These patients have fewer complications and a reduced mortality compared with those who have myocardial infarction without it. (asahq.org)
Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1. (sciendo.com)
A quantitative, randomized study evaluating three methods of mesenchymal stem cell delivery following myocardial infarction. (sciendo.com)
Reperfusion8
ENGLISH ABSTRACT: The Mechanism of -adrenergic preconditioning ( -PC) Ischaemic preconditioning (IPC), a potent endogenous protective intervention against myocardial ischaemia, is induced by exposure of the heart to repetitive short episodes of ischaemia and reperfusion. (sun.ac.za)
Hearts were preconditioned with 5 min isoproterenol 0.1 μM ( 1/ 2-AR agonist), or formoterol 1 nM ( 2-AR agonist) or BRL 37344 1 μM ( 3-AR agonist) followed by 5 min reperfusion. (sun.ac.za)
Both Rp-8-CPT-cAMPs and wortmannin significantly increased infarct size when administered before 1/ 2-AR preconditioning or at the onset of reperfusion while it reduced mechanical recovery during reperfusion. (sun.ac.za)
The NOS inhibitors had no effect on the reduction in infarct size induced by 1/ 2-AR preconditioning, but depressed mechanical function during reperfusion. (sun.ac.za)
Ischemic preconditioning and anesthetic preconditioning (APC) are reported to decrease myocardial infarct size during ischemia-reperfusion injury. (asahq.org)
Ischaemic reperfusion injury (IRI) after tourniquet release during total knee arthroplasty (TKR) is related to postoperative cerebral complications. (medsci.org)
Tourniquet release during the late period of TKR can induce ischaemic-reperfusion injury, eliciting the activation of neutrophils, circulating pro-inflammatory cytokines, and reactive oxygen species [ 2 , 3 ]. (medsci.org)
10. Frässdorf J, De Hert S, Schlack W. Anaesthesia and myocardial ischaemia/reperfusion injury. (sciendo.com)
Infarct size1
PTX pretreatment had no significant effect on the reduction in infarct size induced by 1/ 2-AR or 2-AR preconditioning, however it reduced mechanical recovery in the latter. (sun.ac.za)
Ischaemia4
Ischaemic preconditioning describes the phenomenon where transient and brief ischaemia confers protection against a subsequent prolonged and injurious period of ischaemia. (medsci.org)
However, it is not easy to apply ischaemic preconditioning in a clinical setting because brief organ ischaemia should be preceded after real ischaemic time [ 8 ]. (medsci.org)
Meanwhile, the organ protective effect of ischaemic preconditioning could be induced when the episodic ischaemia is at distant tissues or organs, the concept being termed remote ischaemic preconditioning (RIPC) [ 9 ]. (medsci.org)
The application of RIPC into clinical fields is more useful than ischaemic preconditioning because it is easy to apply briefly preceding ischaemia to distant organs such as the limbs. (medsci.org)
Induce1
Recent studies in the isolated perfused rat heart model have shown that IPC failed to induce cardioprotection in the senescent myocardium. (asahq.org)
Volatile4
6,7 The mechanism of volatile anesthetic preconditioning (APC), although not fully understood, is believed to share similarities with IPC by activation of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channels, particularly in the mitochondria. (asahq.org)
8-11 Volatile anesthetics are now being investigated as pharmacologic agents to precondition the heart during coronary artery bypass surgery, with both positive 12-14 and negative 15 results. (asahq.org)
Stem cell-like human endothelial progenitors show enhanced colony-forming capacity after brief sevoflurane exposure: preconditioning of angiogenic cells by volatile anesthetics. (sciendo.com)
Protective1
Considering that tourniquet application during TKR is related to ischaemic injury, the organ protective effect of ischaemic preconditioning can have a beneficial role after tourniquet release during TKR. (medsci.org)
Phenomenon1
1 demonstrated the phenomenon in dogs, ischemic preconditioning (IPC) has been shown to occur in every mammalian species in which it has been investigated. (asahq.org)
Although the mechanisms of ischemic preconditioning and APC are thought to be similar, it is not known whether the beneficial effects of APC are also reduced in the aged myocardium. (asahq.org)
Given its similarities to IPC, it seems reasonable to hypothesize that the beneficial effects of APC may also be reduced in aged myocardium. (asahq.org)
Mechanism1
the respective roles of the A1-, A2-, A3-adenosine receptors as well as the involvement of the PI3-K/PKB/Akt and ERKp44/p42 signal transduction pathways, in the cardioprotective phenomemon of -adrenergic preconditioning and (iv) the contribution of the mitochondrial KATP channels (mKATP), reactive oxygen species and NO to the mechanism of -AR-induced cardioprotection. (sun.ac.za)
Heart1
Optimizing stem cell function for the treatment of ischemic heart disease. (sciendo.com)
Effect1
The resulting genetically modified MSCs showed enhanced target homing effect and greater retention rate in the ischemic myocardium after the intravenous delivery. (biomedcentral.com)
Shown1
Release of endogenous catecholamines and activation of the beta-adrenergic receptors (b-AR) have also been shown to be involved in ischaemic preconditioning. (sun.ac.za)
Cells3
Endothelial progenitor cells in neovascularization of infarcted myocardium. (sciendo.com)
Dynamics of endothelial progenitor cells following sevoflurane preconditioning. (sciendo.com)
14. Sun X, Fang B, Zhao X, Zhang G, Ma H. Preconditioning of mesenchymal stem cells by sevoflurane to improve their therapeutic potential. (sciendo.com)
Studies1
Remote ischaemic preconditioning (RIPC) is known to minimise IRI in previous studies. (medsci.org)
Infarction1
There are on average 1.5 million episodes of myocardial infarction (heart attack) each year in the United States alone with roughly one-third resulting in death. (springer.com)
Ischemia8
One or more brief episodes of coronary artery occlusion protect or "precondition" the myocardium perfused by that artery from a subsequent episode of sustained ischemia. (nih.gov)
Brief episodes of ischemia in one vascular bed protect remote, virgin myocardium from subsequent sustained coronary artery occlusion in this canine model. (nih.gov)
These data imply that preconditioning may be mediated by factor(s) activated, produced, or transported throughout the heart during brief ischemia/reperfusion. (nih.gov)
Ischemic conditioning has been shown to ameliorate ischemia-reperfusion injury in small animal models. (wjgnet.com)
Ischemic preconditioning refers to that performed before the duration of ischemia of the target organ. (wjgnet.com)
Ischemic perconditioning is performed over the duration of ischemia of the target organ. (wjgnet.com)
Ischemic postconditioning applies brief episodes of ischemia at the onset of reperfusion following a prolonged ischemia. (wjgnet.com)
At 4.5 hours following reperfusion, segment shortening in the left anterior descending coronary artery bed (assessed by sonomicrometry) averaged -21 +/- 19% of baseline in control animals versus 13 +/- 12% of baseline in the preconditioned group (p = NS). (nih.gov)
Coronary1
We sought to determine whether ischemic preconditioning protects only those myocytes subjected to brief coronary occlusion or whether brief occlusions in one vascular bed also limit infarct size and/or attenuate contractile dysfunction in remote virgin myocardium subjected to subsequent sustained coronary occlusion. (nih.gov)
Cardiac1
Beltrami AP, Barlucchi L, Torella D et al (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. (springer.com)
Remote1
Stankiewicz R, Grąt M. Direct, remote and combined ischemic conditioning in liver surgery. (wjgnet.com)
Target1
The resulting genetically modified MSCs showed enhanced target homing effect and greater retention rate in the ischemic myocardium after the intravenous delivery. (biomedcentral.com)