• More than 60% of all RNA modifications are methylated modifications, and m6A is the most abundant chemical modification in eukaryotic messenger RNA (mRNA). (biomedcentral.com)
  • Messenger RNA (mRNA) vaccines represent a relatively new vaccine class showing great promise for the future. (researchgate.net)
  • c12orf71 protein has been found to be present in a protein-protein interaction (PPI) network of the Carboxypeptidase M (CPM) gene, along with nine more genes. (wikipedia.org)
  • MeRIP-seq, RIP-seq and RNA-seq were performed to identify the target genes of KIAA1429. (biomedcentral.com)
  • METHODS: Expression of mucin genes in the UACL from small bowel tissue of patients with Crohn's disease was detected by in situ hybridisation, and localisation of the products by immunohistochemistry. (embl.de)
  • These genes, encoding for RNA binding proteins, contain a highly conserved RNA recognition motif and at least one DAZ repeat encoding for a 24 amino acids sequence able to bind other mRNA binding proteins. (ijbs.com)
  • This approach allowed identifying specific chromosomal regions significantly highly or weakly expressed, and clusters of differentially expressed genes and of transcripts related to specific functional modules. (biomedcentral.com)
  • The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions. (biomedcentral.com)
  • The correlation among co-expression and co-localization of genes was also investigated and confirmed in different organisms [ 12 ]. (biomedcentral.com)
  • For instance, the existence of tissue-specific gene clusters may be related to the efficient activation of gene expression in a particular cell lineage, by genetic and epigenetic mechanisms, or related to the repression of entire chromosomal regions containing genes expressed in a specific cell type, e.g. during the developmental switches leading to different cell lineages [ 25 ]. (biomedcentral.com)
  • Familial AD (FAD) cases are caused by autosomal dominant mutations in the genes for amyloid precursor protein (APP) and the presenilins (PS1 and PS2) ( Sisodia and St George-Hyslop, 2002 ). (jneurosci.org)
  • XREs are found in the promoter region of a variety of genes. (biomedcentral.com)
  • It makes no sense that conserved genes would be producing alternative protein variants that are species specific. (blogspot.com)
  • He is firmly convinced that most human genes express a number of different protein products that are produced as the result of alternatively spliced mRNA precursors. (blogspot.com)
  • My colleague is very knowledgeable about the genes for the major subunits of eukaryotic RNA polymerase since it was his lab that cloned the first one. (blogspot.com)
  • Two of the subunits, Rpb1 and Rbp2, are more commonly known as A and B. In the human genome they are encoded by the genes POLR2A and POLR2B respectively [ RNA Polymerase Genes in the Human Genome ]. (blogspot.com)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • Pansensitive and panresistant genes to 21 NCCN-recommended drugs with concordant mRNA and protein expression were identified. (cdc.gov)
  • N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. (biomedcentral.com)
  • Dicer is an RNase III enzyme found in almost all eukaryotic organisms and responsible for the processing of pre-miRNAs into miRNAs. (biomedcentral.com)
  • Eukaryotic RNA polymerase is a complex protein machine consisting of ten different subunits. (blogspot.com)
  • Several m6A-binding proteins with the YTH domain, containing YTHDF1, YTHDF2, YTHDF3 and YTHDC1, function as the readers to modulate translation and mediate degradation of m6A-modified RNAs [ 6 ]. (biomedcentral.com)
  • and (c) an isotope-coded glycosylation site-specific tagging high-throughput method to identify carrier proteins with the specific lectin epitope. (gene-quantification.de)
  • DAZ family proteins are found almost exclusively in germ cells in distant animal species. (ijbs.com)
  • Basically, Daz family proteins function as adaptors for target mRNA transport and activators of their translation. (ijbs.com)
  • This family includes three members, Boule (or Boll ), Dazl (or Dazla ) and DAZ , encoding RNA binding proteins. (ijbs.com)
  • The localization of DAZ family proteins suggests that they can regulate mRNA translation occurring in the cytoplasm. (ijbs.com)
  • These proteins have a highly conserved RNA recognition motif (RRM) for binding target mRNAs and at least one characteristic sequence of 24 amino acids, which are termed as DAZ repeats [ 1 ]. (ijbs.com)
  • Dazl can regulate the expression, transport and localization of target mRNAs of proteins which control the differentiation, growth and maturation of germ cells. (ijbs.com)
  • Basically, DAZ family proteins have been proposed to function as adaptors for mRNA transport and activators of their translation. (ijbs.com)
  • MiRNAs are generated by stepwise cleavage via double-stranded ribonuclease III enzymes DROSHA and DICER1 and loaded onto Argonaute (AGO) proteins to pair with target sequences on mRNAs 20 . (nature.com)
  • Plastid-specific ribosomal proteins (PSRPs) have been proposed to play roles in the light-dependent regulation of chloroplast translation. (cipsm.de)
  • A high-mannose oligosaccharide precursor is synthesized and transferred to proteins in the endoplasmic reticulum and then processed in the Golgi apparatus ( 4 ). (frontiersin.org)
  • His fields of research comprise RNA-mediated gene silencing processes with a focus on epigenetic phenomena, including studies on RNA-directed DNA methylation, the characterization of virus silencing suppressor proteins, the development of plant bioreactor platforms and viroid research. (degruyter.com)
  • Viroids are non-encapsidated, single-stranded (ss), 250-400 nucleotide (nt)-long circular RNA molecules that do not encode proteins (1, 2). (degruyter.com)
  • The core is composed of 3 major (ie, lambda-1, lambda-2, sigma-2) and several minor proteins that surround 10 segments of double-stranded RNA. (medscape.com)
  • The targeting of RNA transcripts to axons is one of the mechanisms that allows rapid local translation of proteins in response to extracellular signals. (bvsalud.org)
  • 3' Untranslated regions (UTRs) of mRNA are noncoding sequences that play a critical role in determining transcript localization and translation by interacting with specific RNA-binding proteins (RBPs). (bvsalud.org)
  • The remaining 2 mRNA variants (1 spliced, 1 unspliced) appear not to encode good proteins. (blogspot.com)
  • Distribution of the mRNAs encoding the thyrotropin-releasing hormone ( TRH ) precursor and three TRH receptors in the brain and pituitary of Xenopus laevis: effect of background color adaptation on TRH and TRH receptor gene expression. (xenbase.org)
  • The development of species-specific gene microarrays has greatly facilitated gene expression profiling in nonhuman primates. (gene-quantification.de)
  • Consequently, the time of day when RNA samples are collected can influence detection of significant changes in gene expression levels. (gene-quantification.de)
  • MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
  • Micro RNAs are 21- to 24-nucleotide-long, non-coding RNA molecules that regulate gene expression at the post-transcriptional level. (researchsquare.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (appliedbioinfo.com)
  • This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (appliedbioinfo.com)
  • How could a small bit of the large RNA polymerase subunit ever be part of the RNA polymerase protein complex? (blogspot.com)
  • It also opens a new way of thinking for biomedical scientists, whether RNA modification will be another important factor to regulate the biological development of neoplastic diseases. (biomedcentral.com)
  • Additionally, the 5′ and 3′ UTRs flanking the coding region regulate mRNA translation, half-life, and subcellular localization [2]. (researchgate.net)
  • These studies share a common theme in which germline mutations of squamous lineage TFs are frequently found in an overlapping spectrum of human being ectodermal diseases, suggesting that these TFs are instrumental for early ectoderm specification and consequently are repurposed to regulate squamous differentiation. (columbiagypsy.net)
  • We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
  • The miRNA-mRNA pairing triggers casein kinase 1α (CK1α)-induced phosphorylation and dissociation of AGO2 from the active complex, whereas the ANKRD52-PPP6C phosphatase complex dephosphorylates AGO2 to restore its miRNA loading activity 21 , 22 . (nature.com)
  • The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (appliedbioinfo.com)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (appliedbioinfo.com)
  • Subsequently, the duplex unwinds and miRNA loads into RNA-induced silencing complex (RISC) to execute gene-silencing either through cleavage of the complementary mRNA or by suppression of mRNA translation [ 3 ]. (biomedcentral.com)
  • A study of global gene methylation of common warts caused by HPV infection found that c12orf71 gene is differentially methylated in Arab male patients with common warts. (wikipedia.org)
  • KIAA1429 induced m6A methylation on the 3′ UTR of GATA3 pre-mRNA, leading to the separation of the RNA-binding protein HuR and the degradation of GATA3 pre-mRNA. (biomedcentral.com)
  • Recently, Np95 (also known as UHRF1 or ICBP90) has been found to interact with Dnmt1 and to bind hemimethylated DNA, indicating together with genetic studies a central role in the maintenance of DNA methylation. (cipsm.de)
  • Since then, he has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and his main field of interest is RNA-interference (RNAi) and RNA-directed DNA methylation (RdDM) in plants. (degruyter.com)
  • At least in plants, DNA regions that become de novo methylated can be defined by homologous RNA molecules in a process termed RNA-directed DNA methylation (RdDM). (degruyter.com)
  • The recruitment of this machinery results in the production of viroid-derived small RNAs (vd-sRNAs) that mediate RNA degradation and DNA methylation of cognate sequences. (degruyter.com)
  • Prior to serum induction no c-fos RNA is detected, but these transcripts localize to two dots in the interphase nucleus after induction. (northwestern.edu)
  • We have also compared the localization of c-fos transcripts with the speckled nuclear regions that are enriched in snRNPs and the non-snRNP splicing factor SC-35. (northwestern.edu)
  • This study demonstrates a direct link between specific nascent RNA transcripts and nuclear speckles that are enriched in pre-mRNA splicing factors. (northwestern.edu)
  • Spector, David L. / Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors . (northwestern.edu)
  • Differentially expressed miRNAs target 49 transcripts and their gene ontology enrichment analysis showed that the susceptible cultivar responds by modulating the processes of protein localization and pigment synthesis, whereas the resistant cultivar responds by modulating transcription factors and hormone signalling. (researchsquare.com)
  • c12orf71 transcript variant 1 mRNA is 1022 nucleotides long and consists of 2 exons. (wikipedia.org)
  • Our results reveal the function of circIGF2BP3 in causing immune escape from CD8 + T cell-mediated killing through a decrease in PD-L1 ubiquitination and subsequent proteasomal degradation by stabilizing OTUB1 mRNA in a PKP3-dependent manner. (biomedcentral.com)
  • miRNAs are a class of short (∼22 nucleotide) noncoding RNAs (ncRNAs). (frontiersin.org)
  • In situ hybridization histochemistry showing the distribution of TRH precursor mRNA in the brain and pituitary of Xenopus laevis. (xenbase.org)
  • Darkfield photomicrographs illustrating the localization of TRH precursor mRNA hybridization signal in selected regions of the brain of white-adapted Xenopus laevis. (xenbase.org)
  • We have used in situ hybridization and immunocytochemistry to compare the nuclear localization of a specific nascent pre-mRNA and the essential non-snRNP splicing factor SC-35. (northwestern.edu)
  • Cellular localization analysis showed that human c12orf71 protein is found in the cytoplasm of the cell. (wikipedia.org)
  • c12orf71 protein has multiple predicted phosphorylation sites, which can have an impact on the protein interactions and sub-cellular localization as well as affect the protein's stability and activity. (wikipedia.org)
  • Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where multipotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. (biomedcentral.com)
  • By using high-voltage electron microscopy, we have found that the c-fos path extends out and comes into direct contact with the nuclear envelope. (northwestern.edu)
  • It has been found that the effect of m6A modification on RNA metabolism involves processing, nuclear export, translation and even decay. (biomedcentral.com)
  • Our findings shed new light into the complex relationship between nuclear polyadenylation, mRNA localization, and local 3' UTR remodeling in developing neurons. (bvsalud.org)
  • Viroids are pathogenic circular, non-coding, single-stranded RNA molecules. (degruyter.com)
  • Upon inoculation, mature Pospiviroidae RNA molecules enter the plant cell nucleus. (degruyter.com)
  • The neurological properties of N2a-Rα based on AhR activation were evaluated by immunohistochemical analysis of cytoskeletal molecules and by RT-PCR analysis of mRNA expression of neurotransmitter-production related molecules, such as tyrosine hydroxylase (TH). (biomedcentral.com)
  • The mRNA sequence of c12orf71 transcript variant 1 consists of a coding sequence that spans over two exons and 2 poly-A signal sequences. (wikipedia.org)
  • The mRNA vaccines can encode multiple antigens, strengthening the immune response against pathogens and enabling the targeting of multiple microbial variants [19] . (researchgate.net)
  • lncSNHG5 enhanced ZNF281 mRNA stability by binding with the m6A reader IGF2BP2. (thno.org)
  • Despite this, the mRNAs have concerns about their stability and immuno-stimulation, therefore, researchers and companies have concentrated their work to address this issue [2]. (researchgate.net)
  • c12orf71 protein is 269 amino acids long and the unmodified precursor protein has a predicted molecular weight of 30.4 kDa and a theoretical isoelectric point of 5.21. (wikipedia.org)
  • Additionally, the human protein also contains a vacuolar domain, which is mammal specific and may be modulated by phosphorylation. (wikipedia.org)
  • Only one isoform of the c12orf71 protein has been found in this species. (wikipedia.org)
  • Furthermore, PKP3 engages with the RNA-binding protein FXR1 to stabilize OTUB1 mRNA, and OTUB1 elevates PD-L1 abundance by facilitating its deubiquitination. (biomedcentral.com)
  • Presumably, this process involves the interaction between the host's bromodomain-containing viroid RNA-binding protein 1 (VIRP1) and the viroid's TR domain (6). (degruyter.com)
  • Here, we found that miR-574 directly targets the transcript for hyaluron synthase 2 protein (HAS2), a key enzyme in the production of extracellular matrix by the surrounding cumulus cells. (appliedbioinfo.com)
  • Secretory carrier membrane protein 4 (SCAMP4) was predicted to be subject to posttranscriptional gene regulation mediated by small RNA, by annotating small RNA reads mapped to exonic regions in the pig genome. (appliedbioinfo.com)
  • N2a-Rα cells expressed tyrosine hydroxylase (TH) mRNA as a functional marker of catecholaminergic neurotransmitter production. (biomedcentral.com)
  • Since then, she has been working as a postodoc in Dr. Wassenegger's lab (RLP AgroScience GmbH, AlPlanta) and her main field of interest is RNA-interference (RNAi) and viroid biology in plants. (degruyter.com)
  • N6-methyladenine (m6A) mRNA modification is the most abundant form of posttranscriptional RNA modification in eukaryotes. (biomedcentral.com)
  • However, how 3' UTRs contribute to mRNA metabolism and the nature of RBP complexes responsible for these functions remains elusive. (bvsalud.org)
  • Using model predictions, we designed and characterized 47 additional pathway variants to navigate its activity space, find optimal expression regions with desired activity response curves, and relieve rate-limiting steps in metabolism. (omictools.com)
  • Alternative mRNA variants and regulation: The gene contains 29 different introns (28 gt-ag, 1 gc-ag). (blogspot.com)
  • Transcription produces 13 different mRNAs, 11 alternatively spliced variants and 2 unspliced forms. (blogspot.com)
  • Like interleukin 1 beta-converting enzyme and CPP32, the active Mch3 alpha is made of two subunits derived from a precursor (proMch3 alpha). (deathbase.org)
  • THC and CBD act on specific cannabinoid receptors called CB1 and CB2. (biomedcentral.com)
  • We found that receptors in the Toll-like receptor pathway, such as Tlr2 and CD14, were increased under LPS and HSV stimulation. (frontiersin.org)
  • Thanks to the expression of specific receptors, tip cells can sense the microenvironment, and respond to guidance cues to lead the angiogenic sprout. (elifesciences.org)
  • The chemical modification of RNA is a newly discovered epigenetic regulation mechanism in cells and plays a crucial role in a variety of biological processes. (biomedcentral.com)
  • A-F: Frontal brain sections from white-adapted frogs were hybridized with an antisense TRH precursor riboprobe and exposed onto Hyperfilm max for 8 days. (xenbase.org)
  • Strikingly, a long noncoding RNA (lncRNA) GATA3-AS, transcribed from the antisense strand of the GATA3 gene, functioned as a cis -acting element for the preferential interaction of KIAA1429 with GATA3 pre-mRNA. (biomedcentral.com)
  • Neuronal connections are made with exquisite accuracy between specific types of neurons. (stanford.edu)
  • We performed 3' end sequencing of RNA isolated from cell bodies and axons of sympathetic neurons exposed to either nerve growth factor (NGF) or neurotrophin 3 (NTF3, also known as NT-3). (bvsalud.org)
  • A genome engineering study that studied mice knock-outs has found that c12orf71 has a decreased expression in humans compared to mouse testis, however the absence of the c12orf71 had no effect on mouse fertilization. (wikipedia.org)
  • The other approach is to screen CRISPR-Cas9-based guide RNA (gRNA) libraries that target either the whole genome using cancer cell and immune cell co-culture systems 9 , 10 , or focused gene sets using immunocompetent murine tumors 11 , 12 . (nature.com)
  • Mapping small RNA to the pig genome indicates dynamic distribution of small RNA organization across the genome. (appliedbioinfo.com)
  • Many of the small RNA mapped to annotated repetitive elements in the pig genome, of which the SINE/tRNA-Glu and LINE/L1 elements represented a large proportion. (appliedbioinfo.com)
  • Moreover, it would also be useful in the discovery of miRNAs in human genome and design of Dicer specific pre-miRNAs for potent gene silencing. (biomedcentral.com)
  • The genome consists of double-stranded RNA in 10-12 discrete segments, with a total genome size of 16-27 kilobase pair (kbp), depending on the genus. (medscape.com)
  • Simultaneously, SC precursors (SCP) derive from the neural crest cells and migrate from the neural tube around embryonic day E10.5 to contact axons and differentiate into immature SC (iSC) around E15/E16 ( Woodhoo and Sommer, 2008 ). (elifesciences.org)
  • This highly malignant tumor has traditionally been considered to arise from committed skeletal muscle precursor cells that fail to differentiate [ 1 ], although some RMSs develop in organs lacking a skeletal muscle component [ 2 , 3 ]. (oncotarget.com)
  • C: The highest density of silver grains was observed in the magnocellular preoptic nucleus (Mg) and the suprachiasmatic nucleus (SC), with dense accumulation of proTRH mRNA signal over cell bodies. (xenbase.org)
  • Subsequently, the effect of specific lncRNAs on the modulation of immune-related signaling pathways in malaria was determined by fluorescence-activated cell sorting, western blot and enzyme-linked immunosorbent assay. (biomedcentral.com)
  • A previous screen of small RNA in the porcine ovary identified the down regulation of miR-574 during oocyte maturation, although its role during this process was not established. (appliedbioinfo.com)
  • Similar to the expression analysis of other species, these data demonstrate dynamic expression regulation of multiple classes of non-coding RNA during oocyte maturation and development to the blastocyst stage. (appliedbioinfo.com)
  • AEA and 2-AG, which both derive from membrane phospholipid precursors and arachidonic acid, are synthesized and metabolized by different pathways from the ECS. (biomedcentral.com)
  • This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
  • Manual inspection of alignments, has determined that c12orf71 gene is mammalian specific. (wikipedia.org)
  • xTRHRs, including the novel receptor subtype xTRHR3, were widely expressed in the telencephalon and diencephalon , where two or even three xTRHR mRNAs were often simultaneously observed within the same brain structures. (xenbase.org)
  • These results would not have been possible without critical recent innovations in the field, such as the development of safe and efficient materials for in vivo mRNA delivery and advanced protocols for the production of high quality mRNA. (researchgate.net)
  • Subsequently, clusterin has been found to be widely distributed in a variety of tissues in mammals. (washington.edu)
  • Thus, angiogenesis not only allows the rapid vascularization of developing tissues and organs but ensures appropriate vascularization rate adapted to specific needs in nutrients and oxygen ( Carmeliet and Jain, 2011 ). (elifesciences.org)
  • We found RCC tissues displayed significantly higher miR-34a expression level than their corresponding noncancerous tissues, particularly in chromophobic subtype. (hindawi.com)
  • Small RNA Profile of the Cumulus Oocyte Complex and Early Embryos in the Pig. (appliedbioinfo.com)
  • Deep sequencing was performed on small RNA from cumulus cells, oocytes at GV and MII stages, as well as in vitro fertilized derived embryos at 60 h post fertilization (4- to 8-cell) and on Day 6 blastocysts. (appliedbioinfo.com)
  • With the maturation of deep sequencing methodologies for small RNA identification, the number of reported mature miRNAs has drastically increased. (frontiersin.org)
  • In the present study, we have examined the distribution of the mRNAs encoding proTRH and the three receptor subtypes (xTRHR1, xTRHR2 , and xTRHR3) in the frog CNS and pituitary , and we have investigated the effect of background color adaptation on the expression of these mRNAs. (xenbase.org)
  • A good correlation was generally observed between the expression patterns of proTRH and xTRHR mRNAs. (xenbase.org)
  • A RNA sequencing method (RNA-seq) was used to confirm the differential expression profiles of lncRNAs in Plasmodium yeolii 17XL ( P.y 17XL)-infected BALB/c mice. (biomedcentral.com)
  • Morphologically, N2a-Rα cells bore spontaneous neurites exhibiting axon-like properties with the localization of NF-H. In addition, cdc42 expression was increased in comparison to the control cell line. (biomedcentral.com)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • Orthologs of the c12orf71 gene have been found only in mammals, in particular Theria (marsupials and placentals). (wikipedia.org)
  • Mature miRNAs act via complementarity with their target mRNAs. (frontiersin.org)
  • Through the development of m6A RNA sequencing, the relevant molecular mechanism of m6A modification has gradually been revealed. (biomedcentral.com)
  • Recent studies have found that non-coding RNAs and post transcriptional modification of RNAs have become the active fields of cancer research. (biomedcentral.com)
  • Long non-coding RNAs (lncRNAs) participate in regulating biological processes, especially host-pathogen interactions. (biomedcentral.com)
  • Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. (nature.com)
  • Our goal is to convey a picture of pattern formation that draws attention to the principles rather than solely to specific molecular mechanisms. (mpi-cbg.de)
  • We discovered that both NGF and NTF3 affect transcription and alternative polyadenylation in the nucleus and induce the localization of specific 3' UTR isoforms to axons, including short 3' UTR isoforms found exclusively in axons. (bvsalud.org)
  • Members of the Pospiviroidae family replicate in the nucleus through double-stranded RNA intermediates, attracting the host RNA silencing machinery. (degruyter.com)
  • When PSTVd enters the plant cell, a specific signal seems to direct it into the nucleus. (degruyter.com)
  • Therefore, the present inventors have found that various neurologic disorders based on inflammation may be treated since transcription factors Nurr1 and Foxa2 interact with each other to convert glial cells from an M1 phenotype to an M2 phenotype which sets up a therapeutic environment, when the transcription factors are overexpressed in the glial cells. (justia.com)
  • FIP1L1-PDGFRA rearrangement has been found in a variety of cell lineages (neutrophils, monocytes, eosinophils, CD34+ cells, mast cells and even lymphoid) consistent with an origin in an hematopoietic stem cells or early progenitors progenitor (Gotlib and Cools, 2008). (atlasgeneticsoncology.org)