Prdm16 adipose tissue white. Medical search. Frequent questions

Notoginsenosides can treat obesity by reducing lipid synthesis, inhibiting adipogenesis, promoting white adipose tissue browning, increasing energy consumption, and improving insulin sensitivity. (frontiersin.org)
PRDM16 stimulates brown adipogenesis by binding to PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) and activating its transcriptional function. (bioseek.eu)
Taken together, these data indicate that PRDM16 specifies the brown fat lineage from a progenitor that expresses myoblast markers and is not involved in white adipogenesis. (bioseek.eu)
Adipose tissue abundance relies partly on the factors that regulate adipogenesis, i.e. proliferation and differentiation of adipocytes. (biomedcentral.com)
The expression of 10 adipogenesis-regulated miRNAs were studied using real-time qPCR and then we selected 5 miRNAs, that showed robust expression, were profiled in subcutaneous adipose tissue obtained from 20 humans with a range of body mass indices (BMI, range = 21-48, and all samples have U133+2 Affymetrix profiles provided). (biomedcentral.com)
In conclusion, we provide a preliminary analysis of miRNAs associated with primary cell in vitro adipogenesis and demonstrate that the inflammation-associated miRNA, mir-21 is up-regulated in subcutaneous adipose tissue in human obesity. (biomedcentral.com)
MED19 Regulates Adipogenesis and Maintenance of White Adipose Tissue Mass by Mediating PPARg-Dependent Gene Expression. (lodhilab.org)

Here, by conducting transcriptomic profiling at the single-cell and single-nucleus resolution, we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue (iWAT) at thermoneutrality or chronic cold condition. (bvsalud.org)
Thus it appears that the loss of the beige fat destroys the protective abilities of subcutaneous white fat - at least in mice. (drsharma.ca)

It functions in the differentiation between white and brown adipose tissue. (wikipedia.org)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
The protein expression levels of adipocyte differentiation markers PPARγ and C/EBPα in the back and abdominal adipose tissues were lower in dead piglets compared to live piglets. (biomedcentral.com)
The fat deposition and adipocyte differentiation in the dead piglets are insufficient compared to the surviving piglets, which may attenuate the thermogenic ability of white adipose tissue (WAT). (biomedcentral.com)
Loss of PRDM16 from brown fat precursors causes a loss of brown fat characteristics and promotes muscle differentiation. (bioseek.eu)
Conversely, ectopic expression of PRDM16 in myoblasts induces their differentiation into brown fat cells. (bioseek.eu)
The manipulation of fat stores is an obvious therapeutic dream, but disruption of the normal differentiation or development of white adipose tissues (WAT) causes ectopic lipid storage and severe pathology (lipodystrophy) in both humans and experimental animals. (bioseek.eu)
Thus, as an alternative, we produced EXIQON microarray of brown and white primary murine adipocytes (prior to and following differentiation) to yield global profiles of miRNAs. (biomedcentral.com)
Understanding the regulation of the pathways that lead to proliferation and differentiation of white and brown pre-adipocytes could be crucial for revealing the underlying mechanisms of obesity. (biomedcentral.com)
Here we show that the brown adipose differentiation gene, EBF2, activates differentiation-associated signals in the cancer progenitor cells in culture and CSC transplantation models. (amegroups.org)

Furthermore, brown fat programming of mesenchymal stem cells by PRDM-BF1-RIZ1 homologous domain containing 16 (Prdm16), was associated with a dramatic reduction of p107 levels. (mitophysiology.org)
We also demonstrate that the transcriptional regulator PRDM16 (PRD1-BF1-RIZ1 homologous domain containing 16) controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells. (bioseek.eu)

Since skin-embedded adipocytes may provide natural insulation, they provide an important counterpoint to the activation of thermogenic brown and beige adipose tissues, whereby these distinct depots are functionally interrelated and require simultaneous assay. (jci.org)
The prevailing dogma is that thermogenic brown adipose tissue (BAT) contributes to improvements in glucose homeostasis in obesogenic animal models, though much of the evidence supporting this premise is from thermostressed rodents. (diabetesjournals.org)

All major nonimmune cells within the iWAT, including adipose stem and progenitor cells (ASPCs), mature adipocytes, endothelial cells, Schwann cells, and smooth muscle cells, were recovered, allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown remodeling. (bvsalud.org)
In addition to the classic brown adipocytes, a different type of brown fat cells seems to exist in tissues where WAT predominates. (biomedcentral.com)

Due to the absence of brown adipose tissue (BAT), the patterns of thermogenesis of newborn piglets mainly include the shivering thermogenesis and white adipose tissue (WAT) browning. (biomedcentral.com)
Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis. (lodhilab.org)
Lentiviral injection of Fgf11 shRNA into the arcuate nucleus of the mouse hypothalamus decreased weight gain and fat mass, increased brown adipose tissue thermogenesis, and improved glucose and insulin intolerances under high-fat diet conditions. (biomedcentral.com)
Adipocyte-specific FGF21, which is endocrine FGF subfamily, knockout mice exhibit the inhibition of white adipose tissue browning in adaptive thermogenesis, and central infusion of FGF21 in obese rats increases insulin-induced suppression of hepatic glucose production and gluconeogenic expression, which in turn increases energy expenditure and insulin sensitivity. (biomedcentral.com)

Although this lipid layer has been frequently grouped together with s.c. white adipose tissue (sWAT), it is now recognized as a distinct depot that responds to different stimuli. (jci.org)
Most of the lipid reserves in the human body are stored in white adipose tissue (WAT) that predominates in adult humans. (biomedcentral.com)
Problems arise when white fat cells store too much lipid. (drsharma.ca)

p107 is strictly expressed in the stem cell compartment of white adipose tissue depots and completely absent in brown adipose tissue. (mitophysiology.org)
In fact, it seems that most the brown fat in humans is actually beige - these seem to be cells recruited from white fat depots that transform themselves into "brownish" cells with certain stimuli (e.g. cold exposure, physical exercise). (drsharma.ca)

PRDM16 binds to DNA and acts as a transcriptional regulator. (wikipedia.org)

Brown adipose tissue (BAT), despite its ability to accumulate lipids, has a role not in storing but in converting fat into heat. (biomedcentral.com)
Isolation and Mass Spectrometry-Based Profiling of Major Lipids in Brown Adipose Tissue. (lodhilab.org)
Healthy white fat protects the body by providing a 'safe home' for lipids, which can be toxic to other tissues such as muscle or the liver. (drsharma.ca)
The problem is that the macrophages cannot clear up the lipids fast enough, and so they begin to spill over into other tissues, such as the liver and pancreas. (drsharma.ca)

The epidemic of obesity, closely associated with increases in diabetes, hypertension, hyperlipidemia, cancer and other disorders, has propelled a major interest in adipose cells and tissues. (bioseek.eu)
Ectopic obesity is defined as the accumulation of triglycerides in non-adipose tissues [6]. (heraldopenaccess.us)
Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity. (met-vasc.com)
These folks end up depositing their excess fat in those other tissues (e.g. liver, pancreas, muscle, etc), thereby causing exactly the same metabolic problems that are commonly associated with obesity. (drsharma.ca)
The article quotes work by Bruce Spiegelman showing that selectively disabling beige fat in mice by targeting the protein PRDM16, which is found only in these cells, leaving the white and brown fat intact leads to animals with severe metabolic dysfunction - obesity, insulin resistance and fatty livers. (drsharma.ca)

These findings demonstrate that p107 expression in stem cells commits cells to the white versus brown adipose lineage. (mitophysiology.org)
Here we show by in vivo fate mapping that brown, but not white, fat cells arise from precursors that express Myf5, a gene previously thought to be expressed only in the myogenic lineage. (bioseek.eu)
adipose-like lineage is associated with preferential expression of PI3K-p110α. (amegroups.org)

Cancer stem cells (CSCs) and poorly differentiated progenitor cells in pancreatic ductal adenocarcinoma (PDAC) exacerbate hierarchical tissue organization contributing to cell hyperproliferation and therapy resistance. (amegroups.org)

Notably, the sustained expression of p107 blocked the ability of Prdm16 to induce brown fat genes. (mitophysiology.org)

Blood pressure, pulse wave velocity (PWV) and arterial collagen deposition were lower in D-FIN, associated to an improvement in endothelial function due to a reduction in pro-contractile prostaglandins, as well as reactive oxygen species (ROS) and inflammatory cytokines (IL-1, IL-6, TNFα and TGFβ) in perivascular and perirenal adipose tissue (PVAT and PRAT, respectively). (met-vasc.com)

The brain integrates metabolic signals from peripheral tissues such as the liver, pancreas, adipose tissue, gut and muscle. (nature.com)

Avian species do not have brown adipose tissue (BAT), and lack Uncoupling Protein 1 ( UCP1 ) [ 12 ]. (biomedcentral.com)
Electron transport chain (ETC), oxidative phosphorylation, and UCP1 proteins were measured in the interscapular BAT (iBAT) and thoracic perivascular adipose tissue (tPVAT) as well as inflammatory and oxidative parameters. (met-vasc.com)

Finally, Prdm16-deficient brown fat displays an abnormal morphology, reduced thermogenic gene expression and elevated expression of muscle-specific genes. (bioseek.eu)

The brain modulates various aspects of metabolism, such as food intake, energy expenditure, insulin secretion, hepatic glucose production and glucose/fatty acid metabolism in adipose tissue and skeletal muscle. (nature.com)

This hypoxia attracts the protein HIF-1α, which in fat tissue stimulates the extracellular matrix surrounding the cells, leading to fibrosis. (drsharma.ca)

PRDM16 controls a brown fat/skeletal muscle switch. (bioseek.eu)

The intake of fructose in majority of the Hif-p4h-2 gt/gt tissues, including the liver, was 15-35% less than in the WT. (springer.com)

Promotion of increased BAT development in humans, however, offers the possibility of increasing energy expenditure without necessarily causing dysfunction in other tissues. (bioseek.eu)

On both diets, the Hif-p4h-2 gt/gt mice gained less weight and had less white adipose tissue (WAT) and its inflammation, lower serum cholesterol levels, and lighter livers with less steatosis and lower serum ALT levels than the wild type (WT). (springer.com)
Inflammation is the host's protective response against harmful external stimulation that helps tissue repair and remodeling. (bvsalud.org)

Particularly in patients with open fractures, the risk of osteomyelitis is greatly increased as the soft tissue damage and bacterial infection are often more severe. (bvsalud.org)

Until quite recently, brown adipose tissue (BAT) was thought to be of metabolic importance only in smaller mammals and infant humans. (bioseek.eu)
Although, the predominant form of fat tissue in humans is white fat (which, is in fact yellow), we also have other types of fat cells that are either brown or beige. (drsharma.ca)

Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. (unipv.it)

Adipose tissues contain two distinct types of fat cells, white and brown. (bioseek.eu)

Thus, white fat actually plays an important role in protecting us from metabolic disease. (drsharma.ca)

There are two types of fat cells: white fat cells and brown fat cells. (todoslifestyle.com)
While the primary function of white fat cells is to store fat, brown(ish) fat cells specialize in burning it. (drsharma.ca)
This may lead us to believe that brown fat cells are the "good guys" whereas white fat cells are the "bad guys" but this could not be further from the truth. (drsharma.ca)
This is most evident in people who genetically (or in the case of anti-retroviral treatment) lack sufficient white fat cells. (drsharma.ca)

Our data reveal fundamental changes during cold-evoked adipose browning. (bvsalud.org)

Brown fat (adipose) is a metabolically active tissue that dissipates energy as heat rather than storing it as fat. (advancedmolecularlabs.com)
Yes, you understood correctly -- while white fat stores energy, brown fat burns energy! (todoslifestyle.com)
Adipose tissue is not only a main site of energy storage but also an important endocrine organ. (biomedcentral.com)

Dermal white adipose tissue (dWAT) was recently recognized for its potential to modify whole body metabolism. (jci.org)
The body has two forms of fat: white fat, or unwanted fat that can lie directly underneath the skin, and brown fat, which often is found in the shoulder blade region or the neck. (advancedmolecularlabs.com)
The body has two forms of fat - WHITE FAT and BROWN FAT. (advancedmolecularlabs.com)

Histological assessment and measurement of ovarian anti-Mullerian hormone (AMH) were done to assess the degree of tissue damage and the remaining ovarian reserve. (cjphysiology.org)

Indeed, Prdm16 directly suppressed p107 transcription via promoter binding. (mitophysiology.org)

It is expected that liquid biopsy will allow non-invasive examination of cancer, and will be particularly significant for deep tissue lesions which it is difficult to obtain in the clinic. (ijbs.com)

Anatomy33

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