Bone marrowEosinophilsMacrophagesNeutrophilsBasophilsMonocytesDifferentiationStem Cell TransplantColony formationMyeloblastsHematopoieticProliferationMacrophageNeutrophilSubsetMyeloid ProgeFlow cytometryEndothelialImmune responsesGranulocytopeniaFactorTumorPeptidesTumorsPhagocytosisAdaptiveAntibodiesReceptorsBloodAcuteHumanNormalFunctionalTypesResponsibleComplex
Bone marrow10
- most of the neutrophils in the body are contained in the bone marrow, either as mitotically active (one third) or postmitotic mature cells (two thirds). (medscape.com)
- Clone BM-1 reacts with myeloid precursor cells and granulocytes in bone marrow. (teomics.com)
- Thrombopoiesis takes place primarily in the bone marrow through a series of cell differentiation and is influenced by several cytokines. (lecturio.com)
- Basophils are released from the bone marrow as mature cells and then circulate in the blood. (biologyease.com)
- Neutrophil precursors from normal bone marrow. (biologyease.com)
- Long-term cultures of human bone marrow form multinucleated cells (MNC) with many functional characteristics of osteoclasts including: expression of tartrate-resistant acid phosphatase, appropriate responses to osteotropic hormones, calcitonin-induced contraction and formation of resorption lacunae on calcified matrices. (elsevierpure.com)
- Similar to bone-derived osteoclasts, MNC formed in long-term human bone marrow culture expressed osteoclast-specific antigens (detected by monoclonal antibodies 13c2 and 23c6) and did not express Fc receptors, T cell specific antigens, most myeloid antigens or mature macrophage antigens. (elsevierpure.com)
- In contrast to authentic osteoclasts, MNC reacted with a monoclonal antibody (Mo1) which identifies an antigen present on myeloblasts, monocytes, granulocytes, and null cells from human peripheral blood and bone marrow. (elsevierpure.com)
- The symptoms of this disorder come about as the result of interference in the production of granulocytes in the bone marrow. (orthopedicshealth.com)
- A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
Eosinophils4
- Although tumor-promoting functions have been attributed to other granulocytes, like eosinophils ( 17 ), basophils ( 18 ) and mast cells ( 19 ), further research is required to fully elucidate their role in cancer, as antitumoral roles have also been described ( 20 , 21 ). (frontiersin.org)
- Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. (neobiotechnologies.com)
- Eosinophils represent only a small number of circulating leukocytes(1-6%) and are short-lived cells in circulation with a t1/2 of 8-18 h. (biologyease.com)
- Granulocytes include basophils, eosinophils, and neutrophils. (orthopedicshealth.com)
Macrophages5
- Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (uchicago.edu)
- However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. (frontiersin.org)
- Myeloid innate immune cells, such as granulocytes, monocytes, macrophages and dendritic cells (DCs), play an important role in cancer-cell recognition, initiation of inflammation and antitumor responses ( 2 ). (frontiersin.org)
- Granulocyte/macrophage - Colony-stimulating factor (GM-CSF) is a hematopoietic factor that is produced by activated T-cells, B-cells, mast cells, macrophages, fibroblasts, and endothelial cells. (neobiotechnologies.com)
- Being highly motile, neutrophils quickly congregate at a focus of infection , attracted by cytokines expressed by activated endothelium , mast cells and macrophages . (bionity.com)
Neutrophils6
- A common reference range for the absolute neutrophil count (ANC), which is calculated on the basis of the percentage of neutrophils in the white blood cell count (see the Absolute Neutrophil Count calculator) is 2500-8000/µL. (medscape.com)
- It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (uchicago.edu)
- Neutrophils makeup 55 to 70 percent of your white blood cells and are the most abundant type. (biologyease.com)
- Mature neutrophils have the ability to migrate to areas of inflammation (chemotaxis) where, by interaction with selectins, integrins, and other cell adhesion molecules, they become marginated in the vessel lumen and pass into the tissues. (biologyease.com)
- Neutrophil granulocytes , generally referred to as neutrophils , are the most abundant type of white blood cells in humans and form an integral part of the immune system . (bionity.com)
- Human Granulocyte-Colony-Stimulating Factor (G-CSF), a 20 kDa glycoprotein containing internal disulfide bonds, induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. (sydlabs.com)
Basophils4
- Of the granulocytes, basophils are the least common. (biologyease.com)
- Less than 3% of your white blood cells account for Basophils. (biologyease.com)
- Basophils are granulocytes that circulate in sites of allergic inflammation and that react to allergic stimuli by migrating. (biologyease.com)
- Basophils not just act as effector cells but also as promoters of cell differentiation in Th2 play important and nonredundant roles. (biologyease.com)
Monocytes1
- With the eosinophil and the basophil , they form the class of polymorphonuclear cells (PMNs), named for the nucleus 's characteristic multilobulated shape (as compared to lymphocytes and monocytes , the other types of white cells). (bionity.com)
Differentiation1
- For their differentiation from granulocyte precursors, IL-5 signaling appears to be critical. (biologyease.com)
Stem Cell Transplant1
- Granulocyte Colony-Stimulating Factor Use after Autologous Peripheral Blood Stem Cell Transplantation: Comparison of Two Practices. (uchicago.edu)
Colony formation2
- In addition to supporting colony formation of granulocyte/macrophage progenitors, GM-CSF is a growth factor for erythroid, megakaryocyte, and eosinophil progenitors. (neobiotechnologies.com)
- Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
Myeloblasts1
- Morphologically, the earliest recognizable granulocytic cells are myeloblasts. (biologyease.com)
Hematopoietic2
- Planned Granulocyte Colony-Stimulating Factor Adversely Impacts Survival after Allogeneic Hematopoietic Cell Transplantation Performed with Thymoglobulin for Myeloid Malignancy. (uchicago.edu)
- STUDY DESIGN AND METHODS: The hematopoietic progenitor cell (HPC) and lymphocyte subset (LS) content of approximately 8000 CB units were characterized, and these results were correlated with donor ethnicity, birth weight, gestational age, sex, and type of delivery. (emmes.com)
Proliferation1
- Our results indicate a reduction in vascular placental cells, especially cells responsible for structural integrity, and increase in trophoblast proliferation in animals exposed to particulate matter. (nature.com)
Macrophage1
- MNC also reacted with the monoclonal antibody My11, which is present on CFU-GM, the granulocyte-macrophage colony-forming cell, the probable precursor for MNC. (elsevierpure.com)
Neutrophil4
- Promyelocytes, neutrophil myelocytes, neutrophil metamyelocytes, and neutrophil band cells are called the successive stages through which a myeloblast matures into circulating neutrophil granulocytes. (biologyease.com)
- The neutrophil lineage's maturation process is characterized by a decrease in cell size, along with the acquisition of granules containing agents that are essential for their microbicidal function. (biologyease.com)
- the other nucleated cells are two polychromatic erythroblasts and a neutrophil metamyelocyte. (biologyease.com)
- Neutrophil granulocytes have an average volume of 330 femtoliters (fl) and a diameter of 12-15 micrometers (µm) in peripheral blood smears . (bionity.com)
Subset1
- They are a subset of granulocytes with bright pink granules on hematoxylin and eosin-stained blood films. (biologyease.com)
Myeloid Proge2
- Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia. (uchicago.edu)
- In addition to TAMs, solid tumors are also infiltrated by immunosuppressive, immature myeloid progenitor cells, commonly referred to as monocytic or polymorphonuclear myeloid-derived suppressor cells (M/PMN-MDSC) ( 11 - 13 ). (frontiersin.org)
Flow cytometry1
- Placental transcriptomes, at day 19 of gestation, were determined using bulk RNA-seq from whole placentas of exposed (n = 4) and control (n = 4) animals and scRNAseq of three distinct placental layers, followed by flow cytometry analysis of the placental immune cell landscape. (nature.com)
Endothelial1
- Interleukin-17 induces the secretion of G-CSF in epithelial, endothelial, and fibroblastic cells. (sydlabs.com)
Immune responses1
- Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. (frontiersin.org)
Granulocytopenia1
- Symptoms that are associated with rapidly falling white blood cell levels (granulocytopenia) may include the development of infected ulcers in the mucous membranes that line the mouth, throat, and/or intestinal tract. (orthopedicshealth.com)
Factor4
- Granulocyte Colony-Stimulating Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Granulocyte Colony-Stimulating Factor" by people in this website by year, and whether "Granulocyte Colony-Stimulating Factor" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Granulocyte Colony-Stimulating Factor" by people in Profiles. (uchicago.edu)
- Increase in short-term risk of rejection in heart transplant patients receiving granulocyte colony-stimulating factor. (uchicago.edu)
Tumor5
- Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. (frontiersin.org)
- In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression. (frontiersin.org)
- Another myeloid population in the tumor microenvironment (TME) are DCs, that originate from different precursors and display various phenotypes, ranging from immunosuppressive monocyte-derived DCs (Mo-DCs) to immunocompetent cDC1 and cDC2 subsets ( 22 ). (frontiersin.org)
- Nevertheless, the majority of scientific discoveries points toward a more tumor-supporting role for myeloid cells in the TME. (frontiersin.org)
- EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)
Peptides2
- The innate immune response by myeloid cells occurs as a succession of events starting at signaling through cytosolic or surface PRRs, followed by effector responses including the release of cytokines, reactive oxygen species (ROS), reactive nitrogen species (RNS), antibacterial peptides and degranulation ( Figure 1 ). (frontiersin.org)
- Pathogen clearance is mediated by mechanisms such as phagocytosis, respiratory burst with the production of ROS and RNS and release of bacteriostatic peptides, but also through the cell-extrinsic initiation of inflammation via the release of proinflammatory cytokines and chemokines ( 24 ). (frontiersin.org)
Tumors2
- It also may react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH. (teomics.com)
- Immune cells abundantly infiltrate tumors, creating a complex environment mediated by repetitive cycles of antitumor responses and immune evasion ( 1 ). (frontiersin.org)
Phagocytosis1
- Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. (frontiersin.org)
Adaptive1
- Hence, myeloid cells play a dual role in cancer as they can initiate antitumor responses and communicate with cells of the adaptive immune system, but also promote local inflammation leading to chronic cancer-associated inflammation ( 5 , 6 ). (frontiersin.org)
Antibodies3
- PRR on myeloid cells can be triggered by pathogen-associated molecular patterns (PAMPs) or danger-associated molecular patterns (DAMPs), but also indirectly by secondary mechanisms such as complement activation and circulating antibodies (Abs), resulting in cytolytic and phagocytic effector mechanisms. (frontiersin.org)
- In the case of gold, or anti-thyroid drugs, or quinidine, among others, antibodies are created that appear to break the granulocytes down. (orthopedicshealth.com)
- In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
Receptors1
- Cell surface receptors are able to detect chemical gradients of molecules such as interleukin-8 (IL-8), interferon gamma (IFN-gamma), and C5a which these cells use to direct the path of their migration. (bionity.com)
Blood3
- These are white blood cells. (biologyease.com)
- they account for 70% of all white blood cells (leukocytes). (bionity.com)
- Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (orthopedicshealth.com)
Acute1
- Myelodysplastic syndrome and acute myeloid leukemia after receipt of granulocyte colony-stimulating factors in older patients with non-Hodgkin lymphoma. (uchicago.edu)
Human1
- The structure of the recombinant human G-CSF protein expressed in E. coli, such as filgrastim, differs slightly from those of the natural glycoprotein and the recombinant human G-CSF protein expressed in mammalian cells such as CHO cells. (sydlabs.com)
Normal1
- Normal eosinophil count is less than 500 cells per microliter (cells/mcL). (biologyease.com)
Functional1
- Tissues, including the placenta, are comprised of diverse cell types with distinguishable developmental or functional origin that form a complex niche 1 . (nature.com)
Types1
- A comprehensive assessment of cellular heterogeneity is traditionally performed by immunophenotyping which can be biased and relies on a small set of pre-selected markers, limiting the cell types that can be inspected 13 . (nature.com)
Responsible1
- Renal cell carcinoma is responsible for 80%-85% of all primary renal neoplasms. (lecturio.com)
Complex1
- The placenta is a heterogeneous organ whose development involves complex interactions of trophoblasts with decidual, vascular, and immune cells at the fetal-maternal interface. (nature.com)