younger age. (bmj.com)
  • 1 National policies now support targeting of interventions to reduce risk of cardiovascular disease among high risk patients. (bmj.com)
  • Applying this 20% risk threshold for intervention may not identify younger patients who, because of their age, have a low absolute 10 year risk but who have a high relative risk compared with their peers. (bmj.com)
  • Some argue that younger patients with an adverse risk profile may have more to gain during their lifetime if interventions are started at a younger age rather than waiting until they cross the 20% threshold. (bmj.com)
  • 9 10 11 12 Lifetime risks which measure the cumulative risk of developing a disease during the remainder of an individual's life 13 would reflect this relatively high risk and, given that lifetime risk estimates provide assessment over the full life course, they may provide a more appropriate assessment of future risks than estimates limited to 10 years, particularly at younger ages. (bmj.com)
  • ABSTRACT A better understanding of risk factors for neonatal intensive care unit (NICU) admission can inform interventions to improve neonatal survival. (who.int)
  • Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival. (cancercentrum.se)
  • Using higher doses or using it long-term can increase the risk of serious side effects including cancer. (medlineplus.gov)
  • A key difference between the few pancreatic cancer patients who survive long-term and the many whose disease overcomes all treatments is the bacterial signatures on their tumors that either stimulate or suppress immune response, a team led by researchers from The University of Texas MD Anderson Cancer Center reports in the journal Cell . (justbalancinghealth.com)
  • Patients with tumors 2.5-3 cm in initial size went on to develop new or worsened symptoms 17% of the time. (medscape.com)
  • Recent studies have shown that a high aspartate aminotransferase-to-alanine aminotransferase ratio (De Ritis ratio) is associated with a worse prognosis in patients with acute myocardial infarction [2,3] and acute heart failure [4]. (medscimonit.com)
  • We sought to investigate the survival and incidence of acute exacerbations (AEs) and their significant predictors in newly diagnosed patients. (ersjournals.com)
  • Some of these events meet the criteria of acute exacerbations (AEs) and carry a high mortality. (ersjournals.com)
  • A comparison of discharge strategies after chemotherapy completion in pediatric patients with acute myeloid leukemia: A report from the Children's Oncology Group. (chop.edu)
  • 1 Periods of acute worsening of this disease termed exacerbations-which greatly affect the quality of life and health of patients with COPD 2 -will therefore place a greater burden on the health services. (bmj.com)
  • However, patients may also present with other symptoms such as worsening exercise tolerance, fluid retention, increased fatigue, acute confusion, or general malaise. (bmj.com)
  • Association of body mass index with mortality and functional outcome after acute ischemic stroke. (duke.edu)
  • This study was aimed to determine the association of body mass index (BMI) with mortality and functional outcome in patients with acute ischemic stroke. (duke.edu)
  • There is something of a paradox in the relationship between body mass index and hospital mortality in patients with acute coronary syndrome in that the mortality rate decreases as body mass index increases. (hindawi.com)
  • Describing and predicting psychological distress after colorectal cancer. (medscape.org)
  • Predictors of depressive symptomatology of geriatric patients with colorectal cancer: a longitudinal view. (medscape.org)
  • Colorectal cancer-specific and overall mortality according to quintiles of predicted 25(OH)D levels were assessed. (nih.gov)
  • Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002). (nih.gov)
  • The association between being diagnosed with a cardiometabolic disease before cancer and survival in patients with breast cancer and in patients with colorectal cancer was independent of body mass index (BMI). (who.int)
  • Having a higher BMI at ages 20-50 years was associated with poorer survival in patients with breast cancer and in patients with colorectal cancer. (who.int)
  • The levels of postoperative ePD-L1 and ePD-L1 change are independent prognostic factors for overall survival and recurrence free survival of GC patients. (bmj.com)
  • Ovarian cancer is the seventh most common cancer in women worldwide, affecting 225 000 new patients each year. (bmj.com)
  • Introduction/Background The aim of this study was to investigate the role of prognostic nutritional index (PNI) in patients with high-grade serous ovarian cancer (HGSOC) and its relationship with other prognostic factors. (bmj.com)
  • Conclusion Prognostic nutritional index (PNI) is an important prognostic factor in high-grade serous ovarian cancer (HGSOC). (bmj.com)
  • A total of 80 patients with ovarian cancer were selected from the first affiliated hospital of Soochow University in Jiangsu Province from January 2016 to June 2021, including 48 cases that were premenopausal and 32 cases that were menopausal. (hindawi.com)
  • Currently, its standard treatment includes surgery and platinum chemotherapy, but most patients will relapse within 16-22 months due to drug resistance and other factors, and the 5-year survival rate of ovarian cancer is only 46% [ 6 ]. (hindawi.com)
  • Morphometric panel regression equations for predicting body mass in immature humans. (duke.edu)
  • COX regression analysis in the cohort of 127 patients on HD. (revistanefrologia.com)
  • Univariate and bivariate analyses were done to describe the patient population and log-binomial regression was used to quantify the correlates of cytopenia. (biomedcentral.com)
  • Specific guidelines are not yet available for the management of VEGFI-induced hypertension, but expert opinion recommends that patients be fully assessed for hypertension and cardiovascular disease before VEGFI treatment, blood pressure is monitored frequently, and hypertension is aggressively treated to target (less than 140/90 mm Hg). (science20.com)
  • Subjects Patients aged 30-84 years who were free of cardiovascular disease and not taking statins between 1 January 1994 and 30 April 2010: 2 343 759 in the derivation dataset, and 1 267 159 in the validation dataset. (bmj.com)
  • Skeletal muscle mass in relation to 10 year cardiovascular disease incidence among middle aged and older adults: the ATTICA study. (omicsdi.org)
  • When VEGF and other endothelial growth factors bind to their receptors on endothelial cells, signals within these cells are initiated that promote the growth and survival of new blood vessels, which are necessary for tumor growth. (science20.com)
  • PNI is a better predictor of mortality than CA-125 in HGSOC, and that low PNI is associated with high residual tumor burden, advanced stage disease, ascites and platinum resistance, recurrence, and shorter survival. (bmj.com)
  • While recent research has shown that the composition and diversity of microbes living in the digestive tract - the gut microbiome - can affect how cancer immunotherapy works, little research has focused on the bacteria in the tumor and how it might affect prognosis and survival, McAllister said. (justbalancinghealth.com)
  • Due to the large tumor load in advanced patients, drug resistance is easy to occur during chemotherapy. (hindawi.com)
  • Most patients have tumor metastasis and recurrence within 2 years, and the 5-year survival rate is 20%-40% [ 2 ]. (hindawi.com)
  • Although the tumor was considered to have been fully resected and had not spread to any nodes, the patient died of recurrent cancer within 1 year. (medscape.com)
  • Body mass index was a significant, but weak, predictor of revascularization, with higher indexes predicting lower rates of coronary bypass. (elsevierpure.com)
  • Under assessment herein is whether NRI can have higher predictive value than conventional parameters for short-term survival after transcatheter aortic valve replacement (TAVR). (viamedica.pl)
  • Patients with severe aortic stenosis had fewer early strokes with transcatheter aortic valve replacement (TAVR) than with surgical aortic valve replacement (SAVR), new trial results show. (medscape.com)
  • Conclusions The level of plasma postoperative ePD-L1 could be considered as a candidate prognostic biomarker of GC patients after resection. (bmj.com)
  • Conclusions: Extremes of body mass index are associated with lower long-term survival in patients with significant coronary disease. (elsevierpure.com)
  • Conclusions: Although we found a trend favoring full dose cabozantinib, this is likely due to worse baseline disease characteristics among patients starting on a reduced dose. (emory.edu)
  • The reason for this continuing analysis is the need to balance on one hand the desire to help those patients in direct need, versus the statistical likelihood of the patient to survive the procedure, as well as the post-operative risks of infection and transplant rejection. (wikipedia.org)
  • The analysis enrolled 117 patients and the variables included age, body mass index (BMI), neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI), Controlling Nutritional Status score, psoas muscle index (PMI), and peak expiratory flow (PEF). (karger.com)
  • A total of 549 patients were randomly assigned to a training or validation cohort, with a 2:1 ratio. (spandidos-publications.com)
  • While height was not associated with the ability to complete the 10-second OLS, the highest correlation coefficients were found between the inability to complete the test and age and waist-height ratio. (news-medical.net)
  • [ 1 ] Such conditions include chronic pulmonary obstruction (chronic obstructive pulmonary disease [COPD]), interstitial lung disease (ILD), sleep-disordered breathing disorders, alveolar hypoventilation disorders, and long-term exposure to high altitude. (medscape.com)
  • Chronic up-regulation of hypoxic pulmonary vasoconstriction is also the primary mechanism for pulmonary hypertension due to long-term exposure to high altitude. (medscape.com)
  • Yaks have adapted to life in high altitude by blunting pulmonary vasoconstriction in response to chronic hypoxia, which allows them to maintain low pulmonary arterial pressure. (medscape.com)
  • Lung transplantation should be viewed as a potential treatment option for highly selected patients with very advanced chronic lung disease who continue to progress despite maximal medical therapy. (ersjournals.com)
  • However, in some other indications, including chronic obstructive pulmonary disease (COPD), this remains less clear because a substantial improvement in quality of life may not be matched by an increase in overall survival. (ersjournals.com)
  • In the validation cohort from Johns Hopkins, 15 patients had overall survival greater than 10 years, and 10 survived fewer than five years. (justbalancinghealth.com)
  • In many patients with advanced COPD, the small sacs where oxygen and carbon dioxide are exchanged are destroyed, gradually depriving the body of enough oxygen. (adam.com)
  • 4, 5 This is to be expected as patients with COPD may not understand their disease and the importance of seeking treatment, 6- 8 they may be depressed, or lack mobility. (bmj.com)
  • This finding may contribute to improved prognostic stratification in patients with cancer who are affected by cardiometabolic comorbidities. (who.int)
  • Since most patients undergoing TAVR are over 65, the NRI definition for a geriatric population (GNRI) was used. (viamedica.pl)
  • Early (30-day) stroke and postprocedural encephalopathy were higher after SAVR than after TAVR, although at 12 months the rate of stroke did not differ between the two groups. (medscape.com)
  • The results suggest that TAVR might not be worse than SAVR in terms of stroke rate at 1-year follow-up, which adds to the continuously growing body of knowledge that is required for evidence-based treatment decisions for patients with aortic valve stenosis," he said. (medscape.com)
  • The lung allocation score takes into account various measures of a patient's health in order to direct donated organs towards the patients who would best benefit from a lung transplant. (wikipedia.org)
  • The lung allocation score is calculated from a series of formulas that take into account the statistical probability of a patient's survival in the next year without a transplant, and the projected length of survival post-transplant. (wikipedia.org)
  • The scientists developed novel metrics to monitor immunologic resilience and evaluated them in 522 patients with COVID-19 at Audie L. Murphy Memorial Veterans Hospital in San Antonio, a hospital of the U.S. Department of Veterans Affairs (VA). Each patient's level of immunological resilience was assessed on the day of admission and then daily for varying durations. (globalhealthnewswire.com)
  • Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survival. (medscape.org)
  • Oxaliplatin/5FU/LV in adjuvant colon cancer: updated efficacy results of the MOSAIC trial, including survival, with a median follow-up of six years [abstract]. (medscape.org)
  • Hewitt M, Greenfield S, Stovall E. From cancer patient to cancer survivor: lost in transition. (medscape.org)
  • Health-related quality of life of cancer and noncancer patients in Medicare managed care. (medscape.org)
  • Comparison of changes in physical functioning of elderly patients with new diagnoses of cancer. (medscape.org)
  • Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality. (nih.gov)
  • Women who reported the highest levels of physical activity in the year before they were diagnosed with breast cancer may have higher survival, according to a new study. (sciencedaily.com)
  • Identifying factors in cancer patients that predict outcome (i.e., prognosis) is important for physicians planning patient management and patients understanding their disease. (sciencedaily.com)
  • John Wiley & Sons, Inc.. "Exercisers May Have Better Breast Cancer Survival. (sciencedaily.com)
  • Black women have a 36% higher breast cancer mortality rate than other races in spite of having a similar incidence to White women. (sciencedaily.com)
  • This association was independent of whether the patient had been diagnosed with cardiometabolic diseases, such as stroke, myocardial infarction, and type 2 diabetes, before being diagnosed with cancer. (who.int)
  • These results suggest that BMI has a direct effect on cancer survival that is independent of pre-diagnostic cardiometabolic disease. (who.int)
  • Background The satisfactory prognostic indicator of gastric cancer (GC) patients after surgery is still lacking. (bmj.com)
  • And the comparison between postoperative ePD-L1 and conventional serum biomarkers (carcinoembryonic antigen (CEA), cancer antigen 19-9 (CA19-9) and CA72-4) in prognostic of GC patients was made. (bmj.com)
  • The study included female patients aged over 20 years who were diagnosed with primary breast cancer and had medical records in hospitals between January 1, 2009 and December 31, 2020. (tmu.edu.tw)
  • The study successfully established accurate 5-year survival predictive models for breast cancer. (tmu.edu.tw)
  • Furthermore, the study found key factors that could affect breast cancer survival in Taiwanese women. (tmu.edu.tw)
  • 2 Most women are diagnosed with stage III or stage IV cancer, for which the five year survival is 20% and 6%, respectively. (bmj.com)
  • However, the overall 5-year survival from breast cancer reported for Malaysian women was 58% between 1993 and 1997 [ 6 ]. (biomedcentral.com)
  • The purpose of the present study was to investigate the predictive value of metabolic syndrome in evaluating myometrial invasion (MI) in patients with endometrial cancer (EC). (spandidos-publications.com)
  • A number of established nomograms are available to screen lymph node metastasis (LNM), recurrence, overall survival and cancer-specific survival rates in patients with EC ( 5 , 6 ). (spandidos-publications.com)
  • Most patients with pancreatic ductal adenocarcinoma - the most common form of pancreatic cancer - have late-stage disease when diagnosed. (justbalancinghealth.com)
  • Those with earlier stage cancer that can be surgically removed have a high recurrence rate and median survival of 24-30 months. (justbalancinghealth.com)
  • You write that cancer treatments might contribute to subsequent heart disease for patients and might help explain the increase in heart disease mortality. (cdc.gov)
  • Does this analysis suggest that cancer will not overtake heart disease as the leading cause of death in the U.S., which many have been predicting? (cdc.gov)
  • R, Flisberg P, Hedlund L, Östlund I, Bergkvist L. Impact of general anaesthesia on breast cancer survival: a 5-year follow up of a pragmatic, randomised, controlled trial, the CAN-study, comparing propofol and sevoflurane. (cancercentrum.se)
  • The laboratory findings in patients with pancreatic cancer are usually nonspecific. (medscape.com)
  • Although worldwide activity has increased year on year over the last decade ( fig. 1 ), demand has also increased meaning the significant shortage of suitable donor lungs accounts for an unacceptably high waiting list mortality rate in many countries. (ersjournals.com)
  • Prevalence is higher in women, but total mortality is similar in both sexes. (msdmanuals.com)
  • A systematic review of studies documenting the prevalence or incidence of anemia in HIV-infected patient populations reported prevalence rates from 1.3% to 95% [ 5 ]. (biomedcentral.com)
  • The death rates are a reflection of a few things-the prevalence of a disease, how often is occurs in the population, as well as its treatment and survival. (cdc.gov)
  • However, the true prevalence is likely higher than this because autopsy studies reveal that 2.3% of individuals have undiagnosed asymptomatic meningiomas. (medscape.com)
  • The longitudinal associations between bone mineral density and appendicular skeletal muscle mass in Chinese community-dwelling middle aged and elderly men. (omicsdi.org)
  • The present study aimed to investigate longitudinal associations between bone mineral densities (BMDs) and appendicular skeletal muscle (ASM) mass in different regions of the body using three different indicators, in Chinese community-dwelling middle-aged and elderly men. (omicsdi.org)
  • Moreover, primary care clinicians need to decide which patients require urgent investigation or referral and which require routine tests or referral. (bmj.com)
  • Referring clinicians play an essential role in identifying patients who might benefit, but equally need to avoid overwhelming transplant centres with inappropriate referrals which would limit the effectiveness of the centre to assess and list in a timely manner those most likely to benefit. (ersjournals.com)
  • Furthermore, a meticulous approach to post-transplant management in the immediate post-operative period, in the early and long-term has contributed to continually improving long-term survival after lung transplantation. (ersjournals.com)
  • No genomic biomarkers have been identified that shed light on the reasons for long-term survival in that fraction of patients, McAllister said. (justbalancinghealth.com)
  • In the MD Anderson cohort, median survival was 10 years for the long-term survivors (22 patients) and 1.6 years for the short-term survivors (21 patients). (justbalancinghealth.com)
  • DHEA is possibly unsafe when used in high doses or long-term. (medlineplus.gov)
  • [ 2 , 11 ] It is hypothesized that the amount of time spent adapting to life at high altitude is inversely proportional to the magnitude of hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension. (medscape.com)
  • The establishment of this model may promote the use of precision medicine and targeted therapy in EC and has the potential to improve the prognosis of patients affected by EC. (spandidos-publications.com)
  • Baseline evaluation included Medical Research Council dyspnoea score (MRCDS), 6-min walk test, pulmonary function tests, all of which were repeated at 6 months, and high-resolution computed tomography. (ersjournals.com)
  • The impact of baseline BMI, albumin levels, and GNRI on in-hospital and short-term survival was assessed. (viamedica.pl)
  • We evaluated overall survival (OS) and progression-free survival (PFS) associated with baseline lab values. (emory.edu)
  • Increased body mass index (BMI) alters the behavior of adipose tissue, which provides insulin resistance as well as resistance to type-2 diabetes, arterial hypertension, dyslipidemia, and proinflammatory and prothrombotic states, thereby favoring the onset of ischemic cardiopathy [ 3 ]. (hindawi.com)
  • GLP-1 receptor agonists which have been approved for the treatment of type 2 diabetes mellitus have been shown to improve trabecular bone mass in animal studies. (umc.edu)
  • He plans to conduct a non- randomized controlled trial by enrolling 24 post-menopausal patients over 55 years with a history of type 2 diabetes mellitus who are to be started on a GLP-1 receptor agonist with matched controls from the UMMC endocrine clinics. (umc.edu)
  • 70 patients newly diagnosed with IPF were prospectively followed for at least 3 yrs. (ersjournals.com)
  • Moderate or severe haemorrhagic events occurred in 7 patients (0.3%) in the clopidogrel-aspirin group and in 8 (0.3%) in the aspirin group (p=0.73). (bmj.com)
  • Researchers from The University of Texas Health Science Center at San Antonio and the South Texas Veterans Health Care System have unveiled a novel concept, "immunologic resilience," to accurately predict which COVID-19 patients will advance to severe disease and which will not. (globalhealthnewswire.com)
  • Exacerbation rates reported for symptom-based studies tend to be higher than for event-based studies because previous studies have shown that about 50% of exacerbations will not be reported to the research team. (bmj.com)
  • 1 Of these, about 6700 women are in the United Kingdom, giving the UK one of the highest rates in Europe. (bmj.com)
  • However, rHD rates remained higher and were on average 30% greater in NH Black versus NH White males (aRR=1.30 95% CI 1.16, 1.46). (cdc.gov)
  • CONCLUSION: Reported haemophilia-death rates improved in males across all race/ethnicities, but rates were higher Black versus White males. (cdc.gov)
  • Given the inherent limitations of the current study's data source, further investigation of survival rates and disparities in haemophilia are needed. (cdc.gov)
  • In experienced centres, specific patient groups, such as those with cystic fibrosis (CF), can expect a median survival of well over 10 years with some recipients functioning well more than 20 years after their transplant. (ersjournals.com)
  • Stratifying the MD Anderson patients only by this diversity measure showed those with high diversity had median survival of 9.66 years and those with low diversity had median survival of 1.66 years. (justbalancinghealth.com)
  • Results were confirmed in an independent cohort of patients. (ersjournals.com)
  • The results were confirmed in a separate, retrospective cohort of IPF patients from another centre. (ersjournals.com)
  • Results The prognostic value of postoperative ePD-L1 is superior to that of preoperative ePD-L1 on GC patients after resection, and also superior to that of conventional serum biomarkers (CEA, CA19-9 and CA72-4). (bmj.com)
  • Our results suggest that prognostic models for HF in diabetic patients may improve using EHRs in combination with AI techniques for survival analysis, which provide high flexibility and better performance with respect to standard approaches. (units.it)
  • Results: 165 patients were included with a median follow-up time of 33.5 months (mo). (emory.edu)
  • Other lifestyle factors, such as weight, may also predict disease course. (sciencedaily.com)
  • Our analyses suggest that there is a tendency for ALS patients to have lower levels of vitamin D than controls, but most of the studies did not adjust for the mean vitamin D of the country population and failed to report important factors of variability for vitamin D levels (for example, lack of sun exposure). (vitad.org)
  • These factors include measurement of plasma androgens and oestrogens, as well as mammographic density, bone density and body mass index (BMI). (biomedcentral.com)
  • BACKGROUND:A loss of muscle mass may be influenced by multiple factors. (omicsdi.org)
  • In this study, a method based on high performance liquid chromatography-quadrupole/orbitrap mass spectrometry was established for the simultaneous determination of 22 mycotoxins in milk. (bvsalud.org)
  • A total of 3914 patients were included in the study. (tmu.edu.tw)
  • Methodology This retrospective study was conducted on 332 patients. (bmj.com)
  • The study retrospectively included patients with EC who were diagnosed between January 2006 and December 2020 at the Department of Gynecology of Nanjing First Hospital (Nanjing, China). (spandidos-publications.com)
  • In light of this controversy, the goal of this study is to determine the relationship between BMI and intrahospital mortality in patients admitted consecutively for ACS. (hindawi.com)
  • Distribution of study variables in relation to quartiles of total body water, V. (revistanefrologia.com)
  • The objective of this study is to determine the relationship between mortality and Kt/V, Kt and body water content (V) and lean mass (bioimpedance). (revistanefrologia.com)
  • Discussion: This phase II study will explore the benefits of the IL-1β antibody, canakinumab, in the treatment of AH to provide proof of concept that inhibition of IL-1β signaling may improve histology and survival for patients with AH. (imperial.ac.uk)
  • This study evaluated the association between dietary potassium intake and skeletal muscle mass. (omicsdi.org)
  • A retrospective cohort of 68 patients was used for confirmation. (ersjournals.com)