Loading...
  • GVHD
  • The therapeutic potential of DCs in transplantation has recently become the focus of intense research, with the emerging concept of using "tolerogenic" DCs in the graft to silence host immunity and enhance engraftment, while also preventing GVHD ( 12 - 16 ). (rupress.org)
  • vivo
  • This property may be tested directly by explanting tissue in vitro , and is mirrored by significant differences in turnover between DCs and macrophages after stem cell transplantation in vivo . (biomedsearch.com)
  • Prospective scintigraphic studies with 123 I-labelled serum amyloid P component (SAP), a specific quantitative method for imaging amyloid deposits in vivo ( Hawkins et al , 1990 ), have confirmed that amyloid deposits of AA, AL and other types regress in most patients in whom the supply of the respective amyloid fibril precursor protein can be reduced ( Hawkins, 1994 ). (wiley.com)
  • To study the mechanism of the lipoprotein changes on bone marrow transplantation, the in vivo turnover of autologous serum (β)VLDL was studied. (ahajournals.org)
  • biopsy
  • They also undergo a bone marrow biopsy and aspiration. (clinicaltrials.gov)
  • Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell macrocytosis. (wikipedia.org)
  • mice
  • In particular, the bone marrow is the major site of B cell development in adult mice. (pnas.org)
  • This accords with ontogenetic studies in mice showing that most steady-state DCs are derived from committed DC-restricted precursors independently of monocytes. (biomedsearch.com)
  • The influence of apoE gene dosage on serum lipid concentrations was determined by transplantation of homozygous apoE-deficient (apoE −/− ), heterozygous apoE-deficient (apoE +/− ), and wild-type (apoE +/+ ) bone marrow in homozygous apoE-deficient mice. (ahajournals.org)
  • The concentration of apoE detected in serum was found to be gene dosage dependent, being 3.52±0.30%, 1.87±0.17%, and 0% of normal in transplanted mice receiving either apoE +/+ , apoE +/− , or apoE −/− bone marrow, respectively. (ahajournals.org)
  • After 4 months on a "Western-type" diet, atherosclerosis was evidently reduced in mice transplanted with apoE +/+ bone marrow, compared with control transplanted mice. (ahajournals.org)
  • Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of bone marrow-based blood cell formation and the vascular network. (wikipedia.org)
  • citation needed] G-CSF is used clinically (see Neutropenia) but tests in mice suggest it may lead to bone loss. (wikipedia.org)
  • infusion
  • Bone marrow infusion is administered on day 0. (clinicaltrials.gov)
  • Methods and Results- Immediately after hindlimb ischemia was created, rats were randomized to receive AM infusion plus bone marrow-derived mononuclear cell (MNC) transplantation (AM+MNC group), AM infusion alone (AM group), MNC transplantation alone (MNC group), or vehicle infusion (control group). (ahajournals.org)
  • Conclusions- A combination of AM infusion and MNC transplantation caused significantly greater improvement in hindlimb ischemia than MNC transplantation alone. (ahajournals.org)
  • When these findings are taken together, combination therapy with MNC transplantation and AM infusion may have additional or synergetic effects on therapeutic angiogenesis for the treatment of severe peripheral vascular disease. (ahajournals.org)
  • Thus, the purposes of the present study were (1) to investigate whether local infusion of AM enhances the angiogenic potency of MNC transplantation in a rat model of hindlimb ischemia and (2) to investigate the effects of AM on the survival, adhesion, and differentiation of transplanted MNCs. (ahajournals.org)
  • Transplantation of bone marrow-derived MNCs and infusion of AM were performed in 40 rats immediately after hindlimb ischemia was created. (ahajournals.org)
  • This protocol resulted in the creation of 4 groups: (1) AM infusion plus MNC transplantation (AM+MNC group, n=10), (2) AM infusion plus PBS injection (AM group, n=10), (3) vehicle infusion plus MNC transplantation (MNC group, n=10), and (4) vehicle infusion plus PBS injection (control group, n=10). (ahajournals.org)
  • human bone
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • protein
  • All of the members of IL-1 family, except IL-1Ra, are first synthesized as a precursor protein, which means it is synthesized as a long form of a protein which has to be proteolytically cleaved to a shorter, active molecule, which is generally called a mature protein. (wikipedia.org)
  • hematologic
  • He is Head of the Division of Hematologic Oncology, Alan Houghton Chair in Immunology, Attending Physician on the Adult Bone Marrow Transplantation Service, and Member at Memorial Sloan Kettering Cancer Center (MSKCC) in New York, New York. (wikipedia.org)
  • signal peptide
  • IL-1α is a unique member in the cytokine family in the sense that the structure of its initially synthesized precursor does not contain a signal peptide fragment (same is known for IL-1β and IL-18). (wikipedia.org)
  • cartilage
  • Injury to cartilage can lead to pain and stiffness and is the precursor to the development of osteoarthritis (degenerative joint arthritis). (wikipedia.org)
  • blood
  • Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)
  • severe
  • To evaluate a new method of stem cell transplantation that may reduce the possibly of severe side effects or transplant rejection in the recipient. (clinicaltrials.gov)
  • Myelokathexis, a congenital disorder of severe neutropenia characterized by accelerated apoptosis and defective expression of bcl-x in neutrophil precursors" (Free full text). (wikipedia.org)
  • organ
  • An elusive goal in organ transplantation and the treatment of autoimmune diseases is the induction of tolerance. (rupress.org)
  • Bone marrow suppression due to azathioprine can be treated by changing to another medication such as mycophenolate mofetil (for organ transplants) or other disease-modifying drugs in rheumatoid arthritis or Crohn's disease. (wikipedia.org)
  • murine bone
  • Tolerogenic DCs have been generated in the presence of 1,25(OH) 2 D 3 , the active form of vitamin D 3 , and of vitamin D 3 analogues from both human blood monocytes and murine bone marrow and shown to induce Treg ( 8 , 9 , 10 ). (jimmunol.org)
  • clinical
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • vitro
  • In this report, we present evidence that two known immunosuppressive neuropeptides, the vasoactive intestinal peptide (VIP) and the pituitary adenylate cyclase-activating polypeptide (PACAP), contribute to the development of bone marrow-derived tolerogenic DCs in vitro and in vivo. (jimmunol.org)
  • lesions
  • Clinically, the typical initial presentation of BPDCN is presence of asymptomatic cutaneous lesions that are subsequently followed by bone marrow involvement and leukemic dissemination (5, 10). (czytelniamedyczna.pl)
  • No evidence of bone lesions, anemia, hypercalcemia, or renal insufficiency related to the paraprotein, and No evidence of another B-cell proliferative disorder. (wikipedia.org)
  • accumulation
  • Thus, bone fragility, osteoporosis, and osteoporotic fractures are thought to be linked to mechanisms which promote MAT accumulation. (wikipedia.org)
  • phenotype
  • MAT, by its "specific marrow location, and its adipocyte origin from at least LepR+ marrow MSC is separated from non-bone fat storage by larger expression of bone transcription factors", and likely indicates a different fat phenotype. (wikipedia.org)
  • neoplasm
  • At the other end of this spectrum, detection of the myeloid protein indicates the presence of a hematological malignancy, i.e. multiple myeloma, Waldenström's macroglobulinemia, or other B cell-associated neoplasm, that derives stepwise from its MGUS precursors. (wikipedia.org)
  • primarily
  • This is in contrast to Shwachman-Bodian-Diamond syndrome, in which the bone marrow defect results primarily in neutropenia, and Fanconi anemia, where all cell lines are affected resulting in pancytopenia. (wikipedia.org)
  • density
  • A study in mice has shown that G-CSF may decrease bone mineral density. (wikipedia.org)
  • Marrow adipose tissue (MAT) increases in states of low bone density -osteoporosis, anorexia nervosa/ caloric restriction, skeletal unweighting, anti-diabetes therapies). (wikipedia.org)
  • Antiresorptive therapies like risedronate or zoledronate also decrease MAT while increasing bone density, supporting an inverse relationship between bone quantity and MAT. (wikipedia.org)
  • Magnetic resonance imaging (MRI) provides MAT assessment in the vertebral skeleton in conjunction with μCT-based marrow density measurements. (wikipedia.org)
  • however
  • However, alternative splicing of its Precursor mRNA results in multiple transcript variants encoding distinct FIP1L1 protein isoforms. (wikipedia.org)
  • Methods
  • Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)
  • Live
  • Phosphatidylserine and phosphatidylglycerol can serve as precursors of other membrane lipids in bacte- ria (Fig. Reviews the most important thing to start live trafing trading binary options grant date, T. (binaryinternationalreviews.com)
  • role
  • Visceral abdominal fat (VAT) is a distinct type of WAT that is "proportionally associated with negative metabolic and cardiovascular morbidity", regenerates cortisol, and recently has been tied to decreased bone formation Both types of WAT substantially differ from brown adipose tissue (BAT) as by a group of proteins that help BAT's thermogenic role. (wikipedia.org)
  • group
  • This protocol resulted in the creation of 4 groups: (1) AM infusion plus MNC transplantation (AM+MNC group, n=10), (2) AM infusion plus PBS injection (AM group, n=10), (3) vehicle infusion plus MNC transplantation (MNC group, n=10), and (4) vehicle infusion plus PBS injection (control group, n=10). (ahajournals.org)