• We therefore investigated the mechanisms of selection in childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) during induction chemotherapy where maximal cytoreduction occurs. (uea.ac.uk)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
  • Until now we've relied on studies in mice to understand human germ cell differentiation, but the reproductive genes are not the same. (sciencedaily.com)
  • When treated in this manner, about 2 percent of the differentiated human embryonic stem cells were haploid after 14 days of differentiation. (sciencedaily.com)
  • Molecular changes underlying stem cell differentiation are of fundamental interest. (nih.gov)
  • This study reveals effects of cell cycle progression on the expression of lineage specific genes in precursor cells, and suggests that hematopoietic stress changes the balance of renewal and differentiation in these homeostatic cells. (nih.gov)
  • Towards the therapeutic development of inhibitory neuron precursor transplantation for human neurological disorders, we have made significant progress in the differentiation of these cells from human ESCs and will complete optimization of this protocol. (ca.gov)
  • During this first year, we have made considerable headway in the optimization of the human interneuron precursor differentiation protocol, verified functional engraftment of these cells in mice, and begun to collect dose, safety and efficacy data for rodent-derived interneuron transplantation. (ca.gov)
  • As we continue to optimize our ES cell differentiation protocol, these primary interneuron precursors will enable initial human cell dose response and behavior experiments and, along with rodent-derived cells, will provide important baseline measures. (ca.gov)
  • This technique allowed the team to detect cell inefficiencies and develop a new understanding of the underlying cell biology during the differentiation of PSCs. (nextbigfuture.com)
  • We present a predictive bioprocess design strategy employing cell- and molecular-level analysis of rate-limiting steps in human pluripotent stem cell (hPSC) expansion and differentiation, and apply it to produce definitive endoderm (DE) progenitors using a scalable directed-differentiation technology. (nextbigfuture.com)
  • Neural stem cells (NSCs) are undifferentiated neural cells with the capacity for long-term self-renewal and for differentiation into all types of neuronal and glial cells. (sanbio.nl)
  • In this report, we have analyzed the roles for gamma(c)-dependent cytokines in the generation of bone marrow NKP and in their subsequent differentiation to mature NK cells in vivo. (pasteur.fr)
  • Although IL-2, IL-4, and IL-7 have been reported to influence NK cell differentiation, we find that mice deficient in any or all of these cytokines have normal NK cell numbers, phenotype, and effector functions. (pasteur.fr)
  • In contrast, IL-15 plays a dominant role in early NK cell differentiation by maintaining normal numbers of immature and mature NK cells in the bone marrow and spleen. (pasteur.fr)
  • Our understanding of the perturbation of normal cellular differentiation hierarchies to create tumor-propagating stem cell populations is incomplete. (ox.ac.uk)
  • This suggests a new refined model of the relationship between LSCs and normal hemopoiesis in which the nature of genetic/epigenetic changes determines the disordered transcriptional program, resulting in LSC differentiation arrest at stages that are most like either progenitor or precursor stages of hemopoiesis. (ox.ac.uk)
  • The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. (biologists.com)
  • Within the B-cell and T-cell categories, two subdivisions are recognized: precursor neoplasms, which correspond to the earliest stages of differentiation, and more mature differentiated neoplasms. (medscape.com)
  • Differentiation of both CCR7(hi)PD-1(lo) and CCR7(lo)PD-1(hi) subsets required ICOS and BCL6, but not SAP, suggesting that circulating CXCR5â º helper T cells are primarily generated before germinal centers . (bvsalud.org)
  • Therefore, circulating CCR7(lo)PD-1(hi) CXCR5â º CD4â º T cells are generated during active Tfh differentiation and represent a new mechanism of immunological early memory . (bvsalud.org)
  • One complementary therapy could be 're-activating' vasculogenesis (i.e. the differentiation of precursor cells into mature endothelial cells), a mechanism that occurs in the heart during development but is quiescent in adult hearts. (elifesciences.org)
  • It can therefore be proposed that 5-AzaC treatment early after HSCT promotes differentiation of NK cells which can contribute to relevant GvL effects in vivo. (uni-tuebingen.de)
  • Myeloid-related precursor neoplasms derive from precursor cells that have at least one form of myeloid differentiation. (medscape.com)
  • The presence of the characteristic chromosomal translocation always involving the fibroblast growth factor receptor 1 ( FGFR1 ) gene at chromosome 8p11 in both the myeloid and lymphoid malignancies suggests bilineage differentiation from an affected pluripotent stem cell. (medscape.com)
  • Usually, a precursor cell is a stem cell with the capacity to differentiate into only one cell type. (wikipedia.org)
  • In embryology, precursor cells are a group of cells that later differentiate into one organ. (wikipedia.org)
  • Neural progenitors are precursor cells able to further differentiate into various neuronal and glial cells. (sanbio.nl)
  • NK cells differentiate in adult mice from bone marrow hemopoietic progenitors. (pasteur.fr)
  • Upon antigen reencounter, CCR7(lo)PD-1(hi) CXCR5â º precursors rapidly differentiate into mature Tfh cells to promote antibody responses . (bvsalud.org)
  • Our results demonstrated that these immature cells have a natural capacity to differentiate into endothelial cells in infarcted hearts. (elifesciences.org)
  • Using clonogenic sphere formation assays, we showed that this sorted population was enriched in multipotent precursor cells that could differentiate into both neurons and glia. (elsevierpure.com)
  • The researchers plan to use a similar strategy to optimize the production of eggs from embryonic stem cells, as well as investigating whether reprogrammed adult cells called induced pluripotent cells, or iPS cells, can also be used to create germ cells. (sciencedaily.com)
  • Adult p107-null mice had elevated numbers of proliferating progenitor cells in their lateral ventricles. (rupress.org)
  • In Drosophila , a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. (biologists.com)
  • Together, these findings indicate that precursor cells harvested from the embryonic ventral mesencephalon can generate dopaminergic neurons able to restore function to the chemically denervated adult striatum. (elsevierpure.com)
  • Previous studies indicate that these KIR-KIR ligand mismatch constellations significantly increase the outcome for patients suffering from adult acute myeloid leukemia whereas adult acute B cell lymphocytic leukemia (B-ALL) seems to be relative resistant to NK cell-mediated cytotoxicity. (uni-tuebingen.de)
  • Accepted: 24 October 2012 cell yield data, our models require that adult DN1 cells divide multiple times before becoming competent to progress into DN2 stage. (lu.se)
  • The transcriptional signatures of neural precursor cells (NPCs) were used for the first time to test Zika virus (ZIKV) susceptibility in a direct fetal brain infection model. (eneuro.org)
  • Nestin-driven GFP was detected in the mesencephalic ventricular zone, and it colocalized with specific markers for neural precursor cells. (elsevierpure.com)
  • We assessed the prognostic impact of established chromosomal abnormalities and key copy number alterations (CNA) among 652 patients with B-cell precursor ALL treated on a modern MRD driven protocol. (ucl.ac.uk)
  • Die PANGEA-Kohorte (Precursor Asymptomatic Neoplasms by Group Effort Analysis) besteht aus 6441 Patienten mit 4931 (77 %) MGUS- und 1510 (22 %) SMM-Patienten bei Studienbeginn. (oncoletter.ch)
  • Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow stem cells, which can manifest as an increased number of platelets, red blood cells (RBCs), or white blood cells (WBCs). (msdmanuals.com)
  • Importantly, we have achieved the development of a protocol that robustly generates interneuron-like progenitor cells from human ES cells and demonstrated that these progenitors mature in vitro and in vivo into GABAergic inhibitory interneurons with functional potential. (ca.gov)
  • What are neural stem cells (NSCs), neural progenitors, and neural precursors (NPCs)? (sanbio.nl)
  • NSCs and neural progenitors are often regarded as neural precursors (NPCs). (sanbio.nl)
  • Although similar methods have detected committed pre-B cells in mouse fetal liver, earlier progenitors with additional non-B lineage options have not been demonstrated in normal tissues. (pasteur.fr)
  • CD34(-) LSCs have disordered global transcription profiles, but these profiles are enriched for transcriptional signatures of normal CD34(-) mature granulocyte-macrophage precursors, downstream of progenitors. (ox.ac.uk)
  • DN1 stage) T-cell progenitors. (lu.se)
  • Proliferation-linked shifts in eligibility of T-cell progenitors, population dynamics, DN1 cells to undergo specification thus control kinetics of T-cell generation. (lu.se)
  • In detail, thymus-settling progenitors enter the thymus and generate early T-cell progeni- tors (ETP/DN1 stage), which in turn give rise to DN2, DN3 and DN4 cells. (lu.se)
  • We have also compared the behavior of primary fetal cells to these human interneuron precursor-like cells both in vivo and in vitro. (ca.gov)
  • In vitro neurosphere assays revealed striking increases in the number of neurosphere forming cells from p107 −/− brains that exhibited enhanced capacity for self-renewal. (rupress.org)
  • We have previously described committed NK cell precursors (NKPs), which have the capacity to generate NK cells, but not B, T, erythroid, or myeloid cells, after in vitro culture or transfer to a fetal thymic microenvironment. (pasteur.fr)
  • In vitro precursor microRNA processing assays using Drosophila Schneider-2 cell lysates. (elsevierpure.com)
  • In this chapter, we describe in vitro precursor (pre)-miRNA processing assays using Drosophila Schneider-2 (S2) cell lysates and immunopurified materials. (elsevierpure.com)
  • Dive into the research topics of 'In vitro precursor microRNA processing assays using Drosophila Schneider-2 cell lysates. (elsevierpure.com)
  • After sorting by fluorescence-activated cell sorting, the GFP + cells proliferated in vitro and expressed precursor cell markers but not neuronal markers. (elsevierpure.com)
  • Importantly, many neurons generated from nestin-GFP-sorted mesencephalic precursors developed a dopaminergic phenotype in vitro. (elsevierpure.com)
  • The Dnmt-inhibitor 5-azacytidine (5-AzaC) surprisingly does not increase KIR expression on NK cells as previously described for mature NK cells in vitro. (uni-tuebingen.de)
  • Introduction: Myeloid/Natural killer (NK) cell precursor acute leukemia (MNKPL) is a rare hematologic malignancy prevalent in East Asia. (confex.com)
  • Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage. (ox.ac.uk)
  • In human acute myeloid leukemia (AML), current models suggest transformation creates leukemic stem cell (LSC) populations arrested at a progenitor-like stage expressing cell surface CD34. (ox.ac.uk)
  • The image below shows pre-B-cell lymphoblastic leukemia/lymphoma (B-ALL). (medscape.com)
  • Using a NOD-scid IL2Rgammanull (NSG) xenotransplantation model two modes for NK cell-based therapies in pediatric B cell precursor ALL (BCP-ALL) were explored: First, the adoptive transfer of mature cytokine-activated NK cells into leukemia-bearing mice and second graft-versus-leukemia effects (GvL) mediated by transplant-emerging NK cells. (uni-tuebingen.de)
  • Under cytokine support there are relevant GvL effects towards primary B cell precursor leukemia in huNSG mice providing evidence that also early graft-emerging immature NK cells might contribute to alloreactivity. (uni-tuebingen.de)
  • and myeloid cells are seen in stem cell leukemia/lymphoma (SCLL), which is also known as 8p11 myeloproliferative syndrome (EMS). (medscape.com)
  • Stem cell leukemia/lymphoma (SCLL), which is also known as the 8p11 myeloproliferative syndrome (EMS), is characterized in its typical form by the occurrence, either simultaneously or sequentially, of a bcr/abl-negative myeloproliferative disorder and a lymphoma, usually a precursor T-cell lymphoblastic lymphoma. (medscape.com)
  • RUNX1-positive leukemia cells in preclinical models. (lu.se)
  • A precursor cell is also known as a progenitor cell but progenitor cells are multipotent. (wikipedia.org)
  • Primary myelofibrosis results from neoplastic transformation of a multipotent bone marrow stem cell. (msdmanuals.com)
  • A major limitation of adoptive immunotherapy is the availability of T cells specific for both terminally differentiated tumor cells and their clonogenic precursors. (johnshopkins.edu)
  • This connection is initiated by the anchor cell, which invades between the vulF cells in a process analogous to invasive behavior of metastatic tumor cells. (wormbook.org)
  • More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)
  • Lineage-specific genes were differently expressed between cells, and correlated with the cell cycle stages with a specific augmentation of erythroid related genes in the G2/M phase. (nih.gov)
  • Most lineage specific TFs were stochastically expressed in the early precursor cells, but a few, such as Klf1, were detected only at very low levels in few precursor cells. (nih.gov)
  • NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
  • Their dual potential and unrearranged immunoglobulin loci place the precursors before exclusive B-lineage commitment in the haematopoietic hierarchy. (pasteur.fr)
  • The availability of such cells in purified form will allow direct study of lineage choice in cells having both lymphoid and non-lymphoid options. (pasteur.fr)
  • Ring sideroblasts, defined as nucleated erythroid precursors with 5 iron granules or fewer surrounding at least one third of the nucleus, represent 15% or more of the erythroid lineage. (medscape.com)
  • The WHO modification of the REAL classification of NHL is based on morphology and cell lineage. (medscape.com)
  • The reversed polarity of the posterior 2 ° precursor cell lineage requires WNT signaling mediated by both Frizzled class and Ryk class WNT-receptors LIN-17 and LIN-18 , respectively. (wormbook.org)
  • The uninduced VPCs generate a 3 ° lineage, which make epidermal cells that fuse with the large syncytial epidermis hyp7. (wormbook.org)
  • Endothelial cell lineage tracing showed that BNP directly stimulated the proliferation of resident endothelial cells via NPR-A binding and p38 MAP kinase activation. (elifesciences.org)
  • Early and objective assessment of drug response with emphasis on intracellular cell signalling processes including proliferation, MAP kinase pathway/PI3 kinase pathway activities and apoptosis. (imperial.ac.uk)
  • BNP also stimulated the proliferation of WT1 + epicardium-derived cells but only in the hypoxic area of infarcted hearts. (elifesciences.org)
  • The origin of new endothelial cells (i.e. resident or infiltrating) as well as the underlying mechanism leading to their proliferation (partial endothelial-to-mesenchymal transition [EndMT] or not) have long been debated. (elifesciences.org)
  • This could indicate that in CBA mice some of the precursor cells effecting regeneration were intra-thymic at the time of irradiation or, alternatively, moderately high doses of X-irradiation (1,200 rads plus) impaired the intra-thymic proliferation of the progeny of the thymic precursor cell population. (nebraska.edu)
  • It was identified that alliin inhibited proliferation of gastric carcinoma cells by decreasing the cell viability but not in the normal intestinal cells. (phcog.com)
  • The aim of this study was to determine the number and state of activity of cytolytic T lymphocytes (CTL) and their precursors (CTL-P) present in vivo during the early stages of viral infection. (uni-muenchen.de)
  • LYMPHOCYTES (B and T cells) derive continuously from the same multipotential stem cells that produce myeloid cells, including erythrocytes, granulocytes and macrophages. (pasteur.fr)
  • We show here that marrow-infiltrating lymphocytes (MILs) recognize myeloma cells after activation with anti-CD3/CD28 beads with higher frequency than activated peripheral blood lymphocytes from the same patients. (johnshopkins.edu)
  • Le pourcentage de CD44 dans les lymphocytes T périphériques était significativement plus élevé chez les patients que chez les témoins, comme détecté par la cytométrie en flux. (who.int)
  • Additionally, elucidation of cell morphologic features using in utero electroporation (IUE) revealed substantial but incomplete interruption of basal fibers, a finding that implies interference with neuronal migration. (eneuro.org)
  • However, at least Id1 and Hes1 were significantly activated in both HSC and MPP1 cells in anemic mice. (nih.gov)
  • These dosing and safety data will then serve as the baseline for comparison with human interneuron precursors and inform design of preclinical studies of these cells in immunosuppressed mice. (ca.gov)
  • Frequency analysis of cytolytic T cell precursors (CTL-P) generated in vivo during lethal rabies infection of mice. (uni-muenchen.de)
  • Normal numbers of NKPs are found in gamma(c)-deficient mice, suggesting that NK cell commitment is not dependent on IL-2, IL-4, IL-7, IL-9, IL-15, or IL-21. (pasteur.fr)
  • Here we found that within circulating CXCR5â º CD4â º T cells in humans and mice , the CCR7(lo)PD-1(hi) subset has a partial Tfh effector phenotype , whereas CCR7(hi)PD-1(lo) cells have a resting phenotype . (bvsalud.org)
  • To visualize and isolate mesencephalic precursor cells from a mixed population, we used transgenic mice and rats carrying green fluorescent protein (GFP) cDNA under the control of the nestin enhancer. (elsevierpure.com)
  • Considering graft-emerging NK cells mainly immature KIR- NK-cells in stem cell transplanted NSG mice ("humanized NSG") can be detected, thus ideally resembling human NK cell ontogeny of patients post hematopoietic stem cell transplantation (HSCT). (uni-tuebingen.de)
  • Compared to saline treatments, bone-resorbing osteoclasts and bone marrow osteoclast precursor populations were also increased in ODE-treated WT but not IL-6 KO mice. (cdc.gov)
  • The perovskite solar cells fabricated by this aqueous method show good reproducibility of high efficiency with average power conversion efficiency (PCE) of 18.7% and champion PCE of 20.1% under solar simulation. (osti.gov)
  • Perovskite solar cells (PSCs) have attracted great attention due to their high power conversion efficiencies (PCEs) and low fabrication cost. (edu.sa)
  • Sometimes, precursor cell is used as an alternative term for unipotent stem cells. (wikipedia.org)
  • Human embryonic stem cells derived from excess IVF embryos may help scientists unlock the mysteries of infertility for other couples struggling to conceive, according to new research. (sciencedaily.com)
  • In the current study, the researchers treated human embryonic stem cells with proteins known to stimulate germ cell formation and isolated those that began to express germ-cell-specific genes -- about 5 percent of the total. (sciencedaily.com)
  • They then used a technique called RNA silencing to examine how blocking the expression of each of three DAZ family members in the embryonic stem cells affected germ cell development. (sciencedaily.com)
  • The effect of the DAZ family members on the embryonic stem cells varied according to whether the cells were derived from a male or a female embryo. (sciencedaily.com)
  • scRNA-seq on murine hematopoietic stem cells (HSC) and their progeny MPP1 separated the cells into 3 main clusters with distinct features: active, quiescent, and an un-characterized cluster. (nih.gov)
  • During the reporting period, we have developed methods to enable the optimization of inhibitory nerve precursor cell, or MGE cell, derivation from human pluripotent stem cells (hPSCs). (ca.gov)
  • In this reporting period, we continued to improve the acquisition of migratory medial ganglionic eminence (MGE)-type interneurons from human embryonic stem cells (hESC). (ca.gov)
  • Scalable Amounts of Liver and Pancreas Precursor" New Stem Cell Method Developed Increasing the available stem cells by 35 times or more will open the path to more regenerative medicine treatments using stem cells. (nextbigfuture.com)
  • Scientists in Canada have overcome a key research hurdle to developing regenerative treatments for diabetes and liver disease with a technique to produce medically useful amounts of endoderm cells from human pluripotent stem cells. (nextbigfuture.com)
  • NPCs can be differentiated from embryonic stem cells (ESCs) but also from induced pluripotent stem cells (iPSCs) (PMID: 11731782). (sanbio.nl)
  • Tri- and bipotential myeloid intermediates between the multipotential stem cells and later unipotential cells have been identified using clonal methods in culture. (pasteur.fr)
  • Resetting hPGCLCs (rhPGCLCs) are specified from human embryonic stem cells (hESCs) transitioning from the primed into the naïve state of pluripotency. (cam.ac.uk)
  • ring sideroblasts represent 15% or more of nucleated erythroid precursors. (medscape.com)
  • Although dysplasia is limited to the erythroid precursors, neutropenia or thrombocytopenia may be present. (medscape.com)
  • Most often, the bone marrow is hypercellular with a significant increase in erythroid precursors. (medscape.com)
  • Ring sideroblasts (see the images below) represent at least 15% of the nucleated erythroid precursors. (medscape.com)
  • Erythroid precursor with nuclear blebbing. (medscape.com)
  • Transplantation of interneuron precursors therefore holds therapeutic potential for treatment of human neurological diseases involving an imbalance in circuit inhibition/excitation. (ca.gov)
  • Furthermore, activated MILs target both the terminally differentiated CD138 + plasma cells and the myeloma precursor as shown by profound inhibition in a tumor clonogenic assay. (johnshopkins.edu)
  • 1994. Inhibition of Na+-glucose cotransport in kidney cortical cells by cadmium and copper: Protection by zinc. (cdc.gov)
  • Inhibition of HMG-CoA reductase by statin in effect prevents the synthesis of mevalonic acid, a precursor of nonsteroidal isoprenoids, lipid attachment molecules for small G proteins, such as Ras, Rho, and Rac. (cdc.gov)
  • The malignant cells of ALL are lymphoid precursor cells (ie, lymphoblasts) that are arrested in an early stage of development. (medscape.com)
  • Mononuclear cells with pronounced phagocytic ability that are distributed extensively in lymphoid and other organs. (bvsalud.org)
  • Oligodendrocyte precursor cell Myeloblast Thymocyte Meiocyte Megakaryoblast Promegakaryocyte Melanoblast Lymphoblast Bone marrow precursor cells Normoblast Angioblast (endothelial precursor cells) Myeloid precursor cells Plasmablast "4. (wikipedia.org)
  • Myeloblasts account for fewer than 5% of nucleated bone marrow cells, and Auer rods are absent. (medscape.com)
  • The extent and timing of this phase of thymic regeneration was unaffected by shielding or transplanting substantial amounts of bone marrow, suggesting that the precursor cells responsible for effecting regeneration were not derived directly from the bone marrow. (nebraska.edu)
  • Since the initial phase of thymic regeneration was observed in thymus grafts which are repopulated by host bone marrow cells, this indicated that the precursor cell population was ultimately, if not immediately, derived from the bone marrow. (nebraska.edu)
  • The data would appear to be consistent with the hypothesis that the precursor cell population responsible for the initial phase of thymic regeneration after X-irradiation is ultimately derived from the bone marrow, but is in transit to the thymus at the time of irradiation. (nebraska.edu)
  • Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm characterized by bone marrow fibrosis, splenomegaly, and anemia with nucleated and teardrop-shaped red blood cells. (msdmanuals.com)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
  • Porcine fetal neural gabaergic cells and/or precursors aseptically prepared for intracerebral implantation for Huntington's disease. (checkorphan.org)
  • We report the characterization and purification of fetal liver cells that generate clones containing both macrophages and B cells, identified biochemically and morphologically. (pasteur.fr)
  • Here, a novel murine model of fetal ZIKV infection incorporating intraventricular infection and cell type-specific in utero electroporation (IUE) was used to identify the time course of ZIKV infection and to determine the identity of cells that are initially infected or spared during neocortical neurogenesis. (eneuro.org)
  • BNP treatment increased vascularisation and the number of endothelial cells in all areas of infarcted hearts. (elifesciences.org)
  • The term mononuclear phagocyte system has replaced the former reticuloendothelial system, which also included less active phagocytic cells such as fibroblasts and endothelial cells. (bvsalud.org)
  • In vivo time course studies revealed the presence of ZIKV in apical radial glial cells (aRGCs) at early time points following virus exposure, while basal intermediate progenitor cells (bIPCs) became maximally (ZIKV + ) after 3 d of virus exposure. (eneuro.org)
  • The improved specificity of apical radial glial cell (aRGC) labeling afforded by the cell-specific labeling tools uncover functional differences between aRGC types that will have important implications for children exposed to ZIKV as well as for understanding corticogenesis. (eneuro.org)
  • Infection with an endemic human herpesvirus disrupts critical glial precursor cell properties. (bvsalud.org)
  • The chemistry of the precursor from which charge transport layers are formed can significantly affect the device performance of organic solar cells. (aip.org)
  • Here, we compare two common precursors that are used to generate titania electron transport layers and elucidate their effects on the transient characteristics of inverted bulk-heterojunction polymer solar cells comprising poly(3-hexyl hiophene) and [6,6]-phenyl-C 61 -butyric acid methyl ester. (aip.org)
  • Furthermore, organic solar cells with titania electron transport layers prepared with such pre-modified titania precursor exhibit higher power-conversion efficiencies stemming from lower trap densities. (aip.org)
  • Cytokines, including those that signal via receptors using the common cytokine receptor gamma-chain (gamma(c)), have been implicated at various stages of NK cell development. (pasteur.fr)
  • During the L1 and L2 stages, six vulval precursor cells (VPCs) are specified among the 11 Pn.p cells, which are located in the ventral epidermis. (wormbook.org)
  • Experimental protocols were established that allow frequency estimates of in vivo antigen-triggered CTL-P. Data allow a distinction between CTL-P activated in vivo by alloantigen and viral antigen with respect to their different capacity to utilize T cell growth factors (inter-leukins). (uni-muenchen.de)
  • Adoptive transfer experiments show that pediatric BCP-ALL can be targeted by mature NK cells in vivo. (uni-tuebingen.de)
  • A blastoma is any cancer created by malignancies of precursor cells. (wikipedia.org)
  • Rather, it acts on extensive, previously unappreciated, transcriptional and epigenetic heterogeneity in BCP-ALL, dramatically reducing the spectrum of cell states represented, leaving a genetically polyclonal but phenotypically uniform population, with hallmark signatures relating to developmental stage, cell cycle and metabolism. (uea.ac.uk)
  • But unlike mature precursors, LSCs express multiple normal stem cell transcriptional regulators previously implicated in LSC function. (ox.ac.uk)
  • Researchers at the school have devised a way to efficiently coax the cells to become human germ cells -- the precursors of egg and sperm cells -- in the laboratory. (sciencedaily.com)
  • Unlike previous research, which yielded primarily immature germ cells, the cells in this most-recent study functioned well enough to generate sperm cells. (sciencedaily.com)
  • Overexpressing the three proteins together allowed the researchers to generate haploid cells -- those with only one copy of each chromosome -- expressing proteins found in mature sperm. (sciencedaily.com)
  • In many species, the germ cells, precursors of sperm and egg, migrate during embryogenesis. (woofahs.com)
  • Human primordial germ cells (hPGCs), the precursors of eggs and sperm, start their complex development shortly after specification and during their migration to the primitive gonads. (cam.ac.uk)
  • Immunofluorescent staining of PAX6 ( 12323-1-AP , 1:250 dilution) with 4% PFA fixed control human-induced pluripotent stem cell (hiPSC)-derived NPCs. (sanbio.nl)
  • By measuring the fluorescence of cell populations at a later stage the team were able to work out the frequency of cell division, which allowed them to predict how many cells would be present in a population at any given time. (nextbigfuture.com)
  • 98% of cells are CD34(-), there are multiple, nonhierarchically arranged CD34(+) and CD34(-) LSC populations. (ox.ac.uk)
  • Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma. (johnshopkins.edu)
  • Here we show a novel function for Retinoblastoma family member, p107 in controlling stem cell expansion in the mammalian brain. (rupress.org)
  • The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)
  • The two 2 ° precursor cells generate vulA, vulB1, vulB2, vulC and vulD cells but in mirror symmetric polar patterns: ABCD and DCBA. (wormbook.org)
  • The anchor cell also patterns nearby uterine cells, via the DSL ligand LAG-2 and LIN-12 , to generate the four uv1 cells that form the tight connection with the vulva. (wormbook.org)
  • During the L3 stage, a signal from the gonad and signaling among the VPCs specifies three VPCs to generate vulval cells ( Figure 2 ). (wormbook.org)
  • Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
  • 5-AzaC distinctly enhances immature and mature NK cell subsets and along with this the anti-leukemic response. (uni-tuebingen.de)
  • 107 immature T-cells per day competence. (lu.se)
  • They found that one family member, DAZL, functions very early in germ cell development, while two others, DAZ1 and BOULE, stimulate the then-mature germ cells to divide to form gametes. (sciencedaily.com)
  • Surprisingly, the few residual NK cells generated in absence of IL-15 appear relatively mature, expressing a variety of Ly49 receptors and demonstrating lytic and cytokine production capacity. (pasteur.fr)
  • Mature miRNAs are excised from precursors in a stepwise process and subsequently incorporated into an RNA-induced silencing complex (RISC), which mediates either cleavage of the target messenger RNA (mRNA) or translational repression, depending on the complementarity between the miRNA and its target mRNA. (elsevierpure.com)
  • 106 mature cells per day. (lu.se)
  • Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. (nature.com)
  • 2001). Third, the authors report that mutating maternal components of the Hh signaling pathway leads to germ cell migration defects in the progeny (Deshpande et al. (woofahs.com)
  • Previous terms for this disorder have included CD4+CD56+ hematodermic tumor (HDT) and blastic natural killer (NK) cell lymphoma. (medscape.com)
  • Myelodysplastic syndromes (MDS), as defined by the World Health Organization (WHO), represent clonal hematopoietic stem cell disorders resulting in ineffective hematopoiesis. (medscape.com)
  • Pemphigus vulgaris (PV) is a life-threate- disorders and to shed a light on the role of ning blistering skin disease in which pa- mast cells in autoimmune diseases [ 7 ]. (who.int)
  • Trained immunity of natural killer (NK) cells has shown great potential in the treatment of cancers by eliciting enhanced effector responses to restimulation by cytokines or cancer cells for long time periods after preactivation. (cancerbiomed.org)
  • This classification divides NHL into two groups: those of B-cell origin and those of T-cell/natural killer (NK)-cell origin. (medscape.com)
  • Killer-immunoglobulin-like (KIR)-receptors on natural killer (NK) cells and their corresponding HLA ligands play an important role in self-/non-self-discrimination of NK cells. (uni-tuebingen.de)
  • Additional doses of up to 600 rads to the thymus only did not affect the extent of regeneration on the tenth day, suggesting that, in this mouse strain, regeneration was effected by a cell population derived from an extra-thymic source. (nebraska.edu)
  • Sharp, JG & Thomas, DB 1977, ' Origin of the radioresistant precursor cells responsible for the initial phase of thymic regeneration after X irradiation ', RES Journal of the Reticuloendothelial Society , vol. 22, no. 3, pp. 169-179. (nebraska.edu)
  • Downloaded from periodic thymic colonization by progenitor cells guarantees stage. (lu.se)
  • In addition to expressing key genes, these cells also began to remove modifications, or methyl groups, to their DNA that confer cell-specific traits that would interfere with their ability to function as germ cells. (sciencedaily.com)
  • Induction of anemia resulted in mobilization of the quiescent to the active cluster and of the early to later stage of cell cycle, with marked increase in expression of certain transcription factors (TFs) while maintaining expression of interferon response genes. (nih.gov)
  • The results indicate that one class of aRGCs preferentially express the putative ZIKV entry receptor AXL and that these cells are more vulnerable to ZIKV infection than other aRGC subtypes with low AXL expression. (eneuro.org)
  • CD4 cells are a type of white blood cell that are important in maintaining a healthy immune system to help fight infection. (who.int)
  • Additionally, targeted metabolite analysis after stable isotope feeding assays revealed that PAOx can serve as a precursor of phenylacetic acid (PAA) in sorghum and identified benzyl cyanide as an intermediate of PAOx-derived PAA biosynthesis in both sorghum and maize. (biorxiv.org)
  • In contrast to normally maturing precursors with finely granular cytoplasmic morphology seen with PAS staining, severely dysplastic red cells show clumped cytoplasmic morphology. (medscape.com)
  • A novel 5S RNA-protein (RNP) complex in human and mouse cells has been analyzed using patient autoantibodies. (nih.gov)
  • Precursor cells are known as the intermediate cell before they become differentiated after being a stem cell. (wikipedia.org)
  • Intermediate or precursor strains are extrapolated to exist at the interface between avian and human H7N9 subtypes ( 5 , 6 ), but such strains have not been identified. (cdc.gov)
  • Mesencephalic precursor cells may one day provide dopaminergic neurons for the treatment of Parkinson's disease. (elsevierpure.com)
  • However, the generation of dopaminergic neurons from mesencephalic precursors has been difficult to follow, partly because an appropriate means for recognizing mesencephalic ventricular zone precursors has not been available. (elsevierpure.com)
  • Bromodeoxyuridine-tyrosine hydroxylase double-labeling revealed that the transplanted cells generated new dopaminergic neurons within the host striatum. (elsevierpure.com)
  • Studies suggest that in the brain, it helps direct the movement (migration) of nerve cells (neurons) during early development. (medlineplus.gov)
  • Our preliminary data suggests that grafting interneuron precursors into the postnatal rodent brain allows for up to a 35% increase in the number of cortical interneurons. (ca.gov)
  • Dpp, a member of the BMP family, is a morphogen that specifies positional information in Drosophila wing precursors. (elifesciences.org)
  • NPCs are distinct from differentiated cells of the nervous system at the molecular level. (sanbio.nl)
  • Alternatively, NPCs can be isolated from fresh nervous tissues using cell sorting with NPC markers (PMID: 11121071). (sanbio.nl)
  • 2001). Fourth, the authors report that Hmgcr promotes Hh signaling in particular CP-724714 through release or transmission of the Hh ligand and postulate that the function of Hmgcr in germ cell migration is to promote Hh signaling (Deshpande and Schedl, 2005). (woofahs.com)
  • In mismatched KIR-KIR ligand constellations the balance of inhibitory and activating signals is shifted towards target cell lysis. (uni-tuebingen.de)
  • Advances in stem cell research and regenerative medicine have led to the potential use of stem cell therapies for neurodegenerative, developmental and acquired brain disease. (ca.gov)
  • Optimization encompassed increasing MGE cell motility, enhancing MGE cell maturation into inhibitory nerve subtypes, and elimination of tumors post-transplantation into the rodent brain. (ca.gov)
  • Furthermore, we demonstrated that the injected hPSC-MGE cells functionally matured into inhibitory nerves with advanced physiological properties that integrated into the rodent brain. (ca.gov)
  • Prenatal exposure to Zika virus (ZIKV) can result in microencephaly and congenital Zika syndrome, although some brain cells and structures are spared by the virus for unknown reasons. (eneuro.org)
  • When these protein fragments are released from the cell, they can accumulate in the brain and form clumps called amyloid plaques. (medlineplus.gov)
  • Such epigenetic reprogramming is a hallmark of germ cell formation. (sciencedaily.com)
  • 2001). Several different types of CP-724714 experiments CP-724714 were used to analyze Hh function in germ cell migration. (woofahs.com)
  • 1998). Second, the authors report that ectopic expression of leads to germ cell migration defects (Deshpande et al. (woofahs.com)
  • Notably, the rhPGCLC-hindgut co-culture system can also be adapted to study failings in hPGC migration, which are associated with the aetiology of some forms of infertility and germ cell tumours. (cam.ac.uk)
  • This suggests that BOULE may play a larger role than the other proteins in the development of female germ cells. (sciencedaily.com)
  • As a result, future protocols might consider exploitation of NK cell-mediated immuneresponses for relapsing pediatric BCP-ALL patients. (uni-tuebingen.de)
  • abstract = "A multi-functional gelator precursor with high photosensitivity is rationally designed, which can not only selectively target hepatocellular carcinoma (HCC) cells, but also form intracellular self-assembly triggered by light and subsequently inducing cell death. (tau.ac.il)
  • abstract = "Polyadenylated RNA, extracted from a human medullary thyroid carcinoma, was translated in cell-free systems prepared from wheat germ and reticulocyte lysates. (elsevierpure.com)
  • The precise pattern of vulval precursor cell fates involves the graded action of the EGF signaling and LIN-12 (Notch) mediated lateral signaling. (wormbook.org)
  • Thus, the stripe of Dpp ensures that signalling remains above a pro-growth threshold, while at the same time generating a gradient that patterns cell fates. (elifesciences.org)
  • The C. elegans hermaphrodite vulva develops during postembryonic (larval) development from ventral epidermal precursors, and connects the developing uterus to the external environment. (wormbook.org)