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  • acute lymphobl
  • Intrachromosomal amplification of chromosome 21 (iAMP21), defined as the presence of three or more RUNX1 signals on one marker chromosome, is a distinct cytogenetic subgroup of childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) that is known to have a poor prognosis when treated with standard therapy. (bloodresearch.or.kr)
  • Earlier in the past century, infections were regarded as the most likely cause of childhood B-cell precursor acute lymphoblastic leukemia (pB-ALL). (aacrjournals.org)
  • As GSI-I (Z-LLNle-CHO) is also a derivative of a widely used proteosome inhibitor MG-132, we hypothesized that this compound might be active in precursor-B acute lymphoblastic leukemia (ALL) cell lines and patient samples. (pubmedcentralcanada.ca)
  • Precursor-B acute lymphoblastic leukemia (precursor-B ALL) is the most common neoplasm in children and young adults. (pubmedcentralcanada.ca)
  • Amyloid
  • AICD, the C-terminal tail generated from the proteolytic cleavage of the Amyloid Precursor Protein (APP), has been generating interest for its transcriptional modulatory roles. (nus.edu.sg)
  • molecule
  • APP is best known as the precursor molecule whose proteolysis generates beta amyloid (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. (wikipedia.org)
  • progenitor cells
  • Recent studies have shown that several blood-vessel-derived precursor cell populations, purified by flow cytometry from multiple human organs, give rise to bona fide MSCs, suggesting that the vasculature serves as a systemic reservoir of MSC-like stem/progenitor cells. (hindawi.com)
  • Following the hypothesis that blood vessels throughout the body serve as a systemic reservoir of multipotent stem/progenitor cells, we and other researchers have identified, purified, and characterized distinct populations of MSC-like multilineage precursors from the vasculature of multiple human organs [ 17 , 22 ]. (hindawi.com)
  • Precursor cells, or Progenitor cells, have many potential uses in medicine. (wikipedia.org)
  • There is research being done to use these cells to build heart valves, blood vessels and other tissues, by using blood and muscle precursor, or progenitor cells. (wikipedia.org)
  • Variants
  • This chapter discusses the range of oral cavity precursor lesions, the many histologic variants of oral squamous carcinoma, the Risk Model, resection margin assessment, and summarizes the new staging criteria (8th AJCC). (springer.com)
  • analyze
  • A portable, advanced sensor based on infrared spectroscopy in a hollow fiber matched to a silicon-micromachined fast gas chromatography column can analyze illegal stimulants and precursors with nanogram-level sensitivity. (wikipedia.org)
  • The stationary phase approximation can be used to analyze the form of precursor waves without solving the general-form integral given in the Basic Theory section above. (wikipedia.org)
  • cells
  • In this review, we will discuss the identification and characterization of perivascular MSC precursors, including pericytes and adventitial cells, and focus on their cellular kinetics: cell adhesion, migration, engraftment, homing, and intercellular cross-talk during tissue repair and regeneration. (hindawi.com)
  • Recently, several studies have indicated that MSCs represent a heterogeneous entity in culture, and a number of multipotent precursor cells potentially contributing to the MSC pool have been identified in vivo [ 16 , 17 ]. (hindawi.com)
  • In cell biology, a precursor cell, also called a blast cell or simply blast, is a partially differentiated cell, usually referred to as a unipotent cell that has lost most of its stem cells properties. (wikipedia.org)
  • Precursor cells are known as the intermediate cell before they become differentiated after being a stem cell. (wikipedia.org)
  • Sometimes precursor cell is used as an alternative term for unipotent stem cells. (wikipedia.org)
  • The retina is generated from the precursor cells within the inner layer of the optic cup, as opposed to the retinal pigment epithelium that originate from the outer layer of the optic cup. (wikipedia.org)
  • In general, the developing retina is organized so that the least-committed precursor cells are located in the periphery of the retina, while the committed cells are located in the center of the retina. (wikipedia.org)
  • The differentiation of retinal precursor cells into the mature cell types found in the retina is coordinated in time and space by factors within the cell as well as factors in the environment of the cell. (wikipedia.org)
  • Shh has been shown to repress the differentiation of precursor cells into retinal ganglion cells. (wikipedia.org)
  • This expression coincides with the fact that committed cells are located in the center of the developing retina while undifferentiated cells are concentrated in the periphery Fz5 expression is implicated in differentiation of retinal precursor cells to a neural fate. (wikipedia.org)
  • known
  • A precursor cell is also known as a progenitor cell. (wikipedia.org)
  • This solution, which is an oscillatory function with amplitude and period that both increase with increasing time, is characteristic of a particular type of precursor known as the Sommerfeld precursor. (wikipedia.org)
  • The particular type of precursor characterized by increasing period and amplitude is known as the high-frequency Sommerfeld precursor. (wikipedia.org)
  • In religion, a precursor, also known as forerunner, predecessor, harbinger or herald, is a holy person who announced the approaching appearance of a prophet or who identified a prophet during the latter's childhood. (wikipedia.org)
  • Neuropeptide VF precursor, also known as pro-FMRFamide-related neuropeptide VF or RFamide-related peptide precursor, is a propeptide that in mammals is encoded by the NPVF (or RPFP) gene. (wikipedia.org)
  • often
  • In this letter, we show for the first time that electrical precursors are strongly correlated with-and often precede-any outward sign of a slip event in a powder bed. (pnas.org)
  • Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available on short notice and/or in large quantities. (wikipedia.org)
  • products
  • Mixtures and natural products that contain the substances defined above are also considered precursors. (bfarm.de)
  • One mir-2 microRNA in Drosophila, dme-miR-2a-2 , is two nucleotides offset with respect to the canonical products of other mir-2 precursors. (wikipedia.org)
  • export
  • We show that Exportin-5 (Exp5) mediates efficient nuclear export of short miRNA precursors (pre-miRNAs) and that its depletion by RNA interference results in reduced miRNA levels. (sciencemag.org)
  • region
  • Precursors were first theoretically predicted in 1914 by Arnold Sommerfeld for the case of electromagnetic radiation propagating through a neutral dielectric in a region of normal dispersion. (wikipedia.org)
  • In a region of anomalous dispersion, where low-frequency components have faster group velocities than high-frequency ones, the opposite of the above situation occurs: the onset of the precursor is characterized by a long period, and the period of the signal decreases with time. (wikipedia.org)
  • Mutations in critical regions of amyloid precursor protein, including the region that generates amyloid beta (Aβ), cause familial susceptibility to Alzheimer's disease. (wikipedia.org)
  • group
  • The stationary phase approximation states that for any speed of wave propagation determined from any distance and time , the dominant frequency of the precursor is the frequency whose group velocity equals : Therefore, one can determine the approximate period of a precursor waveform at a particular distance and time by calculating the period of the frequency component that would arrive at that distance and time based on its group velocity. (wikipedia.org)
  • surface
  • Trace detection of explosives and their precursors by surface enhanced Raman spectroscopy. (wikipedia.org)
  • This non-specificity has been confirmed by the observation of precursor patterns in different types of electromagnetic radiation (microwaves, visible light, and terahertz radiation) as well as in fluid surface waves and seismic waves. (wikipedia.org)
  • family
  • Mir-2 hairpin precursor sequences are highly conserved, in particular in their 3' arm in which the first 10 nucleotides are identical to all family members. (wikipedia.org)
  • Phenatoma precursor is an extinct species of sea snail, a marine gastropod mollusk in the family Borsoniidae. (wikipedia.org)
  • work
  • However, it was not until 1969 that precursors were first experimentally confirmed for the case of microwaves propagating in a waveguide, and much of the experimental work observing precursors in other types of waves has only been done since the year 2000. (wikipedia.org)
  • The system is vulnerable to "smurfing", a practice where multiple individuals work together by each buying a legal quantity of precursors and pooling them. (wikipedia.org)
  • time
  • As a dispersive phenomenon, the amplitude at any distance and time of a precursor wave propagating in one dimension can be expressed by the Fourier integral where is the Fourier transform of the initial impulse and the complex exponential represents the individual component wavelets summed in the integral. (wikipedia.org)
  • with increasing time, components with lower and lower frequencies arrive, so the period of the precursor becomes longer and longer until the lowest-frequency component arrives. (wikipedia.org)
  • At this time, Fz4 expression is localized in the periphery and is suggested to play a role in precursor cell maintenance. (wikipedia.org)
  • tracks
  • This indicator tracks trends since 1990 in anthropogenic emissions of ozone precursor pollutants: nitrogen oxides (NO X ), carbon monoxide (CO), methane (CH 4 ) and non methane volatile organic compounds (NMVOCs). (europa.eu)
  • Close
  • Sentinel-5 Precursor (Sentinel-5P) is an Earth observation satellite developed by ESA as part of the Copernicus Programme to close the gap in continuity of observations between Envisat and Sentinel-5. (wikipedia.org)