Preclinical molecular imaging. Medical search. Frequent questions

Few years ago, research applications of noninvasive imaging methods such as optical imaging, computed tomography, magnetic resonance, micro-PET-SPECT, and ultrasound were limited to larger animals such as dogs and nonhuman primates. (hindawi.com)
Dr. Wulf I. Jung , President of Bruker's Preclinical Imaging Division, stated: 'With the PMOD acquisition, Bruker is broadening its support for translational research with outstanding imaging tools, from highest-performance preclinical MRI, PET/SPECT and microCT systems to state-of-the-art software. (bruker.com)
Therefore, the use of techniques like computed tomography (CT), positron emission tomography (PET) or single photon emission computed tomography (SPECT) became more frequent when conducting preclinical studies in animal models. (researchsquare.com)
3 - The impact of the novel solid state photomultipliers in Medical Imaging and the advent of multimodality imaging such as PET/CT and SPECT/CT, PET/MRI and SPECT/MRI. (videolectures.net)
Although molecular imaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are not currently used in clinical practice to monitor IBD patients, in vivo molecular imaging of small animals is increasingly being developed for the assessment of disease-specific animal models. (databasefootball.com)
Answering to clinical needs in oncology, neurology, cardiology, and radiology, Siemens Healthineers Molecular Imaging systems provide PET/CT, SPECT, and hybrid SPECT scanner (SPECT/CT) solutions to help clinicians diagnose, treat, and monitor diseases more confidently. (siemens-healthineers.com)
Mediso has announced the Food and Drug Administration (FDA) clearance of the InterView™ FUSION and InterView™ XP multimodality (PET/SPECT/MRI/CT) image processing and reporting software which is specifically adapted for nuclear medicine and molecular imaging workflows. (mediso.com)
Second-tier imaging with molecular methods, preferably with fluorodeoxyglucose positron emission tomography (FDG-PET) (or single-photon emission CT [SPECT] if PET is unavailable), can provide greater diagnostic specificity. (medscape.com)

UBM is useful to investigate the growth and differentiation of tumors as well as to detect early molecular expression of cancer-related biomarkers in vivo and to monitor the effects of cancer therapies. (hindawi.com)
Recently, the introduction of ultrasound contrast microbubbles that is targeted to molecular markers expressed on the vasculature is able to image molecular events of disease and could be used for various applications including quantitative analysis of molecular biomarkers, perfusion studies, microvasculature targeting, and gene and drug delivery [ 7 , 11 ]. (hindawi.com)
Over the past 20 years, molecular imaging emerged as a powerful approach in drug development and identification of new biomarkers of many pathologies 1 . (researchsquare.com)
The Contrast Agent Molecular Engineering Laboratory (CAMEL) has developed molecular imaging methods that evaluate biomarkers of the tumor microenvironment. (mdanderson.org)
CAMEL develops molecular imaging methods that evaluate biomarkers of the tumor microenvironment, including extracellular acidosis, hypoxia, enzyme activity, and vascular perfusion. (mdanderson.org)
Biomarkers have emerged as valuable tools in drug discovery, helping to bridge the gap between preclinical and clinical studies by providing crucial information on drug efficacy, safety, and patient response. (alliedacademies.org)
In the context of drug discovery, biomarkers can be specific molecules, genes, proteins, or even imaging parameters that correlate with a particular disease state or response to treatment. (alliedacademies.org)
In preclinical drug discovery, biomarkers play a vital role in target identification and validation. (alliedacademies.org)
This knowledge is critical for designing and testing drug candidates that specifically modulate the target's activity.Moreover, biomarkers can help assess the pharmacokinetics and pharmacodynamics of drug candidates during preclinical studies. (alliedacademies.org)
Standardization of biomarker assays and methodologies is also essential to ensure reproducibility and comparability of results.In the future, advances in technologies such as omics (genomics, proteomics, metabolomics), molecular imaging, and artificial intelligence are expected to further enhance the discovery and validation of biomarkers. (alliedacademies.org)

The PMOD software is widely used for the analysis of positron emission tomography (PET) studies in neurology, cardiology and oncology, both for preclinical and human molecular imaging research. (bruker.com)
PMOD software includes solutions for image registration, automated volume-of-interest definition in neurology, oncology and cardiology, radiomics feature extraction, 3D image visualization and computational fluid dynamics (CFD) modelling. (bruker.com)
In particular, she has an active program investigating 89 Zr radiolabeled antibodies as molecular imaging agents in preclinical and clinical trials in oncology. (uab.edu)
According to the Society of Surgical Oncology (SSO) Endocrine and Head and Neck Disease Site Working Group, pheochromocytomas constitute about 4-8% of all adrenal incidentalomas, and approximately 21.1-57.6% of all pheochromocytomas are discovered incidentally on imaging studies. (medscape.com)

Novel bioactive and stable neurotensin peptide analogues capable of delivering radiopharmaceuticals and molecular beacons to tumors. (nature.com)
The NIMH PET radiochemistry facility is directed by Victor Pike, PhD. This laboratory is fully equipped for radiochemistry research and development as well as production of PET radiopharmaceuticals for imaging studies. (nih.gov)
As Cyclotron Facility Director, She oversees production of PET radionuclides and imaging radiopharmaceuticals for preclinical research and clinical trials. (uab.edu)
The main emphasis is placed on the development of targeted imaging with radiopharmaceuticals within the broader context of molecular probes to enhance understanding and characterisation of the complex biological processes underlying disease and to develop, test and guide new treatment modalities, including radionuclide therapy. (eanm.org)

In close cooperation with our customers, Bruker is enabling innovation, improved productivity and customer success in life science molecular research, in applied and pharma applications, in microscopy and nanoanalysis, and in industrial applications, as well as in cell biology, preclinical imaging, clinical phenomics and proteomics research and clinical microbiology. (bruker.com)
The development of commercially available transfection reagents for gene transfer applications has revolutionized the field of molecular biology and scientific research. (mdpi.com)
Molecular Imaging and Biology (2017) 19 (3): 421. (aacrjournals.org)
He was an Associate Editor of Brain and Molecular Imaging and Biology. (ncl.ac.uk)
However, using molecular biology tools, Bobadilla was able to identify what type of cells was recruited in both the cocaine and sucrose ensemble. (uwyo.edu)
The accelerated scientific progression in genetics and molecular biology has finally generated what it is now called Molecular Imaging. (videolectures.net)
The Tumor Biology and Microenvironment Program aims to eradicate cancer by identifying the cellular and molecular mechanisms that drive interactions between tumors and their microenvironment, and develop and test innovative diagnostic and treatment strategies. (cancer.gov)
The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. (benthamscience.com)
We combine next generation sequencing, in vitro drug testing , cell- and molecular biology techniques, in vivo drug testing and advanced in vivo imaging to understand and target metastatic and treatment resistant tumors. (lu.se)
Human fertility, health, and food : impact of molecular biology and biotechnology / edited by David Puett. (who.int)

Currently, PET is performed in conjunction with computed tomography (CT) that provides anatomic information and the fused molecular and anatomic (CT) images are interpreted together as PET/CT studies. (hopkinsmedicine.org)
Computed tomography (CT) scanning and magnetic resonance imaging (MRI) have higher sensitivity in detecting pheochromocytomas than nuclear medicine scanning with iodine-131 metaiodobenzylguanidine ( 131 I-MIBG), although 131 I-MIBG uptake is more specific. (medscape.com)
Structural imaging, preferably with MRI when possible and with computed tomography (CT) when not, should be performed as a first-tier approach. (medscape.com)

Additionally, this technique is useful to image the fetal mouse [ 4 - 6 ] and to obtain high-resolution images of mice tumors [ 7 , 8 ]. (hindawi.com)
A new paper on imaging brain tumors from the Gambhir Lab was published in Science Translational Medicine and is also the cover article. (stanford.edu)
Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors. (ucsf.edu)
Some authors prefer to use MIBG uptake scanning as the initial screening modality because it enables whole-body imaging, making it useful for the detection of extra-adrenal tumors and metastatic deposits. (medscape.com)
This project focus on evaluating and optimizing photoacoustic (PA) imaging as a method to detect and outline skin tumors. (lu.se)
The purpose of the project is to develop PA imaging into a diagnostic tool for skin tumors by identifying the spectral signature of the cancerous cells. (lu.se)
One major obstacle in translational cancer research has been the lack of predictive preclinical models that faithfully represent tumors occurring in patients. (lu.se)

This paper will describe some basic principles of high-resolution imaging equipment, and the most important applications in molecular and preclinical imaging in small animal research. (hindawi.com)
UERICH, Switzerland, July 8th, 2019 -- Bruker today announced that it has acquired PMOD Technologies LLC, a highly respected provider of research-use-only software for preclinical and molecular imaging, with a focus on molecular quantification and pharmacokinetic modeling. (bruker.com)
The acquisition confirms Bruker's commitment to provide intuitive end-to-end solutions that make image analysis and quantitative knowledge extraction in nuclear molecular imaging research more productive and precise. (bruker.com)
PMOD extends Bruker's portfolio of imaging software for clinical research and further enhances Bruker's expertise in nuclear molecular imaging. (bruker.com)
Our combined expertise will accelerate the development and integration of novel molecular imaging applications, answering the growing demand for innovative research tools by translational scientists. (bruker.com)
PMOD Technologies aims to equip researchers with best-in-class software tools for biomedical imaging research in humans and animals. (bruker.com)
Interactive and responsive collaborations with leading imaging research institutions ensure that methodology and scope of the PMOD software remain at the leading edge. (bruker.com)
Dr. Anne Muehe , a postdoctoral fellow in the Pediatric Molecular Imaging Laboratory , received a 2015 RSNA Trainee Research Prize for her research that recently assessed the safety profile of ferumoxytol as an intravenous MRI contrast agent in pediatric patients. (stanford.edu)
The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. (researchsquare.com)
The concept that cognitive decline can be identified early and prevented by applying quantitative brain imaging techniques is the focus of "Hot Topics in Research: Preventive Neuroradiology in Brain Aging and Cognitive Decline," a review published online in American Journal of Neuroradiology (AJNR). (eurekalert.org)
His research involves the use of positron emission tomography and magnetic resonance imaging to diagnose and study the progression of Alzheimer's and Parkinson's disease and his work is on the highly cited list with an h index of 123. (ncl.ac.uk)
Her research interests are in the development and translation of new PET radionuclides and molecular imaging agents. (uab.edu)
Her other main area of research interest is in the development of new isotopes for PET imaging such as 45 Ti and 43 Sc. (uab.edu)
The emphasis is on studies at the interface of pre-clinical and clinical research, including studies at the cellular, molecular, integrative, clinical, imaging and psychopharmacology levels. (uwyo.edu)
In this series of three lectures I will try to present how high energy physics and medical imaging development have both benefited by the cross-fertilization of research activities between the two fields and how much they will take advantage in the future. (videolectures.net)
The research objectives of this project were: production of radionuclides with the most appropriate properties for molecular imaging and/or radionuclide therapy, their incorporation in newly designed molecular and supramolecular carriers and finally their pre-clinical evaluation and comparison. (europa.eu)
EJNMMI Research publishes new basic, translational and clinical research in the field of nuclear medicine and molecular imaging. (eanm.org)
Timely reviews provide updates on current applications, issues in imaging research and translational aspects of nuclear medicine and molecular imaging technologies. (eanm.org)
Miniaturized versions of clinical devices are available for small animal imaging in preclinical research. (databasefootball.com)
Our research spans "bench to bedside," including basic science investigations, small animal imaging studies, and clinical translation. (mdanderson.org)
Finally, Dr. Pagel supports the molecular imaging research community by organizing meetings and conferences, reviewing grant applications and manuscripts, and facilitating academia-industry relationships. (mdanderson.org)
Find MI news and information for gaining global support for preclinical research and development, cyclotrons, and chemistry solutions. (siemens-healthineers.com)
However, transitioning from preclinical research to clinical trials in human subjects can be challenging due to differences in biological systems and responses. (alliedacademies.org)
Visit the Molecular Tumor Pathology groups research portal via this link. (lu.se)
PURPOSE: The increasing interest and availability of non-standard positron-emitting radionuclides has heightened the relevance of radionuclide choice in the development and optimization of new positron emission tomography (PET) imaging procedures, both in preclinical research and clinical practice. (bvsalud.org)
Imaging plays a pivotal role in both preclinical and clinical research, offering benefits that significantly impact disease understanding and patient care. (lu.se)
In clinical research, imaging is a vital tool for assessing treatment responses, guiding adjustments to therapeutic interventions, and contributing to the development of targeted and personalized therapies. (lu.se)
position imaging at the core to facilitate collaboration among various research domains. (lu.se)
Part of the research takes place at LBIC (Lund University Bioimaging Centre), a medical imaging centre at Lund University. (lu.se)
Cellular and molecular research, animal studies, examination of human tissues and organs and imaging of patients - can all be carried out at LBIC and can be combined in different ways in the same study. (lu.se)
The idea behind that was that the pairing would serve as a bridge between preclinical and clinical research to facilitate translational research. (lu.se)
The research at WCMM Lund is supported locally and nationally from cutting-edge infrastructure, ranging from advanced imaging techniques, including MAXIV, to the national SciLifeLab platforms. (lu.se)
The daily work at WCMM LU is done by a working group consisting of: director, clinical co-director, preclinical co-director, research coordinator/communicator, economist and two WCMM fellow representatives. (lu.se)

This work reports the first clinical translatable small molecule NIR-II fluorescent dye that can serve as a platform technology and be used in many applications, including in vivo molecular imaging, image-guided surgery and therapy, in vitro cell labelling, diagnosis, bioassays, etc. (stanford.edu)
In the current work, we present ß-eye, a benchtop system for in vivo molecular screening of labeled compounds with Positron Emission Tomography (PET) isotopes. (bvsalud.org)

Bruker's high-performance scientific instruments and high-value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular and microscopic levels. (bruker.com)
To that effect, they have already been able to elucidate important molecular and cellular mechanisms. (uni-heidelberg.de)
Imaging also contributes to the monitoring of disease progression over time, offering insights into molecular and cellular changes. (lu.se)

He then joined as a senior scientist in Biological Imaging Center at the Beckman Institute of California Institute of Technology, California where he worked on high field Magnetic Resonance Microscopy (1999-2003). (selectbiosciences.com)
LBIC handles a number of imaging methods within bioimaging with a focus on different clinical and preclinical cameras (MR, CT and PET) as well as microscopy. (lu.se)

PET is the most advanced nuclear imaging technique, allowing for high-resolution imaging and absolute quantification of biologic mechanisms. (hopkinsmedicine.org)
Established by the NIMH in 2000, the Molecular Imaging Branch (MIB) uses a variety of neuroimaging techniques to explore molecular and chemical mechanisms associated with neural function in health and disease. (nih.gov)
Pathogenic mutations and HGSOC markers were preserved after multiple mouse passages, indicating retention of underlying molecular mechanisms of carcinogenesis. (jci.org)
The Molecular Therapeutics Program focuses on developing new approaches for treating cancer, ranging from drug discovery to mechanism-based efforts emphasizing mechanisms-of-action of novel tumor-targeted and standard agents and critical signaling pathways. (cancer.gov)
PHARM 504a Molecular Mechanisms of Drug Actions. (yale.edu)
Existing treatment strategies lead sooner or later to resistance to therapy where the fundamental molecular mechanisms have been only partially understood, if at all, for most of the procedures generally regarded as standard. (uni-heidelberg.de)

PROCEDURES: To address this need, we have characterized the positron range of several standard and non-standard PET radionuclides (As-72, F-18, Ga-68, Mn-52, Y-86, and Zr-89) through imaging of small-animal quality control phantoms on a benchmark preclinical PET scanner. (bvsalud.org)
PET resolution and quantitative accuracy afforded by various radionuclides in practicable imaging scenarios were characterized using a convolution-based method based on positron annihilation distributions obtained from PHITS. (bvsalud.org)
however, for a specific "benchmark" preclinical PET scanner and reconstruction workflow, these differences were observed to be minimal given radionuclides with average positron energies below ~ 400 keV. (bvsalud.org)
CONCLUSION: Our measurements and simulations of the influence of positron range on PET resolution compare well with previous efforts documented in the literature and provide new data for several radionuclides in increasing clinical and preclinical use. (bvsalud.org)

Rarely are such advanced PET imaging studies performed alone. (hopkinsmedicine.org)
Finally, the performance of our system was evaluated performing small animal imaging studies. (researchsquare.com)
In fact, clinical scanners used for human imaging are bulky and provide a spatial resolution of the order of tens of mm inadequate to that required for studies in mice (≤ 1mm) 2 . (researchsquare.com)
Because different imaging technologies have distinct capabilities, strengths, and limitations, studies are designed so that the same subjects are iteratively studied using multiple techniques to provide complementary information about pathophysiology. (nih.gov)
Most MRI/fMRI studies are carried out on the 3 and 7 Tesla magnets at the Functional Magnetic Resonance Imaging Core Facility or Clinical Center Radiology Department. (nih.gov)
Patients seem to enjoy reviewing results of their imaging studies, more so than reading the results of their blood tests or other clinical evaluations. (eurekalert.org)
The concept involves the use of very low doses of a radionuclide-labeled compound for imaging studies or for assessing plasma pharmacokinetics using equipment that has a highly sensitive readout. (snmjournals.org)
Microdosing regulations specify a reduced preclinical toxicology-assessment package in order to shorten the route to human studies and reduce its cost. (snmjournals.org)
This regulatory framework has had great importance in facilitating human studies of new chemical entities and has been especially valuable for promoting new radionuclide imaging probes. (snmjournals.org)
As the program leader for Development Therapeutics and the PI of a peer-reviewed basic science lab, my main focus is on translating preclinical findings into early-stage clinical trials with extensive PK and integration of PD correlative studies and molecular imaging for patients with advanced stage cancer. (ucsf.edu)
Traditionally, drug discovery has relied heavily on preclinical studies, which involve testing potential drug candidates in laboratory settings and animal models. (alliedacademies.org)
Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. (cdc.gov)
The goal of the design is to provide 2D, real-time radionuclide images of mice, allowing the recording of fast frames and thus perform fast kinetic studies, with spatial resolution of â ¼2 mm. (bvsalud.org)
This capability is crucial for preclinical studies and clinical trials, in which continuous observation is essential. (lu.se)
Imaging studies are not needed unless sinusitis is suspected, in which case, a limited CT scan of the sinuses (without contrast) is indicated. (medscape.com)
It comprises a variety of tools ranging from high-resolution anatomical structure visualization to functional studies and even molecular-level description of metabolic events in the cell. (lu.se)
A variety of imaging modalities, including structural and functional magnetic resonance imaging (MRI) and positron emission tomography (PET) studies of cerebral metabolism, have shown characteristic changes in the brain of patients with Alzheimer disease in prodromal and even presymptomatic states. (medscape.com)
Numerous studies are under way to identify specific imaging markers for different types of dementia, including cerebral volumetric measurements, diffusion imaging, spectroscopy, very-high-field MRI scans of senile plaques, and PET scan markers of senile plaques. (medscape.com)

When it is coupled to Doppler ultrasound with color and power Doppler, it can be used to quantify blood flow and to image microcirculation as well as the response of tumor blood supply to cancer therapy. (hindawi.com)
Combined PET Imaging of the Inflammatory Tumor Microenvironment Identifies Margins of Unique Radiotracer Uptake. (uni-muenster.de)
We developed a preclinical platform for HRD HGSOCs that includes primary tumor cultures, patient-derived xenografts (PDXs), and molecular imaging. (jci.org)
B-Mode image of a prostate tumor in an adult mouse with the prostate, tumor and surrounding structures labelled. (visualsonics.com)
We have also developed and patented analysis methods that improve the evaluation of vascular perfusion using MRI and MSOT imaging methods, which can assess the potential of drug delivery to a solid tumor. (mdanderson.org)
A further study by Gaertner et al concluded the (18)F-LMI1195 is a promising tracer for tumor imaging. (medscape.com)
We are investigating the PA spectral signature of different tumor cells to enable automatic measure-ment of the tumor borders, and test the developed method in the clinical setting, ultimately developing PA imaging into a diagnostic tool for skin cancer. (lu.se)
Diagnosis and tumor border identification with several non-invasive imaging techniques has been attempted, but the results have not been satisfactory. (lu.se)

Positron emission tomography (PET) is a specialized radiology procedure that uses molecular imaging to track and trace both normal and abnormal conditions. (hopkinsmedicine.org)
With particular evidence to Medical Imaging I will address and discuss: 1 - The use of gas, scintillator and solid state detectors in digital radiology and digital mammography, clinical CT and small animal CT. (videolectures.net)
From 2003-2009 he was an Assistant Professor at the Center for Advanced Imaging & Department of Radiology of West Virginia University, United States. (selectbiosciences.com)

The Wallenberg Centre for Molecular Medicine at Lund University is comprised of 10 young internationally excellent WCMM Fellows. (lu.se)

These imaging findings can help spur beneficial lifestyle changes in patients to reduce risk for Alzheimer's disease. (eurekalert.org)
Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. (eurekalert.org)

Ultrasound biomicroscopy (UBM) is a noninvasive multimodality technique that allows high-resolution imaging in mice. (hindawi.com)
Target contrast ultrasound combines ultrasound with novel molecular targeted contrast agent to assess biological processes at molecular level. (hindawi.com)
The availability of real-time imaging of mice anatomy allows performing aspiration procedures under ultrasound guidance as well as the microinjection of cells, viruses, or other agents into precise locations. (hindawi.com)
The consistent ultrasound image obtained with the UBM can be used to visualize and guide injection into target organs [ 9 , 10 ], including mouse embryo, to aid in targeted delivery of drugs and viral particles [ 7 , 11 ]. (hindawi.com)
Ultrasound for molecular imaging and therapy in cancer. (stanford.edu)
Ultrasound molecular imaging with targeted microbubble contrast agents. (stanford.edu)
In that context, PA imaging has shown promise: the technique relies on pulsed laser light and optical absorption detected by ultra-high-frequency ultrasound to reveal the molecular composition of tissue at high resolution. (lu.se)

The equipment of Mediso nanoScan® Family deliver the current and future promise of molecular imaging by maximizing functional information in combination with precise anatomical detail. (mediso.hu)
Mediso Medical Imaging Systems recently installed a state-of-the-art 7T MRI at the University of Milano-Bicocca. (mediso.com)
Since 1990, Mediso is creating new technologies, and molecular imaging systems. (mediso.com)

Several NMR methods are also studied to measure molecular targets (magnetic resonance spectroscopy (MRS)), local neuronal activity (functional MRI (fMRI)), and brain structure (structural MRI). (nih.gov)
The Section on Magnetic Resonance Spectroscopy (MRS) develops and applies both high-resolution and in vivo MRS and imaging techniques. (nih.gov)
In June 2009 he joined the laboratory of molecular imaging, Singapore Bioimaging Consortium as the Head of Magnetic Resonance Spectroscopy and Metabolic Imaging group. (selectbiosciences.com)

We specialize in the synthesis and characterization of chemical contrast agents for magnetic resonance imaging (MRI), positron emission tomography (PET), PET/MRI, and MultiSpectral Optoacoustic Tomography (MSOT). (mdanderson.org)
Differences in achievable resolution arising from positron range can largely influence application suitability of each radionuclide, especially in small-ring preclinical PET where system blurring factors due to annihilation photon acollinearity and detector geometry are less significant. (bvsalud.org)
Some resolution degradation can be mitigated with appropriate range corrections implemented during image reconstruction, the quality of which is contingent on an accurate characterization of positron range. (bvsalud.org)
The results will support current and future improvements in methods for positron range corrections in PET imaging. (bvsalud.org)
Positron emission tomography (PET) is also an alternative imaging test, with agents such as 18F-deoxyglucose (F-FDG), 18F-dihydroxyphenaline (F-DOPA), and 18F-fluorodopamine (F-FDA) being used in cases of negative 123 I-MIBG when there is a high clinical and laboratory suspicion. (medscape.com)

International Journal of Molecular Sciences (2021) 22 (8): 3948. (aacrjournals.org)
International Journal of Molecular Sciences (2021) 22 (5): 2753. (aacrjournals.org)

Radiolabeling efficiency under various conditions, in vitro stability in serum at 37 °C, and in vivo biodistribution and imaging in normal mice over 48 h were studied. (acs.org)

Acoustic and photoacoustic molecular imaging of cancer. (stanford.edu)
The right column shows the images constructed after spectral unmixing was applied to the multiwavelength photoacoustic images. (lu.se)

È coinvolto in progetti di imaging molecolare, è stato membro (2010-2023) e vicedirettore (2017-2023) del CISPIM, Centro Interdipartimentale per lo Sviluppo Preclinico dell'Imaging Molecolare, Università di Firenze. (unifi.it)

Peptides can be labeled with various trivalent radiometals for imaging or targeted radionuclide-therapy applications. (nature.com)

Kleinmanns K, Fosse V, Davidson B, de Jalón EG, Tenstad O, Bjørge L, McCormack E. CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model. (uib.no)

For many imaging probes, use in humans was introduced as microdoses, but not always with the regulatory background of the microdosing concept. (snmjournals.org)
The goals of the Molecular Imaging Program include the development and testing of new imaging methods ranging from preclinical work on the synthesis of new probes and development of new devices to the clinical evaluation of imaging approaches to assess cancer risk, detect cancer, guide treatment and monitor therapy. (cancer.gov)

These markers, including structural, functional, and molecular imaging are being used in the AD diagnositc criteria [AA/NIA], (1)" says Howard Aizenstein, M.D., Ph.D., a psychiatrist at University of Pittsburgh. (eurekalert.org)

She has over 80 publications and is a member of the Board of Directors of the Society of Nuclear Medicine and Molecular Imaging. (uab.edu)

While all the macrocyclic bifunctional chelators are suitable for molecular imaging using 64 Cu-labeled antibody conjugates, NOTA and sar-CO 2 H show significant advantages over the others in that they can be radiolabeled rapidly at room temperature, under dilute conditions, resulting in high specific activity. (acs.org)
The aim of the present work was to obtain stabilized high specific activity (HSA) (111)In-labeled bombesin conjugates for preclinical evaluations. (bvsalud.org)

The results of this study demonstrated the good capability of the system as a suitable tool for preclinical imaging especially in fields like neuroscience for the study of small brain structures. (researchsquare.com)
Although this system is not suitable for human imaging, with the current rate of technical advancements similar systems might become available for humans in the foreseeable future as well. (medgadget.com)
He has developed several magnetic resonance techniques for Magnetic Resonance imaging, EPR Imaging, self-diffusion measurements, high resolution MRS, and localized MRS suitable for pre-clinical and clinical applications. (selectbiosciences.com)
assist researchers in making decisions about selecting the most suitable imaging modality to address specific scientific inquiries. (lu.se)

The lecturer group is comprised with leading experts in Medicinal Chemistry, Neuropharmacology and multiple imaging modalities. (yale.edu)

It is designed to lay a scientific foundation on Medicinal Chemistry, Pharmacology, Neuroscience and Advanced Molecular Imaging for senior undergraduate students and graduate students who are interested in quantitative neuropharmacology. (yale.edu)

Preclinical PET/MR is a fast-growing market, and the expertise of the PMOD team will further strengthen our quantitative molecular imaging solutions. (bruker.com)
The PMOD suite of software tools is a comprehensive platform for quantitative imaging and is a leading solution for PET kinetic modelling and parametric mapping. (bruker.com)
Armed with new knowledge about how neurodegenerative diseases alter brain structures, increasing numbers of neurologists, psychiatrists and other clinicians are adopting quantitative brain imaging as a tool to measure and help manage cognitive declines in patients. (eurekalert.org)
This quantitative analysis is carried out by using circularly delineated Regions of Interest (ROIs) on the images to calculate the maximum [ 18 F]FDG uptake value. (databasefootball.com)

The centres represents an initial ten-year and more than 800 million SEK investment from The Knut and Alice Wallenberg Foundation (KAW), with a prolongation period for 2025-2028 with further funding of 240 million SEK, to support young scientists from the fields of molecular and translational medicine. (lu.se)

The microdosing study-whether a plasma pharmacokinetics study with a highly sensitive readout or an imaging study with measurement of organ distribution-may supply important information on pharmacology, but the results need to be carefully considered. (snmjournals.org)

Bruker BioSpin has just announced their new Icon 1 Tesla desktop MRI scanner for preclinical (animal) and molecular imaging. (medgadget.com)

The massive use in High Energy Physics of position sensitive gas detectors, of high Z and high density scintillators coupled to Photomultiplier (PMT) and Position Sensitive Photomultipliers (PSPMT), and of solid state detectors has triggered during the last 30 years a series of novel applications in Medical Imaging with ionizing radiation. (videolectures.net)
The National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) invite applications to advance the discovery, preclinical development, and testing of new, rationally based candidate medications to treat mental disorders, drug or alcohol addiction, and the development of novel ligands as tools to further characterize existing or to validate new drug targets. (nih.gov)
This course also introduces the theoretical basis of advanced imaging technologies and their applications in the preclinical and clinical neuropharmacology. (yale.edu)
We offer a modern and robust state-of-the-art imaging MRI system and many years of practical experience in a wide verity of MR-applications. (lu.se)

The Multimodality Molecular Imaging Lab (MMIL) held a farewell party for fellow lab members Aileen Hoehne, Ohad Ilovich, and Andrew Sabour. (stanford.edu)

She has trained over 20 graduate students and postdoctoral fellows who overwhelming stay in the field of molecular imaging. (uab.edu)

Working with high-field magnetic resonance spectrometers, this Section develops novel NMR methods and applies them to the study of neurotransmission and neurometabolism, with significant opportunities available for multi-modal collaborative imaging using MRS, MRI, and PET. (nih.gov)

The vision of LUCC imaging is to serve as a cutting-edge hub that integrates advanced technologies, fosters interdisciplinary collaboration, and facilitates groundbreaking discoveries to advance our understanding of biological processes, diseases, and therapeutic interventions. (lu.se)

Practice parameters for diagnosis and evaluation of dementia, as published by the American Academy of Neurology (AAN), consider structural brain imaging to be optimal. (medscape.com)

Recent advances have improved the ability to characterize imaging markers along the trajectory of Alzheimers disease, starting in the pre-clinical phase. (eurekalert.org)

The findings are critical for the development of new ferumoxytol-based MR imaging techniques with better image quality and less toxicity, researchers said. (stanford.edu)
The development of radiation detectors in the field of nuclear and particle physics has had a terrific impact in medical imaging since this latter discipline took off in late '70 with the invention of the CT scanners. (videolectures.net)
Over the past five years, the company has increasingly focused on its fast-growing molecular imaging business", commented Alex Kleinman, Vice President of Marketing and Business Development for Bioscan. (analytica-world.com)
Preclinical nuclear molecular imaging speeds up the mean time from synthesis to market, in drug development process. (bvsalud.org)

These hybrid systems yield maximum structural and biological information with a single noninvasive imaging study, combining the power of PET and CT. (hopkinsmedicine.org)

enhance the current understanding of imaging, novel methodologies, and emerging imaging devices. (lu.se)

UBM is a noninvasive real-time technique that allows accurate and reliable images of the heart and other organs in mice [ 1 - 3 ]. (hindawi.com)

SPECT8

Biomarkers10

Oncology4

Radiopharmaceuticals4

Biology10

Computed tomography3

Tumors7

Research33

Vivo molecular2

Cellular3

Microscopy2

Mechanisms6

Radionuclides4

Studies18

Tumor8

Radiology3

Centre1

Alzheimer's2

Ultrasound7

Mediso3

Magnetic resonance sp3

Positron5

20212

Vitro1

Photoacoustic2

20231

Radionuclide-therapy1

Orthotopic1

Probes2

Functional1

Nuclear medicine and molecular1

Conjugates2

Suitable4

Modalities1

Medicinal Chemistry1

Quantitative4

Translational Medicine1

Pharmacokinetics1

Tesla1

Applications4

Multimodality1

Field of molecular1

Methods1

Therapeutic interventions1

Practice1

Advances1

Development4

Biological1

Methodologies1

Mice1