Preclinical and clinical study. Medical search. Frequent questions

If successful, this network will accelerate the identification of the most promising cerebroprotective therapies for future pivotal clinical trials and span the gap between small businesses, preclinical testing laboratories, and a pipeline to clinical testing, in a cost-and time-effective fashion. (nih.gov)
However, transitioning from preclinical research to clinical trials in human subjects can be challenging due to differences in biological systems and responses. (alliedacademies.org)
Understanding how a drug is metabolized, distributed, and eliminated from the body can guide dosage regimens and improve the chances of success in clinical trials [ 2 ]. (alliedacademies.org)
This process, known as patient stratification, enables researchers to design more targeted clinical trials, increasing the chances of successful outcomes. (alliedacademies.org)
This knowledge is crucial for optimizing treatment plans and minimizing the risk of adverse reactions.Monitoring Treatment Progress.During clinical trials, biomarkers can be used to monitor treatment progress and evaluate drug efficacy. (alliedacademies.org)
Changes in specific biomarker levels can indicate whether the drug is having the desired effect on the disease.Early Safety Assessment Biomarkers can also aid in early safety assessment, allowing researchers to identify potential safety concerns before they become significant issues in clinical trials [ 3 ]. (alliedacademies.org)
Despite their tremendous potential, the incorporation of biomarkers into drug discovery and clinical trials is not without challenges. (alliedacademies.org)
In addition, the outcomes of clinical trials on many pharmaceutical agents against promising therapeutic targets have been disappointing. (cardiff.ac.uk)
However, nutraceutical research has considerably lagged those on pharmaceuticals on two key aspects, large clinical trials and mechanistic insights. (cardiff.ac.uk)
In turn, the Biomedical Research Foundation (Fundación de Investigación Biomédica) collaborates in research through several transversal support units, including the Clinical Trials Coordination Unit, which is responsible for processing the registration process, providing administrative support in the evaluation of the different research projects, and monitoring the development of authorised clinical studies. (idissc.org)
We evaluated 46 studies including 28 animal works ( n = 567) and 18 human trials ( n = 360). (biomedcentral.com)
In clinical trials, stem cell transplantation reduced the CD activity index (SMD − 2.10, P = 0.000), the CD endoscopic index of severity (SMD − 3.40, P = 0.000) and simplified endoscopy score for CD (SMD − 1.71, P = 0.000) and improved the inflammatory bowel disease questionnaire score (SMD 1.33, P = 0.305) compared to control values. (biomedcentral.com)
Five databases (PubMed, Embase, the Web of Science, the Cochrane Library, and Clinical Trials.gov) were searched from their inception dates to February 2021. (biomedcentral.com)
The current work programme provides essential data on Albert Labs' mycelium-based pharmaceutical products in support of clinical trials due to start later this year. (albertlabs.com)
Immunotherapeutic strategies targeting two proteins, β-amyloid (Aβ) and Tau, are being tested in clinical trials. (journalforclinicalstudies.com)
We believe that there is no other active vaccine platform that can achieve these four key elements and are excited about future clinical trials. (journalforclinicalstudies.com)
Journal For Clinical Studies has a distinguished editorial advisory board providing the best guidelines for global clinical trials. (journalforclinicalstudies.com)
Medication use during pregnancy in the absence of pharmacokinetic and safety data is common, particularly for antiretrovirals, as pregnant women are not usually included in clinical trials leading to drug licensure. (springer.com)
Fetal and infant safety concerns have led to the exclusion of pregnant and lactating women from clinical trials during drug development programs for licensure, unless the drug is intended for a pregnancy-specific condition [ 4 , 5 ]. (springer.com)
Such studies also aim towards mimicking human treatment capabilities so that specific validated radiation therapies in animal models can be successfully translated into patient radiotherapy (RT) trials [ 1 ]. (biomedcentral.com)
We are now exploring the utility of these OCT measures as potential clinical biomarkers and as short- and medium-term endpoints in clinical trials. (ed.ac.uk)
Our Biomedical Research Business Development & Licensing team seeks collaborations in most therapeutic areas and technology classes ( see table below ), from idea-generation and early discovery through clinical proof-of-concept (phase IIa clinical trials). (novartis.com)
Clinical data included interventional studies (N = 2) reporting reduced pain sensitivity, and observational studies (N = 9) describing the association between kratom's chronic (daily/frequent) use and safety issues, in terms of health consequences (e.g., learning impairment, high cholesterol level, dependence/withdrawal).CONCLUSIONS: Although the initial (pre)clinical evidence on kratom's therapeutic potential and its safety profile in humans is encouraging, further validation in large, controlled clinical trials is required. (herts.ac.uk)
The mission of California's Stem Cell Agency (CIRM) is to advance stem cell based science toward clinical trials to create opportunities to bring new effective and curative therapies to patients. (ca.gov)
Several clinical trial experts from the United Kingdom spoke at the CIRM-hosted Staying on the Critical Path Workshop to raise awareness about opportunities for California researchers to collaborate on clinical trials with the U.K. The workshop was held at the 2013 CIRM Grantee Meeting in San Francisco. (ca.gov)
The interim guidance is based on results of an international phase 3 clinical trial sponsored by CDC's Tuberculosis Trials Consortium and conducted in collaboration with the National Institutes of Health-sponsored AIDS Clinical Trials Group. (cdc.gov)
Noise -induced hearing loss and its prevention: integration of data from animal models and human clinical trials. (cdc.gov)
This capability is crucial for preclinical studies and clinical trials, in which continuous observation is essential. (lu.se)

OBJECTIVE: Our study aims to investigate (pre)clinical evidence on the efficacy of kratom as a therapeutic aid and its safety profile in humans. (herts.ac.uk)
Preclinical data indicated a therapeutic value in terms of acute/chronic pain (N = 23), morphine/ethanol withdrawal, and dependence (N = 14), among other medical conditions (N = 26). (herts.ac.uk)
He also added that the overall goal of the clinical studies conducted by Clovis and alkermes is to achieve enhanced therapeutic outcomes in cancer patients that have different types of tumors. (biopharmajournal.com)
Performing these pre-clinical studies for stem cell-based products present added challenges since many represent novel therapeutic approaches that have never been tried in humans. (ca.gov)
In clinical research, imaging is a vital tool for assessing treatment responses, guiding adjustments to therapeutic interventions, and contributing to the development of targeted and personalized therapies. (lu.se)

Biomarkers have emerged as valuable tools in drug discovery, helping to bridge the gap between preclinical and clinical studies by providing crucial information on drug efficacy, safety, and patient response. (alliedacademies.org)
Biomodels, founded in 1997, provides pre-clinical efficacy studies for drug development. (clinicaltrialsarena.com)
In this review, we summarized the principal preclinical and clinical studies involving the use of MC in the most common pediatric tumors, with an overview of efficacy, toxicity, pharmacokinetic profile, and biomarkers. (unipi.it)
The two companies designed the study to evaluate the drug combo's efficacy in anti-tumor activity, as well as the action mechanisms of the combination treatment in a mouse model of colon cancer. (biopharmajournal.com)
clinical studies are now needed to assess safety and efficacy in humans. (cdc.gov)

Imaging plays a pivotal role in both preclinical and clinical research, offering benefits that significantly impact disease understanding and patient care. (lu.se)

This knowledge is critical for designing and testing drug candidates that specifically modulate the target's activity.Moreover, biomarkers can help assess the pharmacokinetics and pharmacodynamics of drug candidates during preclinical studies. (alliedacademies.org)
Even for ARVs commonly used during pregnancy and lactation, data on toxicity, pharmacokinetics (PK), and neonatal exposure during breastfeeding are collected sporadically, mainly through postmarketing surveillance and opportunistic studies of women who become pregnant while receiving ARVs. (springer.com)

The preclinical trial and the observational study report promising results, and the lack of KOA pain relief in patients in the phase 4 trial may be explained by the trial design. (medscape.com)
Methods: In this prospective observational paired crossover study, two investigators of opposite genders independently obtained individually reported. (lu.se)
Methods: In this prospective observational paired crossover study, two investigators of opposite genders independently obtained individually reported pain intensity levels with a visual analogue scale in a mixed cohort of adult postoperative study patients at Skåne University Hospital in Malmö, Sweden. (lu.se)
observational study and literature review. (who.int)

Aix Scientifics ® supports your planning, execution and evaluation of pre-clinical research. (aix-scientifics.eu)
evaluation of the study data and writing the study report. (aix-scientifics.eu)

World-renowned scientists from the University of CESPU Health Sciences Department, Portugal are working in partnership with Albert Labs' expert team to conduct safety and toxicology studies, in preparation for KRN-101's use in Real World Evidence studies. (albertlabs.com)

This data is needed prior to the commencement of Albert Labs' Real World Evidence (RWE) clinical trial with its first product candidate, KRN-101. (albertlabs.com)
This guidance is based on an international phase 3 clinical trial (Study 31/A5349), preclinical/animal evidence, prior clinical trial findings, and pharmacokinetic and pharmacodynamic modeling. (cdc.gov)
In this final contribution, study design considerations for NIHL otoprotection in pre-clinical and clinical testing are integrated and broadly discussed with evidence-based guidance offered where possible, drawing on the contributions to this special issue as well as other existing literature. (cdc.gov)

In preclinical drug discovery, biomarkers play a vital role in target identification and validation. (alliedacademies.org)
[ 63 ] The NIA-AA criteria for diagnosis of dementia due to AD are clinical, with biomarkers in an assisting, nonessential role. (medscape.com)
A study by McMillan et al suggests that MRI may provide a reasonably accurate, noninvasive surrogate for cerebrospinal fluid (CSF) biomarkers, reducing the need for lumbar puncture in discriminating AD from frontotemporal lobar degeneration (FTLD). (medscape.com)
[ 73 , 74 ] In a cross-sectional, longitudinal cohort study of 207 older adults with normal cognition, investigators found a correlation between decay in the DMN, as observed on resting-state functional connectivity MRI (rs-fcMRI), and levels of 2 CSF biomarkers of early AD. (medscape.com)

Clovis Oncology Inc (NASDAQ:CLVS) and Alkermes Plc (NASDAQ:ALKS) recently announced that they observed positive pre-clinical results from a study evaluating ALKS 4230 as a combinational therapy with lucitanib. (biopharmajournal.com)
In addition, the study of rare genetic diseases that increase the risk of malignancy in childhood has led to an understanding of important cancer genes, which has wide applicability to oncology in both children and adults. (medscape.com)

Generally medical device investigations, supported by Aix Scientifics ® , start with animal studies prior to the first application on humans. (aix-scientifics.eu)

The preclinical study suggests that the clinical actions of Uliveto water depend mainly on its ability to enhance gastric motor and secretory functions. (nih.gov)
A study by Chen et al suggests that resting state functional MRI can help classify patients with AD, patients with amnestic mild cognitive impairment (MCI), and cognitively healthy patients. (medscape.com)

In this blog post, Dr Louise Hull, an implementation research lead, discusses the development of a new resource to help improve the reporting of implementation studies. (equator-network.org)
The TRG work with the Joint Research Office to handle clinical trial related work. (ucl.ac.uk)
The purpose of this funding opportunity announcement (FOA) is to invite applications for research projects to test promising cerebrovascular interventions in the NINDS Stroke Preclinical Assessment Network (SPAN). (nih.gov)
On occasion, individuals from other research institutions wish to conduct studies at the University of California, Davis. (ucdavis.edu)
To prove the impact on human health of Human Milk Oligosaccharides (HMOs), we lead a rich program of preclinical and clinical studies with more than 40 research and strategic partners across the world. (dsm.com)
Preclinical imaging is the visualization of living animals for research purposes, such as drug development. (wikipedia.org)
Albert Labs International Corp. (CSE: ABRT) (FSE: VB50) (the "Company"), a research and drug development company using advanced culture technology to create pharmaceutical quality medicines, based on the mycelia of Psilocybe, today released further details of their ongoing preclinical studies. (albertlabs.com)
Albert Labs is a clinical research and drug development enterprise, and its team of experts leverage advanced culture and extraction technologies to accelerate the development of effective mental health medicines. (albertlabs.com)
From March 2021 we are part of the newly established clinical academic group (CAG) for multiple myeloma research in Central Norway and we also collaborate closely with the Nordic Myeloma Study Group. (ntnu.edu)
Pre-clinical studies are however necessary to validate the best skin regeneration technique, which could be used in pediatric surgical translational research. (biomedcentral.com)
The two companies also presented the findings from their clinical trial to the American Association for Cancer Research (AACR) through the annual meeting held virtually this year on June 22. (biopharmajournal.com)
In clinical research studies, atrophy of the hippocampi (structures important in mediating memory processes) on coronal MRI is considered a valid biomarker of AD neuropathology. (medscape.com)

We try to ensure a continuous and appropriate harvesting of knowledge from in-vitro experiments, over the in-vivo to the clinical studies. (aix-scientifics.eu)
The partnership established between Albert Labs and CESPU, provides Albert Labs with preclinical drug assessment capabilities, both in vivo and in vitro. (albertlabs.com)
An integrated approach of in vitro, ex vivo, in silico and in vivo studies is key to enable acceleration of availability of pharmacology data in pregnancy and lactation. (springer.com)
therefore, WS serves as a model for studying the aging process in vivo and in vitro. (medscape.com)

Joy Cavagnaro and Keith Wells led the question and answer session for the CIRM-hosted Staying of the Critical Path Workshop which addressed the preclinical, manufacturing and regulatory issues for developing stem cell based therapy products for patients. (ca.gov)
The purpose of this Funding Opportunity Announcement (FOA) is to support translation of advanced HIV-1 vaccine candidates from pre-clinical studies through different phases of process and product development, Current Good Manufacturing Practice (CGMP) manufacturing and regulatory filing to the point of clinical testing. (cdc.gov)

One of the major challenges in drug discovery is translating promising preclinical results into successful clinical outcomes. (alliedacademies.org)
Several studies have evaluated the safety and effectiveness of CD stem cell therapy, but the results remain controversial. (biomedcentral.com)
RESULTS: Both preclinical (N = 57) and clinical (N = 18) studies emerged from our search. (herts.ac.uk)
Results: In total, 245 (129 female) study patients were included and then one female excluded. (lu.se)
Results of a 2010 study on mice suggest that vitamin C supplementation could be beneficial for patients with WS. (medscape.com)
[ 9 ] Preclinical results suggest that everolimus may eventually prove to be of clinical benefit. (medscape.com)

Traditionally, drug discovery has relied heavily on preclinical studies, which involve testing potential drug candidates in laboratory settings and animal models. (alliedacademies.org)

In this review, we summarize the different strategies for the treatment and study of molecular mechanisms of AMR in the ESKAPE pathogens based on the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated (Cas) proteins' technologies: loss of plasmid or cellular viability, random mutation or gene deletion as well directed mutations that lead to a gene's loss of function. (preprints.org)
The pre-clinical study's findings indicate that there was a clear gene expression profile courtesy of the anti-tumor activity as a result of treatment with the mALKS 4230 and lucitanib combination. (biopharmajournal.com)
In young adults, mutation in the Werner syndrome (WS) gene is believed to be associated with clinical symptoms typically found in elderly individuals. (medscape.com)

Owing to the restricted sample size , this pilot study lacks conclusive findings. (bvsalud.org)
Dr. Hopkinson pointed out that the clinical data's compelling trial findings support further exploration of the combination treatment. (biopharmajournal.com)
The article, " Four-Month Rifapentine Regimens with or without Moxifloxacin for Tuberculosis ," published in the New England Journal of Medicine (NEJM) , details findings from Study 31/A5349 - an international, randomized, controlled, open-label, phase 3 noninferiority clinical trial. (cdc.gov)
Conclusions: Main findings of lower pain intensity reported by males to a female than to a male investigator early after surgery in this paired crossover study in mixed postoperative patients, indicate that potential impact of investigator gender on pain perception should be considered and further evaluated in clinical bedside practice. (lu.se)

With this contract, ATCC, as a member in the NIAID selected service provider pool, will support NIAID's Preclinical Services for Biopharmaceutical Product Development in two main areas: the development and validation of analytical assays for product characterization and process development and formulation. (atcc.org)
ATCC's assistance with analytical assay development for product characterization and process development and formulation will be part of the suite of services included in the contract commonly associated with the preclinical development of biopharmaceutical products. (atcc.org)
As a tool to reinforce or modify behaviour by focusing on actual performance (compared with the intended performance level), feedback is central to support cognitive and professional development, especially in the early stages of the clinical curriculum. (scirp.org)
Preclinical studies such as these are a crucial step for any drug development cycle and through this collaboration, we have been able to bring this capability and value in-house. (albertlabs.com)
A phase I, dose-escalation trial of quercetin defined the maximum tolerated dose (MTD) as 1700 mg/m2 three weekly, but the vehicle, dimethyl sulphoxide (DMSO) is unsuitable for further clinical development of quercetin. (ox.ac.uk)

A comprehensive, single source for clinical pathology laboratory services. (idexxbioanalytics.eu)
All preclinical work is conducted under Good Laboratory Practice ("GLP") guidelines and, through the OECD's Mutual Acceptance of Data scheme, will be accepted by leading health regulators such as the FDA and EMA. (albertlabs.com)
For in vivo studies we use different models: xenograft models using myeloma cell lines, a syngeneic mouse model established in the Chesi/Bergsagel lab at the Mayo Clinic in Arizona, US, or a human-mouse scaffold model developed in the laboratory of Anton Martens, the Netherlands. (ntnu.edu)
[ 6 ] Also see Laboratory Studies . (medscape.com)

Commonly used clinical and preclinical methods to detect BBB permeability are described as are animal models used to study BBB breakdown. (cdc.gov)
However, the acute traumatic injury models commonly used in pre-clinical testing are fundamentally different from the chronic and repeated exposures experienced by many human populations. (cdc.gov)
One of the commonly cancer patients who insisted upon using camel urine, to used forms of complementary and alternative medicine establish exactly how they administered the urine and is camel urine alone or in combination with camel whether there were any clinical benefits or harm. (who.int)

However, further studies are needed to investigate the contribution of conversion and Auger electrons in more detail. (frontiersin.org)
The clinical programme will investigate the potential to treat cancer-related distress, an indication thought to affect approximately 15 million patients worldwide. (albertlabs.com)
To investigate the feasibility of using dual-energy CT (DECT) for tissue segmentation and kilovolt (kV) dose calculations in pre-clinical studies and assess potential dose calculation accuracy gain. (biomedcentral.com)
The aim of this study is to investigate the feasibility of using dual-energy CBCT for tissue segmentation and kV dose calculations in pre-clinical studies. (biomedcentral.com)
This study aims to investigate different treatments on new bone formation around immediate implants in the canine posterior mandible with varying sized mesial-distal gap. (bvsalud.org)
The aim of this pre-clinical study was to investigate the effects of intradermal injections of MSC in experimental cutaneous wound repair comparing allogeneic and autologous adipose stem cells (ASCs) and autologous bone marrow-mesenchymal stromal cells (BM-MSCs). (biomedcentral.com)

We are world leaders in pre-clinical models relating to the side effects of chemotherapy and radiation treatments. (clinicaltrialsarena.com)
In this study, we observed and followed up our chemotherapy and radiotherapy ( 1 ). (who.int)

These services, provided by NIAID, help scientific investigators from academia and the private sector obtain the critical data needed to acquire additional funding, gain prospective partnerships, fulfill regulatory requirements, and complete studies needed to apply for an Investigational New Drug (IND) and enter a Phase I trial. (atcc.org)
GESTIÓN EN SALUD PÚBLICA: Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. (blogspot.com)
Preclinical studies and prospective clinical applications for bacteria-targeted imaging: the future is bright. (blogspot.com)

SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent models of transient middle cerebral artery occlusion (tMCAo), with clinically relevant long-term outcomes and in models with common stroke comorbidities (i.e., aging, hypertension, diabetes, hyperlipidemia, obesity, etc. (nih.gov)
In population-based studies utilising high-fidelity linked healthcare data unique to Scotland, we are investigating temporal trends in the incidence and outcomes of cardiovascular disease, including rates of secondary prevention prescribing, in patients with kidney failure. (ed.ac.uk)
Does CDC have data on long-term outcomes for patients enrolled in the clinical trial? (cdc.gov)

Dr. Anahit Ghochikyan, Associate Professor at IMM and one of the lead authors of this study added, "Our transgenic mice data suggest that vaccination with AV-1980R/A may prevent/slow aggregation of Tau and delay manifestation of AD. (journalforclinicalstudies.com)
To date, data are typically generated through opportunistic pregnancy studies performed in the postmarketing setting, leading to a substantial time-lag between initial regulatory approval of a drug and availability of essential pregnancy-specific pharmacokinetic and safety data. (springer.com)
Some preclinical data have shown some anticancer calculated using the statistical formula n = Z2 P(1-P)/ properties of camel urine but it has not been investigated d2, where Z was the statistic corresponding to level of clinically ( 5 - 7 ). (who.int)

ATCC provides clinical and epidemiological study support including collection supplies, sample receipt and storage, biospecimen processing, and distribution. (atcc.org)
Epidemiological studies have noted the effects of cancer genetics, defined family pedigrees and penetrance, and identified subsets of certain cancers and their implications for treatment and prognosis. (medscape.com)

These studies and earlier work has led to the detailed description of many metabolic and regulatory networks in fermentation of milk. (health-ground.com)

CLINICAL RELEVANCE The use of deproteinized bovine bone in conjunction with collagen is a common practice in immediate implantation procedures in the posterior mandible . (bvsalud.org)
The overarching aim of our work is to generate basic knowledge about the interdependent way cells within a tumor relate to each other, as well as produce information that will be immediately useful for the design of clinical practice. (lu.se)

The clinical trial was recognized as one of the NEJM's 2021 Notable Articles . (cdc.gov)
Garvey was lead investigator in the STEP 5 trial of semaglutide and lead author of the American Association of Clinical Endocrinologists 2016 Obesity Management guidelines . (medscape.com)

The SYRCLE risk of bias tool and the MINORS tool were used to assess study quality. (biomedcentral.com)

[ 1 ] The heterogeneity of pediatric cancer is substantial, and even the most common pediatric cancer (ie, acute lymphoblastic leukemia [ALL] ) is characterized by biological and clinical diversity. (medscape.com)
Objectives of this study were to test the hypotheses that pain intensity levels early after acute or scheduled in- or out-hospital surgery are lower when evaluated by a female investigator, and higher when reported by a female patient. (lu.se)

facilitate greater collaboration between preclinical and clinical imaging experts. (lu.se)

Combining treatments with complementary mechanisms may offer synergistic clinical benefit and expand treatment options for a broader set of patient populations," stated Alkermes' Chief Medical Officer, Craig Hopkinson. (biopharmajournal.com)
Both animal models and clinical populations were discussed in this special issue, followed by discussion of individual variation in vulnerability to NIHL. (cdc.gov)

Preclinical experiments were carried out on rats, allowed to drink Uliveto or oligomineral water for 30 days. (nih.gov)

Detailed instructions on how to collect and ship Biochemistry & Haematology Samples for Clinical species. (idexxbioanalytics.eu)

Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. (wikipedia.org)
In the animal studies, the disease activity index dramatically decreased in the mesenchymal stem cell (MSC) treatment groups compared to the control group. (biomedcentral.com)
In this study, we assessed the status of OS in the brain of type 1 and type 2 diabetic animal models. (nature.com)
Pre-clinical radiation studies with small animal models play a significant role in the understanding of cancer radiobiology. (biomedcentral.com)
A number of compounds have yielded benefit in pre-clinical (animal) models. (cdc.gov)

Atherosclerosis is a chronic inflammatory disease of medium and large arteries that can cause clinical complications such as myocardial infarction and cerebrovascular accidents. (cardiff.ac.uk)

The close collaboration with the Department of Hematology at St. Olavs combined with the relevant pre-clinical models is key in our search for new treatment targets. (ntnu.edu)
It is a necessary source of information in the search for primary studies of AL&C for systematic reviews, and it is recommended by Cochrane Collaboration in the Cochrane Handbook. (bvsalud.org)

2) the effects of Uliveto on preclinical models of gastric functions. (nih.gov)

Novel approaches should be applied in pharmacology studies in pregnant and lactating women. (springer.com)

To our knowledge, this is the first study showing a direct molecular association between OS and diabetes-related cognitive decline. (nature.com)
The usability of cytological and molecular tests in pre-clinical diagnostics of non-invasive urothelial carcinoma. (nucleix.com)

To get the most out of this modified assessment, it should be implemented early in the clinical curriculum. (scirp.org)
Work-based assessment (WBA) is potentially the best way of assessing professional competence as it encompasses requisite attributes including communication, clinical reasoning, judgement, emotions, values and reflection (Govaerts & van der Vleuten, 2013) , which theoretical or paper-based assessment might not. (scirp.org)

Importantly, the cellular networks within tumors cannot be studied in isolation. (lu.se)

Prior presentation: Portions of this study were presented at the 2021 American Society of Hematology Annual Meeting and Exposition. (aacrjournals.org)

Using PET/MRI imaging, our pre-clinical study will measure for the first time changes in blood flow, metabolism, structural integrity, and waste removal in the brain as a result of habitual exercise across lifetime. (healthylongevitychallenge.org)
Imaging studies are particularly important for ruling out potentially treatable causes of progressive cognitive decline, such as chronic subdural hematoma or normal-pressure hydrocephalus. (medscape.com)

We are studying the effects of apelin on systemic and renal haemodynamics and endothelial function in healthy volunteers and in patients with CKD. (ed.ac.uk)
Our studies will determine whether apelin could provide additional renoprotective and cardioprotective effects in optimally managed patients with CKD. (ed.ac.uk)
Pediatric patients are treated in cohorts of 3 starting at a dose that is either 75% the adult dose or 10% the lethal dose in mouse studies. (medscape.com)
Pain intensity levels did not differ between female and male study patients (P = 0.210). (lu.se)
Camel urine had no clinical benefits for any of the cancer patients, it may even have caused zoonotic infection. (who.int)

3 Clinical Division of Hematology and Hemostaseology, Department of Medicine I, and Comprehensive Cancer Center, Vienna General Hospital - Medical University of Vienna, Vienna, Austria. (aacrjournals.org)

Adult progeria is usually diagnosed on the basis of characteristic clinical features and typical concomitant diseases. (medscape.com)

Within the limitation, this study demonstrated that although DBBM significantly increase BMD and BVF, the use of DBBM/CM didn't significantly improve bone formation and healing in extraction sockets around the implants in both moderate and large mesial-distal gap. (bvsalud.org)
Scores for pre-clinical students were also significantly higher than those of students in clinical years. (who.int)

No other pre-clinical studies have achieved such levels of effective antibody titers. (journalforclinicalstudies.com)

Anatomy8

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Chemicals and Drugs47

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