• During in vivo immune responses this role is primarily played by dendritic cells (DCs), which are endowed with an extraordinary potential to undertake their antigen-presenting cell function, based on their remarkable migratory capacity, optimal efficiency to capture and process antigens, and high level of expression of major histocompatibility complex (MHC), costimulatory, and adhesion molecules. (bloodjournal.org)
  • In contrast, those cells that do not fulfill these recognition requirements or that recognise auto antigens with high affinity are deleted. (elsevier.com)
  • Supposedly, this separation from the sites of earliest antigen processing and capture provide a protected environment in which opsonized antigens can be displayed for a long time without being proteolyzed or removed by phagocytic cells. (wikipedia.org)
  • Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. (nih.gov)
  • Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics remain unknown. (fujita-hu.ac.jp)
  • LCs play an essential role in the induction of T-lymphocyte responses against viruses, bacteria, and parasites that gain access to those epithelial surfaces, due to their high antigen capture and processing potential and their capacity to present antigen peptides to T cells on migration to the lymph nodes. (bloodjournal.org)
  • Interestingly, we have recently shown that mouse epidermal LCs, expressing neither CD8 nor leukocyte function-associated antigen 1 (LFA-1), underwent a maturation-induced CD8/LFA-1 up-regulation on migration to the lymph nodes (LNs), 9 suggesting that LCs belong to the CD8 + lymphoid DC category. (bloodjournal.org)
  • In contrast, cells isolated from Peyer's patches and mesenteric lymph nodes, which belong in the same intestinal immune compartment but lack c-kit + Lin - cells, failed to do so. (springer.com)
  • An aggressive (fast-growing) type of non-hodgkin lymphoma in which too many lymphoblasts (immature white blood cells) are found in the lymph nodes and the thymus gland. (icd10data.com)
  • Follicular DCs are a non-migratory population found in primary and secondary follicles of the B cell areas of lymph nodes, spleen, and mucosa-associated lymphoid tissue (MALT). (wikipedia.org)
  • our study demonstrates that Flt3L acts as an important regulator of ILCs lymphopoiesis and it can be used as a tool to expand and study ILCs precursors in the BM. (nih.gov)
  • Similar to CD4 + Th cells, ILCs can be grouped according to cytokine production and transcription factor expression. (rupress.org)
  • For example, group 2 ILCs (ILC2s) express the transcription factor GATA3 and produce the cytokines IL-5 and IL-13 in response to the epithelial cell-derived cytokines IL-25, IL-33, and thymic stromal lymphopoietin, whereas ILC3s express RORγt and produce high levels of IL-17A, IL-17F, and IL-22 after stimulation with IL-23. (rupress.org)
  • We now propose a clinical trial to test whether donor lymphocytes infusion (DLI) using TK-transduced cells permits to induce a graft-versus-tumor (GVT) effect for treatment of relapse after HSCT, while GVHD can be controlled by GCV treatment. (bioportfolio.com)
  • Comparison with precursor B-cell acute lymphoblastic leukemia showed several overlapping features, although distinct differences were identified. (elsevier.com)
  • Leukemia, acute lymphoblastic (ALL): A subtype of acute leukemia, a cancer of the white blood cells. (nih.gov)
  • The incidence of MEF2D fusions overall was 2.4% among consecutive precursor B-cell acute lymphoblastic leukemia patients enrolled onto a single clinical trial. (fujita-hu.ac.jp)
  • Mutations of PHF6, recurrent in T-cell acute lymphoblastic leukemia, also showed an unexpectedly high frequency (50%) in these patients. (fujita-hu.ac.jp)
  • Our observations indicate that MEF2D fusions comprise a distinct subgroup of precursor B-cell acute lymphoblastic leukemia with a characteristic immunophenotype and gene expression signature, associated with distinct clinical features. (fujita-hu.ac.jp)
  • Rocha B,Vassali P, Guy-Grand D: The VΒ repertoire of mouse gut homodimeric α CD8 + intraepi-thelial T cell receptor α/Β + lym-phocytes reveals a major extra-thymic pathway of T cell differ-entiation. (springer.com)
  • Laky K, Lefrancois L, Puddington L: Age-dependent intestinal lym-phoproliferative disorder due to stem cell factor receptor deficiency. (springer.com)
  • 1999). Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. (springer.com)
  • We further elucidated unique signaling downstream of a representative ITIM-containing receptor in leukemia cells. (utsouthwestern.edu)
  • 1999. HMG-1 Stimulates Estrogen Response Element Binding by Estrogen Receptor from Stably Expressed HeLa Cells. (utsouthwestern.edu)
  • Upon seeding, thymus T cell precursors undergo a complex series of maturational events that involve antigen receptor gene assembly by somatic recombination of gene segments. (elsevier.com)
  • This process is largely stochastic, therefore a mechanism must exist to shape this antigen receptor repertoire in order to achieve both self restriction (defined as the capacity of a T cell to recognise a peptide antigen in the context of self major histocompatibility complex molecules and self tolerance. (elsevier.com)
  • This review will focus on the development of the major subset of T cells (i.e. those equipped with a T cell receptor αβ) and on the molecular mechanisms by which a T cell with an apparently unchanging antigen receptor is alternately positively and negatively selected. (elsevier.com)
  • TNF-a binds on the TNFRI receptor, while LT interacts with LTβ-receptor expressed on FDC precursors. (wikipedia.org)
  • B cells lacking CXCR5, the receptor for CXCL13, still enter the white pulp, but are mislocalized and disorganized. (wikipedia.org)
  • The activation of LILRBs on immune cells by their ligands may contribute to immune evasion by tumors. (utsouthwestern.edu)
  • The goal of this clinical research study is to learn if giving donor lymphocyte cells and SGI-110 will help control AML and MDS. (bioportfolio.com)
  • Primary Objectives: This a pilot project to determine the feasibility of the preemptive CD8+ depleted T-cell donor lymphocyte infusion (DLI) in: - Reducing the incidence of graf. (bioportfolio.com)
  • To test this hypothesis in preclinical settings, we have previously developed several experimental models of GVHD using TK+ T-cells in mice. (bioportfolio.com)
  • Loss of Rank Impacts Invariant Vγ5+ Dendritic Epidermal T Cells(A and B) Epidermal sheets from WT and Tnfrsf11a−/− neonatal mice were analyzed by flow cytometry for CD3+ T cells (A), together with expression of the Vγ5TCR (B).(C) Frequency of CD3+Vγ5+ DETCs in WT (white bars) and Tnfrsf11a−/− (black bars) neonatal epidermis. (nih.gov)
  • Again, we found a dramatic reduction in the frequency of cells expressing high levels of both the Vγ5TCR and CD45RB (Figures 5A-5C), which resulted in a skewing in the mature:immature DETC ratio in Tnfrsf11a−/− mice (1:100) as compared to WT littermate controls (1:3) (Figure 5D). (nih.gov)
  • In addition, analysis of neonatal epidermal preparations showed that Tnfrsf11a−/− mice have a dramatic reduction in the frequency of total epidermal CD3+ T cells (Figure 6A), as well as a disproportionate reduction in those expressing the Vγ5TCR (Figures 6B and 6C). (nih.gov)
  • In mice lacking B cells, or with blocked TNF-a and lymphotoxin (LT) production, cells with FDC phenotype are missing. (wikipedia.org)
  • Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells. (nih.gov)
  • This results in the formation of GC, where antigen-activated B cells are trapped to undergo somatic mutation, positive and negative selection, isotype switching, and differentiation into high-affinity plasma cells and memory B cells. (wikipedia.org)
  • Activated B-cells with low affinity to antigen captured on FDCs surface as well as autoreactive B-cells undergo apoptosis, whereas B cells bound to FDCs through the antigen complex, survive due to apoptosis blockage caused by interaction with FDCs. (wikipedia.org)
  • Boismenu R, Havran ML: Modu-lation of epithelial cell growth by intraepithelial γδ T cells. (springer.com)
  • A literature review yielded 105 patients with a diagnosis of precursor B-cell LYL based on less than 25% marrow involvement. (elsevier.com)
  • However, Ueno and Weissman provided the earliest contradiction to the hemangioblast theory when they saw that distinct ES cells mixed into a blastocyst resulted in more than 1 ES cell contributing to the majority of the blood islands found in the resultant embryo. (wikipedia.org)
  • Specifically, metabolites from the commensal microbiota such as short-chain fatty acids have been identified to maintain tolerogenic conditions in the intestine, e.g., promoting regulatory T cells and down-modulating pro-inflammatory signaling pathways. (springer.com)
  • Puddington L, Olson S, LefrancoisL: Interactions between stem cell factor and c-kit are required for in-testinal immune system heme-ostasis. (springer.com)
  • B-cells collected from patients with Common Variable Immune Deficiency show evidence for BLyS binding to B cells and enhanced immunoglobulin secretion. (bioportfolio.com)
  • 2014). Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. (springer.com)
  • The long-term goal of our laboratory is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. (utsouthwestern.edu)
  • LILRB 1-5 transduce signals via ITIMs that recruit phosphatase SHP-1, SHP-2, or SHIP, leading to negative regulation of immune cell activation. (utsouthwestern.edu)