Loading...
  • myeloid
  • Myelofibrosis is a form of myeloid metaplasia, which refers to a change in cell type in the blood-forming tissue of the bone marrow, and often the two terms are used synonymously. (wikipedia.org)
  • radiation therapy
  • The consequences of the treatment of the squamous cell carcinomas of the upper aerodigestive tract (bone removal and external radiation therapy) are constant. (springer.com)
  • Radiation-therapy effects on bone density. (springer.com)
  • endothelial
  • Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts. (degruyter.com)
  • In addition, expression levels of brain-derived neurotrophic factor, vascular endothelial growth factor, and neurotrophic growth factor were increased following transplantation of EPCs. (frontiersin.org)
  • In collaboration with Dr . Shahin Raffi in 1994, a bone marrow-derived endothelial progenitor cell was identified and shown to play an important role in the development of the blood supply of developing tumors. (wikipedia.org)
  • acute
  • CNS prophylaxis: Beginning at least 2 months after transplantation, patients with acute lymphocytic leukemia (ALL) and no history of CNS leukemia receive cytarabine intrathecally (IT) monthly for 6 months and patients with ALL and a history of CNS leukemia receive cytarabine IT monthly for 12 months. (clinicaltrials.gov)
  • transplants
  • Just in the past 12 months, more than 70 patients have received blood and marrow transplants at Perlmutter Cancer Center, which are performed in the specially designed Rita J. and Stanley H. Kaplan Stem Cell and Bone Marrow Transplant Center , located in the brand-new Kimmel Pavilion on NYU Langone's main campus in Manhattan. (pharmiweb.com)
  • Such combinations can prevent the use of other extended and burdensome prophylactic traditional agents and are applicable to people with limited kidney function, who are often denied blood and marrow transplants. (pharmiweb.com)
  • Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. (wikipedia.org)
  • neutropenia
  • Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors" (Free full text). (wikipedia.org)
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • citation needed] G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. (wikipedia.org)
  • ineligible
  • Assess disease free and overall survival and toxicity associated with sequential regimens of mercaptopurine, methotrexate and vincristine, doxorubicin, dexamethasone, and cyclophosphamide, thioguanine, and cytarabine in ALL patients in first remission who are ineligible for allogeneic bone marrow transplantation. (clinicaltrials.gov)
  • Patients
  • PURPOSE: Randomized phase II/III trial to compare the effectiveness of conventional bone marrow transplantation with T cell-depleted bone marrow transplantation in treating patients who have leukemia, myelodysplasia, or lymphoblastic lymphoma. (clinicaltrials.gov)
  • Patients are assigned to one of two treatment arms, one with conventional bone marrow transplantation (arm I) and one with T cell depletion of the bone marrow (arm II). (clinicaltrials.gov)
  • Assess disease free and overall survival and toxicity associated with allogeneic bone marrow transplantation for ALL patients in first remission following induction and consolidation therapy. (clinicaltrials.gov)
  • In BMT group patients will be received CNS radiotherapy at +100 day after transplantation. (clinicaltrials.gov)
  • Ongoing research initiatives include use of MSC infusions for patients who have some evidence of regenerating marrow but have delayed or incomplete hematopoiesis. (springer.com)
  • Based on pioneering work done at Johns Hopkins Cancer Center, the Blood and Marrow Transplant Program also offers haploidentical transplantation to patients. (pharmiweb.com)
  • The Blood and Marrow Transplant Program works closely with the Clinical Leukemia Program at Perlmutter Cancer Center , led by Raoul Tibes, MD, PhD . Dr. Al-Homsi evaluates leukemia patients who require transplantation after their initial treatment provided by the hematologist-oncologists in the leukemia program. (pharmiweb.com)
  • The Clinical Leukemia and Blood and Marrow Transplant Programs really go hand-in-hand, and care for many of the same patients," says Tibes. (pharmiweb.com)
  • In immunocompromised patients, B19 infection may persist for months, leading to chronic anemia with B19 viremia due to chronic marrow suppression. (wikipedia.org)
  • biopsy
  • Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell macrocytosis. (wikipedia.org)
  • Typically, a diagnosis of DBA is made through a blood count and a bone marrow biopsy. (wikipedia.org)
  • infusion
  • Bone marrow infusion is administered on day 0. (clinicaltrials.gov)
  • By combining total body irradiation (TBI) with infusion of allogeneic bone marrow, Thomas's group in 1959 demonstrated the first leukemia cure by HSCT [ 4 ]. (hindawi.com)
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • Conclusions- A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. (ahajournals.org)
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • Transplantation of bone marrow-derived MNCs and infusion of AM were performed in 40 rats immediately after hindlimb ischemia was created. (ahajournals.org)
  • This protocol resulted in the creation of 4 groups: (1) AM infusion plus MNC transplantation (AM+MNC group, n=10), (2) AM infusion plus PBS injection (AM group, n=10), (3) vehicle infusion plus MNC transplantation (MNC group, n=10), and (4) vehicle infusion plus PBS injection (control group, n=10). (ahajournals.org)
  • significantly
  • The rate of bone ingrowth was significantly higher after implantation of BCP + TBM mixture. (springer.com)
  • NEW YORK, Aug. 20, 2018 /PRNewswire/ -- To further advance the study and treatment of blood cancers, Perlmutter Cancer Center at NYU Langone Health has significantly expanded its Blood and Marrow Transplant Program. (pharmiweb.com)
  • platelets
  • Bone pain Bruising and easy bleeding due to inadequate numbers of platelets Cachexia (loss of appetite, weight loss, and fatigue) Enlargement of both the liver and spleen Fatigue Gout and high uric acid levels Increased susceptibility to infection, such as pneumonia Pallor and shortness of breath due to anemia In rarer cases, a raised red blood cell volume Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules. (wikipedia.org)
  • blood
  • The Blood and Marrow Transplant Program is led by nationally renowned hematologist-oncologist, Samer Al-Homsi, MD, MBA , who joined Perlmutter Cancer Center - one of the 70 cancer centers across the country designated by the National Institutes of Health -- in June 2017 to lead the program. (pharmiweb.com)
  • Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of bone marrow-based blood cell formation and the vascular network. (wikipedia.org)
  • Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)
  • cartilage
  • Injury to cartilage can lead to pain and stiffness and is the precursor to the development of osteoarthritis (degenerative joint arthritis). (wikipedia.org)