• Any patient with newly diagnosed acute lymphoblastic leukemia meeting other criteria. (clinicaltrials.gov)
  • The investigators will also study the tumor cells at the level of the participant's genes to develop treatment strategies as well as to better understand how biologic differences affect patient outcomes. (clinicaltrials.gov)
  • If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
  • T cells are removed from a patient and modified so that they express receptors specific to the patient's particular cancer. (wikipedia.org)
  • The T cells, which can then recognize and kill the cancer cells, are reintroduced into the patient. (wikipedia.org)
  • Modification of T-cells sourced from donors other than the patient are also under investigation. (wikipedia.org)
  • Adoptive cell transfer (ACT) is the transfer of cells into a patient. (wikipedia.org)
  • The cells may have originated from the patient or from another individual. (wikipedia.org)
  • In autologous cancer immunotherapy, T cells are extracted from the patient, genetically modified and cultured in vitro and returned to the same patient. (wikipedia.org)
  • Comparatively, allogeneic therapies involve cells isolated and expanded from a donor separate from the patient receiving the cells. (wikipedia.org)
  • Carcinogenesis is a gradual process, involving multiple genetic mutations, thus every patient with malignancy presents with a heterogeneous population of cells. (wikipedia.org)
  • Karyotyping of chromosome structures from individuals with B-cell chronic lymphocytic leukaemias (B-CLL) found that more than half have alterations in the 13q14 region. (wikipedia.org)