• In Edinburgh in the pre-genomics era, he collaborated with Chris Leaver and cloned several key enzymes of plant metabolism, including malate synthase, isocitrate lyase and PEP carboxykinase. (wikipedia.org)
  • An increased PC activity upon ammonia exposure and the importance of PC activity for glutamine synthesis has previously been demonstrated while the importance of GDH for generation of glutamate as precursor for glutamine synthesis has received little attention. (123dok.net)
  • It is produced during synthesis of spermidine and spermine, and also of N-acylhomoserine lactone synthases in Gram-negative bacteria [ 7 ] and 1-aminocyclopropane-1-carboxylate (ACC) synthase in plants (and possibly in bacteria producing ethylene). (biomedcentral.com)
  • In this study, we aimed to investigate the physiology of P4HB synthesis, and to reduce the total production cost by using cheap and widely available xylose as the growth substrate and sodium 4-hydroxybutyrate (Na-4HB) as the precursor for P4HB synthesis. (biomedcentral.com)
  • Additionally, we detected increased levels of active glycogen synthase kinase 3 β, a physiological kinase of TAU, in neurons derived from AD iPSCs, as well as significant upregulation of amyloid precursor protein (APP) synthesis and APP carboxy-terminal fragment cleavage. (biomedcentral.com)
  • The antifungal drugs most widely used to treated fungal infections are compounds that inhibit cytochrome P450-dependent C14α-demethylase (CYP51), but other enzymes of this pathway, such as squalene synthase (SQS) which catalyses the first committed step in sterol biosynthesis, could be viable targets. (biomedcentral.com)
  • In salt-stressed C. nivalis there were decreases in the abundance of UDP-sulfoquinovose (− 1.77-fold change), which is involved in sulfoquinovosyl diacylglycerol metabolism, and in citrate synthase (− 2.7-fold change), also involved in the TCA cycle. (biomedcentral.com)
  • Acute intermittent porphyria (AIP) is one of the porphyrias, a group of hereditary diseases that involve defects in heme metabolism and result in excessive secretion of porphyrins and porphyrin precursors. (medscape.com)
  • In the soleus of SDT fatty rats, liraglutide led to greater citrate synthase activity and cytochrome c oxidase subunit 5 B protein expression, independently of blood glucose and blood pressure levels. (bvsalud.org)
  • SIRT3 deacetylated and increased citrate synthase activity in PD model. (en-journal.org)
  • High conversion rate and P4HB contents from xylose and precursor were achieved here by simple batch culture, which was only possible previously through fed-batch high cell density cultures with glucose. (biomedcentral.com)
  • Provides negative feedback to the heme synthetic pathway and shuts down productions of porphyrins and porphyrin precursors. (medscape.com)
  • Acute intermittent porphyria (AIP) is one of the porphyrias, a group of hereditary diseases that involve defects in heme metabolism and result in excessive secretion of porphyrins and porphyrin precursors. (medscape.com)
  • also known as hydroxymethylbilane synthase [HMBS]), which catalyzes the conversion of porphobilinogen to hydroxymethylbilane. (medscape.com)
  • This gradient is then utilized by the ATP synthase, which, in a rotary mechanism, catalyzes the formation of the high-energy γ-phosphate chemical bond between ADP and inorganic phosphate. (biomed.news)
  • On average, out of 100 patients with the genetic defect, perhaps 10-20 secrete excess porphyrin precursors and only 1-2 have symptoms. (medscape.com)