Preclinical mouse models mice immunotherapy adoptive. Medical search. Frequent questions

We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy, which will inspire further clinical investigations and eventually benefit cancer patients. (nature.com)
In this respect, the introduction of checkpoint inhibitors to unleash the activity of tumor-reactive T cells has been a milestone in cancer immunotherapy. (nature.com)
Recent studies in mouse tumor models have shown that T RM cells are induced by cancer vaccines delivered in peripheral tissue sites, or by the depletion of regulatory T cells. (frontiersin.org)
As the field of cancer immunotherapy advances rapidly, it is now crucial to understand how the dissemination and maintenance of tumor-specific T cells can be optimally achieved. (frontiersin.org)
Adoptive T-cell therapy with T cell receptor (TCR) -engineered T cells is an attractive strategy for cancer treatment and the success in this therapy is dependent on the functional avidity of the transduced TCRs against targeted tumor antigens. (oncotarget.com)
Adoptive immunotherapy using tumor-associated antigen (TAA)-specific CD8 + cytotoxic T lymphocytes (CTLs) and/or CD4 + helper T (Th) cells can induce the regression of large established tumor in not only mouse models but also cancer patients [ 1 - 3 ]. (oncotarget.com)
In response to a cancer-germline self-antigen P1A, akin to human MAGE-like antigens, our pioneering studies using TCR-P1A transgenic mice (J Immunol 172:5069) established normal thymic development of CD8 T cells and discovered a paradigm of CD8 T cell help for innate NK effector function in solid tumor microenvironments. (vumc.org)
20 nM) into mice does not induce cell death in lymphoid or myeloid cells, nor does it affect antigen presentation or proliferation of antigen-specific CD4 or CD8 T cells (Cancer Res 75:5260). (vumc.org)
These results offer a preclinical proof for combining bortezomib or PCC with lymphocyte transfers to improve the outcomes of cancer immunotherapy. (vumc.org)
During the past two decades, due to the better understanding of cancer pathogenesis, targeted therapy and immunotherapy have been extensively developed and utilized in cancer treatment. (nhri.org.tw)
Moreover, the inhibitory mechanisms in tumor microenvironment may also influence the efficacy of the cancer immunotherapy. (nhri.org.tw)
We are interested to study other types of cancer in the immune-humanized mouse model to see if it is possible to model diseases other than melanoma. (taconic.com)
Her current research interests are in understanding the interaction between the immune system and cancer, and in the use of immunotherapy to treat cancer. (asi2022.org)
Dr. Paul Beavis is a Group Leader at the Peter MacCallum Cancer Centre, where his team are focussed upon developing novel immunotherapies for cancer. (asi2022.org)
The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. (taconic.com)
Despite significant recent improvements in the field of immunotherapy, cancer remains a heavy burden on patients and healthcare systems. (mdpi.com)
Thus, addressing the presence of immunosuppressive myeloid cell populations in the periphery and tumor microenvironment of patients with cancer is likely to be required for effective NK cell-based immunotherapy. (elifesciences.org)
Jessica D. Mackert, PhD (Wake Forest University) described preclinical data supporting CD47 as a target for the treatment of brain metastases in triple-negative breast cancer (TNBC). (sitcancer.org)
Defined immune thresholds for tumor protection and the factors affecting such thresholds have not well been investigated in cancer immunotherapy. (bmj.com)
Methods We generated CMV-based vaccine vectors expressing the E7 epitope and tested these in preclinical models of HPV16-induced cancer. (bmj.com)
The Workshop associated with the 27th Annual Meeting of the Society for Immunotherapy of Cancer (SITC), North Bethesda, MD, October 24-25, 2012 focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
To support these efforts, the Society for Immunotherapy of Cancer (SITC) held a workshop focused on targeting the tumor microenvironment as part of an integrative approach to immune-based cancer therapy. (biomedcentral.com)
SITC is a non-profit group of medical professionals established in 1984 to facilitate the exchange and promotion of scientific information about the promise and breakthroughs of immunotherapy for cancer patients. (biomedcentral.com)
To aid in this effort, SITC provides a venue to facilitate the discussion of current clinical trial results and methodologies, as well as means to collaborate on new initiatives in tumor immunology and cancer immunotherapy with the ultimate goal of improving cancer patient outcomes. (biomedcentral.com)
Adoptive cell transfer (ACT) is a promising cancer immunotherapy that involves isolating T cells from cancer patients that are capable of targeting their tumor, selecting the more active T cells and expanding those in the lab, and then transfusing them back into patients. (blogspot.com)
Combining ACT with a pan-PIM kinase inhibitor and a PD1 inhibitor improves outcomes in a preclinical model, report researchers at the Medical University of South Carolina (MUSC) in an article published online in October by Clinical Cancer Research . (blogspot.com)
That's important for ACT, because the longer the transfused T cells say inside the host to fight tumor cells, the better," says Shikhar Mehrotra, Ph.D., senior author of the article, who is co-scientific director of the oncology and immunotherapy programs in the Department of Surgery at the Medical University of South Carolina and a member of the Hollings Cancer Center. (blogspot.com)
Clinical successes with checkpoint inhibitors, including PD1 and PDL1inhibitors, ushered in immunotherapy as the fifth pillar of cancer therapy, where it joined the ranks of chemotherapy, surgery, radiotherapy and targeted therapy. (blogspot.com)
To include the patient's individual biological status, patient derived xenograft (PDX) models have emerged as a powerful tool in cancer research. (europdxworkshop.eu)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022), organized by the Fondazione Melanoma Onlus, Naples, Italy, in collaboration with the Society for Immunotherapy of Cancer. (biomedcentral.com)
2019). "Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcgammaR affinity" Nat Commun 10(1): 2141. (bioxcell.com)
As a proof of this concept, we have developed LVGN6051, a humanized 4-1BB mAb-AG that shows high anti-tumor efficacy in the absence of liver toxicity in a mouse model of cancer immunotherapy. (bioxcell.com)
Now, researchers at La Jolla Institute for Immunology identified a progenitor of neutrophils in the bone marrow of mice and humans and tied it to cancer-promoting activities. (lji.org)
When transferred in mouse cancer models, both the murine and human neutrophil progenitors promoted tumor growth. (lji.org)
Altogether, our study in mice demonstrates that αGC/CD1d-antitumor fusion protein greatly increases the efficacy of a therapeutic CpG-based cancer vaccine, first as an adjuvant during T cell priming and second, as a therapeutic agent to redirect immune responses to the tumor site. (biomedcentral.com)
Cancer-specific adoptive T cell therapy has achieved successful milestones in multiple clinical treatments. (biomedcentral.com)
Collectively, the BsAb-armed T cell technology represents a simple, time-saving, and highly safe method to generate highly pure cancer-specific effector T cells, thereby providing an affordable T cell immunotherapy to patients. (biomedcentral.com)
Immunotherapy is among the most effective approaches for treating cancer. (mdpi.com)

We were the first to show that administration of bortezomib, a proteasome inhibitor, in mice bearing mammary and renal tumors sensitized tumor cells to apoptosis by amplifying tumor cell caspase-8 activation following treatment with TRAIL receptor agonist antibody (JNCI 100:649). (vumc.org)
According to Elin Forsberg, a doctoral student working in the lab of Dr. Jonas Nilsson at the University of Gothenburg, IL-2 transgenic humanized NOG mice can be used to study the effect of CAR-T therapy on human tumors. (taconic.com)
One notable observation was that in the immune-humanized mouse model, mice receiving T cells would develop a lymphoproliferative disease after the tumors disappeared because the IL-2 signaling was constitutive, driving T cell proliferation. (taconic.com)
It is possible that poor effects or lack of durability of CAR-T cell therapies for solid tumors in other mouse models can be explained by the lack of human IL-2. (taconic.com)
In mice bearing brain metastatic 4T1br3 tumors, anti-CD47 treatment shrank tumors by roughly 50% compared to controls, which accompanied by a 5-fold increase in expression of F4/80 macrophage markers in the tumors. (sitcancer.org)
PDX models are an important tool to develop novel strategies against drug-and/or radio-resistant tumors in preclinical trials. (europdxworkshop.eu)
To investigate the effect of hyperglycemia on anti-tumor function induced by anti-PD-1 antibody treatment, we treated STZ-induced diabetic mice with subcutaneous MC38 colon carcinoma tumors with anti-PD-1 antibody, and examined changes in tumor growth, the number of tumor-infiltrating immune cells, and the expression of chemokines and chemokine receptors. (nature.com)
Fifteen genetically diverse models developed bone marrow (BM) tumors fulfilling MM pathogenesis. (unav.edu)
However, not all patients respond to immunotherapy, acquired resistance remains a challenge, and responses are poor in certain tumors which are considered to be immunologically cold. (biomedcentral.com)
Notably, the BsAb-armed T cells did not cause obvious cytokine release syndrome or tissue toxicity in SCID mice bearing human tumors. (biomedcentral.com)
However, it also points out the weaknesses of immunotherapy, as not all tumors respond to therapy and the co-administration of different immunomodulators may be severely limited due to their systemic toxicity. (mdpi.com)

To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy, the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized, and clinical safety and efficacy also need to be proven. (nature.com)
Finally, it retrospectively analyze the activation strategies and clinical relevance of existing γδ T cell adoptive immunotherapies. (explorationpub.com)
These preclinical and clinical evidences encourage us to develop T-cell adoptive immunotherapy using genetically engineered T cells that are transduced with a T-cell receptor (TCR) gene specific for TAA. (oncotarget.com)
We previously published an immune-humanized mouse model in which we transplanted tumor cells and autologous tumor-infiltrating lymphocytes (TILs) from patients in a clinical trial of adoptive T cell transfer (ACT) in Herlev, Denmark - and demonstrated that responses in IL-2 transgenic NOG mice correlated to the responses of the patients in the trial 2 . (taconic.com)
Background While radiation and chemotherapy are primarily purposed for their cytotoxic effects, a growing body of preclinical and clinical evidence demonstrates an immunogenic potential for these standard therapies. (bmj.com)
Numerous clinical trials and real-world experience provide evidence of improved response and survival outcomes with multiple immunotherapy agents and different combinations in various cancers. (biomedcentral.com)
Costimulation of T cell responses with monoclonal antibody agonists (mAb-AG) targeting 4-1BB showed robust anti-tumor activity in preclinical models, but their clinical development was hampered by low efficacy (Utomilumab) or severe liver toxicity (Urelumab). (bioxcell.com)
Which radionuclide, carrier molecule and clinical indication for alpha-immunotherapy? (hal.science)
Using this clinical model, we will test the utility of rational strategies identified in our preclinical models. (dukecancerinstitute.org)
Induction of immunologic tolerance has been achieved and studied in numerous laboratory animal models, but it remains an elusive goal in clinical organ transplantation and in the management of autoimmune disease in humans. (medscape.com)

Dr. Huang has profound experiences working on immune cell interactions in the liver microenvironment and also on T-cell engineering and currently is developing immunotherapies for treatment of cancers based on these well-established immunological knowledge and technologies in the laboratory. (nhri.org.tw)
Integrative analyses of similar to 500 mice and similar to 1,000 patients revealed a common MAPK-MYC genetic pathway that accelerated time to progression from precursor states across genetically heterogeneous MM. MYC-dependent time to progression conditioned immune evasion mechanisms that remodeled the BM microenvironment differently. (unav.edu)

According to current challenges, there is a need to explore innovative immunotherapies, maximize the tumor-killing efficacy of γδ T cells, and attenuate or eliminate tumor immunosuppression. (explorationpub.com)
The antigen specificity, life span and effector functions of the resultant T cells from immunotherapies may determine their efficacy. (nhri.org.tw)
Researchers have previously shown that mitophagy (the recycling and renewal of mitochondria) in mouse epithelial cells can increase CD8+ T cells in early intestinal tumorigenesis, but the efficacy of immunotherapy is limited by T cell exhaustion. (frontlinegenomics.com)

Upcoming potential applications of T cell targeted immunoPET consist of monitoring immune system cell subsets in response to immunotherapy, autoimmunity, and lymphoproliferative disorders, adding general to preclinical immune system cell monitoring. (bioskinrevive.com)
Background Neoantigens, new immunogenic sequences arising from tumor mutations, have been associated with response to immunotherapy and are considered potential targets for vaccination. (unav.edu)

Results We showed that subpopulations surviving clinically relevant doses of radiation or cisplatin therapy were more susceptible to CTL-mediated lysis in four of four tumor models of HPV-associated malignancies, serving as a model for HPV therapeutic vaccine or T-cell receptor adoptive cell transfer. (bmj.com)
To demonstrate the therapeutic potential of UA, the team used UA food supplements in a mouse preclinical model and showed how this limited tumour growth. (frontlinegenomics.com)
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. (unav.edu)
This has led to the need for new immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and novel immune checkpoint inhibitors. (biomedcentral.com)
This has resulted in the development of additional immunotherapy-based approaches, including adoptive cell transfer (ACT), therapeutic vaccines, and inhibitors of other immune checkpoints. (biomedcentral.com)
Adoptive immunotherapy is an established and evolving therapeutic approach. (ashpublications.org)

They showed that this triple combination treatment (PPiT) doubled the migration of anti-tumor T cells to the tumor site and quadrupled survival in mice compared to ACT alone. (blogspot.com)

A membrane-based antibody array for the parallel determination of the relative levels of selected mouse cytokines and chemokines. (rndsystems.com)
The Mouse Cytokine Array, Panel A utilizes capture antibodies spotted onto a nitrocellulose membrane to allow high-throughput multi-analyte profiling of 40 cytokines, chemokines, and more in a single sample. (rndsystems.com)

CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. (taconic.com)
We also tested the CAR-T cells in xenograft models of uveal melanoma (one cell line-derived xenograft and one patient-derived xenograft) and found that uveal melanoma was sensitive to the HER2 CAR-T therapy. (taconic.com)
Conclusion Standard of care radiation or cisplatin therapy induced immunogenic cell stress in preclinical models of HPV-associated malignancies, presenting an opportunity poised for exploitation by employing IO strategies in combination with standard of care. (bmj.com)
The team's results support the use of UA in combination with immune checkpoint blockade or in adoptive T cell therapy. (frontlinegenomics.com)
By possibly improving combination therapy with existing immunotherapies, the study opens up meaningful possibilities for further application in the clinic. (frontlinegenomics.com)
These preclinical findings support further development of FT536 as a universal adoptive cell therapy. (sitcancer.org)
Indeed, in a mouse model, the triple combination therapy, or PPiT, better controlled the growth of established melanoma than ACT, checkpoint therapy, or PIM kinase inhibitors alone or dual combinations of ACT and a PIM kinase inhibitor or ACT and checkpoint therapy. (blogspot.com)
Our experimental models enable the correlation of MM genetic and immunological traits with preclinical therapy responses, which may inform the next-generation immunotherapy trials. (unav.edu)
New experimental models provide much-needed tools for understanding how genetically diverse multiple myeloma progresses and evolves in response to therapy. (unav.edu)
There are number of potential advantages to ACT therapy compared with other immunotherapies. (biomedcentral.com)

Failed T cell-based immunotherapies in the presence of genomic alterations in antigen presentations pathways may be overcome by NK cell-based immunotherapy. (elifesciences.org)
T cell-based immunotherapy, such as immune checkpoint blockade or adoptive T cell transfer, is limited by the ability of T cells to detect major histocompatibility complex (MHC)-presented antigen by tumor cells. (elifesciences.org)
Natural killer (NK) cell-based immunotherapy may overcome genetic mechanisms of resistance to T cell-based immunotherapy through antigen- and MHC-independent recognition of malignant cells. (elifesciences.org)
Bryan Hancock, PhD (Fate Therapeutics) previewed the preclinical studies supporting the investigational new drug application for FT536, a CAR NK cell product derived from an inducible pluripotent stem-cell line engineered for enhanced effector cell functionality, persistence, and multi-antigen targeting capabilities through CD16-mediated antibody dependent cellular cytotoxicity (ADCC). (sitcancer.org)
However, the number of antigen-specific CD8(+) but not CD4(+) T cells declined more rapidly and to a greater extent in c-IAP2(H570A) mice than in WT controls. (bioxcell.com)
Clinically, EBV-associated malignancies such as Hodgkin's lymphoma offer a unique model to explore antigen-defined immunotherapy approaches because EBV-derived tumor antigens are specific for tumor cells only. (dukecancerinstitute.org)

These new approaches are focused on patients with an inadequate response to current treatments, with emerging evidence of improved responses in various cancers with new immunotherapy agents, often in combinations with existing agents. (biomedcentral.com)
In vivo adoptive transfer approaches confirmed that this progenitor gives rise only to neutrophils, bringing a decades-long search for a committed neutrophil progenitor to its successful conclusion. (lji.org)

While their initial research studied melanoma, Forsberg is interested to study other cancers and combination therapies in this mouse model 1 . (taconic.com)
Moreover, we were also interested to study the use of CAR-T therapies in uveal melanoma in the immune-humanized mouse model, an uncommon type of melanoma arising in the eye. (taconic.com)
The antitumor aftereffect of PSB1115 had not been seen in melanoma-bearing nude mice. (biospraysehatalami.com)
The consequences were studied by us of PSB1115 a selective A2bR antagonist within a well-established mouse melanoma super model tiffany livingston. (biospraysehatalami.com)
Immunotherapy shows guarantee in preclinical and scientific studies and presently melanoma is normally among few malignancies that there's a Meals and Medication Administration (FDA)-accepted immunotherapeutic agent ipilimumab [14-17]. (biospraysehatalami.com)

in vivo in the spleen and lymph nodes of crazy type mice, with specificity confirmed through in vivo obstructing and depletion studies. (bioskinrevive.com)
Subsequently, a murine model of HSC transplantation shown successful in vivo detection of T cell repopulation at 2, 4, and 8 weeks post-HSC transplant using the 89Zr-radiolabeled anti-CD4 and -CD8 cDbs. (bioskinrevive.com)
In vitro observations were translated using an in vivo xenograft NSG mouse model of human cervical carcinoma evaluating cisplatin in combination with CTL adoptive cell transfer. (bmj.com)
In vivo, cisplatin-induced immunogenic cell stress synergistically potentiated CTL-mediated tumor control in a human model of HPV-associated malignancy. (bmj.com)

0.3% of the total circulating CD8 T cell population fully protects mice against lethal tumor challenge. (bmj.com)

Experimental Pharmacology & Oncology (EPO) GmbH uses 1st and 2nd generation NOG mice provided by Taconic for its preclinical oncology service. (taconic.com)

As of January 1, 2022, Oncotarget has shifted to a continuous publishing model. (oncotarget.com)
The use of cell therapies, drivers of immune response, and trends in immunotherapy were the focus of the Immunotherapy Bridge (November 30th-December 1st, 2022). (biomedcentral.com)

In principle, immunotherapy aims to generate effective T cell response for direct killing of tumor cells and induce long-term immune surveillance against cancers. (nhri.org.tw)
May be an improved model for differentiation/engraftment of IL-2 dependent cells including certain blood cancers. (taconic.com)
In recent years, immunotherapies have led to remarkable strides in treating certain cancers. (mdpi.com)

Lymphocyte monitoring during immunotherapy protocols, such as for example recognition of circulating lymphocytes from entire tumor or bloodstream infiltrating lymphocytes from tissues biopsy, will not supply the whole selection of spatial and dynamic Kaempferol information required. (bioskinrevive.com)

T cell transfer, Kaempferol hematopoietic stem cell or progenitor cell transfer, little molecule and antibody-based immunotherapies, and combos thereof, entire body immuno-positron emission tomography (immunoPET) concentrating on of immune system cell subtypes could offer spatial and temporal details that is difficult utilizing current strategies. (bioskinrevive.com)
Adoptive transfer of Compact disc11b+Gr1+ cells abrogated the antitumor activity of PSB1115. (biospraysehatalami.com)
Studies with T-cell adoptive transfer demonstrated that the enhanced decay of memory cells was T-cell intrinsic. (bioxcell.com)

Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy. (nature.com)

Indeed a wealth of studies from humans and mouse models establishes a particularly potent role for CD8 T cells in controlling the outgrowth of malignancies ( 3 ). (frontiersin.org)
Accordingly, we sought to characterize the immunogenic potential of radiation and cisplatin in human tumor models of HPV-associated malignancies. (bmj.com)
MDSCs donate to tumor immune system tolerance by launching adenosine within a Compact disc73-reliant way [10 11 Furthermore A2bR blockade can decrease the development of bladder and breasts malignancies in mice by marketing a T cell-mediated response within a chemokine C-X-C receptor 3 (CXCR3)-reliant way [12]. (biospraysehatalami.com)
4. Immunotherapy for EBV-associated Malignancies. (dukecancerinstitute.org)

Mouse monoclonal to CD22.K22 reacts with CD22, a 140 kDa B-cell specific molecule, expressed in the cytoplasm of all B lymphocytes and on the cell surface of only mature B cells. (bioskinrevive.com)
In xenograft models, directly thawed frozen FT536 significantly slowed tumor growth, which was further enhanced when infused in combination with the monoclonal antibodies. (sitcancer.org)
The 3H3 monoclonal antibody reacts with mouse 4-1BB, a TNF receptor superfamily member also known as CD137. (bioxcell.com)

Here, we show that effector and memory T cells from mice expressing a dominant negative E3-inactive c-IAP2 (c-IAP2(H570A) ) have impaired signaling downstream of 4-1BB. (bioxcell.com)

In ICB-refractory MM models, increasing CD8(+) T cell cytotoxicity or depleting T-reg cells reversed immunotherapy resistance and yielded prolonged MM control. (unav.edu)

Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
These mice are included in novel concepts for the development of personalized treatment options and especially suited for humanization strategies. (taconic.com)

We are capitalizing on these findings to develop efficient adoptive cell immunotherapy protocols. (vumc.org)

Sustained persistence of FT536 for 33 days post-infusion were also seen in a murine model of lung adenocarcinoma. (sitcancer.org)
On the other hand arousal of A3 adenosine receptor (A3R) subtype can markedly limit tumor development by promoting a competent antitumor immune system response in mice [4 5 There's growing evidence which the A2b receptor subtype (A2bR) may also impact tumor progression in a few murine tumor versions. (biospraysehatalami.com)

Mice were subsequently challenged with tumor cells, and the tumor protection was monitored. (bmj.com)

Interestingly, responses were only achieved in IL-2 transgenic NOG mice and not in regular NOG mice. (taconic.com)
Fukuchi Y, Miyakawa Y, Kobayashi K, Kuramochi T, Shimamura K, Tamaoki N, Nomura T, Ueyama Y, Ito M. (1998) Cytokine dependent growth of human TF-1 leukemic cell line in human GM-CSF and IL-3 producing transgenic SCID mice. (taconic.com)
Katano I, Takahashi T, Ito R, Kamisako T, Mizusawa T, Ka Y, Ogura T, Suemizu H, Kawakami Y, Ito M. (2015) Predominant development of mature and functional human NK cells in a novel human IL-2-producing transgenic NOG mouse. (taconic.com)

We wanted to find a way to convert a non-responder of ACT to a responder somehow and decided to test CAR-T cells in the mouse model. (taconic.com)
We purchased commercially available HER2 CAR-T cells from ProMab and tested them in our immune-humanized mouse model. (taconic.com)
It is an important observation that human IL-2 seems to be necessary for beneficial effects of human CAR-T cells in mice. (taconic.com)
Q: Would you envision the hIL-2 NOG model benefiting other CAR therapies based upon other immune cells (e.g. (taconic.com)
Predominant differentiation of human NK cells following human HSC engraftment, with>10-fold higher CD56+ NK cell numbers compared to the base NOG mouse. (taconic.com)
Human NK cells developed in hIL-2 NOG mice express various NK receptors and produce both granzyme A and perforin upon stimulation. (taconic.com)
mouse: an excellent recipient mouse model for engraftment of human cells. (taconic.com)
Furthermore, we assessed the expression of chemokines by polymerase chain reaction (PCR) array in tumor-draining lymph nodes (dLNs) of these mice and MC38 cells cultured in different glucose concentrations. (nature.com)
This was accompanied by fewer tumor-infiltrating CD8 + T cells, and STZ-mice had fewer tumor-infiltrating CD11c + dendritic cells (DCs) than normoglycemic mice. (nature.com)
mRNA expression levels of CXCL9, a chemokine recruiting CD8 + T cells, were lower in dLNs of STZ-mice than in normoglycemic mice after PD-1-Ab treatment, and its protein was expressed in DCs. (nature.com)
To induce hyperglycemia, mice were intraperitoneally injected with STZ, which can damage pancreatic β cells resulting in the development of insulin dependent diabetes, a model of type 1 diabetes mellitus (T1DM). (nature.com)
Mice were intraperitoneally injected with STZ or sodium citrate buffer (CB) 7 days before subcutaneous inoculation with MC38 cells in the right flank on day 0 (Fig. 1 A). Then, the mice were treated with anti-PD-1 antibody or normal rat IgG on days 5, 8, and 11. (nature.com)
Recently it's been showed that A2bR promotes the extension of myeloid-derived suppressor cells (MDSCs) from mouse hematopoietic progenitors [10]. (biospraysehatalami.com)
MDSCs discovered in mice as Compact disc11b positive Gr1 positive (Compact disc11b+Gr1+) cells [21] are powerful suppressors of T cell-mediated replies and. (biospraysehatalami.com)
If living cells from mouse strain CBA were injected into an adult mouse of strain A, some immunologic process destroyed the CBA cells, and the A-line mouse that received the CBA cells quickly destroyed any subsequent graft from the same donor strain. (medscape.com)

The effect of anti-PD-1 antibody on MC38 tumor is attenuated in STZ-induced diabetic mice. (nature.com)

One of the key aspects for successful immunotherapy is to achieve a strong and stable antitumor immune response. (mdpi.com)

To circumvent this limitation, we screened mice engineered to carry eight MM lesions (NF-kappa B, KRAS, MYC, TP53, BCL2, cyclin D1, MMSET/NSD2 and c-MAF) combinatorially activated in B lymphocytes following T cell-driven immunization. (unav.edu)

I then decided to pursue a Ph.D. in viral immunology at the University of Cambridge where I learned a lot about the immune system and vaccine models. (wrfseattle.org)
Therefore, the combination of vaccine + gemcitabine with anti-PD-1 was superior to anti-PD-1 monotherapy in both models. (unav.edu)

Primary tumor material (P) derived from patients undergoing surgery for head and neck squamous cell carcinoma (HNSCC) or glioblastoma multiforme (GBM) was transplanted subcutaneously into NMRI Foxn1 nu/nu mice. (europdxworkshop.eu)

The CIEA NOG mouse ® was developed by backcrossing the C57BL/6JJic-Il2rg line to the NOD/ShiJic-Prkdc scid line for a total of eight generations. (taconic.com)

Knockout of CD47 led to 60% increased survival and 89% decreased metastatic brain lesions in 4T1-bearing mice compared to controls. (sitcancer.org)

Studies in infectious disease models have provided a wealth of information regarding memory CD8 T cell generation and localization. (frontiersin.org)

Q: How do you see this model/approach impacting preclinical CAR-T and immunotherapy development? (taconic.com)
This fact has huge implications for research focusing on preclinical CAR-T (or other immunotherapy) development. (taconic.com)
The Filgotinib development of Lewis lung carcinoma was low in A2bR-deficient mice in comparison to that Filgotinib in wild-type handles. (biospraysehatalami.com)

Anatomy25

Organisms16

Diseases30

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Psychiatry and Psychology5

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20222

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