Precursors cancer cells bone marrow transplantation. Medical search. Frequent questions

Thrombocytopenia 5 is associated with an increased incidence of developing hematological (e.g. chronic myelomonocytic leukemia, acute myelocytic leukemia, B cell acute lymphoblastic leukemia, mixed phenotype acute leukemia, Myelodysplastic syndrome, and multiple myeloma) and non-hematological (e.g. skin and colon) cancers as well as non-malignant diseases such as refractory anemia myopathies, and gastroesophageal reflux disease. (wikipedia.org)
I am a hematologist-oncologist specializing in the care of patients with multiple myeloma and other disorders affecting plasma cells (the cells that produce the antibodies that protect us against infection). (mskcc.org)
Multiple myeloma is a cancer of plasma cells. (invivoscribe.com)
The treatment of multiple myeloma is highly personalized at John Theurer Cancer Center, part of Hackensack University Medical Center in New Jersey. (sparkcures.com)
When you come to John Theurer Cancer Center for multiple myeloma care, we'll perform a comprehensive molecular analysis of your cancer to determine its subtype, and match you with the most appropriate therapy. (sparkcures.com)
John Theurer Cancer Center has one of the largest bone marrow or stem cell transplantation programs in the country for multiple myeloma, performing over 250 transplants a year. (sparkcures.com)
Our program features physicians whose primary focus is transplantation for multiple myeloma. (sparkcures.com)
We also perform more allogeneic transplants (using stem cells from a healthy donor) for multiple myeloma than any other center in our region. (sparkcures.com)
These "precursor" disorders include smoldering multiple myeloma and MGUS (monoclonal gammopathy of undetermined significance). (sparkcures.com)
The Institute for Multiple Myeloma will be located in a state-of-the art research facility at the Hackensack Meridian Health Interprofessional Health Sciences Campus in Nutley and Clifton, NJ, and led by founding director, Dr. David Siegel, chief of the Multiple Myeloma Division at John Theurer Cancer Center. (sparkcures.com)
We bring together all the multiple myeloma experts you may need-offering dedicated highly specialized providers trained at the world's best academic medical centers-from hematology/medical oncology, immunology, stem cell transplantation, infectious diseases, pathology, radiation oncology, orthopedics, and nursing to provide you with a tailored plan of care based on the specific features of your disease and your personal condition. (sparkcures.com)
Engraftment, clinical, and molecular follow-up of patients with multiple myeloma who were reinfused with highly purified CD34+ cells to support single or tandem high-dose chemotherapy. (shengsci.com)
Eighty-two patients with advanced multiple myeloma (MM) were enrolled in 2 sequential clinical studies of 1 or 2 courses of myeloablative therapy with stem cell support. (shengsci.com)
According to the American Cancer Society, about 35,000 multiple myeloma cases are diagnosed yearly in the United States. (karmanos.org)
I do it to give hope to people diagnosed with multiple myeloma that they can get through their cancer journey. (karmanos.org)
Further tests revealed Raithel had smoldering myeloma-a precursor to multiple myeloma. (karmanos.org)
He sought treatment at the Karmanos Cancer Center, where he met with Dr. Zonder, leader of the Multiple Myeloma and Amyloidosis Multidisciplinary Team (MDT) and member of the Hematology Oncology MDT. (karmanos.org)
Karmanos' BMT program is one of the largest in the country with numerous options for treating multiple myeloma and other cancers of blood-forming organs. (karmanos.org)
A Phase 3, randomized, double-blind, placebo-controlled, multicenter study, evaluating the safety, tolerability and efficacy of BL-8040 in combination with G-CSF, compared to placebo and G-CSF, for the mobilization of CD34 cells for autologous transplantation in multiple myeloma patients have already initiated. (biokine.com)
The most commonly diagnosed blood cancers are non-Hodgkin lymphoma, chronic lymphocytic leukemia, acute myeloid leukemia, acute lymphoblastic leukemia and multiple myeloma. (medgadget.com)
To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)
Of all the other cancers, multiple myeloma causes this complication the most. (webmd.com)
Patients with multiple myeloma typically have a preceding phase of disease in which there are changes in the bone marrow but no symptoms or organ damage. (themmrf.org)
The use of a patient's immune system to fight cancer-cancer immunotherapy-is an exciting area of multiple myeloma research. (themmrf.org)

Dr. Tisdale and his colleagues recently completed a modified bone marrow transplant strategy for the first time in adult patients with sickle cell disease. (nih.gov)
In a recent study, they demonstrated that they could transplant bone marrow cells from HLA-matched sibling donors without needing to completely destroy the patient's immune system. (nih.gov)
the Division of Pediatric Blood and Marrow Transplant, University of Minnesota, Minneapolis (M.R.V., H.E.S. (nih.gov)
the Division of Pediatric Blood and Marrow Transplant, Duke University Medical Center, Durham, NC (P.L.M. (nih.gov)
Peter is a senior clinician who established and leads the Paediatric Blood and Marrow Transplant (BMT) Team at The Children's Hospital, Westmead. (kidsresearch.org.au)
Dr. Zonder is referring to the bone marrow transplant that Raithel had just 15 months before he completed the climb across treacherous paths and jagged rocks to reach the Mount Everest base camp at 17,500 feet. (karmanos.org)
His transplant was also done at the Karmanos Cancer Center . (karmanos.org)
After further discussing his treatment options, Raithel opted for a bone marrow transplant (BMT) in January 2016, performed by Lois Ayash, M.D. , hematologist and medical oncologist, and member of the Bone Marrow and Stem Cell Transplant Multidisciplinary Team . (karmanos.org)
Very few patients in this trial were treated with bone marrow transplant which had previously been the standard of care. (childrensmercy.org)
This paved the way for the idea that given the right factors, our own differentiated cells can have their internal clocks turned back, to turn them back into a stem cell just like the one that makes all of those trillion cells that make us who we are, and one day we might be able to use them to grow tissues for transplant. (nhsbt.nhs.uk)
Cook Children's is one of the more experienced pediatric transplant programs in the Southwest, providing children with bone marrow and stem cell transplants since 1986. (cookchildrens.org)
We have been a National Marrow Donor Program transplant center for nearly three decades. (cookchildrens.org)
As a collaborator with leading research facilities and consortiums, Cook Children's is at the forefront of care for patients in need of bone marrow and stem cell transplant. (cookchildrens.org)
Dr. Abutalib is Assistant Director in the Stem Cell Transplant & Cell Therapy Program at Cancer Treatment Centers of America in Chicago. (ascopost.com)
Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
This is an important study, and ultimately, I think our goal is to overcome the use of chemotherapy and radiation, which can destroy healthy cells along with malignant ones," commented Catherine Bollard, MD, MBChB, a bone and marrow transplant specialist at George Washington University/Children's National Medical Health System, Washington, DC. (medscape.com)
Understanding how stem cells behave in the niche is extremely important in order to extract these cells from their natural habitat, expand them in vitro and transplant the stem cells back to the patient, to repair and/or regenerate tissues and organs, with no risks to the individual's integrity. (bvsalud.org)

We hypothesize that engagement of E-selectin ligands on human acute leukemia cells programs efficient BM metastasis and also enables niche lodgment, serving to displace resident HSPCs from their proper growth microenvironment and thereby promoting leukemic cell proliferation. (cancer.gov)
In this proposal, using E-selectin binding assays under both static and fluid shear conditions, together with complementary techniques in flow cytometry and western blotting, we will analyze the E-selectin binding activity of leukemia cells isolated from blood and BM of patients with acute leukemias. (cancer.gov)
This information will be integrated with various biochemical approaches including metabolic inhibition of glycosylation and cell surface glycoengineering to custom-modify sLeX display to assess the extent to which sLeX presentation on a specific protein and/or lipid scaffold licenses E-selectin binding among blasts from various subtypes of human acute leukemias, and the impact of the relevant E-selectin receptor/ligand interaction(s) in leukemia cell biology. (cancer.gov)
The results of proposed studies will be key to elucidating the glycobiology of leukemogenesis, and should also pro- vide fundamental insights for establishing novel strategies to treat acute leukemias by selectively interrupting sLeX expression and/or E-selectin ligand-mediated processes, and for potential therapy/prognosis stratification schemas based on sLeX levels and/or the expression of distinct E-selectin ligands on acute leukemia cells. (cancer.gov)
Relevance: Acute leukemia arises because abnormal white cell precursors proliferate within special growth zones within the bone marrow. (cancer.gov)
Increase in blood cells is typically categorized as myelogenous or lymphocyte and each case have acute or chronic form in relation to the cell type involved. (nmmra.org)
however, because lymphoblastic lymphoma and acute lymphoblastic leukemia (ALL) are known to represent the same disease entity, the World Health Organization (WHO) classification has unified these entities as precursor B-cell and T-cell lymphoblastic leukemia/lymphoma. (medscape.com)
Besides, IL-11 can increase the production of proteins in the liver during acute inflammation, and inhibit the formation of fat cells. (creative-proteomics.com)
Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. (shengsci.com)
Previous studies have shown that children with acute myeloid leukemia (AML) who developed mixed chimerism (MC) were at high risk for relapse after allogeneic stem-cell transplantation (allo-SCT). (shengsci.com)
In the context of relapsed and refractory childhood pre-B cell acute lymphoblastic leukemia (R/R B-ALL), CD19-targeting chimeric antigen receptor (CAR)-T cells often induce durable remissions, which requires the persistence of CAR-T cells. (nature.com)
B-lineage acute lymphoblastic leukemia (B-ALL) is the most common type of childhood cancer and mostly derives from immature B cells that carry the cell surface antigen CD19 (ref. 1 ). (nature.com)
CLINICAL CASE: 7-year-old male schoolboy diagnosed with T-precursor acute lymphoid leukemia, finishing induction chemotherapy cycle with PETHEMA 2013 protocol. (bvsalud.org)
In a single-center phase 1-2a study, the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel produced high rates of complete remission and was associated with serious but mainly reversible toxic effects in children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). (nih.gov)
2013) High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation. (kidsresearch.org.au)
In August of 2017, tisagenlecleucel (Kymriah) was approved for the treatment of children and adolescents with B-cell acute lymphoblastic leukemia (ALL) who have relapsed or not responded to chemotherapy. (childrensmercy.org)
Patient-Reported Quality of Life After Tisagenlecleucel Infusion in Children and Young Adults with Relapsed or Refractory B-Cell Acute Lymphoblastic Leukaemia: A Global, Single-Arm, Phase 2 Trial. (childrensmercy.org)
Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia. (childrensmercy.org)
Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
Cook Children's is honored to be one of only five pediatric cancer treatment centers to participate in Total Therapy Study XVII , a clinical research trial for patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. (cookchildrens.org)
Attention is focused on clonal myeloid disorders, acute lymphoblastic leukemia, lymphoma, and plasma cell dyscrasias. (ascopost.com)
Immunoglobulin Heavy Chain High-Throughput Sequencing in Pediatric B-Precursor Acute Lymphoblastic Leukemia: Is the Clonality of the Disease at Diagnosis Related to Its Prognosis? (frontiersin.org)
High-throughput sequencing (HTS) of the immunoglobulin heavy chain ( IgH ) locus is a recent very efficient technique to monitor minimal residual disease of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). (frontiersin.org)
B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is the most common pediatric neoplasm ( 1 , 2 ). (frontiersin.org)
The results seen with the recently approved novel agent blinatumomab ( Blincyto , Amgen Inc) are "notable," say authors reporting a trial in which monotherapy produced complete remission in almost half of patients with relapses or refractory B-precursor acute lymphoblastic leukemia (ALL). (medscape.com)
After acute infection, EBV establishes a lifetime latent infection in B cells. (yusukeokuno.com)

TRANSPLANTATION: 2-Drug Combination Myeloablative Chemotherapy followed by Radiotherapy followed by Hematopoietic Rescue plus GVHD Prophylaxis. (knowcancer.com)
Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
For many hematopoietic malignancies, collection and infusion of CD34+ hematopoietic stem/progenitor cells following chemotherapy is critical. (bdbiosciences.com)
Bone marrow transplants from healthy donors are used successfully to treat certain blood cancers for which the course of the disease is so severe that the destruction of the patient's own immune system through high-dose chemotherapy and radiation seems an effective compromise. (nih.gov)
However, relapsed ALL remains a leading cause of childhood death despite intensive cytotoxic chemotherapy often including allogeneic bone marrow transplantation. (nature.com)
They can also be used for increasing white blood cell survival and for chemotherapy. (justia.com)
Treatment of various cancers increasingly involves cytoreductive therapy, including high dose chemotherapy or radiation therapy. (justia.com)
After harvesting, the patient is given high dose chemotherapy or radiotherapy and the bone marrow function is reconstituted by infusion of the cells harvested earlier. (justia.com)
The use of high-dosage chemotherapy or radiotherapy for bone marrow ablation requires subsequent incorporation of hematopoietic stem cells into the patient, in which case prior harvesting of such cells is required. (justia.com)
Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
The most common situations are for patients receiving chemotherapy, requiring surgery (especially cardiac surgery) or having experienced severe haemorrhage (e.g. from pregnancy or childbirth, trauma, largely from road traffic accidents, or severe anaemia in the young, often caused by malaria), often being combined with other blood products such as fresh frozen plasma (FFP) and red blood cells (RBCs) in a massive transfusion protocol. (nhsbt.nhs.uk)
Mobilization human CD34+ cells for the purpose of donor (allogeneic) transplantation after high-dose chemotherapy is currently performed using a 4-5-day treatment cycle with G-CSF and a 1-2 day apheresis procedure. (biokine.com)
Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
G-CSF decreases the morbidity of cancer chemotherapy by reducing the incidence of febrile neutropenia, the morbidity of high-dose chemotherapy supported by marrow transplantation, and the incidence and duration of infection in patients with severe chronic neutropenia. (allindianpatents.com)

Although human HSCs as vehicles to treat metachromatic leukodystrophy (MLD) has been used to treat patients with early onset MLD in a phase I/II trial, the HSCs give rise to all different blood cell lineages, such as the myeloid and lymphoid cell lineages [ 11 ]. (hindawi.com)
MDS is a clonal disorder of myeloid stem cells. (medscape.com)
[ 1 ] ETP-ALL frequently has mutations in RUNX1 and/or ETV6 in addition to genes that are more commonly associated with myeloid neoplasms and are otherwise rare in T-cell lymphoblastic leukemia/lymphoma (such as FLT3 , IDH1/2 , TET2 , and DNMT3A mutations). (medscape.com)
Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
And, malignancy in the myeloid lineage that includes precursor cells to red blood cells, platelets and white blood cells such as granulocytes. (medgadget.com)
Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)
U2AF1 pathogenic variants in myeloid neoplasms and precursor states: distribution of co-mutations and prognostic heterogeneity. (cdc.gov)

2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
Myelodysplastic syndrome (MDS) in childhood is a diverse group of clonal bone marrow disorders characterized by peripheral cytopenia, dysplastic changes in the bone marrow, and ineffective hematopoiesis. (medscape.com)
Applications Tested: This 2H7 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. (thermofisher.com)
Between February 1986 and March 1990, 56 patients with relapsed Hodgkin's disease treated with high-dose cyclophosphamide, carmustine, and etoposide (CBV) received an autologous peripheral stem cell transplantation (PSCT) rather than an autologous bone marrow transplantation (ABMT) because each patient had a marrow abnormality, either hypocellularity or tumor involvement. (shengsci.com)
At least 6.5 x 10(8) [corrected] mononuclear cells/kg patient weight were collected from the peripheral blood of each patient, cyropreserved, and returned intravenously following CBV administration. (shengsci.com)
Recent studies have shown that soluble factors elaborated by human T lymphocytes enhance erythroid burst formation by human peripheral blood null cells. (shengsci.com)
Improved methods and pharmaceutical compositions are provided herein for mobilizing hematopoietic progenitor cells from bone marrow into peripheral blood, comprising the administration of an effective amount of an inhibitor of GTPases, such as Rac1 and Rac2 alone or in combination. (justia.com)
Specifically, methods are disclosed for mobilizing hematopoietic stem cells into a subject's peripheral blood. (justia.com)
In particular, embodiments of the method involve inhibition of both Rac1 and Rac2 GTPases to increase the numbers of hematopoietic stem cells into a subject's peripheral blood of a subject. (justia.com)
Therefore, hematopoietic stem cells mobilized into a subject's peripheral blood by the method of the invention is useful as a source of donor cells in bone marrow transplantation for the treatment of a variety of disorders, including cancer, anemia, autoimmunity and immunodeficiency. (justia.com)
The present invention relates generally to improved methods and pharmaceutical compositions for mobilizing hematopoietic stem and progenitor cell from bone marrow into peripheral blood by administration of at least one inhibitor of a GTPase, such as Rac1 and/or Rac2 GTPase. (justia.com)
In such procedures, patients undergo successive treatments with cell mobilization agents to cause mobilization of hematopoietic progenitor cells from the bone marrow to the peripheral circulation for harvesting. (justia.com)
NK cells were obtained from peripheral blood (PB) of healthy volunteers. (springer.com)
Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
The researchers used whole-exome sequencing to detect the presence of clonal hematopoiesis of indeterminate potential in peripheral blood cells and associated that discovery with coronary heart disease using samples from 4 case-control studies that together enrolled 4,726 participants with coronary heart disease and 3,529 controls. (ascopost.com)
Diagnosis requires demonstration of peripheral normocytic anemia and a normocellular bone marrow biopsy with absence of erythroid precursors. (msdmanuals.com)
Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)

Blinatumomab engages the T lymphcytes to destroy leukemia cells (FDA, 2014). (southcarolinablues.com)
This state may persist until a clone undergoes further transformation to leukemia and the marrow becomes fibrotic and aplastic. (medscape.com)
Leukemia: Cancer that starts in blood-forming tissue such as the bone marrow and causes large numbers of blood cells to be produced and enter the bloodstream. (nmmra.org)
Leukemia, the most common blood cancer, includes several diseases. (nmmra.org)
Although leukemia affects approximately 10 times more adults than children, leukemia is the most common cancer among children, with ALL accounting for approximately 73 percent of all childhood leukemia's. (nmmra.org)
Although several subtypes of T-cell lymphoblastic leukemia/lymphoma exist, early T-cell precursor lymphoblastic leukemia (ETP-ALL) is the only subtype recognized as an entity in the revised 2016 WHO tumor classification. (medscape.com)
Non-ETP subtypes of T-cell lymphoblastic leukemia/lymphoma, in contrast, are associated with activating NOTCH1 mutations in over half of all patients and an additional 10% to 15% of cases have FBXW7 mutations, which also result in increased NOTCH signaling. (medscape.com)
This persistence signature was also detected in two adult patients with chronic lymphocytic leukemia with decade-long remissions who received a different CD19 CAR-T cell product. (nature.com)
An exception was long-lived CAR-T cells in two adult individuals with a different cancer-chronic lymphocytic leukemia (CLL)-in whom anti-CD19 CAR-T cells have persisted for almost a decade thus far 7 . (nature.com)
Kymriah is a novel cellular immunotherapy that reprograms a patient's own immune system to identify and kill leukemia cells. (childrensmercy.org)
Kymriah is manufactured by harvesting the patient's own T-cells using leukapheresis and engineering these cells to attack a specific target on leukemia cells, CD19. (childrensmercy.org)
ALL is the most common type of cancer and leukemia in children in the United States. (medscape.com)
The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
According to Leukemia Research Foundation, in2019, every three minutes, someone is diagnosed with blood cancer more than 175,000 new cases are expected in the United States. (medgadget.com)
Additionally,Leukemia is diagnosed 10 times more often in adults than children.New cases of leukemia, lymphoma and myeloma are expected to account for 10 percent of the estimated 1,762,450 new cancer cases diagnosed in the US in 2019. (medgadget.com)
RUNX1-positive leukemia cells in preclinical models. (lu.se)

In 30-50% of patients, the lymphoblasts infiltrate bone marrow, causing ineffective hematopoiesis. (medscape.com)
A generalized marrow dysfunction with an abnormal bone marrow stroma (in terms of its ability to support and maintain hematopoiesis) is thought to be present in addition to a stem cell defect. (medscape.com)
Depending on the degree of bone marrow damage (i.e., suppression), patients who undergo cytoreductive therapy must also receive therapy to reconstitute bone marrow function (hematopoiesis). (justia.com)
Although bone marrow fibrosis is seen in a variety of malignant and non-malignant disease states, the deposition of reticulin and collagen fibrosis in the bone marrow of patients with myelofibrosis is believed to be mediated by the myelofibrosis hematopoietic stem/progenitor cell, contributing to an impaired microenvironment favoring malignant over normal hematopoiesis. (haematologica.org)
4 Maintenance of hematopoiesis: role of early b cell factor 2 matthias kieslinger. (vinastemcelllab.com)

Upregulate the expression in various malignant diseases, and play a role in promoting cancer proliferation, tumor survival and metastasis by activating JAK / STAT3, RAS / ERK, PI3K / mTOR and other signaling pathways. (creative-proteomics.com)
IL-11 cooperates with IL-3 and IL-4 to stimulate the proliferation of hematopoietic stem cells at rest, and affects the generation and differentiation of red blood cells. (creative-proteomics.com)
CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. (thermofisher.com)
NK cell proliferation, phenotypic expression and cytotoxic activity were evaluated. (springer.com)
It stimulates the survival, proliferation, differentiation and function of neutrophil granulocyte progenitor cells and mature neutrophils. (allindianpatents.com)
describes a novel colony stimulating factor (CSF) that has the ability to promote the differentiation and proliferation of human bone marrow cells to neutrophils, and a method to produce the same from a novel cell line which has been established from tumor cells in patients with oral cancer, The most published studies have used filgrastim as it was the first form of G-CSF to be approved. (allindianpatents.com)
1 Neural stem/progenitor cell proliferation and differentiation: role of sonic hedgehog and wingless/int-1 proteins. (vinastemcelllab.com)
13 Proliferation of bone marrow-derived human mesenchymal stem cells: role of enamel matrix proteins. (vinastemcelllab.com)
Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)

Relapsed or refractory was defined as relapsed with first remission duration of less than 12 months in the first salvage, or relapsed or refractory after first salvage therapy, or relapsed within 12 months of allogeneic hematopoietic stem cell transplantation (HSCT), and had greater than 10 percent blasts in bone marrow. (southcarolinablues.com)
The objective of this investigation is to assess the impact of VZV infection on patients' long-term survival following allogeneic hematopoietic stem cell transplantation (allo-HSCT). (bvsalud.org)
METHODS: This retrospective study investigated the association between varicella-zoster virus (VZV) reactivation and outcomes in 219 individuals who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) at the Sun Yat-sen University's First Affiliated Hospital. (bvsalud.org)
Following treatment with blinatumomab, 45 out of 61 (74%) patients in CR1 and 14 out of 25 (56%) patients in CR2 underwent allogeneic hematopoietic stem cell transplantation in continuous hematologic complete remission. (ons.org)

30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
An accurate measurement of CD34 is critical for dose requirement protocols in stem cell transplantation. (bdbiosciences.com)
Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
The BD ® Stem Cell Enumeration (SCE) Assay enumerates total viable CD34+ and CD45+ cells as a percentage of total viable leukocytes. (bdbiosciences.com)
This is a tool to help students find the right project for their Bachelor's and Master's thesis at Lund Stem Cell Center. (lu.se)
The construction of this cell line is the first promising step in the regulation of GAL secretion from hTERT-immortalized BMSCs, and the potential application of this system may provide a stem cell-based research platform for pain. (hindawi.com)
Studies have increasingly focused on the potential therapeutic effects of stem cell transplantation for neurological diseases [ 10 ]. (hindawi.com)
Indeed, the potent pathotropic migratory properties of BMSCs and ability to circumvent both the complications associated with immune rejection of allogenic cells and many of the moral reasons associated with embryonic stem cell use suggest that BMSCs are most promising stem cells as a potential target for the clinical use of genetically engineered stem cells [ 14 , 15 ]. (hindawi.com)
How- ever, conspicuously, E-selectin is constitutively expressed on bone marrow (BM) sinusoidal vessels where it is known to play a key role in mediating migration of circulating cells to BM, a process critical to blood cell recovery following hematopoietic stem cell transplantation (HSCT). (cancer.gov)
For pediatric patients with refractory cytopenia, certain cytogenetic abnormalities, or malignant transformation, hematopoietic stem cell transplantation (HSCT) from a matched related or unrelated donor early in the course of the disease is the treatment of choice. (medscape.com)
Aberration occurs in a stem cell that can give rise to multiple lineages. (medscape.com)
Lymphomas related to lymphoproliferative disorders following bone marrow or stem cell transplantation are usually B-cell non-Hodgkin lymphomas. (nmmra.org)
Curative options for sickle cell disease: haploidentical stem cell transplantation or gene therapy? (nih.gov)
the Division of Stem Cell Transplantation and Immunology, Hospital for Children and Adolescents, University Hospital Frankfurt, Frankfurt, Germany (P.B. (nih.gov)
the Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, and the Cancer Research Institute Ghent (CRIG), Ghent, Belgium (B.D.M. (nih.gov)
the Stem Cell Transplantation Unit, St. Anna Children's Hospital, Vienna (C.P. (nih.gov)
This special cell is a blood stem cell and we now routinely use radiation and bone marrow transplantation to cure many blood cancers. (nhsbt.nhs.uk)
It also used to be thought that once a stem cell differentiates, it can never go back. (nhsbt.nhs.uk)
Yamanaka and colleagues discovered in the mid-2000s how to "reprogram" fully differentiated cells (like a bit of your skin) back into a stem cell state, winning them a Nobel Prize - these are called induced pluripotent stem cells, or iPSCs. (nhsbt.nhs.uk)
Hematopoietic stem cell transplantation remains the only curative therapeutic approach that reliably results in resolution of bone marrow fibrosis in patients with myelofibrosis. (haematologica.org)
3 Myelofibrosis (MF) refers to the Philadelphia chromosome ( BCR-ABL1 )-negative myeloproliferative neoplasm (MPN) originating at the level of the multipotent hematopoietic stem cell. (haematologica.org)
Under normal conditions the CXCR4 pathway regulates the hematopoietic stem cell niche in the bone marrow (BM)-a property that has led to the approval of the CXCR4 antagonist plerixafor together with G-CSF (AMD3100, Mozobil) for mobilization from the BM and collection of hematopoietic precursors from the blood for transplantation of myeloma and lymphoma patients. (biokine.com)
In order to better appreciate the role of stem cell research in reproductive medicine, there is a need to understand the critical biological principles of stem cell research and its potential applications to medicine. (jcpa.org)
While there is a great deal published on the potential medical applications of stem cell research to treat or cure diseases such as diabetes, Alzheimer's disease, Parkinson's disease, cancer, and heart disease, much less has been published on the future impact of stem cell research in reproductive medicine. (jcpa.org)
Stem cell research is, in part, a quest to understand cellular differentiation, the process by which a human being develops from one fertilized cell into a multicellular organism composed of over 200 different cell types - for example muscle, nerve, blood cell, or kidney. (jcpa.org)
Cellular differentiation begins with the fertilized egg which serves as the identifying characteristic of an embryonic stem cell. (jcpa.org)
In addition, specific proteins or biological substances can be added to these stem cell cultures to transform them in the laboratory into a large variety of specialized cell types, such as nerve, liver, muscle, bone, and blood cells. (jcpa.org)
In 2009, in a major reversal of U.S. policy, President Obama signed an executive order pledging to "vigorously support" embryonic stem cell research. (jcpa.org)
Hematopoietic Stem Cell Transplantation Hematopoietic stem cell (HSC) transplantation is a rapidly evolving technique that offers a potential cure for hematologic cancers ( leukemias, lymphomas, myeloma) and other hematologic disorders. (msdmanuals.com)
Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)
To determine whether antigen-specific immunity, induced in the stem cell donor, can be passively transferred to the allogeneic SCT recipient in the setting of a non-myeloablative conditioning regimen. (drugpatentwatch.com)
Autologous Stem Cell Transplantation (ASCT) remains the standard of care for newly diagnosed, eligible patients. (themmrf.org)
A third of these patients subsequently underwent allogeneic hemopoietic stem cell transplantation. (medscape.com)
The study reported by Dr Topp and colleagues enrolled 189 patients with Philadelphia chromosome-negative, primary refractory or relapsed disease (first relapse within 12 months of first remission, relapse within 12 months after allogeneic hemopoietic stem cell transplantation, or no response to or relapse after first salvage therapy or beyond). (medscape.com)
Stem cell therapy has the potential to overcome these limitations and may offer the best outcomes for treating diabetes mellitus. (vinastemcelllab.com)
Based on the pathophysiology of diabetes mellitus, stem cell therapy targets two mechanisms, namely cell replacement and immune correction. (vinastemcelllab.com)
These findings provide hope for a new strategy that can improve the outcomes of stem cell-based therapy for diabetes in humans. (vinastemcelllab.com)
12 Induced pluripotent stem cell production and characterization: an overview of somatic cell reprogramming. (vinastemcelllab.com)
19 Mesenchymal stem cell-natural killer cell interactions. (vinastemcelllab.com)
21 The cancer stem cell hypothesis and its impact on the design of new cancer therapies. (vinastemcelllab.com)
22 Breast cancer stem cell: translating to the clinic. (vinastemcelllab.com)
24 Proteomic characterization of mesenchymal stem cell-like populations derived from various tissue types. (vinastemcelllab.com)
25 Severe combined immunodefieciency patients: immune recovery after stem cell transplantation. (vinastemcelllab.com)
Comparable survival outcomes with haploidentical stem cell transplantation and unrelated bone marrow transplantation. (cdc.gov)
Some adult stem cell niches have already been described, but the majority of them remain unclear, including the dental pulp stem cell niches. (bvsalud.org)
Likewise, the knowledge of stem cell biology is crucial to the development of stem cell therapies, based on tissue engineering applied to dentistry, seeking the regeneration of dental tissues damaged or lost by caries, trauma or genetic diseases. (bvsalud.org)
However, further studies are required to gain complete understanding of stem cell biology, which is fundamental for the development of successful cell-based therapies 1-3 . (bvsalud.org)

For the reconstruction of bone marrow hematopoietic function after bone marrow transplantation and radiotherapy Sexual blood cell deficiency is of great value. (creative-proteomics.com)

CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. (thermofisher.com)
2013) Limb preservation surgery with extracorporeal irradiation in the management of malignant bone tumor: the oncological outcomes of 101 patients. (kidsresearch.org.au)
Malignant cancer cells accumulate in the bone marrow, crowding out normal plasma cells that fight infection. (karmanos.org)
The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
20 Malignant gliomas: treatment using genetically-modified neural stem cells. (vinastemcelllab.com)
This study revealed the malignant transformation of EBV-infected cells in CAEBV. (yusukeokuno.com)
The lytic reactivation caused by the deletions is suggested to drive the malignant transformation of infected cells. (yusukeokuno.com)

Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients, report researchers publishing in the current issue of Cell Transplantation (19:11). (medicaldaily.com)
Transduction of CLL cells by CD40 ligand enhances an antigen-specific immune recognition by autologous T cells. (shengsci.com)
G-CSF can be used to increase the numbers of circulating haemopoietic precursor cells which are then harvested by leucapheresis and used either as a supplement to or a substitute for aspirated bone marrow cells in autologous haemopoietic cell transplants. (allindianpatents.com)
Cell Replacement Therapy for Parkinson's Disease - Evaluating the potential of autologous grafting. (lu.se)

Childhood MDS is more commonly associated with inherited bone marrow failure syndromes and other genetic disorders. (medscape.com)
Shwachman-Diamond syndrome is considered one of the inherited bone marrow failure syndromes. (medscape.com)

Dr. Tisdale has an active research program in trying to characterize tolerance and create conditions in which patients will more easily tolerate donor cells and tissues without the need for destroying the immune system or perpetual use of immunosuppressant drugs. (nih.gov)

Bone marrow stem cells, including the pluripotent hematopoietic stem cells (HSCs) and bone mesenchymal stem cells (BMSCs), are being considered as potential targets for cell and gene therapy-based approaches against a variety of different diseases. (hindawi.com)
Genetic abnormalities associated with MDS block differentiation of hematopoietic stem and progenitor cells. (medscape.com)
IL-11 has effects on hematopoietic stem cells, megakaryocytes, lymphocytes and fat cells. (creative-proteomics.com)
In addition, strategies to correct the underlying mutation which causes sickle cell disease are being pursued utilizing newly developed gene editing tools, and work in the laboratory to develop methods for efficient editing of hematopoietic stem cells is underway. (nih.gov)
The various mature blood cell types are all ultimately derived from a single class of progenitor cell known as hematopoietic stem cells. (justia.com)
Other cell types derived from hematopoietic stem cells include platelets and erythrocytes. (justia.com)
Current treatments to manage the problems that result from prolonged bone marrow suppression include the reinfusion of a patient's own previously harvested hematopoietic stem and progenitor cells. (justia.com)
In many cases, successfully mobilization is not effected in the patient and inadequate numbers of hematopoietic stem cells are harvested from these patients using current methods. (justia.com)
MSCs were obtained from the bone marrow (BM) cells remaining in the bag and filter used in the transplantation of hematopoietic stem cells. (springer.com)
We discuss the rationale of various anti-fibrogenic treatment strategies targeting the clonal hematopoietic stem/progenitor cell, aberrant signaling pathways, fibrogenic cytokines, and the tumor microenvironment. (haematologica.org)
It is arise from hematopoietic stem and progenitor cells in the bone marrow. (medgadget.com)
Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) were derived from syngenic mouse bone marrow. (vinastemcelllab.com)
Early fate decisions in hematopoietic stem and progenitor cells. (lu.se)

Partner with us to treat your patient's cancer. (mskcc.org)
After extracting and isolating precursor CD34+ cells from patients, they use viral transduction to insert a correct copy of the β-globin gene before returning the cells to the patient's bone marrow. (nih.gov)
These therapies decrease a patient's white blood cell counts, suppress bone marrow hematopoietic activity, and increase the patient's risk of infection and/or hemorrhage. (justia.com)
Our Cellular Immunotherapy team is committed to providing individualized treatment that specifically targets a patient's cancer, with the goal of decreasing side effects and improving cure rates. (cookchildrens.org)

We employed in vitro cultures and two in vivo models to investigate whether androgens exert these effects directly on marrow lymphoid precursors or whether actions on marrow stromal elements are required. (jci.org)

Non-Hodgkin Lymphoma: Any of a large group of cancers of the immune system. (nmmra.org)
There are many different types of non-Hodgkin lymphoma, which can be divided into aggressive (fast-growing) and indolent (slow-growing) types and can be classified as either B-cell or T-cell non-Hodgkin lymphoma. (nmmra.org)
B-cell non-Hodgkin lymphomas include Burkitt lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, precursor B-lymphoblastic lymphoma, and mantle cell lymphoma. (nmmra.org)
T-cell non-Hodgkin lymphomas include mycosis fungoides, anaplastic large cell lymphoma, and precursor T-lymphoblastic lymphoma. (nmmra.org)
20% lymphoblasts in marrow), a diagnosis of lymphoblastic lymphoma is made. (medscape.com)
Lymphoma is a cancer that starts in cells that are part of the body's immune system. (invivoscribe.com)
Under the leadership of Dr. Siegel, and alongside hematology experts like Dr. André Goy, chairman and executive director, division chief of Lymphoma at John Theurer Cancer Center, the Institute will focus on driving innovative research, and continuing the development of precision medicine for each patient. (sparkcures.com)
Large deletions of the viral genome were frequent across three diseases (CAEBV, extranodal NK/T-cell lymphoma, diffuse large B-cell lymphoma). (yusukeokuno.com)

Myeloma cells destroy bone , which releases calcium, a condition called hypercalcemia. (webmd.com)
Myeloma cells produce excess abnormal proteins, called paraproteins, in the bone marrow that can cause your blood to become so thick that it flows sluggishly in your body, a condition called hyperviscosity. (webmd.com)
Abnormal proteins from myeloma cells can also damage the kidneys. (webmd.com)

Bone marrow transplantation 2022 9 57 (12): 1781-1787. (cdc.gov)

The FDA approval of Blincyto was based on results of Amgen's '211 trial, a phase 2, multicenter, single-arm open-label study involving 185 adults with Philadelphia chromosome-negative relapsed or refractory precursor B-cell ALL (Amgen, 2014). (southcarolinablues.com)
Eligible patients were greater than 18 years of age with Ph- relapsed or refractory B-cell precursor ALL. (southcarolinablues.com)
The FDA is requiring the manufacturer to conduct a study to verify that the drug improves survival in participants with relapsed or refractory Philadelphia-negative precursor B-cell ALL. (southcarolinablues.com)
CAT CAR-T cells showed greater cytotoxicity and proliferative responses in vitro and maintained long-lived molecular remissions in children with relapsed or refractory ALL, as demonstrated in the CARPALL study 3 . (nature.com)
We conducted a phase 2, single-cohort, 25-center, global study of tisagenlecleucel in pediatric and young adult patients with CD19+ relapsed or refractory B-cell ALL. (nih.gov)
In this global study of CAR T-cell therapy, a single infusion of tisagenlecleucel provided durable remission with long-term persistence in pediatric and young adult patients with relapsed or refractory B-cell ALL, with transient high-grade toxic effects. (nih.gov)
An international phase 2 study treated 75 patients with relapsed or refractory B-cell ALL with Kymriah. (childrensmercy.org)
The drug was recently approved by the US Food and Drug Administration for patients with Philadelphia chromosome-negative precursor B-cell ALL who have relapsed or who were refractory to previous treatment. (medscape.com)

Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell macrocytosis. (wikipedia.org)
In this setting, immediately perform a bone marrow aspiration and obtain a biopsy from the posterior iliac crest. (medscape.com)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
We know that innate immune cells are required for blastema progenitor cell formation, but are lacking an understanding of the immune cell processes and functions that are required for inducing and maintaining these progenitors cells. (lu.se)
This project will delve into innate immune cell function, establishing in vitro and in vivo systems test innate immune cell function in regeneration. (lu.se)
This will be coupled with next generation sequencing based approaches to understanding the consequences of perturbing immune cell function. (lu.se)
Normal plasma cells are found in the bone marrow and are an important part of the immune system. (invivoscribe.com)
For example, we are the first team in the world to combine checkpoint inhibitors (drugs that work by inhibiting the proteins cancer cells use to evade detection by the immune system) after transplantation, at a time where the newly reset immune system has the best opportunity to eliminate residual cancer cells. (sparkcures.com)
The issue of immune tolerance is, of course, central to transplantation research. (nih.gov)
BACKGROUND: A virus infection may lead the body to produce more immune cells of particular types or stimulate the production of new ones, both of which may have anti-leukemic effects. (bvsalud.org)
There has been no research on whether immune cells stimulated by varicella-zoster virus (VZV) infection have anti-leukemic effects. (bvsalud.org)
BL8040 which as the ability to reshape the microenvironment and is tested in pancreatic cancer indication together with immune check point inhibitors such as Pembrolizumab (Keytruda, Merck) and Atezolizumab (Tecentriq, Genentech/Roche). (biokine.com)
Pure red blood cell (RBC) aplasia is most often due to an inappropriate immune response causing suppression of erythropoiesis. (msdmanuals.com)
The many distinct sorts of mature blood cells, like red blood cells for carrying oxygen, white blood cells for immune protection and platelets for wound clotting. (medgadget.com)
This strategy, along with others, is harnessing our immune system to target cancer cells. (medscape.com)
However, blinatumomab's dependence on circulating immune cells may limit the ability to combine it with myelosuppressive therapies, Dr Thomas notes. (medscape.com)
The aim of this series of studies was to evaluate the efficiency of diabetic treatment by combining cell replacement therapy with immune correction therapy. (vinastemcelllab.com)
2) T cell deficiencies affect the function in killing infected cells or helping other immune cells. (lu.se)

the Department of Pediatrics and Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, and the Pauline Allen Gill Center for Cancer and Blood Disorders, Children's Health, Dallas (T.W.L. (nih.gov)
Aflac Cancer and Blood Disorders Center, Emory University, Atlanta (M.Q. (nih.gov)
That is why at Cook Children's Hematology and Oncology Center, we are working every day to bring more innovative research, ground-breaking medical treatments and trail-blazing clinical trials to children with cancer and blood disorders - so that one day - our wish to erase kid cancer and blood disorders will come true. (cookchildrens.org)
The Cook Children's Histiocytic Disorders Program is experienced in treating a wide range of histiocytic disorders including Langerhans cell histiocytosis (LCH) and hemophagocytic lymphohistiocytosis (HLH) and offers the most comprehensive and highest level of care in North Texas. (cookchildrens.org)
Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
1) Antibody deficiency disorders are defects in immunoglobulin-producing B cells . (lu.se)

The SBDS gene may not be required for neutrophil maturation but may act to maintain survival of granulocyte precursor cells. (medscape.com)
The 30 patients who had no marrow metastases at the time of PSC harvesting had an actuarial event-free survival of 47%, while those 26 patients with marrow metastases had a significantly different actuarial event-free survival of 27% (P = .02). (shengsci.com)
CBV and PSCT for patients with relapsed Hodgkin's diseases who have marrow hypocellularity in traditional harvest sites or histopathologic evidence of BM metastases can result in long-term event-free survival. (shengsci.com)
A 2018 study suggests that thinking problems are tied to lower survival rates in people with blood cancer . (webmd.com)
The results showed that transplantation of both IPCs and HSCs elicited greater improvements in body weight, blood glucose level and survival time than did transplantation of HSCs or IPCs alone. (vinastemcelllab.com)

ALL in samples of leukemic blood and bone marrow. (knowcancer.com)
Although a subset of children can be cured, up to 60% of children experience further, typically fatal, disease recurrence due to non-persistence of CAR-T cells or CD19 − leukemic escape 3 , 4 . (nature.com)
6 Causes of early death include leukemic transformation, complications arising from progressive bone marrow failure, portal/pulmonary hypertension, infections, thrombosis and bleeding. (haematologica.org)
The precise pathogenetic events leading to the development of ALL are still unknown, but evidence supports the hypothesis of driver mutations followed by secondary events, that can occur in subclones of the original leukemic cell following different evolution patterns ( 5 , 6 ). (frontiersin.org)
2 Sensitivity of hematopoietic and leukemic stem cells to hoxa gene levels. (vinastemcelllab.com)

however, this virus occasionally causes cancer or intractable diseases. (yusukeokuno.com)
Therapies based on the application of stem cells have great potential in the prevention and treatment of several diseases, such as cancer, diabetes, cardiovascular disease, spinal cord injuries, neurological diseases such as Parkinson's and Alzheimer's, and in the regeneration of various tissues and organs. (bvsalud.org)

Flow cytometric applications for CD34+ cell identification and enumeration provide a rapid, quantitative and reproducible method to evaluate the progenitor cell population. (bdbiosciences.com)
Enhancement of human erythroid progenitor cell growth by media conditioned by a human t-lymphocyte line. (shengsci.com)

Immature B cells from normal mouse bone marrow were not responsive to the suppressive effect of androgens unless they were cocultured with marrow stromal cells or with supernatants from androgen-treated stromal cells, suggesting that the androgen effects are exerted through marrow stromal elements by production of a diffusible mediator. (jci.org)

Blinatumomab is the first of a novel class of drugs known as bispecific T-cell engagers and is designed to direct cytotoxic T cells to CD19-expressing cancer cells. (medscape.com)

Studies to understand the pathophysiology of bone marrow failure are currently underway. (medscape.com)

For patients with precursor B-cell ALL (pre-B ALL), about 10-15% of these patients don't respond to traditional treatments or relapse. (cookchildrens.org)

Does Transplantation Induce Aging In Patients? (medicaldaily.com)
National Cancer Consciousness Week is a week-long celebration held annually to increase public knowledge and understanding of cancer and to provide support to cancer patients and survivors. (nmmra.org)
It is unclear whether one can generalize from two adult patients treated for CLL to other hematological malignancies and patient groups, in particular to childhood ALL, or to other CAR-T cell products. (nature.com)
We studied 15 consecutive patients with high-risk or relapsed CD19 + B-ALL treated with CD19 CAR-T cell therapy on the CARPALL study ( NCT02443831 ) and in whom adequate CAR-T cells could be isolated for subsequent analyses from cryopreserved samples of blood or bone marrow. (nature.com)
The Children's Hospital at Westmead cares for several hundred young cancer patients every year. (kidsresearch.org.au)
The research our doctors conduct continuously informs their care decisions for children with cancer, and our clinical trials ensure constant improvement in the outcomes of our patients. (kidsresearch.org.au)
CMH is now one of only a handful of children's hospitals treating patients on a clinical trail for newly diagnosed patients with B-cell ALL with a slower than expected response to treatment. (childrensmercy.org)
Purchase a shirt embellished with a shiny gold ribbon to honor our patients who are fighting childhood cancer. (cookchildrens.org)
We're so excited to offer KYMRIAH® which is the first and only FDA approved CAR T-cell therapy for pediatric pre-B ALL patients. (cookchildrens.org)
About 20% of cancer patients get hypercalcemia during their illness. (webmd.com)
This webcast features evidence-based presentations along with patient cases designed to address the nuances of T cell-activating therapy use, identification of patients that are the best candidates for these approaches, and options for patients who may not be candidates for this therapy. (themmrf.org)
The most common adverse reactions to blinatumomab in at least 20% of patients with MRD-positive B-cell precursor ALL were pyrexia, infusion related reactions, headache, infections (pathogen unspecified), tremor, and chills. (ons.org)
In collaboration with the FDA and as a service to our members, ONS provides updates on recent FDA approvals and other important FDA actions (e.g., updated safety information, new prescribing information) pertaining to therapies for patients with cancer. (ons.org)
20% of the patients carried somatic driver mutations such as DDX3X mutations in their EBV-infected cells. (yusukeokuno.com)
Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
En outre, il y avait une aug- mentation significative de la forme soluble du c-kit dans le sérum des patients atteints de pemphigus vulgaire actif par rapport aux témoins. (who.int)

However, its gene, ETV6 frequently suffers various mutations that lead to an array of potentially lethal cancers, i.e. (wikipedia.org)
However, ETV6 is also an anti-oncogene or tumor suppressor gene in that mutations in it that encode for a truncated and therefore inactive protein are also associated with certain types of cancers. (wikipedia.org)
the gene is expressed in virtually all cell types and tissues. (wikipedia.org)
Mice depleted of the ETV6 gene by Gene knockout die between day 10.5 and 11.5 of embryonic life with defective yolk sac angiogenesis and extensive losses in mesenchymal and neural cells due to apoptosis. (wikipedia.org)
Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of bone marrow-based blood cell formation and the vascular network. (wikipedia.org)
The human IL-11 gene encodes a precursor protein containing 199 amino acids. (creative-proteomics.com)
The laboratory has focused on optimizing the conditions for viral transduction, including selecting and modifying viral strains for study in animal models, optimizing growth conditions for transduced hematopoietic cells, and designing gene vectors to ensure appropriate placement and expression of the inserted gene. (nih.gov)
In this study, we systematically analyzed CD19 CAR-T cells of 10 children with R/R B-ALL enrolled in the CARPALL trial via high-throughput single-cell gene expression and T cell receptor sequencing of infusion products and serial blood and bone marrow samples up to 5 years after infusion. (nature.com)
Geoffrey is a Paediatric Oncologist and a lead investigator on the MGMT Cancer Gene Therapy Trial. (kidsresearch.org.au)

A common reference range for the absolute neutrophil count (ANC), which is calculated on the basis of the percentage of neutrophils in the white blood cell count (see the Absolute Neutrophil Count calculator) is 2500-8000/µL. (medscape.com)
CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
There is increasing evidence that these growth zones are created by the display of particular sugar molecules on the surface of blood cells that act like Velcro to anchor the cells to marrow vessels. (cancer.gov)
Diagnosis of MDS is made based upon evaluation of blood and bone marrow, cytogenetic abnormalities, and blast percentage. (medscape.com)
Kidney cancer includes renal cell carcinoma (cancer that forms in the lining of very small tubes in the kidney that filter the blood and remove waste products) and renal pelvis carcinoma (cancer that forms in the center of the kidney where urine collects). (nmmra.org)
IL-11 used in vivo can effectively shorten the period of bone marrow suppression, accelerate the recovery of white blood cells and platelets. (creative-proteomics.com)
The Cellular and Molecular Therapeutics Laboratory, led by Dr. John F. Tisdale, is working on multiple strategies both in the laboratory and in the clinic to cure sickle cell disease by repairing or replacing the precursor bone marrow cells that give rise to sickled red blood cells. (nih.gov)
The unadulterated mutation encourages hemoglobin to clump and deform red blood cells, leading to anemia, increased hemolysis, and vascular occlusions that affect multiple organs. (nih.gov)
Sequential rounds of division and differentiation give rise to an enormous amplification of cell numbers, necessary for the production of mature blood cells. (justia.com)
These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
Radiation affects cells that divide quickly, especially blood - red cells only last about 120 days in circulation, and platelets only 5 days. (nhsbt.nhs.uk)
Research found that by transplanting just one specific bone marrow cell, it was possible to regenerate the entire blood forming system. (nhsbt.nhs.uk)
There have been no major advances to improve the storage of platelets beyond 7 days, compared with 35-40 days for red blood cells, making these a comparatively perishable blood product. (nhsbt.nhs.uk)
Acquired pure red blood cell aplasia is a disorder of erythroid precursors that results in an isolated normocytic anemia. (msdmanuals.com)
White blood cells and platelets are not affected. (msdmanuals.com)
Overview of Decreased Erythropoiesis Anemia, a decrease in the number of red blood cells (RBCs), hemoglobin (Hb) content, or hematocrit (Hct), can result from decreased RBC production (erythropoiesis), increased RBC destruction. (msdmanuals.com)
The onset of pure red blood cell anemia usually is insidious, often occurring over weeks or months. (msdmanuals.com)
Pure RBC aplasia manifests with a normocytic anemia but normal white blood cell and platelet counts. (msdmanuals.com)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)
hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
Hematological malignancies are the kinds of cancer affecting blood, bone marrow and lymph nodes. (medgadget.com)
A malignancy in the lymphoid lineage that includes white blood cells such as T lymphocytes and B lymphocytes. (medgadget.com)
Rising incidence of blood cancer and availability of advanced healthcare infrastructure are the majorfactors driving the growth of the Hematologic Malignancie market. (medgadget.com)
The researchers advise doctors to test people with blood cancer for problems with their thinking skills to better care for them. (webmd.com)
Blood cancer journal 2023 9 13 (1): 149. (cdc.gov)
thymus from marrow-derived progenitors circulating in the blood. (lu.se)
HN - 2008 BX - Granulosa Cells, Cumulus MH - Coronary Sinus UI - D054326 MN - A07.231.908.194.500 MS - A short vein that collects about two thirds of the venous blood from the MYOCARDIUM and drains into the RIGHT ATRIUM. (bvsalud.org)

The drug acts as a connector between CD19 protein, which is found on the surface of most B-cell lymphoblasts, and CD3 protein, which is found on T-cell lymphocytes. (southcarolinablues.com)
Lymphocytes, B and T cells, can respond selectively to thousands of non-self materials. (lu.se)

It also includes Wilms tumor, which is a type of kidney cancer that usually develops in children under the age of 5. (nmmra.org)
Evidence suggests that the CXC-chemokine receptor-4 (CXCR4) pathway plays a major role in cancer cell homing and metastasis and in shaping the tumor microenvironment (TME), and thus represents a potential target for cancer therapy. (biokine.com)

This condition arises from immature T cells in more than 80% of cases and immature B cells in the remainder of cases. (medscape.com)
107 immature T-cells per day competence. (lu.se)

Lymphoblastic leukemias/lymphomas are neoplasms of precursor T cells and B cells or lymphoblasts. (medscape.com)
See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)

IL-11 can enhance the differentiation of pluripotent stem cells under the growth factor, and promote the differentiation of B cells that produce immunoglobulin under T cell dependence. (creative-proteomics.com)
True stem cells are both pluripotent-that is they can give rise to all cell types-and capable of self-renewal. (justia.com)
6 Induced pluripotent stem cells from human extra-embryonic amnion cells: role of dna methylation in mainting stemness. (vinastemcelllab.com)
14 Pluripotent cell-derived glial precursor cells for the delivery of therapeutic proteins to the central nervous system. (vinastemcelllab.com)

Mr Souradip Mookerjee is an MB/PhD student in Dr Cedric Ghevaert's Lab at the University of Cambridge, working on the translational research of making platelets from stem cells. (nhsbt.nhs.uk)

A number of studies indicate that bone marrow fibrosis is an adverse prognostic variable in myeloproliferative neoplasms. (haematologica.org)

The specific effect on bone marrow fibrosis of JAK2 inhibition, and other rationally based therapies currently being evaluated in myelofibrosis, has yet to be fully elucidated. (haematologica.org)
At the ASH meeting, one expert commented that she believes that new therapies such as this one will revolutionize treatment of hematologic cancers. (medscape.com)

ETV6 interacts with other proteins that regulate the differentiation and growth of cells. (wikipedia.org)
This process of division and differentiation is subject to regulation at many levels to control cell production. (justia.com)
2016). Natural killer cell-based adoptive immunotherapy eradicates and drives differentiation of chemoresistant bladder cancer stem-like cells. (springer.com)
5 Differentiation of periodontal stem/progenitor cells: roles of tgf-β1. (vinastemcelllab.com)
7 Smooth muscle cell differentiation from embryonic stem cells: role of hdac7 and pdgf-bb. (vinastemcelllab.com)
9 Tendon injury: role of differentiation of aduilt and embryonic derived stem cells. (vinastemcelllab.com)
At these sites, which are a compound of stromal cells, extracellular matrix and soluble factors, complex molecular interactions that maintain the essential properties of stem cells occur, such as self-renewal and differentiation into multiple lineages, according to the organism's needs. (bvsalud.org)

1 Improvements in transplantation techniques, including the wider use of cell selection, have contributed to a significant reduction in the morbidity and mortality associated with conventional transplantation. (bdbiosciences.com)

Scientists have now come up with a new technology that involves cancer diagnosis through a simple urine test using a strip of paper, making diagnosis simple and affordable for people. (medicaldaily.com)
Conversely, a diagnosis of ALL generally requires at least 20% lymphoblasts in marrow. (medscape.com)

The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)
The stromal cell products responsible for these effects of estrogens have not been identified. (jci.org)
When administered post-stroke, mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) induce neuroprotection, promote brain remodeling and plasticity, and enhance neurological recovery in rodents and non-human primates via mechanisms that involve immunomodulation and anti-inflammation. (explorationpub.com)
Recently, mesenchymal stromal cell (MSC)-derived small extracellular vesicles (EVs) have emerged as a potential new therapeutic agent for stroke treatment. (explorationpub.com)

Cancers 2021;13(3). (yusukeokuno.com)

The ETV6 protein regulates the development and growth of diverse cell types, particularly those of hematological tissues. (wikipedia.org)
Inspired from developmental processes, human mesenchymal cell lines can be programmed to form cartilage, bone and bone marrow tissues in vitro and in vivo. (lu.se)
Kidney (Renal Cell) Cancer: Cancer that forms in tissues of the kidneys. (nmmra.org)
Lung Cancer: Cancer that forms in tissues of the lung, usually in the cells lining air passages. (nmmra.org)
Examination of single T cell transcriptomes from a wide range of healthy and diseased tissues across children and adults indicated that the persistence signature may be specific to long-lived CAR-T cells. (nature.com)

We systematically studied molecular features and clonal dynamics of CAR-T cells in children enrolled in the CARPALL study at serial timepoints, from production to persistence, up to 5 years after infusion. (nature.com)

The use of human telomerase reverse transcriptase-immortalized bone marrow mesenchymal stromal cells (hTERT-BMSCs) as vehicles to deliver antinociceptive galanin (GAL) molecules into pain-processing centers represents a novel cell therapy strategy for pain management. (hindawi.com)

This event explains the presence of multiple derangements observed in the bone marrow that involve several cell lineages. (medscape.com)

Anatomy24

Organisms13

Diseases62

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment78

Psychiatry and Psychology1

Phenomena and Processes48

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Named Groups2

Health Care14

Multiple myeloma24

Transplant17

Acute28

Chemotherapy15

Myeloid7

Peripheral19

Leukemia16

Hematopoiesis5

Proliferation9

Allogeneic hematopoietic stem c4

Stem cell47

Radiotherapy1

Malignant7

Autologous4

Inherited bone marrow failure syndromes2

Donor1

Hematopoietic stem13

Patient's4

Lymphoid precursors1

Lymphoma8

Myeloma3

20221

Refractory8

Biopsy2

Immune16

Disorders7

Survival5

Leukemic5

Diseases2

Progenitor cell2

Mouse bone marrow1

Cytotoxic1

Pathophysiology1

Relapse1

Patients16

Gene9

Blood27

Lymphocytes2

Tumor2

Immature2

Leukemias3

Pluripotent4

Platelets1

Neoplasms1

Therapies2

Differentiation7

Morbidity and morta1

Diagnosis2

Stromal cell4

20211

Tissues5

Clonal1

Mesenchymal stromal1

Lineages1