• The full sequencing of the human genome revealed the surprising existence of a vast assortment of small RNA molecules that have the ability to regulate the activity of genes. (pewtrusts.org)
  • Some miRNAs are hosted in pri-miRNAs annotated as long non-coding RNAs (lncRNAs) and defined as MIRHGs (for miRNA Host Genes). (mdpi.com)
  • Long noncoding RNAs (lncRNAs) represent a large subgroup of RNA transcripts that lack the function of coding proteins and may be essential universal genes involved in carcinogenesis and metastasis. (bvsalud.org)
  • Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
  • CRT effects are related to alterations in genes and microRNAs (miRs) expression, which regulate cardiac processes involved in cardiac apoptosis, cardiac fibrosis, cardiac hypertrophy and angiogenesis, and membrane channel ionic currents. (hindawi.com)
  • Because of their unique expression profile and special functions, miRNAs have been used as molecular markers to define the direction and processes of cell differentiation by regulating one or several target genes. (researchsquare.com)
  • Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
  • 2004) Evolution of microRNA genes by inverted duplication of target gene sequences in Arabidopsis thaliana . (ttu.edu)
  • With the identification of microRNAs and siRNAs in diverse organisms, increasing evidences indicate that these short npcRNAs play important roles in development, responses to biotic and abiotic stresses by cleavage of target mRNAs or by interfering with translation of target genes [ 5 - 9 ]. (biomedcentral.com)
  • There were 29 MADS-box genes, as well as a large number of floral-related regulators and hormone-responsive genes, considered as candidates regulating floral patterning of C. goeringii . (biomedcentral.com)
  • Small RNA sequencing revealed 132 conserved miRNA families expressed in flowers of C. goeringii , and 11 miRNAs corresponding to 455 putative target genes were considered to be responsible for multi-tepal development. (biomedcentral.com)
  • Genes controlling floral organ identity have been identified through the genetic analysis of homeotic mutants, leading to the ABCDE model, in which five classes of regulatory genes (A, B, C, D and E) work in a combinatorial manner to confer the organ identities of the four whorls [ 10 ]. (biomedcentral.com)
  • In this work, we present a different paradigm for predicting miRNA-regulated genes based on the encoded proteins. (frontiersin.org)
  • We conclude that duplicated paralogous genes that often changed their function, also diverse in their tendency to be miRNA regulated. (frontiersin.org)
  • MicroRNAs (miRNAs) post-transcriptionally regulate genes across all animals and plants. (frontiersin.org)
  • An additional nine genes were identified in tammar that do not have an orthologous miRNA target in human and likely represent novel miRNA-regulated genes in the tammar. (biomedcentral.com)
  • The characterization of new miRNA target genes and a unique profile for crasiRNAs has allowed for insight into multiple RNA mediated processes in the tammar, including gene regulation, species incompatibilities, centromere and chromosome function. (biomedcentral.com)
  • RNA was prepared separately from peripheral blood mononuclear cells (PBMC) and granulocytes to UNC1215 identify differentially expressed genes using whole genome microarrays. (tech-strategy.org)
  • 2-fold down) in the glioblastoma multiforme patient microvesicle RNA, validated by qRT-PCR on several genes. (biomedcentral.com)
  • Gene ontology of the down-regulated genes indicated these are coding for ribosomal proteins and genes related to ribosome production. (biomedcentral.com)
  • The individual genome encodes 2000 miRNAs that regulate the appearance of multiple genes (2). (innovation-ecosystems-agora.com)
  • Hence, LGP2 continues to be proven to inhibit RNA silencing aimed by TRBP-bound miRNAs and upregulate appearance of their focus on genes (15). (innovation-ecosystems-agora.com)
  • Right here, we present that LGP2 upregulated apoptosis regulatory genes by inhibition of TRBP-bound pre-miRNA maturation by competitive binding with TRBP, and improved apoptosis during Sendai trojan (SeV) an infection. (innovation-ecosystems-agora.com)
  • Induced LGP2 protein interacted with TRBP and decreased RNA silencing aimed by an average TRBP-bound miRNA, miR-106b, leading to upregulation of its focus on genes, including initiator or executioner caspases, or indirectly directly. (innovation-ecosystems-agora.com)
  • MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • miRNAs are a class of small non-coding RNAs transcribed from miRNA genes ( MIRs ). (biomedcentral.com)
  • MIR genes are transcribed into primary miRNAs (pri-miRNAs) that are spliced to form stem-loop precursor miRNAs (pre-miRNAs). (biomedcentral.com)
  • Thus, gene expression must be tightly regulated so that only appropriate genes are expressed in a particular cell type. (ernolaszlo.com)
  • Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
  • Chatterjee S, Fasler M, Büssing I, Großhans H. Target-mediated protection of endogenous microRNAs in C. elegans. (eurekaselect.com)
  • MicroRNAs (miRs) are endogenous non-coding RNAs of ∼ 23-mer, which have important roles in regulation of gene expression. (nature.com)
  • Circular RNAs (circRNAs) are a large group of endogenous non-coding RNAs which are key members of gene regulatory processes. (ijbs.com)
  • Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs with a covalently closed continuous loop that lacks 5'-3' polarity structure. (ijbs.com)
  • Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
  • We will also identify proteins that specifically interact with and alter the structure of the large primary microRNA, differentially altering access to the enzymes that process and release its individual microRNAs. (pewtrusts.org)
  • The endoribonuclease PUCH, a trimer of Schlafen-like-domain proteins, initiates piRNA processing in the nematode Caenorhabditis elegans through 5′-end piRNA precursor cleavage. (nature.com)
  • Recent studies suggest that most of the genome are transcribed, among the transcripts only a small portion encode for proteins, whereas a large portion of the transcripts do not encode any proteins, which are generally termed non-protein coding RNAs (npcRNA). (biomedcentral.com)
  • One strand from the miRNA can be then preferentially included in to the RISC proteins complex, which ribonucleoprotein complicated binds to messenger RNAs and prevents their expressionCbut this regular processing can be dys-regulated in tumor [24]. (irjs.info)
  • While most membranous and disease related proteins are regulated by miRNAs, the G-protein coupled receptor (GPCR) family is an exception, being mostly unregulated by miRNAs. (frontiersin.org)
  • Structures of mammalian GLD-2 proteins reveal molecular basis of their functional diversity in mRNA and microRNA processing. (xenbase.org)
  • Tet proteins regulate gene expression by removing methyl groups from DNA bases. (natureasia.com)
  • During viral an infection, viral RNAs are named exogenous RNAs by viral sensor proteins and activate the antiviral innate immune system response (16,17). (innovation-ecosystems-agora.com)
  • The single-stranded mature miRNA can then associate with an Argonaute protein, which mediates its function of mRNA regulation through direct mRNA target cleavage or interactions with associated RNA-induced silencing complex (RISC) proteins [ 24 ]. (biomedcentral.com)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • After transcription, the pre-mRNA transcript is spliced, joining coding exons together while excising introns and generating messenger RNA (mRNA), which is exported from the nucleus and read by ribosomes to produce polypeptides that fold into the final 3-dimensional structure of proteins ( Figure 1.1) . (ernolaszlo.com)
  • microRNAs are transcribed as ~80 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~23 nucleotide products. (wikipedia.org)
  • Most eukaryotic organisms possess highly conserved RNA silencing machinery that generates 21- ~ 24-nucleotide small RNAs from double stranded RNA precursors. (ttu.edu)
  • These are excised from much longer RNAs and prepared in the nucleus as brief hairpin pre-miRNA, and so are further prepared in the cytoplasm right into a double-stranded, 22-nucleotide RNA. (irjs.info)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • Pre-miRNA is exported to the cytoplasm by exportin-5 and cleaved by Dicer (an RNA degrading enzyme) and produces approximately 22 nucleotide RNA duplexes. (archivesofmedicalscience.com)
  • Germ granules are membraneless organelles that act as organizing centers for small RNA biogenesis during germline development. (nature.com)
  • Xie Z . (2011) Biogenesis and function of virus-derived small interfering RNAs in plants. (ttu.edu)
  • Qi X, Bao FS, and Xie Z. (2009) Small RNA Deep Sequencing Reveals Role for Arabidopsis thaliana RNA-Dependent RNA Polymerases in Viral siRNA Biogenesis. (ttu.edu)
  • 2005) microRNA-directed phasing during trans-acting siRNA biogenesis in plants. (ttu.edu)
  • Clearly, miRNA activity is kept in check by various regulatory mechanisms that control their biogenesis and decay pathways. (eurekaselect.com)
  • MicroRNA biogenesis is quite complex [ 2 ]. (archivesofmedicalscience.com)
  • Post-transcriptional regulation in multicellular organisms is mediated by microRNAs. (frontiersin.org)
  • Small RNAs play important roles in many aspects of pre- and post-transcriptional gene regulation, epigenetic modifications, chromosome segregation and genome structure. (biomedcentral.com)
  • In addition, circRNAs can regulate gene expression at transcriptional or post-transcriptional levels by titrating microRNAs (miRNAs), regulating transcription and interfering with splicing [ 13 , 14 ]. (ijbs.com)
  • Thus, the maturing oocyte is reliant on processes such as post-transcriptional gene regulation (PTGR) to regulate the mRNA and protein repertoire. (biomedcentral.com)
  • The inability to transcribe mRNA during this stage of development and the probable necessity for post-transcriptional gene regulation (PTGR) suggests an important role for non-coding RNA in the maturing oocyte. (biomedcentral.com)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • The mature products are thought to have regulatory roles through complementarity to mRNA. (wikipedia.org)
  • Among these regulatory RNAs, microRNAs play critical roles in the control of gene expression. (pewtrusts.org)
  • These small RNAs, which include microRNA (miRNA) and several classes of small interfering RNAs (siRNA), play important roles in regulating gene expression, heterochromatin formation, and defense against invading viruses. (ttu.edu)
  • Emerging evidences suggest that long non-protein coding RNAs (npcRNAs) are developmentally regulated and play roles in development and stress responses of plants. (biomedcentral.com)
  • Emerging evidences also suggest that long npcRNAs are developmentally regulated and responsive to external stimuli, and play roles in development and stress responses of plants and disease in human. (biomedcentral.com)
  • 87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
  • After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)
  • The core components of RNA silencing machinery involve several evolutionarily conserved protein families, including DICER (DCR) or DICER-LIKE (DCL), ARGONAUTE (AGO), and, in some cases, RNA-DEPENDENT RNA POLYMERASE (RDR). (ttu.edu)
  • The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • Non-coding RNAs (ncRNAs) are ribonucleic acid (RNA) molecules that are not translated into protein products. (nature.com)
  • Protein conformation is critically linked to function and often controlled by interactions with regulatory factors. (cipsm.de)
  • Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP. (eurekaselect.com)
  • Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation. (xenbase.org)
  • Inhibition of interleukin-1β plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2. (xenbase.org)
  • The mature miRNA is then loaded onto an Argonaute protein (Ago2 in humans) where it then interacts with and regulates the mRNA target. (biomedcentral.com)
  • The RNA-binding protein FMR1 has a key role in the neurodevelopmental disorder fragile X syndrome, but the RNAs targeted by the protein were mostly unknown. (natureasia.com)
  • The finding that the SIRT6 protein suppresses tumour formation by regulating metabolism adds weight to this view. (natureasia.com)
  • TAR-RNA binding protein (TRBP) is normally a double-stranded RNA (dsRNA) binding protein defined Terphenyllin as one factor that binds to individual immunodeficiency trojan type 1 TAR RNA (11), and features as an RNA silencing enhancer (12,13). (innovation-ecosystems-agora.com)
  • To accomplish this, the transcriptional unit is preceded by regulatory elements, such as promoters and enhancers, that modulate production of its protein encoding transcript ( Figure 1.2 ). (ernolaszlo.com)
  • SeV is normally a single-stranded RNA trojan acknowledged by RIG-I, and its own an infection induces IFN creation, which induces LGP2 expression strongly. (innovation-ecosystems-agora.com)
  • When a signal is sent to express a specific gene, the DNA sequence encoding that gene is used as a template to produce single-stranded RNA in a process called transcription. (ernolaszlo.com)
  • MicroRNAs (miRNAs) are a class of small (20-24 nucleotides (nt) long) non-coding RNAs. (biomedcentral.com)
  • RNA modifications have emerged as key gene regulators. (nature.com)
  • MicroRNAs, a key class of gene expression regulators, have emerged as crucial players in various biological processes such as cellular proliferation and differentia-tion, development and apoptosis. (123dok.net)
  • Colorectal cancer Core tip: MicroRNAs (miRNAs), a key class of gene ex-pression regulators, have emerged as crucial players in various biological processes such as cellular prolifera-tion and differentiaprolifera-tion, development and apoptosis. (123dok.net)
  • Some recent reports have demonstrated that both PTI and ETI can be deliberately regulated by immunity-associated regulators that could reduce or abolish the fitness cost (Deng et al. (biomedcentral.com)
  • These microRNAs are encoded in larger RNA transcripts that must be trimmed to produce the active regulatory molecules. (pewtrusts.org)
  • To complicate things further, some precursor transcripts contain an array of different microRNAs that must be generated independently, as they are often present in different quantities in the cell. (pewtrusts.org)
  • Using techniques in molecular and structural biology combined with a method I developed for monitoring the structure of large RNA molecules, my lab will elucidate the conformational "switch" that directs the processing of microRNAs encoded on large primary transcripts. (pewtrusts.org)
  • MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and processed into mature miRNAs. (mdpi.com)
  • In Arabidopsis , long npcRNA, COOLAIR (cold induced long antisense intragenic RNA), is cold-induced FLC antisense transcripts, and has an early role in the epigenetic silencing of FLC and to silence FLC transcription transiently [ 19 ]. (biomedcentral.com)
  • RNA from exosomes and other microvesicles contain transcripts of tumour origin. (biomedcentral.com)
  • If smORFs present within lncRNAs can encode functional small peptides, they can also constitute cis -regulatory elements involved in lncRNA decay. (mdpi.com)
  • The first class of small RNAs identified were the micro RNAs (miRNAs), which are small (~22 nt) non-coding RNAs that regulate gene expression by base pairing to mRNAs where they direct either mRNA cleavage or repress translation [ 8 ]. (biomedcentral.com)
  • One strand from the miRNA duplex is normally packed onto Argonaute (AGO), a primary element of the RNA-induced silencing complicated, leading to destabilization or translational repression of focus on mRNAs with series complementarities (9,10). (innovation-ecosystems-agora.com)
  • Through this mechanism, a single microRNA can alter the function of multiple mRNAs. (archivesofmedicalscience.com)
  • The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA molecules. (pewtrusts.org)
  • RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
  • More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
  • Small RNAs have proven to be essential regulatory molecules encoded within eukaryotic genomes. (biomedcentral.com)
  • As part of the genome sequencing initiative for the tammar, we have explored the evolution of each of the major classes of mammalian small RNAs in an Australian marsupial for the first time, including the first genome-scale analysis of the newest class of small RNAs, centromere repeat associated short interacting RNAs (crasiRNAs). (biomedcentral.com)
  • Heart muscle cells die en masse after injury, yet the adult mammalian heart retains little capacity to regenerate them. (natureasia.com)
  • Our finding demonstrated which the crosstalk between RNA silencing and RLR signaling features to stimulate apoptosis as an antiviral immune system in mammalian cells. (innovation-ecosystems-agora.com)
  • Toll-like receptor 3 (TLR3) and retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I (or DDX58), melanoma-differentiation-associated gene 5 (MDA5 or IFIH1), and lab of Terphenyllin genetics and physiology 2 (LGP2 or DHX58), are representative receptors for viral RNAs in the endosome and cytoplasm, respectively (18C20). (innovation-ecosystems-agora.com)
  • Research in my laboratory is directed to understand how multiple small RNA pathways operate in plants using genetic, genomic, and biochemical approaches. (ttu.edu)
  • Plants, therefore, provide a unique system to study the genetic diversification and functional adaptation of small RNA pathways. (ttu.edu)
  • Xie Z , and Qi X. (2008) Diverse small RNA-directed silencing pathways in plants. (ttu.edu)
  • 2004) Genetic and functional diversification of small RNA pathways in plants. (ttu.edu)
  • This review provides a bird's eye view of miRNAs expressed in different subcellular locations, thus affecting the gene regulatory pathways therein. (eurekaselect.com)
  • Among them, some were precursors of small RNAs such as microRNAs and siRNAs, two long npcRNAs were identified as signal recognition particle (SRP) 7S RNA variants, and three were characterized as U3 snoRNAs. (biomedcentral.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • This competitive binding inhibits the binding of 40 types of pre-miRNAs with TRBP in HeLa cells, aswell as the maturation of these miRNAs by Dicer/TRBP, and their following RNA silencing actions (15). (innovation-ecosystems-agora.com)
  • Xie Z ., Cheng H. (2017) Interplay and transition between small RNA-directed posttranscriptional and transcriptional gene silencing in plants. (ttu.edu)
  • When RIG-I identifies 5-triphosphate- or 5-diphosphate-containing RNA and little RNA duplexes (21C25), or MDA5 identifies lengthy RNA duplexes as exogenous RNAs (26), they transfer indicators to downstream substances through their caspase recruitment domains (Credit cards) (27C29). (innovation-ecosystems-agora.com)
  • A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
  • When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)
  • Role of the proline-rich disordered domain of DROSHA in intronic microRNA processing. (xenbase.org)
  • Principal miRNAs transcribed in the genome are prepared into precursor-miRNAs (pre-miRNAs) by an endoribonuclease, Drosha, in the nucleus (3C5). (innovation-ecosystems-agora.com)
  • After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
  • Xie Z , Khanna K, Ruan S. (2010) Expression of MicroRNAs and Its Regulation in Plants. (ttu.edu)
  • Regulation of microRNA function in animals. (eurekaselect.com)
  • These short RNAs participate in a diverse array of cellular processes including gene regulation, chromatin dynamics and genome defense. (biomedcentral.com)
  • Among these miRNAs, we focused on miRNA-31 (miR-31) because miR-31 was the only miR that has been reported to regulate tumor phenotype, an anti-metastatic effect in breast cancer. (nature.com)
  • Tumor suppressor miRNAs are thought as those that lower development or invasion and so are generally down-regulated in GBM. (irjs.info)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • 2004) Role of Arabidopsis ARGONAUTE4 in RNA-directed DNA methylation triggered by inverted repeats. (ttu.edu)
  • A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)
  • presents an opportunity to manipulate gene expression within the cells to treat various diseases, and acts as a powerful tool for studying gene function utilizing antisense agents to manage the diseases by regulating the expression of the specific factor that actually causes the particular disease. (genomicglossaries.com)
  • CircRNAs play a critical role in biological processes including transcription, mRNA splicing, RNA decay and translation [ 15 ]. (ijbs.com)
  • RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
  • Confocal microscopy revealed that HNF4a is present in both T UNC1215 UNC1215 lymphocytes and granulocytes, suggesting a previously unsuspected role for this transcription factor in regulating leukocyte function and therapeutic response in JIA. (tech-strategy.org)
  • miR-96 microRNA precursor is a small non-coding RNA that regulates gene expression. (wikipedia.org)
  • MicroRNAs (miRNAs) serve a role in gene expression, primarily by interacting with messenger RNAs, and may be potential biomarkers for detecting cancer. (spandidos-publications.com)
  • Here the authors identify chromatin-bound RNAs and their binding sites in human embryonic stem cells suggesting that most chromatin-associated RNAs act proximal to their encoding loci and single RNAs are unlikely to alter gene expression. (nature.com)
  • Gene expression-based prognostic signatures have a significant effect on predicting the survival of patients with malignant tumors, such as non-small cell lung cancer [ 7 ] and pediatric acute myeloid leukemia [ 8 ]. (aging-us.com)
  • Liu X, Huang J, Wang Y, Khanna K, Xie Z , Owen HA, Zhao D. (2010) The role of floral organs in carpels , an Arabidopsis loss-of-function mutation in MicroRNA160a , in organogenesis and the mechanism regulating its expression. (ttu.edu)
  • Compartmentalization of miRNAs adds complexity to the regulatory circuits of miRNA expression, thereby providing superior control over the miRNA function. (eurekaselect.com)
  • MicroRNA expression profiles classify human cancers. (eurekaselect.com)
  • Cardiac microRNA expression profile in response to estivation. (xenbase.org)
  • Expression profiles of microvesicle RNA correctly separated individuals in two groups by unsupervised clustering. (biomedcentral.com)
  • In this study we sought to identify biomarkers of glioblastoma multiforme in microvesicle RNA from serum of affected patients. (biomedcentral.com)
  • Microvesicle RNA from serum from patients with de-novo primary glioblastoma multiforme (N = 9) and normal controls (N = 7) were analyzed by microarray analysis. (biomedcentral.com)
  • RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
  • MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. (archivesofmedicalscience.com)
  • Recent studies, including our previous findings, have demonstrated that miRNAs play an important role in regulating biological functions [6-8]. (researchsquare.com)
  • Each class of small RNAs is synthesized by a distinct mechanism and each has discrete biological functions. (biomedcentral.com)
  • Targeted Transcriptomics of Frog Virus 3 in Infected Frog Tissues Reveal Non-Coding Regulatory Elements and microRNAs in the Ranaviral Genome and Their Potential Interaction with Host Immune Response. (xenbase.org)
  • In this review, we discuss our current understanding of microRNAs with a focus on their role and mode of action in regulating the immune system during inflammation and carcinogenesis. (123dok.net)
  • A survey of the tammar gonadal piRNAs shows that these small RNAs are enriched in retroelements and carry members from both marsupial and tammar-specific repeat classes. (biomedcentral.com)
  • Another class of important small RNAs is the piRNAs. (biomedcentral.com)
  • dGLYAT was found to regulate Gadd45 -mediated JNK pathway activation and cell invasion. (sdbonline.org)
  • Similarly, the miRNA signature shows predictive value in adults with T-cell lymphoblastic lymphoma [ 9 ], and long noncoding RNA shows predictive value in adults with localized clear cell renal cell carcinoma [ 10 ]. (aging-us.com)
  • We investigated the mechanism of chemoresistance by analysis of microRNAs using the ovarian cancer cell line KFr13 and its PTX-resistant derivative (KFr13Tx). (nature.com)
  • There is certainly accumulating evidence that this glioma cell-of-origin is usually a standard stem or precursor cell from your sub-ventricular zone. (irjs.info)
  • and the miR319/TCP4-miR396/GRF regulatory cascade probably regulating cell proliferation of the multi-tepal development. (biomedcentral.com)
  • TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway. (xenbase.org)
  • Microvesicles are very stable and can protect cell-free RNA stored in the freezer for many years. (biomedcentral.com)
  • Of particular importance is miRNA-21 (MIR21) due to its role in regulating programmed cell death 4 (PDCD4). (biomedcentral.com)
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
  • MicroRNA (miRNA) are a class of functional small RNA that target mRNA to affect their abundance and translational efficiency. (biomedcentral.com)
  • Many types of RNAs are associated with chromatin. (nature.com)
  • Furthermore, circulating microRNAs in the serum are resistant to lysis and are stable against RNase, as they are hidden in microparticles, apoptotic bodies, etc. [ 1 ]. (archivesofmedicalscience.com)
  • In view of the limited understanding of molecular mechanism of m6A and lactylation in As-IPF, MeRIP-seq, RNA-seq and ChIP-seq were analyzed to verify the target gene regulated by m6A and H3K18 lactylation (H3K18la). (bvsalud.org)
  • MicroRNAs (miRNAs) have become a hot topic in cancer research, but the underlying mechanism of its involvement in cancer remains unclear. (researchsquare.com)
  • Therefore, it is of great significance to explore the mechanism of tumorigenesis in breast cancer and further identify key regulatory factors. (researchsquare.com)
  • In this Journal Club, Edmund Loh explores the pioneering work of Kurt Nordström and colleagues, which uncovers the importance of a small RNA in plasmid replication and elucidates its mechanism of action. (nature.com)
  • In addition, it is unclear if the microRNA-mediated mechanism related to root growth complies with a common mechanism in monocots and dicots under N deficiency. (frontiersin.org)